Pgrmc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pgrmc1
Entrez Gene ID	291948
Full Name	progesterone receptor membrane component 1
Synonyms	25-Dx,25Dx,MPR,VEMA
General protein information	Preferred Names progesterone receptor membrane component 1 Names membrane-associated progesterone receptor component 1 acidic 25 kDa protein membrane-bound progesterone receptor ventral midline antigen
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq35
Summary	may be involved in regulation of axon guidance in the central nervous system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021766.1	NP_068534.1	membrane-associated progesterone receptor component 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PGRMC1	NP_006658.1
	PGRMC1	XP_002806413.1
Bos taurus (cattle)	PGRMC1	NP_001068601.1
Mus musculus (house mouse)	Pgrmc1	NP_058063.2
Gallus gallus (chicken)	PGRMC1	NP_001258868.1
Eremothecium gossypii	AGOS_AAL106W	NP_982436.1
Magnaporthe oryzae (rice blast fungus)	MGG_00274	XP_003718823.1
Neurospora crassa	NCU07286	XP_962140.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000767	XP_311303.4
Schizosaccharomyces pombe (fission yeast)	dap1	NP_594461.1
Rattus norvegicus (Norway rat)	Pgrmc1	NP_068534.1
Saccharomyces cerevisiae (baker's yeast)	DAP1	NP_015155.1
Kluyveromyces lactis	KLLA0C09757g	XP_452633.1
Caenorhabditis elegans (roundworm)	vem-1	NP_001024769.1
Xenopus tropicalis (tropical clawed frog)	pgrmc1	NP_001006842.1
Canis lupus familiaris (dog)	PGRMC1	NP_001182077.1
Danio rerio (zebrafish)	pgrmc1	NP_001007393.1
Drosophila melanogaster (fruit fly)	MSBP	NP_001162765.1

Gene Ontology
Bibliography

Related articles in PubMed

The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells.
Zeng C, Garg N, Mach RH
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging18(2)172-9(2016 Apr)

Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells.
Peluso JJ, Griffin D, Liu X, Horne M
Biology of reproduction91(5)104(2014 Nov)

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.
Izzo NJ, Staniszewski A, To L, Fa M, Teich AF, Saeed F, Wostein H, Walko T 3rd, Vaswani A, Wardius M, Syed Z, Ravenscroft J, Mozzoni K, Silky C, Rehak C, Yurko R, Finn P, Look G, Rishton G, Safferstein H, Miller M, Johanson C, Stopa E, Windisch M, Hutter-Paier B, Shamloo M, Arancio O, LeVine H 3rd, Catalano SM
PloS one9(11)e111898(2014)

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.
Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H 3rd, Spires-Jones TL, Catalano SM
PloS one9(11)e111899(2014)

Progesterone antagonism of neurite outgrowth depends on microglial activation via Pgrmc1/S2R.
Bali N, Arimoto JM, Morgan TE, Finch CE
Endocrinology154(7)2468-80(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The PGRMC1 expression level correlates with the binding activity of SW120 in rat brain cells.
Title: The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells.

PGRMC1 and PGRMC2 are involved in regulating entry into the G1 stage of the cell cycle.
Title: Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells.

Knockdown by siRNA-Pgrmc1 in microglia before add-back to astrocyte-neuron cocultures suppressed the P4-E2 antagonism of neurite outgrowth
Title: Progesterone antagonism of neurite outgrowth depends on microglial activation via Pgrmc1/S2R.

After brain injury, mPRalpha expression was induced in oligodendrocytes, astrocytes and reactive microglia. This points to a role in mediating modulatory effects of progesterone in inflammation, ion and water homeostasis and myelin repair in the injured brain
Title: Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury.

These studies support the concept that the interaction between PAIRBP1-PGRMC1 is an essential component of the mechanism through which progesterone inhibits apoptosis.
Title: Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells.

The following Pgrmc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pgrmc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05208	NM_021766.1 Latest version!	Rattus norvegicus progesterone receptor membrane component 1 (Pgrmc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pgrmc1 ( NM_021766.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068534.1 Rattus norvegicus progesterone receptor membrane component 1 (Pgrmc1), mRNA.

Price & Availability↑

CloneID	ORa05208
Clone ID Related Accession (Same CDS sequence)	NM_021766.1
Accession Version	NM_021766.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	membrane-associated progesterone receptor component 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U63315.1. On Jan 12, 2005 this sequence version replaced XM_212843.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U63315.1, BC062073.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCCG AGGATGTGGT GGCGACTGGC GCCGACCCCA GCGAGCTGGA GGGCGGCGGG 
CTGCTTCAAG AGATTTTCAC GTCGCCTCTC AACCTGCTGC TCCTTGGCCT CTGCATCTTC 
CTGCTCTACA AGATCGTTCG CGGGGACCAG CCCGGTGCCA GTGGGGACAA CGACGACGAC 
GAGCCGCCCC CGCTGCCTCG CCTCAAGCCG CGTGACTTCA CCCCTGCCGA ACTAAGGCGA 
TACGATGGAG TCCAGGACCC GCGCATTCTT ATGGCCATCA ACGGCAAGGT GTTCGACGTG 
ACCAAAGGCC GCAAGTTCTA TGGGCCGGAG GGACCATACG GGGTCTTTGC TGGAAGAGAT 
GCATCCAGGG GCCTTGCCAC ATTTTGCCTG GACAAAGAAG CACTGAAGGA TGAGTATGAT 
GACCTTTCTG ACCTCACTCC TGCCCAGCAG GAGACCCTGA ATGACTGGGA CTCTCAGTTC 
AGTTCACCTT CAAGTACCAT CACGTGGGGA AAACTGCTTG AAGGAGCGGA GGAGCCGATT 
GTGTACTCGG ATGATGAAGA ACAAAAGATG AGGCTGCTCG GAAGAGTGAC TGAAGCAGTC 
AGTGGAGCAT ATCTATTTTT GTATTTTGCA AAATCATTTG TAACATTCCA GTCTGTCTTT 
ACAACATGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068534.1
CDS	98..769
Translation	MAAEDVVATGADPSELEGGGLLQEIFTSPLNLLLLGLCIFLLYKIVRGDQPGASGDNDDDEPPPLPRLKPRDFTPAELRRYDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLNDWDSQFSSPSSTITWGKLLEGAEEPIVYSDDEEQKMRLLGRVTEAVSGAYLFLYFAKSFVTFQSVFTTW

Target ORF information:

RefSeq Version	NM_021766.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus progesterone receptor membrane component 1 (Pgrmc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021766.1

ORF Insert Sequence:

ATGGCTGCCG AGGATGTGGT GGCGACTGGC GCCGACCCCA GCGAGCTGGA GGGCGGCGGG 
CTGCTTCAAG AGATTTTCAC GTCGCCTCTC AACCTGCTGC TCCTTGGCCT CTGCATCTTC 
CTGCTCTACA AGATCGTTCG CGGGGACCAG CCCGGTGCCA GTGGGGACAA CGACGACGAC 
GAGCCGCCCC CGCTGCCTCG CCTCAAGCCG CGTGACTTCA CCCCTGCCGA ACTAAGGCGA 
TACGATGGAG TCCAGGACCC GCGCATTCTT ATGGCCATCA ACGGCAAGGT GTTCGACGTG 
ACCAAAGGCC GCAAGTTCTA TGGGCCGGAG GGACCATACG GGGTCTTTGC TGGAAGAGAT 
GCATCCAGGG GCCTTGCCAC ATTTTGCCTG GACAAAGAAG CACTGAAGGA TGAGTATGAT 
GACCTTTCTG ACCTCACTCC TGCCCAGCAG GAGACCCTGA ATGACTGGGA CTCTCAGTTC 
AGTTCACCTT CAAGTACCAT CACGTGGGGA AAACTGCTTG AAGGAGCGGA GGAGCCGATT 
GTGTACTCGG ATGATGAAGA ACAAAAGATG AGGCTGCTCG GAAGAGTGAC TGAAGCAGTC 
AGTGGAGCAT ATCTATTTTT GTATTTTGCA AAATCATTTG TAACATTCCA GTCTGTCTTT 
ACAACATGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging18(2)172-9(2016 Apr)
Zeng C,Garg N,Mach RH

Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells.
Biology of reproduction91(5)104(2014 Nov)
Peluso JJ,Griffin D,Liu X,Horne M

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.
PloS one9(11)e111898(2014)
Izzo NJ,Staniszewski A,To L,Fa M,Teich AF,Saeed F,Wostein H,Walko T 3rd,Vaswani A,Wardius M,Syed Z,Ravenscroft J,Mozzoni K,Silky C,Rehak C,Yurko R,Finn P,Look G,Rishton G,Safferstein H,Miller M,Johanson C,Stopa E,Windisch M,Hutter-Paier B,Shamloo M,Arancio O,LeVine H 3rd,Catalano SM

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.
PloS one9(11)e111899(2014)
Izzo NJ,Xu J,Zeng C,Kirk MJ,Mozzoni K,Silky C,Rehak C,Yurko R,Look G,Rishton G,Safferstein H,Cruchaga C,Goate A,Cahill MA,Arancio O,Mach RH,Craven R,Head E,LeVine H 3rd,Spires-Jones TL,Catalano SM

Progesterone antagonism of neurite outgrowth depends on microglial activation via Pgrmc1/S2R.
Endocrinology154(7)2468-80(2013 Jul)
Bali N,Arimoto JM,Morgan TE,Finch CE

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Pgrmc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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