Hax1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hax1
Entrez Gene ID	291202
Full Name	HCLS1 associated protein X-1
Synonyms	HAX-1,Hs1bp1
General protein information	Preferred Names HCLS1 associated protein X-1 Names HCLS1-associated protein X-1 HS1 binding protein HS1-associating protein X-1 HS1-binding protein 1 HSP1BP-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	protein that may bind to bile salt export protein and may regulate its abundance in membranes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181627.2	NP_853658.1	HCLS1-associated protein X-1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HAX1	NP_001039418.2
Danio rerio (zebrafish)	hax1	NP_001002337.1
	HAX1	XP_002801842.1
Pan troglodytes (chimpanzee)	HAX1	XP_001150932.1
Canis lupus familiaris (dog)	HAX1	XP_005622847.1
Mus musculus (house mouse)	Hax1	NP_035956.1
Xenopus tropicalis (tropical clawed frog)	LOC100485912	XP_002943156.2
Homo sapiens (human)	HAX1	NP_006109.2
Rattus norvegicus (Norway rat)	Hax1	NP_853658.1

Gene Ontology
Bibliography

Related articles in PubMed

Endoplasmic reticulum (ER) stress triggers Hax1-dependent mitochondrial apoptotic events in cardiac cells.
Abdelwahid E, Li H, Wu J, Irioda AC, de Carvalho KA, Luo X
Apoptosis : an international journal on programmed cell death21(11)1227-1239(2016 Nov)

Alterations in the expression of Hs1-associated protein X-1 in the rat retina after optic nerve crush.
Cui L, He WJ, Xu F, Jiang L, Lv ML, Huang H, Xu JP, Wu Y, Zhong HB, Zhang SY, Chen LF, Shen CL, Yao G, Li L, Li M, Zeng SM
Molecular medicine reports14(5)4761-4766(2016 Nov)

Competition through dimerization between antiapoptotic and proapoptotic HS-1-associated protein X-1 (Hax-1).
Koontz J, Kontrogianni-Konstantopoulos A
The Journal of biological chemistry289(6)3468-77(2014 Feb)

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K
Nature medicine18(10)1550-9(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results suggested that Hax1 may participate in regulating RGC apoptosis via interacting with caspase3 and HtrA2 following ONC.
Title: Alterations in the expression of Hs1-associated protein X-1 in the rat retina after optic nerve crush.

Hax-1 is a family of anti- and proapoptotic regulators that may modulate cell survival and death through homo- or heterodimerization.
Title: Competition through dimerization between antiapoptotic and proapoptotic HS-1-associated protein X-1 (Hax-1).

Results suggest that Hax-1 may be involved in the pathophysiology of TBI and further research is needed to have a good understanding of its function and mechanism.
Title: Traumatic brain injury induces an up-regulation of Hs1-associated protein X-1 (Hax-1) in rat brain cortex.

HAX-1 is a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells
Title: HAX-1: a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells.

The existence of at least three protein isoforms was confirmed.
Title: Identification and expression analysis of alternative splice variants of the rat Hax-1 gene.

The following Hax1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hax1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12785	NM_181627.2 Latest version!	Rattus norvegicus HCLS1 associated protein X-1 (Hax1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hax1 ( NM_181627.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_853658.1 Rattus norvegicus HCLS1 associated protein X-1 (Hax1), mRNA.

Price & Availability↑

CloneID	ORa12785
Clone ID Related Accession (Same CDS sequence)	NM_181627.2
Accession Version	NM_181627.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	HCLS1-associated protein X-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY291062.1. On Jun 17, 2003 this sequence version replaced NM_181627.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY291062.1, FQ213378.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906349, SAMN01906351 [ECO:0000350] ##Evidence-Data-END##

ATGAGCGTCT TTGATCTTTT CCGAGGCTTT TTCGGCTTCC CTGGACCTCG GAGCCACAGA 
GATCCTTTTT TTGGAGGGAT GACTCGAGAT GATGACGATG ATGAAGACGA CGAAGAGGAG 
GAAGACAGTG GTGCGTGGGG TCGAGAGAGC TATGCGTTTG ATGGTTTTCA CCCTACAGAG 
GAATTCGGTT TCAGCTTCAG CCCCAGAGGA GGGATGCGAT TCCATGGCAA CTTTGGCTTT 
GATGATCTAG TTCGAGATTT TAATAGCATC TTCAGCGAGA TGGGGGCCTG GACCTTGCCT 
TCCCACTCTC CTGAACTTCC AGGTCCTGAG TCAGAAACAC CTGGTGTGAG ATTGCGAGAG 
GGGCAGACAC TTCGTGACTC AATGCTTAAG TACCCAGATA GTCACCAACC CAGGATCTTT 
GAGGGGGTCT TGGAGAGTCA TGCAAAACCT GAATCCTCCA AACCAGCTCC AGATTGGGGG 
TCCCAGGGAC CTTTTCATAG GTTGGATGAT ACATGGCCTG TGAGTCCCCA TTCTAGAGCC 
AGAGAGGACA AGGATCTTGA CTCCCAGGTT TCCCAGGAAG GTCTGGGTCC ACTTCTTCAA 
CCCCAGCCTA AATCCTATTT CAAAAGCATC TCTGTGACCA AGATCACTAA GCCAGATGGG 
ACAGTGGAGG AACACCGCAC TGTGGTGGAC AGTGAGGGCC GGAGAGAGAC CACAGTGACC 
CATCAAGAAG CCCATGACAG TTCCAGAAGT GATCCAGATC CTCCAAGATC TTCAGCTTTG 
GATGATCCCT TTTCCATCCT GGACCTGCTT CTAGGACGTT GGTTTCGGTC CCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_853658.1
CDS	67..903
Translation	MSVFDLFRGFFGFPGPRSHRDPFFGGMTRDDDDDEDDEEEEDSGAWGRESYAFDGFHPTEEFGFSFSPRGGMRFHGNFGFDDLVRDFNSIFSEMGAWTLPSHSPELPGPESETPGVRLREGQTLRDSMLKYPDSHQPRIFEGVLESHAKPESSKPAPDWGSQGPFHRLDDTWPVSPHSRAREDKDLDSQVSQEGLGPLLQPQPKSYFKSISVTKITKPDGTVEEHRTVVDSEGRRETTVTHQEAHDSSRSDPDPPRSSALDDPFSILDLLLGRWFRSR

Target ORF information:

RefSeq Version	NM_181627.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HCLS1 associated protein X-1 (Hax1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181627.2

ORF Insert Sequence:

ATGAGCGTCT TTGATCTTTT CCGAGGCTTT TTCGGCTTCC CTGGACCTCG GAGCCACAGA 
GATCCTTTTT TTGGAGGGAT GACTCGAGAT GATGACGATG ATGAAGACGA CGAAGAGGAG 
GAAGACAGTG GTGCGTGGGG TCGAGAGAGC TATGCGTTTG ATGGTTTTCA CCCTACAGAG 
GAATTCGGTT TCAGCTTCAG CCCCAGAGGA GGGATGCGAT TCCATGGCAA CTTTGGCTTT 
GATGATCTAG TTCGAGATTT TAATAGCATC TTCAGCGAGA TGGGGGCCTG GACCTTGCCT 
TCCCACTCTC CTGAACTTCC AGGTCCTGAG TCAGAAACAC CTGGTGTGAG ATTGCGAGAG 
GGGCAGACAC TTCGTGACTC AATGCTTAAG TACCCAGATA GTCACCAACC CAGGATCTTT 
GAGGGGGTCT TGGAGAGTCA TGCAAAACCT GAATCCTCCA AACCAGCTCC AGATTGGGGG 
TCCCAGGGAC CTTTTCATAG GTTGGATGAT ACATGGCCTG TGAGTCCCCA TTCTAGAGCC 
AGAGAGGACA AGGATCTTGA CTCCCAGGTT TCCCAGGAAG GTCTGGGTCC ACTTCTTCAA 
CCCCAGCCTA AATCCTATTT CAAAAGCATC TCTGTGACCA AGATCACTAA GCCAGATGGG 
ACAGTGGAGG AACACCGCAC TGTGGTGGAC AGTGAGGGCC GGAGAGAGAC CACAGTGACC 
CATCAAGAAG CCCATGACAG TTCCAGAAGT GATCCAGATC CTCCAAGATC TTCAGCTTTG 
GATGATCCCT TTTCCATCCT GGACCTGCTT CTAGGACGTT GGTTTCGGTC CCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endoplasmic reticulum (ER) stress triggers Hax1-dependent mitochondrial apoptotic events in cardiac cells.
Apoptosis : an international journal on programmed cell death21(11)1227-1239(2016 Nov)
Abdelwahid E,Li H,Wu J,Irioda AC,de Carvalho KA,Luo X

Alterations in the expression of Hs1-associated protein X-1 in the rat retina after optic nerve crush.
Molecular medicine reports14(5)4761-4766(2016 Nov)
Cui L,He WJ,Xu F,Jiang L,Lv ML,Huang H,Xu JP,Wu Y,Zhong HB,Zhang SY,Chen LF,Shen CL,Yao G,Li L,Li M,Zeng SM

Competition through dimerization between antiapoptotic and proapoptotic HS-1-associated protein X-1 (Hax-1).
The Journal of biological chemistry289(6)3468-77(2014 Feb)
Koontz J,Kontrogianni-Konstantopoulos A

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Nature medicine18(10)1550-9(2012 Oct)
Skokowa J,Klimiankou M,Klimenkova O,Lan D,Gupta K,Hussein K,Carrizosa E,Kusnetsova I,Li Z,Sustmann C,Ganser A,Zeidler C,Kreipe HH,Burkhardt J,Grosschedl R,Welte K

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Hax1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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