Gnl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gnl3
Entrez Gene ID	290556
Full Name	G protein nucleolar 3
Synonyms	Ns
General protein information	Preferred Names G protein nucleolar 3 Names guanine nucleotide-binding protein-like 3 guanine nucleotide binding protein-like 3 (nucleolar) nucleolar GTP-binding protein 3 nucleostemin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p16
Summary	involved in controlling cell proliferation in stem cells and cancer cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_175580.2	NP_783170.1	guanine nucleotide-binding protein-like 3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GNL3	XP_002697062.1
Mus musculus (house mouse)	Gnl3	NP_705775.2
Danio rerio (zebrafish)	gnl3	NP_001002297.1
Homo sapiens (human)	GNL3	NP_055181.3
	GNL3	XP_001086259.1
Pan troglodytes (chimpanzee)	GNL3	XP_003309875.1
Canis lupus familiaris (dog)	GNL3	XP_003432846.1
Rattus norvegicus (Norway rat)	Gnl3	NP_783170.1
Gallus gallus (chicken)	GNL3	XP_414249.4
Xenopus tropicalis (tropical clawed frog)	gnl3	NP_001263611.1

Gene Ontology
Bibliography

Related articles in PubMed

Nucleostemin exerts anti-apoptotic function via p53 signaling pathway in cardiomyocytes.
Zhang C, Shi J, Qian L, Zhang C, Wu K, Yang C, Yan D, Wu X, Liu X
In vitro cellular & developmental biology. Animal51(10)1064-71(2015 Nov)

Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A
Stem cells (Dayton, Ohio)33(4)1089-101(2015 Apr)

Telomerase reverse transcriptase regulates microRNAs.
Lassmann T, Maida Y, Tomaru Y, Yasukawa M, Ando Y, Kojima M, Kasim V, Simon C, Daub CO, Carninci P, Hayashizaki Y, Masutomi K
International journal of molecular sciences16(1)1192-208(2015 Jan)

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
B?hm D, Keller K, Pieter J, Boehm N, Wolters D, Siggelkow W, Lebrecht A, Schmidt M, K?lbl H, Pfeiffer N, Grus FH
Oncology reports28(2)429-38(2012 Aug)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In summary, this report suggested that Nucleostemin may exert the anti-apoptotic effect through Nucleostemin-p53 signaling pathway after myocardial reperfusion injury.
Title: Nucleostemin exerts anti-apoptotic function via p53 signaling pathway in cardiomyocytes.

Nucleostemin expression in cardiomyocytes is induced by fibroblast growth factor-2 and accumulates in response to Pim-1 kinase activity.
Title: Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge.

cell cycle arrest/inhibitory role of nucleostemin is unlikely to be related to its proposed property of interaction with p53
Title: Knocking-down the expression of nucleostemin significantly decreases rate of proliferation of rat bone marrow stromal stem cells in an apparently p53-independent manner.

Results suggest that nucleostemin, but not Oct-4 or Nanog, is expressed in bone marrow stromal cells where it possibly regulates self-renewal cell proliferation.
Title: Nucleostemin, a coordinator of self-renewal, is expressed in rat marrow stromal cells and turns off after induction of neural differentiation.

analysis of nucleolar localization of stem cell protein nucleostemin
Title: A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin.

The following Gnl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gnl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03793	NM_175580.2 Latest version!	Rattus norvegicus G protein nucleolar 3 (Gnl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gnl3 ( NM_175580.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_783170.1 Rattus norvegicus G protein nucleolar 3 (Gnl3), mRNA.

Price & Availability↑

CloneID	ORa03793
Clone ID Related Accession (Same CDS sequence)	NM_175580.2
Accession Version	NM_175580.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	guanine nucleotide-binding protein-like 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY181024.1. On Jun 3, 2003 this sequence version replaced NM_175580.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY181024.1, BC093602.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAAGAGGC CGAAGTTAAA GAAAGCAAGT AAACGTATGA CCTGTCATAA GCGGTATAAA 
ATCCAGAAAA AGGTTCGAGA ACATCATCGA AAATTAAGGA AGGAAGCTAA AAAGCGGGGT 
CACAAGAAGC CTAAGAAGGA CCCAGGAGTT CCAAATAGTG CTCCCTTTAA AGAGGCTCTT 
CTTCGTGAAG CTGAGCTAAG GAAACAGCAG CTTGAAGAAC TAAAACAGCA GCAGAAACTT 
GACAGGCAAA AAGAACAAGA ACGAAAAAGA AAACTTGAAA TTAGCCCTGA TGATGAGCAA 
TCTAATGTGG AAACTCAGGA GGAATCTGAT GAGCCCAAAA TAAAGAAAGC TAAATCAGGC 
AAACAGAATC CAAAGAAGTT ACATTGTCAG GAACTTAAAA AGGTGATTGA AGCCTCAGAC 
ATTGTGTTAG AAGTTTTGGA TGCCAGAGAT CCTCTTGGTT GCAGGTGTCC TCAAGTAGAA 
GAAGCTGTTA TCCAAAGTGG ATGTAAAAAA CTAGTACTTG TATTAAATAA GTCAGATCTA 
GTACCAAAAG AGAATCTAGA GAACTGGCTA ACTTACTTGA ATAAGGAATT GCCAACAGTG 
GTGTTCAAAG CCTCAACAAA CTTAAAGAAC AGAAAGAAGA CATTCAAGAT AAAGAAGAAA 
GTTGTTCCAT TCCAAAGTAA ACTCTGCTGT GGCAAGGAAG CACTGTGGAA GCTCCTTGGA 
GGTTTTCAGC AGTCCTGTGG AAAAGGAGTT CAGGTTGGAG TGGTTGGTTT CCCAAATGTG 
GGAAAAAGCA GCATCATTAA TAGTTTAAAA CAAGAAAGGA TTTGCAGTGT TGGAGTTTCC 
ATGGGACTTA CAAGGAGTAT GCAGATTGTC CCTTTAGACA AACAGATCAC AATCATAGAT 
AGTCCGTGCT TCATTATCTC ACCTTGTAAC TCCCCTGCTG CACTTGCCCT CCGAAGTCCA 
GCAAGTATTG AAGTTCTAAG ACCATTGGAG GCTGCCAGTG CCATCCTGTC TCAGGCTGAT 
AGTCAACAGG TGGTGTTAAA ATATACTGTC CCGGGGTATA AGGATTCTCT GGATTTTTTT 
ACTAAACTTG CTCAGAGAAG AGGTCTGCAC CAAAAAGGTG GAAGCCCAAA TGTCGAAAGT 
GCTGCTAAGC TGCTATGGTC TGAGTGGACA GGTGCCTCAT TAGGTTACTA CTGCCATCCC 
CCTGCATCCT GGAATCATTC TCCTCATTTT AATGAGAATA TTACAGCAAT CATGAAGAGG 
GGCTTTAATC TAGAAGAACT AGAAAAGAAT AATGCACACA GCATACAAGT CCTCAAGGGC 
CCTCATTTAA CTAATAAAAT CCTTTTCCGG TCTTCGGGCC TGACAAATGG AATACTAGAA 
GAAAAGGACA TCCCCGAAGA GTCACCAAAA CAGACAGAAG ACCAACAGGA TGGTGATGAT 
CAAGAACATG TTACTGGTGA AAAAAATGCA GAGATCTCAG ATGTGACTCC TGTAGAAGAG 
ACCAGGGAGA TGTCACCTGG GCAATCAACA GCAAGTAAAC CATCTGACAG ATCCTTTATC 
TTGGATAAAA TGAGTGAAGA AGACGATGCC TATGACTTTA CCACAGATTA TATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_783170.1
CDS	52..1668
Translation	MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPKKDPGVPNSAPFKEALLREAELRKQQLEELKQQQKLDRQKEQERKRKLEISPDDEQSNVETQEESDEPKIKKAKSGKQNPKKLHCQELKKVIEASDIVLEVLDARDPLGCRCPQVEEAVIQSGCKKLVLVLNKSDLVPKENLENWLTYLNKELPTVVFKASTNLKNRKKTFKIKKKVVPFQSKLCCGKEALWKLLGGFQQSCGKGVQVGVVGFPNVGKSSIINSLKQERICSVGVSMGLTRSMQIVPLDKQITIIDSPCFIISPCNSPAALALRSPASIEVLRPLEAASAILSQADSQQVVLKYTVPGYKDSLDFFTKLAQRRGLHQKGGSPNVESAAKLLWSEWTGASLGYYCHPPASWNHSPHFNENITAIMKRGFNLEELEKNNAHSIQVLKGPHLTNKILFRSSGLTNGILEEKDIPEESPKQTEDQQDGDDQEHVTGEKNAEISDVTPVEETREMSPGQSTASKPSDRSFILDKMSEEDDAYDFTTDYI

Target ORF information:

RefSeq Version	NM_175580.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein nucleolar 3 (Gnl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175580.2

ORF Insert Sequence:

ATGAAGAGGC CGAAGTTAAA GAAAGCAAGT AAACGTATGA CCTGTCATAA GCGGTATAAA 
ATCCAGAAAA AGGTTCGAGA ACATCATCGA AAATTAAGGA AGGAAGCTAA AAAGCGGGGT 
CACAAGAAGC CTAAGAAGGA CCCAGGAGTT CCAAATAGTG CTCCCTTTAA AGAGGCTCTT 
CTTCGTGAAG CTGAGCTAAG GAAACAGCAG CTTGAAGAAC TAAAACAGCA GCAGAAACTT 
GACAGGCAAA AAGAACAAGA ACGAAAAAGA AAACTTGAAA TTAGCCCTGA TGATGAGCAA 
TCTAATGTGG AAACTCAGGA GGAATCTGAT GAGCCCAAAA TAAAGAAAGC TAAATCAGGC 
AAACAGAATC CAAAGAAGTT ACATTGTCAG GAACTTAAAA AGGTGATTGA AGCCTCAGAC 
ATTGTGTTAG AAGTTTTGGA TGCCAGAGAT CCTCTTGGTT GCAGGTGTCC TCAAGTAGAA 
GAAGCTGTTA TCCAAAGTGG ATGTAAAAAA CTAGTACTTG TATTAAATAA GTCAGATCTA 
GTACCAAAAG AGAATCTAGA GAACTGGCTA ACTTACTTGA ATAAGGAATT GCCAACAGTG 
GTGTTCAAAG CCTCAACAAA CTTAAAGAAC AGAAAGAAGA CATTCAAGAT AAAGAAGAAA 
GTTGTTCCAT TCCAAAGTAA ACTCTGCTGT GGCAAGGAAG CACTGTGGAA GCTCCTTGGA 
GGTTTTCAGC AGTCCTGTGG AAAAGGAGTT CAGGTTGGAG TGGTTGGTTT CCCAAATGTG 
GGAAAAAGCA GCATCATTAA TAGTTTAAAA CAAGAAAGGA TTTGCAGTGT TGGAGTTTCC 
ATGGGACTTA CAAGGAGTAT GCAGATTGTC CCTTTAGACA AACAGATCAC AATCATAGAT 
AGTCCGTGCT TCATTATCTC ACCTTGTAAC TCCCCTGCTG CACTTGCCCT CCGAAGTCCA 
GCAAGTATTG AAGTTCTAAG ACCATTGGAG GCTGCCAGTG CCATCCTGTC TCAGGCTGAT 
AGTCAACAGG TGGTGTTAAA ATATACTGTC CCGGGGTATA AGGATTCTCT GGATTTTTTT 
ACTAAACTTG CTCAGAGAAG AGGTCTGCAC CAAAAAGGTG GAAGCCCAAA TGTCGAAAGT 
GCTGCTAAGC TGCTATGGTC TGAGTGGACA GGTGCCTCAT TAGGTTACTA CTGCCATCCC 
CCTGCATCCT GGAATCATTC TCCTCATTTT AATGAGAATA TTACAGCAAT CATGAAGAGG 
GGCTTTAATC TAGAAGAACT AGAAAAGAAT AATGCACACA GCATACAAGT CCTCAAGGGC 
CCTCATTTAA CTAATAAAAT CCTTTTCCGG TCTTCGGGCC TGACAAATGG AATACTAGAA 
GAAAAGGACA TCCCCGAAGA GTCACCAAAA CAGACAGAAG ACCAACAGGA TGGTGATGAT 
CAAGAACATG TTACTGGTGA AAAAAATGCA GAGATCTCAG ATGTGACTCC TGTAGAAGAG 
ACCAGGGAGA TGTCACCTGG GCAATCAACA GCAAGTAAAC CATCTGACAG ATCCTTTATC 
TTGGATAAAA TGAGTGAAGA AGACGATGCC TATGACTTTA CCACAGATTA TATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nucleostemin exerts anti-apoptotic function via p53 signaling pathway in cardiomyocytes.
In vitro cellular & developmental biology. Animal51(10)1064-71(2015 Nov)
Zhang C,Shi J,Qian L,Zhang C,Wu K,Yang C,Yan D,Wu X,Liu X

Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
Stem cells (Dayton, Ohio)33(4)1089-101(2015 Apr)
Katano M,Ema M,Nakachi Y,Mizuno Y,Hirasaki M,Suzuki A,Ueda A,Nishimoto M,Takahashi S,Okazaki Y,Okuda A

Telomerase reverse transcriptase regulates microRNAs.
International journal of molecular sciences16(1)1192-208(2015 Jan)
Lassmann T,Maida Y,Tomaru Y,Yasukawa M,Ando Y,Kojima M,Kasim V,Simon C,Daub CO,Carninci P,Hayashizaki Y,Masutomi K

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Oncology reports28(2)429-38(2012 Aug)
B?hm D,Keller K,Pieter J,Boehm N,Wolters D,Siggelkow W,Lebrecht A,Schmidt M,K?lbl H,Pfeiffer N,Grus FH

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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Gnl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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