Nudt15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nudt15
Entrez Gene ID	290365
Full Name	nudix hydrolase 15
General protein information	Preferred Names nudix hydrolase 15 Names probable 8-oxo-dGTP diphosphatase NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106049.1	NP_001099519.1	probable 8-oxo-dGTP diphosphatase NUDT15
XM_008770862.2	XP_008769084.1	probable 8-oxo-dGTP diphosphatase NUDT15 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nudt15	NP_766115.1
Rattus norvegicus (Norway rat)	Nudt15	NP_001099519.1
Gallus gallus (chicken)	NUDT15	XP_004938758.1
Arabidopsis thaliana (thale cress)	NUDX1	NP_177044.1
Pan troglodytes (chimpanzee)	NUDT15	XP_001151276.1
Canis lupus familiaris (dog)	NUDT15	XP_003433130.1
Homo sapiens (human)	NUDT15	NP_060753.1
Bos taurus (cattle)	NUDT15	XP_003586745.1
Danio rerio (zebrafish)	nudt15	NP_001002107.1
Neurospora crassa	NCU02895	XP_965577.1
Xenopus tropicalis (tropical clawed frog)	nudt15	XP_002935160.2
Magnaporthe oryzae (rice blast fungus)	MGG_09400	XP_003720209.1

Gene Ontology
Bibliography

Related articles in PubMed

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.
Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, Lin TN, Hoshitsuki K, Nersting J, Kihira K, Hofmann U, Komada Y, Kato M, McCorkle R, Li L, Koh K, Najera CR, Kham SK, Isobe T, Chen Z, Chiew EK, Bhojwani D, Jeffries C, Lu Y, Schwab M, Inaba H, Pui CH, Relling MV, Manabe A, Hori H, Schmiegelow K, Yeoh AE, Evans WE, Yang JJ
Nature genetics48(4)367-73(2016 Apr)

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Bostr?m J, Warpman Berglund U, Helleday T, Stenmark P
Nature communications67871(2015 Aug)

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M
The Journal of biological chemistry287(25)21541-9(2012 Jun)

Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2.
Yu Y, Cai JP, Tu B, Wu L, Zhao Y, Liu X, Li L, McNutt MA, Feng J, He Q, Yang Y, Wang H, Sekiguchi M, Zhu WG
The Journal of biological chemistry284(29)19310-20(2009 Jul)

Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides.
Cai JP, Ishibashi T, Takagi Y, Hayakawa H, Sekiguchi M
Biochemical and biophysical research communications305(4)1073-7(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nudt15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nudt15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00092	NM_001106049.1 Latest version!	Rattus norvegicus nudix hydrolase 15 (Nudt15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa00092	XM_008770862.2 Latest version!	Rattus norvegicus nudix hydrolase 15 (Nudt15), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nudt15 ( NM_001106049.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099519.1 Rattus norvegicus nudix hydrolase 15 (Nudt15), mRNA.

Price & Availability↑

CloneID	ORa00092
Clone ID Related Accession (Same CDS sequence)	NM_001106049.1 , XM_008770862.2
Accession Version	NM_001106049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	probable 8-oxo-dGTP diphosphatase NUDT15
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473951.1. On or before Oct 4, 2007 this sequence version replaced XM_214236.3, XM_001071270.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCACTA ACGCGGAGCA GAGGCGGCGG CCGGGAGTTG GGGTCGGCGT GGTGGTGTTG 
AGCTGCGAGC ATCCTCGTTG CGTCCTTCTG GGGAAAAGGA AAGGGTCGTT TGGAGCCGGC 
AGTTTCCAGC TTCCTGGGGG CCACTTGGAA TTTGGTGAGA CCTGGGAAGA ATGCGCTCAG 
AGGGAAACCT GGGAAGAGGC TGGGCTTCGC CTGAAAAATG TGCGCTTTGC TTCGGTGGTA 
AATACTTTTG TTGAGAAGGA GAATTACCAT TATGTCACCA TATTAATGAA AGGAGAGGTG 
GACGTGACTC ACGAGTCAGA ACCAAGGAAT ATGGAACCAG AAAAGAATGA AAGTTGGGAG 
TGGGTTCCCT GGGAAGAGTT TCCTCCCTTG GACCAGCTTT TCTGGGCTCT CCGTTGTCTA 
AAAGAGCAAG GCTATGATCC ATTTAAAGAG GACCTGAATC ACCTGGAAGG GTACAGAGGA 
AAGCACCTTG AAAAGACACC AAAGATTCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099519.1
CDS	285..797
Translation	MATNAEQRRRPGVGVGVVVLSCEHPRCVLLGKRKGSFGAGSFQLPGGHLEFGETWEECAQRETWEEAGLRLKNVRFASVVNTFVEKENYHYVTILMKGEVDVTHESEPRNMEPEKNESWEWVPWEEFPPLDQLFWALRCLKEQGYDPFKEDLNHLEGYRGKHLEKTPKIP

Target ORF information:

RefSeq Version	NM_001106049.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nudix hydrolase 15 (Nudt15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106049.1

ORF Insert Sequence:

ATGGCCACTA ACGCGGAGCA GAGGCGGCGG CCGGGAGTTG GGGTCGGCGT GGTGGTGTTG 
AGCTGCGAGC ATCCTCGTTG CGTCCTTCTG GGGAAAAGGA AAGGGTCGTT TGGAGCCGGC 
AGTTTCCAGC TTCCTGGGGG CCACTTGGAA TTTGGTGAGA CCTGGGAAGA ATGCGCTCAG 
AGGGAAACCT GGGAAGAGGC TGGGCTTCGC CTGAAAAATG TGCGCTTTGC TTCGGTGGTA 
AATACTTTTG TTGAGAAGGA GAATTACCAT TATGTCACCA TATTAATGAA AGGAGAGGTG 
GACGTGACTC ACGAGTCAGA ACCAAGGAAT ATGGAACCAG AAAAGAATGA AAGTTGGGAG 
TGGGTTCCCT GGGAAGAGTT TCCTCCCTTG GACCAGCTTT TCTGGGCTCT CCGTTGTCTA 
AAAGAGCAAG GCTATGATCC ATTTAAAGAG GACCTGAATC ACCTGGAAGG GTACAGAGGA 
AAGCACCTTG AAAAGACACC AAAGATTCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nudt15 ( XM_008770862.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008769084.1 Rattus norvegicus nudix hydrolase 15 (Nudt15), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa00092
Clone ID Related Accession (Same CDS sequence)	NM_001106049.1 , XM_008770862.2
Accession Version	XM_008770862.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	probable 8-oxo-dGTP diphosphatase NUDT15 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770862.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCACTA ACGCGGAGCA GAGGCGGCGG CCGGGAGTTG GGGTCGGCGT GGTGGTGTTG 
AGCTGCGAGC ATCCTCGTTG CGTCCTTCTG GGGAAAAGGA AAGGGTCGTT TGGAGCCGGC 
AGTTTCCAGC TTCCTGGGGG CCACTTGGAA TTTGGTGAGA CCTGGGAAGA ATGCGCTCAG 
AGGGAAACCT GGGAAGAGGC TGGGCTTCGC CTGAAAAATG TGCGCTTTGC TTCGGTGGTA 
AATACTTTTG TTGAGAAGGA GAATTACCAT TATGTCACCA TATTAATGAA AGGAGAGGTG 
GACGTGACTC ACGAGTCAGA ACCAAGGAAT ATGGAACCAG AAAAGAATGA AAGTTGGGAG 
TGGGTTCCCT GGGAAGAGTT TCCTCCCTTG GACCAGCTTT TCTGGGCTCT CCGTTGTCTA 
AAAGAGCAAG GCTATGATCC ATTTAAAGAG GACCTGAATC ACCTGGAAGG GTACAGAGGA 
AAGCACCTTG AAAAGACACC AAAGATTCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008769084.1
CDS	406..918
Translation	MATNAEQRRRPGVGVGVVVLSCEHPRCVLLGKRKGSFGAGSFQLPGGHLEFGETWEECAQRETWEEAGLRLKNVRFASVVNTFVEKENYHYVTILMKGEVDVTHESEPRNMEPEKNESWEWVPWEEFPPLDQLFWALRCLKEQGYDPFKEDLNHLEGYRGKHLEKTPKIP

Target ORF information:

RefSeq Version	XM_008770862.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nudix hydrolase 15 (Nudt15), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770862.2

ORF Insert Sequence:

ATGGCCACTA ACGCGGAGCA GAGGCGGCGG CCGGGAGTTG GGGTCGGCGT GGTGGTGTTG 
AGCTGCGAGC ATCCTCGTTG CGTCCTTCTG GGGAAAAGGA AAGGGTCGTT TGGAGCCGGC 
AGTTTCCAGC TTCCTGGGGG CCACTTGGAA TTTGGTGAGA CCTGGGAAGA ATGCGCTCAG 
AGGGAAACCT GGGAAGAGGC TGGGCTTCGC CTGAAAAATG TGCGCTTTGC TTCGGTGGTA 
AATACTTTTG TTGAGAAGGA GAATTACCAT TATGTCACCA TATTAATGAA AGGAGAGGTG 
GACGTGACTC ACGAGTCAGA ACCAAGGAAT ATGGAACCAG AAAAGAATGA AAGTTGGGAG 
TGGGTTCCCT GGGAAGAGTT TCCTCCCTTG GACCAGCTTT TCTGGGCTCT CCGTTGTCTA 
AAAGAGCAAG GCTATGATCC ATTTAAAGAG GACCTGAATC ACCTGGAAGG GTACAGAGGA 
AAGCACCTTG AAAAGACACC AAAGATTCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.
Nature genetics48(4)367-73(2016 Apr)
Moriyama T,Nishii R,Perez-Andreu V,Yang W,Klussmann FA,Zhao X,Lin TN,Hoshitsuki K,Nersting J,Kihira K,Hofmann U,Komada Y,Kato M,McCorkle R,Li L,Koh K,Najera CR,Kham SK,Isobe T,Chen Z,Chiew EK,Bhojwani D,Jeffries C,Lu Y,Schwab M,Inaba H,Pui CH,Relling MV,Manabe A,Hori H,Schmiegelow K,Yeoh AE,Evans WE,Yang JJ

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Nature communications67871(2015 Aug)
Carter M,Jemth AS,Hagenkort A,Page BD,Gustafsson R,Griese JJ,Gad H,Valerie NC,Desroses M,Bostr?m J,Warpman Berglund U,Helleday T,Stenmark P

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
The Journal of biological chemistry287(25)21541-9(2012 Jun)
Takagi Y,Setoyama D,Ito R,Kamiya H,Yamagata Y,Sekiguchi M

Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2.
The Journal of biological chemistry284(29)19310-20(2009 Jul)
Yu Y,Cai JP,Tu B,Wu L,Zhao Y,Liu X,Li L,McNutt MA,Feng J,He Q,Yang Y,Wang H,Sekiguchi M,Zhu WG

Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides.
Biochemical and biophysical research communications305(4)1073-7(2003 Jun)
Cai JP,Ishibashi T,Takagi Y,Hayakawa H,Sekiguchi M

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Nudt15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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