Myh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Myh1
Entrez Gene ID	287408
Full Name	myosin heavy chain 1
Synonyms	MYHC
General protein information	Preferred Names myosin heavy chain 1 Names myosin, heavy polypeptide 1, skeletal muscle, adult myosin, heavy chain 1, skeletal muscle, adult type 2X myosin heavy chain
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	one of three isoforms of myosin heavy chain; components of fast-twitch fibers in skeletal muscle; responsible for myosin ATPase activity and control of fiber shortening speed and resistance to fatigue [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001135158.1	NP_001128630.1	myosin, heavy polypeptide 1, skeletal muscle, adult

Pathways from BioSystems

Homologies

Homo sapiens (human)	MYH1	NP_005954.3
Xenopus tropicalis (tropical clawed frog)	myh8	XP_004916771.1
Xenopus tropicalis (tropical clawed frog)	LOC100495802	XP_002935255.1
Bos taurus (cattle)	MYH1	NP_776542.1
Xenopus tropicalis (tropical clawed frog)	myh4	NP_001001244.1
Xenopus tropicalis (tropical clawed frog)	myh2	NP_001006805.1
Xenopus tropicalis (tropical clawed frog)	LOC100495968	XP_002935256.2
Pan troglodytes (chimpanzee)	MYH1	XP_003953177.1
Canis lupus familiaris (dog)	MYH1	NP_001107189.1
Mus musculus (house mouse)	Myh1	NP_109604.1
Rattus norvegicus (Norway rat)	Myh1	NP_001128630.1
Xenopus tropicalis (tropical clawed frog)	LOC100495638	XP_002935254.1

Gene Ontology
Bibliography

Related articles in PubMed

Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
Damatto RL, Martinez PF, Lima AR, Cezar MD, Campos DH, Oliveira Junior SA, Guizoni DM, Bonomo C, Nakatani BT, Dal Pai Silva M, Carvalho RF, Okoshi K, Okoshi MP
International journal of cardiology167(3)698-703(2013 Aug)

Interferon-? causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis.
Cosper PF, Harvey PA, Leinwand LA
The American journal of pathology181(6)2038-46(2012 Dec)

Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.
Pandorf CE, Haddad F, Wright C, Bodell PW, Baldwin KM
American journal of physiology. Cell physiology297(1)C6-16(2009 Jul)

The slow sarco/endoplasmic reticulum Ca2+ -ATPase declines independently of slow myosin in soleus muscle of diabetic rats.
R?cz G, Szab? A, V?r A, Z?dor E
Acta biochimica Polonica56(3)487-93(2009)

Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations.
Ajima R, Akazawa H, Kodama M, Takeshita F, Otsuka A, Kohno T, Komuro I, Ochiya T, Yokota J
Genes to cells : devoted to molecular & cellular mechanisms13(10)987-99(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The relative amount of type I MyHC isoform is increased in spontaneously hypertensive rats (SHR) compared to the Wistar-Kyoto strain.
Title: Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.

IFN-gamma increased both proteasome and immunoproteasome activity in cardiac myocytes and their inhibition blocked myosin heavy chain loss and myocyte atrophy.
Title: Interferon-? causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis.

Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.
Title: Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.

MyHC1 levels were not different on immunoblots of the soleus of streptozocin-treated and control rats.
Title: The slow sarco/endoplasmic reticulum Ca2+ -ATPase declines independently of slow myosin in soleus muscle of diabetic rats.

Results obtained with IIx MHC promoter-reporters show that the loss of the native chromatin environment and other cis elements may preclude use of the gene transfer approach, suggesting that there are hidden layers of regulation for this gene.
Title: IIx myosin heavy chain promoter regulation cannot be characterized in vivo by direct gene transfer.

The following Myh1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myh1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12673	NM_001135158.1 Latest version!	Rattus norvegicus myosin heavy chain 1 (Myh1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$1700.30 $2429.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Myh1 ( NM_001135158.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001128630.1 Rattus norvegicus myosin heavy chain 1 (Myh1), mRNA.

Price & Availability↑

CloneID	ORa12673
Clone ID Related Accession (Same CDS sequence)	NM_001135158.1
Accession Version	NM_001135158.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5829bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	myosin, heavy polypeptide 1, skeletal muscle, adult
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07029832.1. On or before Sep 25, 2008 this sequence version replaced XM_001078018.1, XM_001077982.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689600, SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTCCG ACGCCGAGAT GGCCGTTTTC GGGGAGGCTG CTCCTTACCT CCGGAAGTCT 
GAAAAGGAGC GAATCGAGGC TCAGAACAAG CCTTTTGATG CCAAGTCATC CGTGTTTGTG 
GTGGATGCTA AGGAGTCTTT TGTAAAAGCA ACGGTGCAGA GCAGGGAAGG GGGGAAGGTG 
ACAGCCAAGA CCGAAGGTGG CGCTACTGTA ACAGTAAAAG ATGATCAAGT CTTCCCCATG 
AACCCTCCCA AGTACGACAA GATCGAGGAC ATGGCCATGA TGACCCACCT CCACGAGCCT 
GCTGTGCTGT ACAACCTCAA AGAGCGTTAC GCAGCCTGGA TGATCTACAC CTACTCGGGC 
CTGTTCTGTG TCACTGTCAA CCCCTACAAG TGGCTGCCAG TGTATAATGC AGAGGTGGTG 
GCAGCTTACC GAGGCAAAAA GCGCCAGGAG GCCCCGCCCC ACATCTTCTC TATCTCTGAC 
AACGCCTACC AGTTCATGTT GACAGATCGG GAGAACCAGT CTATTTTGAT CACCGGAGAA 
TCTGGGGCTG GGAAGACTGT GAACACGAAG CGTGTCATCC AGTACTTTGC AACAATTGCA 
GTCACTGGGG AGAAGAAGAA GGAGGAAGCA CCTTCTGGCA AAATGCAGGG GACCCTGGAG 
GATCAAATCA TCAGTGCCAA TCCTCTGCTG GAAGCCTTCG GGAATGCCAA GACCGTGAGG 
AATGACAACT CCTCTCGCTT TGGTAAATTC ATCAGGATCC ACTTTGGTAC CACAGGGAAG 
CTGGCTTCTG CTGATATTGA AACATATCTT CTGGAGAAGT CTAGAGTCAC CTTCCAGCTA 
AAAGCTGAGA GAAGCTACCA TATTTTTTAC CAGATCATGT CTAACAAGAA GCCAGATCTA 
ATTGAAATGC TCCTGATCAC CACCAACCCA TACGACTACG CCTTTGTCAG TCAGGGGGAG 
ATCACAGTGC CCAGCATTGA TGACCAAGAA GAGTTGATGG CCACAGATAG TGCCATTGAT 
ATTCTGGGCT TCACTTCTGA TGAAAGAGTC TCCATCTATA AGCTCACGGG GGCTGTGATG 
CATTATGGGA ACATGAAGTT CAAGCAGAAG CAACGTGAGG AGCAGGCTGA GCCGGATGGC 
ACGGAAGTGG CTGACAAGGC TGCCTATCTC CAAAATCTGA ACTCTGCTGA CCTGCTCAAA 
GCCCTGTGTT ACCCCAGGGT CAAGGTCGGC AATGAGTATG TCACCAAAGG CCAGACTGTG 
CAGCAGGTGT ACAACGCTGT GGGTGCCCTG GCCAAAGCTG TCTACGAGAA GATGTTCCTT 
TGGATGGTCA CCCGCATCAA CCAGCAGCTG GACACCAAGC AGCCCAGGCA GTACTTCATC 
GGGGTCTTGG ACATCGCTGG CTTTGAGATC TTTGATTTCA ACAGCCTGGA GCAGCTGTGC 
ATCAACTTCA CCAACGAGAA ACTGCAACAG TTTTTCAACC ACCACATGTT CGTGCTGGAG 
CAGGAGGAGT ACAAGAAGGA AGGCATCGAG TGGGAGTTCA TCGACTTCGG GATGGACCTG 
GCGGCCTGCA TCGAGCTCAT CGAGAAGCCA ATGGGCATCT TCTCCATCCT GGAAGAGGAG 
TGCATGTTCC CCAAAGCGAC AGACACCTCC TTCAAGAACA AGCTGTATGA ACAGCATCTT 
GGAAAGTCCA ACAACTTCCA GAAGCCCAAA CCCGCCAAAG GCAAGGTTGA GGCCCACTTC 
TCTCTGGTGC ACTATGCCGG CACCGTTGAC TACAACATCG CTGGCTGGCT GGACAAGAAC 
AAGGACCCCC TGAATGAGAC CGTGGTGGGG CTGTACCAGA AGTCTTCAAT GAAAACTCTG 
GCTTACCTCT TCTCTGGGGC AGCAGCTGCT GCTGAAGCAG AGTCTGGTGG CGGTGGTGGA 
AAGAAAGGGG CAAAGAAGAA GGGTTCTTCC TTCCAGACTG TGTCAGCTCT CTTCAGGGAG 
AACCTGAATA AGCTGATGAC CAATCTGAGG AGCACTCACC CCCACTTTGT CCGGTGCATC 
ATCCCCAATG AGACTAAGAC GCCTGGTGCC ATGGAGCACG AACTGGTCCT GCACCAGCTG 
AGGTGTAACG GGGTACTGGA AGGCATCCGC ATCTGCAGGA AGGGGTTCCC CAGCAGGATC 
CTCTACGCAG ACTTCAAGCA GAGATACAAG GTGTTAAATG CAAGTGCCAT CCCCGAGGGA 
CAATTCATCG ATAGCAAGAA GGCTTCTGAG AAGCTCCTTG GCTCCATCGA CATTGACCAC 
ACTCAGTATA AGTTTGGTCA CACCAAGGTC TTTTTCAAAG CTGGTCTTCT GGGGCTCCTA 
GAGGAGATGA GAGATGACAA GTTGGCCCAG CTGATTACCC GGACGCAGGC CATGTGCCGA 
GGGTACTTGG CAAGAGTGGA GTACCAGAAG ATGGTGGAGC GAAGAGAGTC CATCTTCTGC 
ATCCAGTACA ACGTCCGAGC CTTCATGAAT GTGAAACACT GGCCCTGGAT GAAGCTGTAT 
TTCAAGATCA AACCTCTCTT GAAGAGTGCC GAGACAGAGA AGGAGATGGC CAACATGAAG 
GAAGAGTTTG AAAAAACTAA AGAAAACCTT GCAAAGGCAG AGGCCAAAAG GAAAGAGCTA 
GAAGAAAAGA TGGTGGCTCT GATGCAGGAG AAAAATGACC TGCAGCTCCA AGTTCAGTCT 
GAAGCAGACA GCTTGGCTGA TGCTGAGGAA AGATGCGACC AGCTGATCAA AACCAAAATC 
CAGCTGGAGG CCAAAATCAA AGAGGTGACT GAGAGAGCAG AGGATGAGGA AGAGATCAAC 
GCCGAGCTCA CCGCCAAGAA GAGGAAGCTG GAGGACGAGT GCTCAGAGCT GAAGAAAGAC 
ATCGATGACC TTGAGCTGAC ACTGGCCAAG GTTGAGAAGG AGAAGCACGC CACGGAGAAC 
AAGGTGAAAA ACCTCACAGA GGAGATGGCG GGCCTGGACG AAACCATCGC CAAGCTGACC 
AAGGAGAAGA AGGCCTTGCA GGAGGCCCAC CAGCAGACCC TGGATGACCT GCAGGCAGAG 
GAGGACAAAG TCAACACCCT GACCAAAGCC AAAATCAAGC TGGAACAGCA AGTGGATGAC 
CTTGAAGGCT CTCTGGAACA AGAAAAGAAA ATCCGGATGG ATCTTGAAAG AGCCAAGAGG 
AAACTCGAGG GGGACCTAAA ACTGGCCCAA GAGTCCACAA TGGACGTAGA AAATGACAAA 
CAGCAGCTCG ATGAGAAACT CAAAAAGAAA GAGTTTGAAA TGAGCAACCT GCAGAGCAAG 
ATCGAGGATG AACAGGCCCT CGGCATGCAG CTGCAGAAGA AGATCAAGGA GTTGCAGGCT 
CGCATTGAGG AGCTGGAGGA GGAAATCGAG GCAGAGCGGG CCTCCAGGGC CAAAGCAGAG 
AAGCAGCGCT CTGACCTCTC CCGGGAACTG GAGGAGATCA GCGAGCGGCT GGAAGAAGCC 
GGCGGGGCCA CTTCAGCCCA GATCGAGATG AACAAGAAGA GAGAGGCCGA GTTCCAGAAA 
ATGCGCAGGG ACCTGGAGGA GGCCACCCTG CAGCACGAAG CCACAGCAGC CACCCTGAGG 
AAGAAGCACG CGGACAGCGT GGCTGAGCTC GGGGAGCAGA TCGACAACCT GCAGCGGGTG 
AAGCAGAAGC TGGAGAAGGA GAAGAGCGAG ATGAAGATGG AGATCGACGA CCTCGCTAGC 
AACATGGAGG TCATTTCCAA ATCCAAGGGA AACCTTGAGA AGATGTGCCG CACTCTGGAG 
GACCAGGTGA GCGAGCTGAA GACCAAGGAG GAGGAGCAGC AGCGGCTCAT CAACGAGCTG 
ACCGCGCAGA GGGGGCGTCT GCAGACAGAG TCAGGTGAAT ATTCACGCCA GCTGGATGAA 
AAGGATTCAT TAGTTTCTCA GCTCTCCAGG GGCAAACAGG CATTCACTCA ACAGATTGAG 
GAGCTGAAGA GGCAGCTTGA AGAGGAAGTA AAGGCCAAGA GTGCCCTGGC TCATGCTCTT 
CAGTCCTCCC GCCATGACTG TGACCTTCTG CGGGAACAGT ATGAAGAAGA ACAGGAAGCC 
AAGGCTGAAC TGCAGAGGGC CATGTCCAAG GCCAACAGTG AAGTGGCCCA GTGGAGGACG 
AAATATGAGA CGGATGCCAT CCAGCGCACG GAAGAACTGG AGGAGGCCAA GAAGAAGCTG 
GCTCAGCGTC TGCAGGATGC TGAGGAGCAC GTAGAAGCCG TGAACGCCAA GTGTGCTTCC 
CTGGAGAAGA CGAAGCAGAG GCTGCAGAAT GAGGTGGAGG ACCTCATGAT TGATGTGGAG 
AGGACCAACG CTGCCTGTGC CGCCCTGGAC AAGAAGCAGA GAAACTTCGA CAAGATCCTG 
GCAGAATGGA AACAGAAGTA TGAGGAAACG CATGCTGAAC TTGAAGCCTC CCAGAAGGAG 
TCCCGCTCTC TCAGCACAGA GTTGTTCAAG ATTAAGAATG CTTATGAGGA ATCTTTAGAC 
CAACTTGAAA CCTTGAAAAG GGAAAATAAG AATTTGCAAC AGGAGATCTC TGACCTCACT 
GAACAGATTG CAGAAGGAGG GAAACGTATC CATGAACTGG AAAAAATAAA GAAGCAAATT 
GAGCAAGAAA AATCCGAGCT CCAGGCTGCT TTAGAGGAAG CAGAGGCATC TCTGGAGCAC 
GAGGAGGGAA AGATCCTGCG CATCCAGCTG GAGCTGAACC AAGTCAAGTC TGAGATCGAC 
AGGAAGATTG CTGAGAAGGA TGAGGAAATT GACCAGCTGA AGAGAAACCA CATTCGAGTC 
GTGGAGTCCA TGCAGAGCAC GCTGGATGCC GAGATCAGGA GCAGGAATGA CGCCATCAGG 
ATCAAGAAGA AGATGGAGGG AGACCTCAAT GAGATGGAAA TCCAGCTGAA CCACTCCAAC 
CGCATGGCTG CTGAGGCCCT GAGAAACTAC AGGAACACCC AAGGCATCCT CAAGGACACC 
CAGTTGCACC TGGATGACGC TCTCCGGGGC CAGGAGGACC TGAAGGAGCA GCTGGCCATG 
GTGGAGCGCA GAGCCAACCT GCTGCAGGCT GAGATCGAGG AGCTGCGGGC CACTCTGGAG 
CAGACTGAGA GGAGCAGGAA GATTGCAGAG CAGGAACTGC TGGACGCCAG TGAGCGCGTG 
CAGCTCCTCC ACACCCAGAA CACCAGCCTC ATCAACACCA AGAAGAAGCT GGAGACAGAC 
ATTTCCCAGA TCCAGGGAGA GATGGAGGAC ATCGTCCAGG AAGCCCGCAA TGCAGAAGAG 
AAGGCCAAGA AAGCCATCAC TGACGCCGCC ATGATGGCGG AGGAGCTGAA GAAGGAGCAG 
GACACCAGCG CCCATCTGGA GCGGATGAAG AAGAACCTGG AGCAGACGGT GAAGGACCTG 
CAGCACCGTC TGGACGAGGC TGAGCAGCTG GCGCTGAAGG GCGGCAAGAA GCAGATCCAG 
AAACTGGAGG CCAGGGTCCG TGAACTTGAA GGAGAAGTTG AAAACGAACA GAAGCGCAAT 
GTTGAAGCTA TCAAGGGTCT GCGCAAACAT GAGAGAAGAG TGAAAGAACT CACTTACCAA 
ACTGAGGAAG ACCGCAAGAA CGTTCTCAGG CTCCAGGACC TTGTGGACAA ACTGCAATCA 
AAGGTCAAAG CATACAAGAG ACAAGCCGAG GAAGCGGAGG AACAATCCAA CGTCAACCTG 
GCCAAGTTCC GCAAGATCCA GCACGAGCTG GAGGAAGCCG AGGAGCGGGC TGACATCGCC 
GAGTCCCAGG TCAACAAGCT GCGGGTGAAG AGCCGCGAGG TTCACACCAA AATCATAAGC 
GAAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128630.1
CDS	96..5924
Translation	MSSDAEMAVFGEAAPYLRKSEKERIEAQNKPFDAKSSVFVVDAKESFVKATVQSREGGKVTAKTEGGATVTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEAPSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLAYLFSGAAAAAEAESGGGGGKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGYLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKENLAKAEAKRKELEEKMVALMQEKNDLQLQVQSEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDVENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEVISKSKGNLEKMCRTLEDQVSELKTKEEEQQRLINELTAQRGRLQTESGEYSRQLDEKDSLVSQLSRGKQAFTQQIEELKRQLEEEVKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQIEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNVEAIKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQSKVKAYKRQAEEAEEQSNVNLAKFRKIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE

Target ORF information:

RefSeq Version	NM_001135158.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myosin heavy chain 1 (Myh1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135158.1

ORF Insert Sequence:

ATGAGTTCCG ACGCCGAGAT GGCCGTTTTC GGGGAGGCTG CTCCTTACCT CCGGAAGTCT 
GAAAAGGAGC GAATCGAGGC TCAGAACAAG CCTTTTGATG CCAAGTCATC CGTGTTTGTG 
GTGGATGCTA AGGAGTCTTT TGTAAAAGCA ACGGTGCAGA GCAGGGAAGG GGGGAAGGTG 
ACAGCCAAGA CCGAAGGTGG CGCTACTGTA ACAGTAAAAG ATGATCAAGT CTTCCCCATG 
AACCCTCCCA AGTACGACAA GATCGAGGAC ATGGCCATGA TGACCCACCT CCACGAGCCT 
GCTGTGCTGT ACAACCTCAA AGAGCGTTAC GCAGCCTGGA TGATCTACAC CTACTCGGGC 
CTGTTCTGTG TCACTGTCAA CCCCTACAAG TGGCTGCCAG TGTATAATGC AGAGGTGGTG 
GCAGCTTACC GAGGCAAAAA GCGCCAGGAG GCCCCGCCCC ACATCTTCTC TATCTCTGAC 
AACGCCTACC AGTTCATGTT GACAGATCGG GAGAACCAGT CTATTTTGAT CACCGGAGAA 
TCTGGGGCTG GGAAGACTGT GAACACGAAG CGTGTCATCC AGTACTTTGC AACAATTGCA 
GTCACTGGGG AGAAGAAGAA GGAGGAAGCA CCTTCTGGCA AAATGCAGGG GACCCTGGAG 
GATCAAATCA TCAGTGCCAA TCCTCTGCTG GAAGCCTTCG GGAATGCCAA GACCGTGAGG 
AATGACAACT CCTCTCGCTT TGGTAAATTC ATCAGGATCC ACTTTGGTAC CACAGGGAAG 
CTGGCTTCTG CTGATATTGA AACATATCTT CTGGAGAAGT CTAGAGTCAC CTTCCAGCTA 
AAAGCTGAGA GAAGCTACCA TATTTTTTAC CAGATCATGT CTAACAAGAA GCCAGATCTA 
ATTGAAATGC TCCTGATCAC CACCAACCCA TACGACTACG CCTTTGTCAG TCAGGGGGAG 
ATCACAGTGC CCAGCATTGA TGACCAAGAA GAGTTGATGG CCACAGATAG TGCCATTGAT 
ATTCTGGGCT TCACTTCTGA TGAAAGAGTC TCCATCTATA AGCTCACGGG GGCTGTGATG 
CATTATGGGA ACATGAAGTT CAAGCAGAAG CAACGTGAGG AGCAGGCTGA GCCGGATGGC 
ACGGAAGTGG CTGACAAGGC TGCCTATCTC CAAAATCTGA ACTCTGCTGA CCTGCTCAAA 
GCCCTGTGTT ACCCCAGGGT CAAGGTCGGC AATGAGTATG TCACCAAAGG CCAGACTGTG 
CAGCAGGTGT ACAACGCTGT GGGTGCCCTG GCCAAAGCTG TCTACGAGAA GATGTTCCTT 
TGGATGGTCA CCCGCATCAA CCAGCAGCTG GACACCAAGC AGCCCAGGCA GTACTTCATC 
GGGGTCTTGG ACATCGCTGG CTTTGAGATC TTTGATTTCA ACAGCCTGGA GCAGCTGTGC 
ATCAACTTCA CCAACGAGAA ACTGCAACAG TTTTTCAACC ACCACATGTT CGTGCTGGAG 
CAGGAGGAGT ACAAGAAGGA AGGCATCGAG TGGGAGTTCA TCGACTTCGG GATGGACCTG 
GCGGCCTGCA TCGAGCTCAT CGAGAAGCCA ATGGGCATCT TCTCCATCCT GGAAGAGGAG 
TGCATGTTCC CCAAAGCGAC AGACACCTCC TTCAAGAACA AGCTGTATGA ACAGCATCTT 
GGAAAGTCCA ACAACTTCCA GAAGCCCAAA CCCGCCAAAG GCAAGGTTGA GGCCCACTTC 
TCTCTGGTGC ACTATGCCGG CACCGTTGAC TACAACATCG CTGGCTGGCT GGACAAGAAC 
AAGGACCCCC TGAATGAGAC CGTGGTGGGG CTGTACCAGA AGTCTTCAAT GAAAACTCTG 
GCTTACCTCT TCTCTGGGGC AGCAGCTGCT GCTGAAGCAG AGTCTGGTGG CGGTGGTGGA 
AAGAAAGGGG CAAAGAAGAA GGGTTCTTCC TTCCAGACTG TGTCAGCTCT CTTCAGGGAG 
AACCTGAATA AGCTGATGAC CAATCTGAGG AGCACTCACC CCCACTTTGT CCGGTGCATC 
ATCCCCAATG AGACTAAGAC GCCTGGTGCC ATGGAGCACG AACTGGTCCT GCACCAGCTG 
AGGTGTAACG GGGTACTGGA AGGCATCCGC ATCTGCAGGA AGGGGTTCCC CAGCAGGATC 
CTCTACGCAG ACTTCAAGCA GAGATACAAG GTGTTAAATG CAAGTGCCAT CCCCGAGGGA 
CAATTCATCG ATAGCAAGAA GGCTTCTGAG AAGCTCCTTG GCTCCATCGA CATTGACCAC 
ACTCAGTATA AGTTTGGTCA CACCAAGGTC TTTTTCAAAG CTGGTCTTCT GGGGCTCCTA 
GAGGAGATGA GAGATGACAA GTTGGCCCAG CTGATTACCC GGACGCAGGC CATGTGCCGA 
GGGTACTTGG CAAGAGTGGA GTACCAGAAG ATGGTGGAGC GAAGAGAGTC CATCTTCTGC 
ATCCAGTACA ACGTCCGAGC CTTCATGAAT GTGAAACACT GGCCCTGGAT GAAGCTGTAT 
TTCAAGATCA AACCTCTCTT GAAGAGTGCC GAGACAGAGA AGGAGATGGC CAACATGAAG 
GAAGAGTTTG AAAAAACTAA AGAAAACCTT GCAAAGGCAG AGGCCAAAAG GAAAGAGCTA 
GAAGAAAAGA TGGTGGCTCT GATGCAGGAG AAAAATGACC TGCAGCTCCA AGTTCAGTCT 
GAAGCAGACA GCTTGGCTGA TGCTGAGGAA AGATGCGACC AGCTGATCAA AACCAAAATC 
CAGCTGGAGG CCAAAATCAA AGAGGTGACT GAGAGAGCAG AGGATGAGGA AGAGATCAAC 
GCCGAGCTCA CCGCCAAGAA GAGGAAGCTG GAGGACGAGT GCTCAGAGCT GAAGAAAGAC 
ATCGATGACC TTGAGCTGAC ACTGGCCAAG GTTGAGAAGG AGAAGCACGC CACGGAGAAC 
AAGGTGAAAA ACCTCACAGA GGAGATGGCG GGCCTGGACG AAACCATCGC CAAGCTGACC 
AAGGAGAAGA AGGCCTTGCA GGAGGCCCAC CAGCAGACCC TGGATGACCT GCAGGCAGAG 
GAGGACAAAG TCAACACCCT GACCAAAGCC AAAATCAAGC TGGAACAGCA AGTGGATGAC 
CTTGAAGGCT CTCTGGAACA AGAAAAGAAA ATCCGGATGG ATCTTGAAAG AGCCAAGAGG 
AAACTCGAGG GGGACCTAAA ACTGGCCCAA GAGTCCACAA TGGACGTAGA AAATGACAAA 
CAGCAGCTCG ATGAGAAACT CAAAAAGAAA GAGTTTGAAA TGAGCAACCT GCAGAGCAAG 
ATCGAGGATG AACAGGCCCT CGGCATGCAG CTGCAGAAGA AGATCAAGGA GTTGCAGGCT 
CGCATTGAGG AGCTGGAGGA GGAAATCGAG GCAGAGCGGG CCTCCAGGGC CAAAGCAGAG 
AAGCAGCGCT CTGACCTCTC CCGGGAACTG GAGGAGATCA GCGAGCGGCT GGAAGAAGCC 
GGCGGGGCCA CTTCAGCCCA GATCGAGATG AACAAGAAGA GAGAGGCCGA GTTCCAGAAA 
ATGCGCAGGG ACCTGGAGGA GGCCACCCTG CAGCACGAAG CCACAGCAGC CACCCTGAGG 
AAGAAGCACG CGGACAGCGT GGCTGAGCTC GGGGAGCAGA TCGACAACCT GCAGCGGGTG 
AAGCAGAAGC TGGAGAAGGA GAAGAGCGAG ATGAAGATGG AGATCGACGA CCTCGCTAGC 
AACATGGAGG TCATTTCCAA ATCCAAGGGA AACCTTGAGA AGATGTGCCG CACTCTGGAG 
GACCAGGTGA GCGAGCTGAA GACCAAGGAG GAGGAGCAGC AGCGGCTCAT CAACGAGCTG 
ACCGCGCAGA GGGGGCGTCT GCAGACAGAG TCAGGTGAAT ATTCACGCCA GCTGGATGAA 
AAGGATTCAT TAGTTTCTCA GCTCTCCAGG GGCAAACAGG CATTCACTCA ACAGATTGAG 
GAGCTGAAGA GGCAGCTTGA AGAGGAAGTA AAGGCCAAGA GTGCCCTGGC TCATGCTCTT 
CAGTCCTCCC GCCATGACTG TGACCTTCTG CGGGAACAGT ATGAAGAAGA ACAGGAAGCC 
AAGGCTGAAC TGCAGAGGGC CATGTCCAAG GCCAACAGTG AAGTGGCCCA GTGGAGGACG 
AAATATGAGA CGGATGCCAT CCAGCGCACG GAAGAACTGG AGGAGGCCAA GAAGAAGCTG 
GCTCAGCGTC TGCAGGATGC TGAGGAGCAC GTAGAAGCCG TGAACGCCAA GTGTGCTTCC 
CTGGAGAAGA CGAAGCAGAG GCTGCAGAAT GAGGTGGAGG ACCTCATGAT TGATGTGGAG 
AGGACCAACG CTGCCTGTGC CGCCCTGGAC AAGAAGCAGA GAAACTTCGA CAAGATCCTG 
GCAGAATGGA AACAGAAGTA TGAGGAAACG CATGCTGAAC TTGAAGCCTC CCAGAAGGAG 
TCCCGCTCTC TCAGCACAGA GTTGTTCAAG ATTAAGAATG CTTATGAGGA ATCTTTAGAC 
CAACTTGAAA CCTTGAAAAG GGAAAATAAG AATTTGCAAC AGGAGATCTC TGACCTCACT 
GAACAGATTG CAGAAGGAGG GAAACGTATC CATGAACTGG AAAAAATAAA GAAGCAAATT 
GAGCAAGAAA AATCCGAGCT CCAGGCTGCT TTAGAGGAAG CAGAGGCATC TCTGGAGCAC 
GAGGAGGGAA AGATCCTGCG CATCCAGCTG GAGCTGAACC AAGTCAAGTC TGAGATCGAC 
AGGAAGATTG CTGAGAAGGA TGAGGAAATT GACCAGCTGA AGAGAAACCA CATTCGAGTC 
GTGGAGTCCA TGCAGAGCAC GCTGGATGCC GAGATCAGGA GCAGGAATGA CGCCATCAGG 
ATCAAGAAGA AGATGGAGGG AGACCTCAAT GAGATGGAAA TCCAGCTGAA CCACTCCAAC 
CGCATGGCTG CTGAGGCCCT GAGAAACTAC AGGAACACCC AAGGCATCCT CAAGGACACC 
CAGTTGCACC TGGATGACGC TCTCCGGGGC CAGGAGGACC TGAAGGAGCA GCTGGCCATG 
GTGGAGCGCA GAGCCAACCT GCTGCAGGCT GAGATCGAGG AGCTGCGGGC CACTCTGGAG 
CAGACTGAGA GGAGCAGGAA GATTGCAGAG CAGGAACTGC TGGACGCCAG TGAGCGCGTG 
CAGCTCCTCC ACACCCAGAA CACCAGCCTC ATCAACACCA AGAAGAAGCT GGAGACAGAC 
ATTTCCCAGA TCCAGGGAGA GATGGAGGAC ATCGTCCAGG AAGCCCGCAA TGCAGAAGAG 
AAGGCCAAGA AAGCCATCAC TGACGCCGCC ATGATGGCGG AGGAGCTGAA GAAGGAGCAG 
GACACCAGCG CCCATCTGGA GCGGATGAAG AAGAACCTGG AGCAGACGGT GAAGGACCTG 
CAGCACCGTC TGGACGAGGC TGAGCAGCTG GCGCTGAAGG GCGGCAAGAA GCAGATCCAG 
AAACTGGAGG CCAGGGTCCG TGAACTTGAA GGAGAAGTTG AAAACGAACA GAAGCGCAAT 
GTTGAAGCTA TCAAGGGTCT GCGCAAACAT GAGAGAAGAG TGAAAGAACT CACTTACCAA 
ACTGAGGAAG ACCGCAAGAA CGTTCTCAGG CTCCAGGACC TTGTGGACAA ACTGCAATCA 
AAGGTCAAAG CATACAAGAG ACAAGCCGAG GAAGCGGAGG AACAATCCAA CGTCAACCTG 
GCCAAGTTCC GCAAGATCCA GCACGAGCTG GAGGAAGCCG AGGAGCGGGC TGACATCGCC 
GAGTCCCAGG TCAACAAGCT GCGGGTGAAG AGCCGCGAGG TTCACACCAA AATCATAAGC 
GAAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
International journal of cardiology167(3)698-703(2013 Aug)
Damatto RL,Martinez PF,Lima AR,Cezar MD,Campos DH,Oliveira Junior SA,Guizoni DM,Bonomo C,Nakatani BT,Dal Pai Silva M,Carvalho RF,Okoshi K,Okoshi MP

Interferon-? causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis.
The American journal of pathology181(6)2038-46(2012 Dec)
Cosper PF,Harvey PA,Leinwand LA

Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.
American journal of physiology. Cell physiology297(1)C6-16(2009 Jul)
Pandorf CE,Haddad F,Wright C,Bodell PW,Baldwin KM

The slow sarco/endoplasmic reticulum Ca2+ -ATPase declines independently of slow myosin in soleus muscle of diabetic rats.
Acta biochimica Polonica56(3)487-93(2009)
R?cz G,Szab? A,V?r A,Z?dor E

Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations.
Genes to cells : devoted to molecular & cellular mechanisms13(10)987-99(2008 Oct)
Ajima R,Akazawa H,Kodama M,Takeshita F,Otsuka A,Kohno T,Komuro I,Ochiya T,Yokota J

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Myh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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