Pgp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pgp
Entrez Gene ID	287115
Full Name	phosphoglycolate phosphatase
Synonyms	AUM,G3PP,RGD1307773
General protein information	Preferred Names phosphoglycolate phosphatase Names glycerol-3-phosphate phosphatase aspartate-based ubiquitous Mg(2+)-dependent phosphatase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001169152.1	NP_001162623.1	glycerol-3-phosphate phosphatase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PGP	XP_001162359.2
	LOC695591	XP_001084229.2
Canis lupus familiaris (dog)	PGP	XP_005622146.1
Rattus norvegicus (Norway rat)	Pgp	NP_001162623.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011350	XP_309300.4
Caenorhabditis elegans (roundworm)	C53A3.2	NP_504511.1
Caenorhabditis elegans (roundworm)	CELE_K09H11.7	NP_504509.1
Caenorhabditis elegans (roundworm)	C45E5.1	NP_500857.2
Saccharomyces cerevisiae (baker's yeast)	PHO13	NP_010045.1
Kluyveromyces lactis	KLLA0D19382g	XP_453922.1
Schizosaccharomyces pombe (fission yeast)	pho2	NP_596255.1
Neurospora crassa	NCU00088	XP_957212.1
Bos taurus (cattle)	PGP	NP_001033261.1
Caenorhabditis elegans (roundworm)	F44E7.2	NP_504512.1
Magnaporthe oryzae (rice blast fungus)	MGG_10149	XP_003713787.1
Arabidopsis thaliana (thale cress)	PGLP2	NP_199587.1
Gallus gallus (chicken)	PGP	NP_001025809.1
Caenorhabditis elegans (roundworm)	K02D10.1	NP_001122707.1
Oryza sativa (rice)	Os09g0261300	NP_001062708.2
Xenopus tropicalis (tropical clawed frog)	pgp	XP_002932481.1
Homo sapiens (human)	PGP	NP_001035830.1
Mus musculus (house mouse)	Pgp	NP_080230.2
Danio rerio (zebrafish)	pgp	NP_997891.2
Drosophila melanogaster (fruit fly)	CG5567	NP_649015.2
Eremothecium gossypii	AGOS_ABL184W	NP_982763.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.
Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SR, Prentki M
Proceedings of the National Academy of Sciences of the United States of America113(4)E430-9(2016 Jan)

Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Seifried A, Knobloch G, Duraphe PS, Segerer G, Manhard J, Schindelin H, Schultz J, Gohla A
The Journal of biological chemistry289(6)3416-31(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In vivo overexpression of PGP (functioning as glycerol-3-phosphate phosphatase) in rat liver lowers body weight gain and hepatic glucose production from glycerol and elevates plasma HDL levels. It is expressed in different tissues and nutritional states.
Title: Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.

The following Pgp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pgp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06123	NM_001169152.1 Latest version!	Rattus norvegicus phosphoglycolate phosphatase (Pgp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pgp ( NM_001169152.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001162623.1 Rattus norvegicus phosphoglycolate phosphatase (Pgp), mRNA.

Price & Availability↑

CloneID	ORa06123
Clone ID Related Accession (Same CDS sequence)	NM_001169152.1
Accession Version	NM_001169152.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-21
Organism	Rattus norvegicus(Norway rat)
Product	glycerol-3-phosphate phosphatase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC103090.7. On or before Dec 18, 2009 this sequence version replaced XM_001055264.1, XM_213235.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CV126709.1, AW916145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAGG CGGAGGCCGG CGGCGACGAA GTCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCCAAGTTGC TGCTGGCCGA AGTGGACACG CTGCTGTTCG ACTGCGATGG CGTGCTGTGG 
CGCGGCGAGA CGGCCGTGCC GGGCGCGCCG GAGACTCTGC GGGCGCTGCG GGCCCGCGGC 
AAGCGACTGG GCTTCATCAC CAACAACAGC AGCAAGACTC GTACGGCCTA CGCGGAGAAG 
CTCAGGCGCT TGGGTTTCGG TGGCCCGATG GGGCCCGAAG CGGGCCTCGA GGTCTTCGGC 
ACGGCCTACT GCAGCGCGCT CTATCTGCGC CAACGCCTGG CCGGCGTGCC GGACCCCAAG 
GCCTACGTGC TGGGCAGCCC GGCCTTAGCC GCGGAGCTGG AGGCCGTGGG TGTCACTAGC 
GTGGGCGTGG GCCCGGACGT GCTTCACGGC GATGGCCCAA GCGACTGGCT AGCCGTGCCG 
CTCGAACCCG ACGTGCGCGC GGTAGTGGTG GGCTTCGACC CACACTTCAG CTACATGAAG 
CTTACCAAGG CCGTGCGGTA CCTGCAGCAG CCCGACTGTC TGCTCGTGGG CACCAACATG 
GACAACCGGC TCCCGCTAGA GAACGGCCGT TTCATTGCGG GTACCGGCTG TCTGGTGCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCG GACATCATCG GGAAGCCTAG CCGCTTCATC 
TTCGACTGCG TGTCCCAGGA GTATGGTATC AACCCGGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTGGGCTCC ACCTGTAGCC TGAAGACTAT CCTGACCCTC 
ACCGGAGTCT CCAGTCTTGA GGATGTGAAG AGCAATCAGG AAAGTGACTG CATGTTCAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATAGCCG ACCTCTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001162623.1
CDS	40..1005
Translation	MAEAEAGGDEVRCVRLSAERAKLLLAEVDTLLFDCDGVLWRGETAVPGAPETLRALRARGKRLGFITNNSSKTRTAYAEKLRRLGFGGPMGPEAGLEVFGTAYCSALYLRQRLAGVPDPKAYVLGSPALAAELEAVGVTSVGVGPDVLHGDGPSDWLAVPLEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGSTCSLKTILTLTGVSSLEDVKSNQESDCMFKKKMVPDFYVDSIADLLPALQG

Target ORF information:

RefSeq Version	NM_001169152.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phosphoglycolate phosphatase (Pgp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001169152.1

ORF Insert Sequence:

ATGGCGGAGG CGGAGGCCGG CGGCGACGAA GTCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCCAAGTTGC TGCTGGCCGA AGTGGACACG CTGCTGTTCG ACTGCGATGG CGTGCTGTGG 
CGCGGCGAGA CGGCCGTGCC GGGCGCGCCG GAGACTCTGC GGGCGCTGCG GGCCCGCGGC 
AAGCGACTGG GCTTCATCAC CAACAACAGC AGCAAGACTC GTACGGCCTA CGCGGAGAAG 
CTCAGGCGCT TGGGTTTCGG TGGCCCGATG GGGCCCGAAG CGGGCCTCGA GGTCTTCGGC 
ACGGCCTACT GCAGCGCGCT CTATCTGCGC CAACGCCTGG CCGGCGTGCC GGACCCCAAG 
GCCTACGTGC TGGGCAGCCC GGCCTTAGCC GCGGAGCTGG AGGCCGTGGG TGTCACTAGC 
GTGGGCGTGG GCCCGGACGT GCTTCACGGC GATGGCCCAA GCGACTGGCT AGCCGTGCCG 
CTCGAACCCG ACGTGCGCGC GGTAGTGGTG GGCTTCGACC CACACTTCAG CTACATGAAG 
CTTACCAAGG CCGTGCGGTA CCTGCAGCAG CCCGACTGTC TGCTCGTGGG CACCAACATG 
GACAACCGGC TCCCGCTAGA GAACGGCCGT TTCATTGCGG GTACCGGCTG TCTGGTGCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCG GACATCATCG GGAAGCCTAG CCGCTTCATC 
TTCGACTGCG TGTCCCAGGA GTATGGTATC AACCCGGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTGGGCTCC ACCTGTAGCC TGAAGACTAT CCTGACCCTC 
ACCGGAGTCT CCAGTCTTGA GGATGTGAAG AGCAATCAGG AAAGTGACTG CATGTTCAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATAGCCG ACCTCTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America113(4)E430-9(2016 Jan)
Mugabo Y,Zhao S,Seifried A,Gezzar S,Al-Mass A,Zhang D,Lamontagne J,Attane C,Poursharifi P,Iglesias J,Joly E,Peyot ML,Gohla A,Madiraju SR,Prentki M

Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
The Journal of biological chemistry289(6)3416-31(2014 Feb)
Seifried A,Knobloch G,Duraphe PS,Segerer G,Manhard J,Schindelin H,Schultz J,Gohla A