Taok1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Taok1
Entrez Gene ID	286993
Full Name	TAO kinase 1
General protein information	Preferred Names TAO kinase 1 Names serine/threonine-protein kinase TAO1 thousand and one amino acid protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	protein kinase; involved in regulation of the p38-containing stress-responsive MAP kinase pathway [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_173327.1	NP_775449.1	serine/threonine-protein kinase TAO1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TAOK1	NP_065842.1
Gallus gallus (chicken)	TAOK1	XP_415829.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003202	XP_001237504.2
Mus musculus (house mouse)	Taok1	NP_659074.2
Canis lupus familiaris (dog)	TAOK1	XP_005624944.1
Rattus norvegicus (Norway rat)	Taok1	NP_775449.1
Danio rerio (zebrafish)	LOC100004576	XP_001343838.1
Bos taurus (cattle)	TAOK1	NP_001193029.1
Caenorhabditis elegans (roundworm)	kin-18	NP_001022767.1
Xenopus tropicalis (tropical clawed frog)	taok1	NP_001116260.1
Pan troglodytes (chimpanzee)	TAOK1	XP_001138940.1
Drosophila melanogaster (fruit fly)	Tao	NP_728268.1

Gene Ontology
Bibliography

Related articles in PubMed

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells.
Sun Y, Chiu TT, Foley KP, Bilan PJ, Klip A
Molecular biology of the cell25(7)1159-70(2014 Apr)

The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.
Patel M, Cai Q, Ding D, Salvi R, Hu Z, Hu BH
PloS one8(3)e58471(2013)

Mechanisms and functions of p38 MAPK signalling.
Cuadrado A, Nebreda AR
The Biochemical journal429(3)403-17(2010 Aug)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.
Johne C, Matenia D, Li XY, Timm T, Balusamy K, Mandelkow EM
Molecular biology of the cell19(4)1391-403(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inhibition of miR-183 in cochlear organotypic culture leads to upregulation of Taok1. Exposure to noise caused a significant upregulation of Taok1.
Title: The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.

The following Taok1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Taok1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42516	NM_173327.1 Latest version!	Rattus norvegicus TAO kinase 1 (Taok1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$734.30 $1049.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Taok1 ( NM_173327.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_775449.1 Rattus norvegicus TAO kinase 1 (Taok1), mRNA.

Price & Availability↑

CloneID	ORa42516
Clone ID Related Accession (Same CDS sequence)	NM_173327.1
Accession Version	NM_173327.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3006bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase TAO1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF084205.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF084205.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCATCAA CTAACAGAGC AGGCAGTCTA AAGGACCCTG AAATCGCAGA GCTCTTCTTC 
AAAGAAGATC CGGAAAAACT CTTCACAGAT CTCAGAGAAA TCGGCCATGG GAGCTTTGGA 
GCAGTTTATT TTGCACGAGA TGTGCGTACT AATGAAGTGG TGGCCATCAA GAAAATGTCT 
TATAGTGGAA AGCAGTCTAC TGAGAAATGG CAGGATATTA TTAAGGAAGT CAAGTTTCTA 
CAAAGAATAA AACATCCCAA CAGTATAGAA TACAAAGGCT GCTATTTACG TGAACACACA 
GCATGGCTTG TAATGGAATA TTGTTTAGGA TCTGCTTCGG ATTTACTAGA AGTTCATAAA 
AAGCCATTAC AAGAAGTGGA AATAGCAGCA ATTACACATG GTGCTCTCCA GGGATTAGCT 
TATTTACATT CTCATACCAT GATCCATAGA GATATCAAAG CAGGAAATAT CCTTCTGACA 
GAACCAGGCC AAGTGAAACT TGCTGACTTT GGATCTGCTT CCATGGCCTC CCCTGCCAAT 
TCTTTTGTGG GAACACCATA TTGGATGGCC CCAGAAGTAA TTTTAGCCAT GGATGAAGGA 
CAATATGATG GCAAAGTTGA TGTATGGTCT CTTGGAATAA CATGTATTGA ATTAGCCGAG 
AGGAAGCCTC CTTTATTTAA TATGAATGCA ATGAGTGCCT TATATCACAT AGCCCAAAAT 
GAATCCCCTA CACTACAGTC TAATGAATGG TCTGATTATT TTCGAAACTT TGTAGATTCT 
TGCCTCCAGA AAATCCCTCA AGATCGCCCT ACATCAGAGG AACTTTTAAA GCACATGTTT 
GTTCTTCGAG AGCGCCCTGA AACAGTGTTA ATAGATCTTA TTCAAAGGAC AAAGGATGCA 
GTAAGAGAGC TGGACAATCT ACAATATCGA AAGATGAAGA AACTCCTTTT CCAGGAGGCA 
CATAATGGAC CAGCAGTAGA AGCACAGGAA GAAGAGGAGG AGCAAGATCA TGGTGGTGGC 
CGGACAGGAA CAGTAAATAG TGTTGGAAGC AATCAGTCTA TCCCCAGTAT GTCTATCAGT 
GCCAGTAGCC AAAGCAGCAG TGTTAATAGT CTTCCAGATG CATCGGATGA CAAGAGTGAG 
CTAGACATGA TGGAGGGAGA CCATACAGTG ATGTCTAACA GTTCTGTCAT CCACTTAAAA 
CCTGAGGAGG AAAATTACCA AGAAGAAGGA GATCCTAGAA CAAGAGCATC AGCTCCACAG 
TCTCCACCTC AAGTGTCTCG TCACAAATCA CATTATCGTA ATAGAGAACA CTTTGCAACT 
ATACGAACAG CATCACTGGT TACAAGACAG ATGCAAGAAC ATGAGCAGGA CTCTGAACTT 
AGAGAACAGA TGTCTGGTTA TAAGCGGATG AGGCGACAGC ATCAGAAGCA GCTGATGACT 
CTGGAAAATA AACTGAAGGC AGAAATGGAC GAACATCGGC TCAGATTAGA CAAAGATCTT 
GAAACTCAGC GCAACAATTT CGCTGCAGAA ATGGAGAAAC TTATTAAGAA ACACCAAGCT 
TCTATGGAAA AAGAGGCTAA AGTGATGGCC AACGAGGAGA AAAAATTCCA ACAACACATT 
CAGGCTCAAC AGAAGAAAGA ACTGAATAGC TTTTTGGAGT CTCAAAAAAG AGAATATAAA 
CTTCGAAAAG AGCAGCTTAA GGAGGAGCTG AATGAAAACC AGAGCACACC TAAAAAAGAA 
AAGCAGGAAT GGCTTTCAAA GCAGAAGGAG AATATTCAAC ATTTTCAGGC AGAAGAAGAA 
GCTAATCTTC TTCGACGTCA AAGGCAGTAT CTAGAGCTAG AATGTCGTCG CTTCAAAAGA 
AGAATGTTAC TTGGTCGGCA TAACTTGGAA CAGGACCTTG TCAGGGAGGA GTTAAACAAA 
AGGCAGACTC AGAAGGACTT AGAACATGCA ATGTTACTGC GACAGCATGA ATCCATGCAA 
GAACTGGAGT TTCGCCACCT CAACACTATT CAGAAGATGC GCTGTGAGTT GATCAGACTG 
CAACATCAAA CTGAGCTTAC TAACCAGCTG GAATACAATA AGAGAAGGGA ACGGGAACTA 
AGACGGAAAC ATGTCATGGA AGTTCGACAG CAGCCTAAGA GTTTGAAGTC TAAAGAACTC 
CAAATAAAAA AGCAGTTTCA GGATACCTGC AAAATTCAAA CCAGACAGTA CAAAGCATTA 
AGGAATCACC TACTGGAGAC TACACCAAAG AGTGAGCACA AAGCTGTTCT GAAAAGACTC 
AAGGAGGAAC AGACTCGGAA GTTAGCCATC TTGGCTGAGC AGTATGATCA TAGCATTAAT 
GAAATGCTCT CCACACAAGC TCTGCGTTTG GATGAAGCAC AGGAAGCAGA ATGCCAGGTT 
TTGAAGATGC AGCTACAGCA GGAACTGGAG CTGTTGAATG CATATCAGAG CAAAATCAAG 
ATGCAGGCTG AGGCCCAACA TGATCGAGAG CTTCGAGAGC TGGAACAAAG GGTCTCCCTT 
CGGAGAGCAC TCTTAGAACA GAAGATTGAA GAAGAGATGT TGGCTTTGCA GAATGAACGC 
ACAGAACGAA TACGTAGCCT GCTCGAGCGC CAGGCCAGAG AAATTGAAGC TTTTGACTCT 
GAAAGCATGA GATTAGGTTT TAGTAACATG GTCCTTTCTA ATCTCTCCCC TGAGGCATTC 
AGCCACAGCT ACCCAGGAGC TTCTAGCTGG TCTCACAATC CTACTGGGGG TTCAGGACCT 
CACTGGGGTC ATCCCATGGG TGGCACACCA CAAGCTTGGG GTCATCCGAT GCAAGGCGGA 
CCCCAACCAT GGGGTCACCC CTCAGGGCCA ATGCAAGGGG TACCTCGAGG TAGCAGTATA 
GGAGTCCGCA ATAGCCCCCA GGCTCTGAGG CGGACAGCTT CTGGGGGACG GACGGAACAG 
GGCATGAGCA GAAGCACGAG TGTCACTTCA CAAATATCCA ATGGGTCACA CATGTCTTAC 
ACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775449.1
CDS	121..3126
Translation	MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGGGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMSNSSVIHLKPEEENYQEEGDPRTRASAPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQASMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASSWSHNPTGGSGPHWGHPMGGTPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSIGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT

Target ORF information:

RefSeq Version	NM_173327.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TAO kinase 1 (Taok1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173327.1

ORF Insert Sequence:

ATGCCATCAA CTAACAGAGC AGGCAGTCTA AAGGACCCTG AAATCGCAGA GCTCTTCTTC 
AAAGAAGATC CGGAAAAACT CTTCACAGAT CTCAGAGAAA TCGGCCATGG GAGCTTTGGA 
GCAGTTTATT TTGCACGAGA TGTGCGTACT AATGAAGTGG TGGCCATCAA GAAAATGTCT 
TATAGTGGAA AGCAGTCTAC TGAGAAATGG CAGGATATTA TTAAGGAAGT CAAGTTTCTA 
CAAAGAATAA AACATCCCAA CAGTATAGAA TACAAAGGCT GCTATTTACG TGAACACACA 
GCATGGCTTG TAATGGAATA TTGTTTAGGA TCTGCTTCGG ATTTACTAGA AGTTCATAAA 
AAGCCATTAC AAGAAGTGGA AATAGCAGCA ATTACACATG GTGCTCTCCA GGGATTAGCT 
TATTTACATT CTCATACCAT GATCCATAGA GATATCAAAG CAGGAAATAT CCTTCTGACA 
GAACCAGGCC AAGTGAAACT TGCTGACTTT GGATCTGCTT CCATGGCCTC CCCTGCCAAT 
TCTTTTGTGG GAACACCATA TTGGATGGCC CCAGAAGTAA TTTTAGCCAT GGATGAAGGA 
CAATATGATG GCAAAGTTGA TGTATGGTCT CTTGGAATAA CATGTATTGA ATTAGCCGAG 
AGGAAGCCTC CTTTATTTAA TATGAATGCA ATGAGTGCCT TATATCACAT AGCCCAAAAT 
GAATCCCCTA CACTACAGTC TAATGAATGG TCTGATTATT TTCGAAACTT TGTAGATTCT 
TGCCTCCAGA AAATCCCTCA AGATCGCCCT ACATCAGAGG AACTTTTAAA GCACATGTTT 
GTTCTTCGAG AGCGCCCTGA AACAGTGTTA ATAGATCTTA TTCAAAGGAC AAAGGATGCA 
GTAAGAGAGC TGGACAATCT ACAATATCGA AAGATGAAGA AACTCCTTTT CCAGGAGGCA 
CATAATGGAC CAGCAGTAGA AGCACAGGAA GAAGAGGAGG AGCAAGATCA TGGTGGTGGC 
CGGACAGGAA CAGTAAATAG TGTTGGAAGC AATCAGTCTA TCCCCAGTAT GTCTATCAGT 
GCCAGTAGCC AAAGCAGCAG TGTTAATAGT CTTCCAGATG CATCGGATGA CAAGAGTGAG 
CTAGACATGA TGGAGGGAGA CCATACAGTG ATGTCTAACA GTTCTGTCAT CCACTTAAAA 
CCTGAGGAGG AAAATTACCA AGAAGAAGGA GATCCTAGAA CAAGAGCATC AGCTCCACAG 
TCTCCACCTC AAGTGTCTCG TCACAAATCA CATTATCGTA ATAGAGAACA CTTTGCAACT 
ATACGAACAG CATCACTGGT TACAAGACAG ATGCAAGAAC ATGAGCAGGA CTCTGAACTT 
AGAGAACAGA TGTCTGGTTA TAAGCGGATG AGGCGACAGC ATCAGAAGCA GCTGATGACT 
CTGGAAAATA AACTGAAGGC AGAAATGGAC GAACATCGGC TCAGATTAGA CAAAGATCTT 
GAAACTCAGC GCAACAATTT CGCTGCAGAA ATGGAGAAAC TTATTAAGAA ACACCAAGCT 
TCTATGGAAA AAGAGGCTAA AGTGATGGCC AACGAGGAGA AAAAATTCCA ACAACACATT 
CAGGCTCAAC AGAAGAAAGA ACTGAATAGC TTTTTGGAGT CTCAAAAAAG AGAATATAAA 
CTTCGAAAAG AGCAGCTTAA GGAGGAGCTG AATGAAAACC AGAGCACACC TAAAAAAGAA 
AAGCAGGAAT GGCTTTCAAA GCAGAAGGAG AATATTCAAC ATTTTCAGGC AGAAGAAGAA 
GCTAATCTTC TTCGACGTCA AAGGCAGTAT CTAGAGCTAG AATGTCGTCG CTTCAAAAGA 
AGAATGTTAC TTGGTCGGCA TAACTTGGAA CAGGACCTTG TCAGGGAGGA GTTAAACAAA 
AGGCAGACTC AGAAGGACTT AGAACATGCA ATGTTACTGC GACAGCATGA ATCCATGCAA 
GAACTGGAGT TTCGCCACCT CAACACTATT CAGAAGATGC GCTGTGAGTT GATCAGACTG 
CAACATCAAA CTGAGCTTAC TAACCAGCTG GAATACAATA AGAGAAGGGA ACGGGAACTA 
AGACGGAAAC ATGTCATGGA AGTTCGACAG CAGCCTAAGA GTTTGAAGTC TAAAGAACTC 
CAAATAAAAA AGCAGTTTCA GGATACCTGC AAAATTCAAA CCAGACAGTA CAAAGCATTA 
AGGAATCACC TACTGGAGAC TACACCAAAG AGTGAGCACA AAGCTGTTCT GAAAAGACTC 
AAGGAGGAAC AGACTCGGAA GTTAGCCATC TTGGCTGAGC AGTATGATCA TAGCATTAAT 
GAAATGCTCT CCACACAAGC TCTGCGTTTG GATGAAGCAC AGGAAGCAGA ATGCCAGGTT 
TTGAAGATGC AGCTACAGCA GGAACTGGAG CTGTTGAATG CATATCAGAG CAAAATCAAG 
ATGCAGGCTG AGGCCCAACA TGATCGAGAG CTTCGAGAGC TGGAACAAAG GGTCTCCCTT 
CGGAGAGCAC TCTTAGAACA GAAGATTGAA GAAGAGATGT TGGCTTTGCA GAATGAACGC 
ACAGAACGAA TACGTAGCCT GCTCGAGCGC CAGGCCAGAG AAATTGAAGC TTTTGACTCT 
GAAAGCATGA GATTAGGTTT TAGTAACATG GTCCTTTCTA ATCTCTCCCC TGAGGCATTC 
AGCCACAGCT ACCCAGGAGC TTCTAGCTGG TCTCACAATC CTACTGGGGG TTCAGGACCT 
CACTGGGGTC ATCCCATGGG TGGCACACCA CAAGCTTGGG GTCATCCGAT GCAAGGCGGA 
CCCCAACCAT GGGGTCACCC CTCAGGGCCA ATGCAAGGGG TACCTCGAGG TAGCAGTATA 
GGAGTCCGCA ATAGCCCCCA GGCTCTGAGG CGGACAGCTT CTGGGGGACG GACGGAACAG 
GGCATGAGCA GAAGCACGAG TGTCACTTCA CAAATATCCA ATGGGTCACA CATGTCTTAC 
ACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells.
Molecular biology of the cell25(7)1159-70(2014 Apr)
Sun Y,Chiu TT,Foley KP,Bilan PJ,Klip A

The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.
PloS one8(3)e58471(2013)
Patel M,Cai Q,Ding D,Salvi R,Hu Z,Hu BH

Mechanisms and functions of p38 MAPK signalling.
The Biochemical journal429(3)403-17(2010 Aug)
Cuadrado A,Nebreda AR

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.
Molecular biology of the cell19(4)1391-403(2008 Apr)
Johne C,Matenia D,Li XY,Timm T,Balusamy K,Mandelkow EM