Mrgprx1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mrgprx1
Entrez Gene ID	282547
Full Name	MAS-related GPR, member X1
Synonyms	Mgrg2,Mrgprc11,Snsr1
General protein information	Preferred Names MAS-related GPR, member X1 Names mas-related G-protein coupled receptor member X1 G protein-coupled receptor SNSR MAS-related GPR, member C11 Mas-related G protein-coupled receptor g2 sensory neuron-specific G-protein coupled receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	G-protein coupled receptor; may be involved in regulation of sensory neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017588843.1	XP_017444332.1	mas-related G-protein coupled receptor member X1 isoform X1
NM_172158.2	NP_750845.2	mas-related G-protein coupled receptor member X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MRGPRX4	XP_521855.1
Rattus norvegicus (Norway rat)	Mrgprx1	NP_750845.2
Homo sapiens (human)	MRGPRX4	NP_473373.2
	MRGPRX4	NP_001035708.1
Mus musculus (house mouse)	Mrgprx1	NP_997423.1

Gene Ontology
Bibliography

Related articles in PubMed

Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.
Premzl M
Gene540(1)16-9(2014 Apr)

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T
Cancer cell24(3)305-17(2013 Sep)

Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.
Akiyama T, Tominaga M, Davoodi A, Nagamine M, Blansit K, Horwitz A, Carstens MI, Carstens E
Neuroscience226305-12(2012 Dec)

Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.
Solinski HJ, Zierler S, Gudermann T, Breit A
The Journal of biological chemistry287(49)40956-71(2012 Nov)

Role of rat sensory neuron-specific receptor (rSNSR1) in inflammatory pain: contribution of TRPV1 to SNSR signaling in the pain pathway.
Ndong C, Pradhan A, Puma C, Morello JP, Hoffert C, Groblewski T, O'Donnell D, Laird JM
Pain143(1-2)130-7(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analysis of the functional interactions between MRGPR-X1 and TRPV1
Title: Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.

We propose that rSNSR1 represents a new member of the receptors expressed on chemosensitive nociceptors responsible for detecting the "inflammatory soup" of mediators generated by tissue damage.
Title: Role of rat sensory neuron-specific receptor (rSNSR1) in inflammatory pain: contribution of TRPV1 to SNSR signaling in the pain pathway.

The following Mrgprx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mrgprx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12585	NM_172158.2 Latest version!	Rattus norvegicus MAS-related GPR, member X1 (Mrgprx1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa56418	XM_017588843.1 Latest version!	Rattus norvegicus MAS-related GPR, member X1 (Mrgprx1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mrgprx1 ( NM_172158.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_750845.2 Rattus norvegicus MAS-related GPR, member X1 (Mrgprx1), mRNA.

Price & Availability↑

CloneID	ORa12585
Clone ID Related Accession (Same CDS sequence)	NM_172158.2
Accession Version	NM_172158.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-09
Organism	Rattus norvegicus(Norway rat)
Product	mas-related G-protein coupled receptor member X1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF474986.2. On Jul 24, 2003 this sequence version replaced NM_172158.1.

ATGGTTTGTG TTCTCAGGGA CACTACTGGA AGATTTGTGA GCATGGATCC AACCATCTCA 
TCCCTCAGTA CAGAATCTAC AACACTGAAT AAAACTGGTC ATCCCAGTTG CAGGCCAATC 
CTCACCCTGT CCTTCCTGGT CCCCATCATC ACCCTGCTTG GATTGGCAGG AAACACCATT 
GTACTCTGGC TCTTGGGATT CCGCATGCGC AGGAAAGCCA TCTCAGTCTA CGTCCTCAAC 
CTGTCTCTGG CAGACTCCTT CTTCCTCTGC TGCCATTTTA TTGACTCTCT GATGCGGATC 
ATGAACTTCT ATGGCATCTA TGCCCATAAA TTAAGCAAAG AAATCTTAGG CAATGCAGCA 
ATCATTCCCT ATATCTCAGG CCTGAGCATC CTCAGTGCTA TCAGCACGGA GCGCTGCCTG 
TCTGTATTGT GGCCAATCTG GTACCACTGC CACCGCCCAA GAAACATGTC AGCTATTATA 
TGTGTTCTAA TCTGGGTTCT GTCCTTTCTC ATGGGCATCC TTGACTGGTT CTTCTCAGGA 
TTCCTGGGTG AGACTCACCA TCATTTGTGG AAAAATGTTG ACTTTATTGT AACTGCATTT 
CTGATTTTTT TATTTATGCT TCTCTTTGGG TCCAGTCTGG CGCTACTGGT GAGGATCCTC 
TGTGGTTCCA GACGGAAACC ACTGTCCAGG CTGTACGTTA CAATCTCTCT CACAGTGATG 
GTCTACCTCA TCTGCGGCCT GCCTCTCGGG CTTTACTTGT TCCTGCTATA TTGGTTTGGG 
ATCCATTTAC ATTATCCCTT TTGTCACATT TACCAAGTTA CTGTGCTCCT GTCCTGTGTG 
AACAGCTCTG CCAACCCCAT CATTTACTTC CTTGTAGGGT CCTTTAGGCA CCGTAAAAAG 
CATCGGTCCC TCAAAATGGT TCTTAAGAGG GCTCTGGAGG AGACTCCTGA GGAGGATGAA 
TATACAGACA GCCATGTTCA GAAACCCACT GAGATCTCAG AAAGGAGATG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_750845.2
CDS	1..1014
Translation	MVCVLRDTTGRFVSMDPTISSLSTESTTLNKTGHPSCRPILTLSFLVPIITLLGLAGNTIVLWLLGFRMRRKAISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAHKLSKEILGNAAIIPYISGLSILSAISTERCLSVLWPIWYHCHRPRNMSAIICVLIWVLSFLMGILDWFFSGFLGETHHHLWKNVDFIVTAFLIFLFMLLFGSSLALLVRILCGSRRKPLSRLYVTISLTVMVYLICGLPLGLYLFLLYWFGIHLHYPFCHIYQVTVLLSCVNSSANPIIYFLVGSFRHRKKHRSLKMVLKRALEETPEEDEYTDSHVQKPTEISERRC

Target ORF information:

RefSeq Version	NM_172158.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAS-related GPR, member X1 (Mrgprx1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172158.2

ORF Insert Sequence:

ATGGTTTGTG TTCTCAGGGA CACTACTGGA AGATTTGTGA GCATGGATCC AACCATCTCA 
TCCCTCAGTA CAGAATCTAC AACACTGAAT AAAACTGGTC ATCCCAGTTG CAGGCCAATC 
CTCACCCTGT CCTTCCTGGT CCCCATCATC ACCCTGCTTG GATTGGCAGG AAACACCATT 
GTACTCTGGC TCTTGGGATT CCGCATGCGC AGGAAAGCCA TCTCAGTCTA CGTCCTCAAC 
CTGTCTCTGG CAGACTCCTT CTTCCTCTGC TGCCATTTTA TTGACTCTCT GATGCGGATC 
ATGAACTTCT ATGGCATCTA TGCCCATAAA TTAAGCAAAG AAATCTTAGG CAATGCAGCA 
ATCATTCCCT ATATCTCAGG CCTGAGCATC CTCAGTGCTA TCAGCACGGA GCGCTGCCTG 
TCTGTATTGT GGCCAATCTG GTACCACTGC CACCGCCCAA GAAACATGTC AGCTATTATA 
TGTGTTCTAA TCTGGGTTCT GTCCTTTCTC ATGGGCATCC TTGACTGGTT CTTCTCAGGA 
TTCCTGGGTG AGACTCACCA TCATTTGTGG AAAAATGTTG ACTTTATTGT AACTGCATTT 
CTGATTTTTT TATTTATGCT TCTCTTTGGG TCCAGTCTGG CGCTACTGGT GAGGATCCTC 
TGTGGTTCCA GACGGAAACC ACTGTCCAGG CTGTACGTTA CAATCTCTCT CACAGTGATG 
GTCTACCTCA TCTGCGGCCT GCCTCTCGGG CTTTACTTGT TCCTGCTATA TTGGTTTGGG 
ATCCATTTAC ATTATCCCTT TTGTCACATT TACCAAGTTA CTGTGCTCCT GTCCTGTGTG 
AACAGCTCTG CCAACCCCAT CATTTACTTC CTTGTAGGGT CCTTTAGGCA CCGTAAAAAG 
CATCGGTCCC TCAAAATGGT TCTTAAGAGG GCTCTGGAGG AGACTCCTGA GGAGGATGAA 
TATACAGACA GCCATGTTCA GAAACCCACT GAGATCTCAG AAAGGAGATG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mrgprx1 ( XM_017588843.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444332.1 Rattus norvegicus MAS-related GPR, member X1 (Mrgprx1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56418
Clone ID Related Accession (Same CDS sequence)	XM_017588843.1
Accession Version	XM_017588843.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mas-related G-protein coupled receptor member X1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCCAA CCATCTCATC CCTCAGTACA GAATCTACAA CACTGAATAA AACTGGTCAT 
CCCAGTTGCA GGCCAATCCT CACCCTGTCC TTCCTGGTCC CCATCATCAC CCTGCTTGGA 
TTGGCAGGAA ACACCATTGT ACTCTGGCTC TTGGGATTCC GCATGCGCAG GAAAGCCATC 
TCAGTCTACG TCCTCAACCT GTCTCTGGCA GACTCCTTCT TCCTCTGCTG CCATTTTATT 
GACTCTCTGA TGCGGATCAT GAACTTCTAT GGCATCTATG CCCATAAATT AAGCAAAGAA 
ATCTTAGGCA ATGCAGCAAT CATTCCCTAT ATCTCAGGCC TGAGCATCCT CAGTGCTATC 
AGCACGGAGC GCTGCCTGTC TGTATTGTGG CCAATCTGGT ACCACTGCCA CCGCCCAAGA 
AACATGTCAG CTATTATATG TGTTCTAATC TGGGTTCTGT CCTTTCTCAT GGGCATCCTT 
GACTGGTTCT TCTCAGGATT CCTGGGTGAG ACTCACCATC ATTTGTGGAA AAATGTTGAC 
TTTATTGTAA CTGCATTTCT GATTTTTTTA TTTATGCTTC TCTTTGGGTC CAGTCTGGCG 
CTACTGGTGA GGATCCTCTG TGGTTCCAGA CGGAAACCAC TGTCCAGGCT GTACGTTACA 
ATCTCTCTCA CAGTGATGGT CTACCTCATC TGCGGCCTGC CTCTCGGGCT TTACTTGTTC 
CTGCTATATT GGTTTGGGAT CCATTTACAT TATCCCTTTT GTCACATTTA CCAAGTTACT 
GTGCTCCTGT CCTGTGTGAA CAGCTCTGCC AACCCCATCA TTTACTTCCT TGTAGGGTCC 
TTTAGGCACC GTAAAAAGCA TCGGTCCCTC AAAATGGTTC TTAAGAGGGC TCTGGAGGAG 
ACTCCTGAGG AGGATGAATA TACAGACAGC CATGTTCAGA AACCCACTGA GATCTCAGAA 
AGGAGATGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444332.1
CDS	529..1500
Translation	MDPTISSLSTESTTLNKTGHPSCRPILTLSFLVPIITLLGLAGNTIVLWLLGFRMRRKAISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAHKLSKEILGNAAIIPYISGLSILSAISTERCLSVLWPIWYHCHRPRNMSAIICVLIWVLSFLMGILDWFFSGFLGETHHHLWKNVDFIVTAFLIFLFMLLFGSSLALLVRILCGSRRKPLSRLYVTISLTVMVYLICGLPLGLYLFLLYWFGIHLHYPFCHIYQVTVLLSCVNSSANPIIYFLVGSFRHRKKHRSLKMVLKRALEETPEEDEYTDSHVQKPTEISERRC

Target ORF information:

RefSeq Version	XM_017588843.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAS-related GPR, member X1 (Mrgprx1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017588843.1

ORF Insert Sequence:

ATGGATCCAA CCATCTCATC CCTCAGTACA GAATCTACAA CACTGAATAA AACTGGTCAT 
CCCAGTTGCA GGCCAATCCT CACCCTGTCC TTCCTGGTCC CCATCATCAC CCTGCTTGGA 
TTGGCAGGAA ACACCATTGT ACTCTGGCTC TTGGGATTCC GCATGCGCAG GAAAGCCATC 
TCAGTCTACG TCCTCAACCT GTCTCTGGCA GACTCCTTCT TCCTCTGCTG CCATTTTATT 
GACTCTCTGA TGCGGATCAT GAACTTCTAT GGCATCTATG CCCATAAATT AAGCAAAGAA 
ATCTTAGGCA ATGCAGCAAT CATTCCCTAT ATCTCAGGCC TGAGCATCCT CAGTGCTATC 
AGCACGGAGC GCTGCCTGTC TGTATTGTGG CCAATCTGGT ACCACTGCCA CCGCCCAAGA 
AACATGTCAG CTATTATATG TGTTCTAATC TGGGTTCTGT CCTTTCTCAT GGGCATCCTT 
GACTGGTTCT TCTCAGGATT CCTGGGTGAG ACTCACCATC ATTTGTGGAA AAATGTTGAC 
TTTATTGTAA CTGCATTTCT GATTTTTTTA TTTATGCTTC TCTTTGGGTC CAGTCTGGCG 
CTACTGGTGA GGATCCTCTG TGGTTCCAGA CGGAAACCAC TGTCCAGGCT GTACGTTACA 
ATCTCTCTCA CAGTGATGGT CTACCTCATC TGCGGCCTGC CTCTCGGGCT TTACTTGTTC 
CTGCTATATT GGTTTGGGAT CCATTTACAT TATCCCTTTT GTCACATTTA CCAAGTTACT 
GTGCTCCTGT CCTGTGTGAA CAGCTCTGCC AACCCCATCA TTTACTTCCT TGTAGGGTCC 
TTTAGGCACC GTAAAAAGCA TCGGTCCCTC AAAATGGTTC TTAAGAGGGC TCTGGAGGAG 
ACTCCTGAGG AGGATGAATA TACAGACAGC CATGTTCAGA AACCCACTGA GATCTCAGAA 
AGGAGATGTT GA