Npas4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Npas4
Entrez Gene ID	266734
Full Name	neuronal PAS domain protein 4
Synonyms	Nxf
General protein information	Preferred Names neuronal PAS domain protein 4 Names neuronal PAS domain-containing protein 4 HLH-PAS transcription factor NXF bHLH-PAS type transcription factor NXF neuronal PAS4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43
Summary	may act as a transcription factor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_153626.1	NP_705890.1	neuronal PAS domain-containing protein 4
XM_017588841.1	XP_017444330.1	neuronal PAS domain-containing protein 4 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NPAS4	XP_540832.2
Danio rerio (zebrafish)	npas4a	NP_001038786.1
Gallus gallus (chicken)	LOC101750093	XP_004940231.1
Pan troglodytes (chimpanzee)	NPAS4	XP_001171566.1
Danio rerio (zebrafish)	LOC794051	XP_001333944.2
Mus musculus (house mouse)	Npas4	NP_705781.1
Danio rerio (zebrafish)	LOC100534657	XP_003200884.2
Xenopus tropicalis (tropical clawed frog)	npas4	NP_001072906.2
Homo sapiens (human)	NPAS4	NP_849195.2
	NPAS4	XP_001110331.1
Bos taurus (cattle)	NPAS4	XP_002699401.1
Rattus norvegicus (Norway rat)	Npas4	NP_705890.1

Gene Ontology
Bibliography

Related articles in PubMed

Stress-induced hippocampus Npas4 mRNA expression relates to specific psychophysiological patterns of stress response.
Drouet JB, Peinnequin A, Faure P, Denis J, Fidier N, Maury R, Buguet A, Cespuglio R, Canini F
Brain research167975-83(2018 Jan)

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.
Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Kalivas PW, Self DW, Lin Y, Cowan CW
Neuron96(1)130-144.e6(2017 Sep)

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Wu D, Su X, Potluri N, Kim Y, Rastinejad F
eLife5(2016 10)

NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons.
Fan W, Long Y, Lai Y, Wang X, Chen G, Zhu B
Journal of molecular neuroscience : MN58(4)401-10(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. We also discovered that HDAC5 associates with an activity-sensitive enhancer of the Npas4 gene and negatively regulates NPAS4 expression.
Title: HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.

Overexpression of NPAS4 induced autophagy and effectively facilitated the clearance of endogenous total and phosphorylated tau in rat primary cortical neurons.
Title: NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons.

Relative hippocampal NPAS4 expression was significantly lower in depression model rats compared to controls but there was no significant difference in hippocampal ARNT2 expression between groups
Title: Hippocampal expression of aryl hydrocarbon receptor nuclear translocator 2 and neuronal PAS domain protein 4 in a rat model of depression.

The Npas4 protein levels increased in the acute phase of seizures (between 6 h and 72 h) and decreased in the chronic phases (between 7 d and 60 d) in the rat model.
Title: The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats.

The findings suggest that stroke-induced Npas4 upregulation may be involved in a transcriptional regulatory program within the corticolimbic circuitry following an ischemic insult.
Title: Upregulation of the neuronal Per-Arnt-Sim domain protein 4 (Npas4) in the rat corticolimbic system following focal cerebral ischemia.

The following Npas4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Npas4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03105	NM_153626.1 Latest version!	Rattus norvegicus neuronal PAS domain protein 4 (Npas4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa03105	XM_017588841.1 Latest version!	Rattus norvegicus neuronal PAS domain protein 4 (Npas4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Npas4 ( NM_153626.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_705890.1 Rattus norvegicus neuronal PAS domain protein 4 (Npas4), mRNA.

Price & Availability↑

CloneID	ORa03105
Clone ID Related Accession (Same CDS sequence)	NM_153626.1 , XM_017588841.1
Accession Version	NM_153626.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	neuronal PAS domain-containing protein 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB050103.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB050103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTACCGAT CCACCAAGGG CGCCTCCAAG GCGCGCCGCG ACCAGATCAA CGCCGAGATT 
CGGAACCTCA AGGAACTGCT GCCGTTGGCT GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GTCTTGCCTG CATCTACACT CGCAAGGGTG TCTTCTTTGC TGGAGGCACT 
CCTTTGGCTG GCCCCACGGG GCTTCTCTCT GCTCAAGAGC TTGAAGACAT AGTGGCAGCA 
CTACCTGGAT TTCTACTTGT GTTCACAGCT GAGGGGAAGT TGCTATACCT GTCGGAGAGT 
GTGAGCGAGC ATCTGGGCCA TTCTATGGTG GATCTGGTTG CCCAGGGTGA CAGTATTTAC 
GACATCATTG ACCCTGCTGA CCATCTCACT GTGCGCCAGC AGCTCACCAT GCCCTCTGCT 
CTGGATGCTG ATCGCCTTTT CCGTTGTCGA TTTAACACAT CCAAGTCCCT CCGGCGCCAG 
AGTGCAGGCA ACAAACTGGT GCTTATTCGA GGTCGATTCC ATGCTCACCC ACCTGGGGCC 
TACTGGGCAG GAAACCCCGT GTTCACAGCT TTCTGTGCCC CACTGGAGCC AAGACCCCGT 
CCCGGCCCTG GCCCTGGCCC TGGCCCTGGT CCTGCCTCTC TCTTCCTGGC CATGTTCCAG 
AGCCGGCATG CTAAGGACCT AGCCCTACTG GACATTTCTG AAAGTGTCCT AATCTACCTG 
GGCTTTGAGC GCAGCGAACT GCTCTGTAAA TCATGGTATG GACTGCTACA CCCCGAGGAC 
CTGGCCCACG CTTCTTCTCA ACACTACCGC CTGTTGGCTG AAAATGGAGA TATTCAGGCT 
GAAATGGTGG TGAGACTTCA AGCCAAGCAT GGAGGCTGGA CATGGATTTA CTGCATGCTA 
TACTCGGATG GTCCAGAAGG CCCTATTACT GCCAATAACT ACCCTATCAG TGACACGGAA 
GCCTGGAGTC TTCGCCAGCA GCTAAACTCT GAAAACACCC AGGCAGCCTA TGTCCTAGGA 
ACCCCAGCTG TGCTACCCTC ATTCTCTGAG AATGTCTTCT CCCAGGAGCA CTGCTCTAAT 
CCACTCTTTA CACCAGCCCT GGGGACTCCT AGAAGTGCCA GCTTCCCCAG GGCCCCTGAA 
CTAGGTGTGA TCTCAACATC AGAAGAGCTT GCCCAACCCT CCAAAGAACT GGACTTCAGT 
TACCTGCCAT TCCCTGCAAG GCCTGAGCCT TCCCTCCAAG CAGACTTGAG CAAGGATTTG 
GTGTGTACTC CACCTTACAC ACCCCACCAG CCAGGAGGCT GCGCCTTCCT CTTCAGCCTC 
CATGAACCCT TCCAGACTCA CTTGCCCCCT CCATCCAGCT CTCTCCAAGA ACAGCTGACG 
CCAAGCACGG TGACTTTCTC TGAACAGTTG ACACCAAGCA GTGCAACCTT CCCAGATCCA 
CTAACCAGTT CACTACAAGG ACAGTTGACT GAAAGCTCAG CCAGAAGCTT TGAAGAACAA 
TTGACTCCGT GCACCTCTAC CTTCCCTGAC CAGCTGCTTC CCAGCACTGC CACGTTCCCA 
GAACCTCTGG GTAGCCCCAC CCATGAGCAG CTGACTCCTC CCAGCACAGC ATTCCAAGCA 
CATCTGAACA GTCCTAGCCA AACCTTCCCA GAGCAACTGA GCCCTAATCC TACCAAGACT 
TACTTCGCCC AGGAGGGATG CAGTTTTCTC TATGAGAAGT TGCCCCCAAG TCCTAGCAGC 
CCTGGTAATG GGGACTGTAC ACTCTTGGCC CTAGCTCAAC TCCGGGGTCC CCTCTCTGTG 
GACGTCCCCC TGGTGCCTGA AGGCCTGCTC ACACCTGAGG CCTCTCCAGT CAAGCAAAGT 
TTCTTCCACT ATACAGAGAA AGAGCAGAAT GAGATAGATC GTCTCATCCA GCAGATCAGC 
CAGTTGGCTC AGGGCATGGA CAGGCCCTTC TCAGCTGAGG CTGGCACTGG GGGGCTGGAG 
CCACTTGGAG GGCTGGAGCC CCTGAACCCC AACCTGTCCC TGTCAGGGGC TGGACCCCCT 
GTGCTTAGCC TGGATCTTAA ACCCTGGAAA TGCCAGGAGC TGGACTTCTT GGTTGACCCT 
GATAATTTAT TCCTGGAAGA GACGCCAGTG GAAGACATCT TCATGGATCT TTCTACTCCA 
GACCCCAATG GGGAATGGGG TTCAGGGGAT CCTGAGGCAG AGGTCCCAGG AGGGACCCTG 
TCACCTTGCA ACAACCTGTC CCCAGAAGAT CACAGCTTCC TGGAGGACTT GGCCACCTAT 
GAAACCGCCT TTGAGACAGG TGTCTCAACA TTCCCCTATG AAGGGTTTGC TGATGAGTTG 
CATCAACTCC AGAGCCAAGT TCAAGACAGC TTCCATGAAG ATGGAAGTGG AGGGGAACCA 
ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_705890.1
CDS	35..2443
Translation	MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTMPSALDADRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASSQHYRLLAENGDIQAEMVVRLQAKHGGWTWIYCMLYSDGPEGPITANNYPISDTEAWSLRQQLNSENTQAAYVLGTPAVLPSFSENVFSQEHCSNPLFTPALGTPRSASFPRAPELGVISTSEELAQPSKELDFSYLPFPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPPPSSSLQEQLTPSTVTFSEQLTPSSATFPDPLTSSLQGQLTESSARSFEEQLTPCTSTFPDQLLPSTATFPEPLGSPTHEQLTPPSTAFQAHLNSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYTEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLNPNLSLSGAGPPVLSLDLKPWKCQELDFLVDPDNLFLEETPVEDIFMDLSTPDPNGEWGSGDPEAEVPGGTLSPCNNLSPEDHSFLEDLATYETAFETGVSTFPYEGFADELHQLQSQVQDSFHEDGSGGEPTF

Target ORF information:

RefSeq Version	NM_153626.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuronal PAS domain protein 4 (Npas4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153626.1

ORF Insert Sequence:

ATGTACCGAT CCACCAAGGG CGCCTCCAAG GCGCGCCGCG ACCAGATCAA CGCCGAGATT 
CGGAACCTCA AGGAACTGCT GCCGTTGGCT GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GTCTTGCCTG CATCTACACT CGCAAGGGTG TCTTCTTTGC TGGAGGCACT 
CCTTTGGCTG GCCCCACGGG GCTTCTCTCT GCTCAAGAGC TTGAAGACAT AGTGGCAGCA 
CTACCTGGAT TTCTACTTGT GTTCACAGCT GAGGGGAAGT TGCTATACCT GTCGGAGAGT 
GTGAGCGAGC ATCTGGGCCA TTCTATGGTG GATCTGGTTG CCCAGGGTGA CAGTATTTAC 
GACATCATTG ACCCTGCTGA CCATCTCACT GTGCGCCAGC AGCTCACCAT GCCCTCTGCT 
CTGGATGCTG ATCGCCTTTT CCGTTGTCGA TTTAACACAT CCAAGTCCCT CCGGCGCCAG 
AGTGCAGGCA ACAAACTGGT GCTTATTCGA GGTCGATTCC ATGCTCACCC ACCTGGGGCC 
TACTGGGCAG GAAACCCCGT GTTCACAGCT TTCTGTGCCC CACTGGAGCC AAGACCCCGT 
CCCGGCCCTG GCCCTGGCCC TGGCCCTGGT CCTGCCTCTC TCTTCCTGGC CATGTTCCAG 
AGCCGGCATG CTAAGGACCT AGCCCTACTG GACATTTCTG AAAGTGTCCT AATCTACCTG 
GGCTTTGAGC GCAGCGAACT GCTCTGTAAA TCATGGTATG GACTGCTACA CCCCGAGGAC 
CTGGCCCACG CTTCTTCTCA ACACTACCGC CTGTTGGCTG AAAATGGAGA TATTCAGGCT 
GAAATGGTGG TGAGACTTCA AGCCAAGCAT GGAGGCTGGA CATGGATTTA CTGCATGCTA 
TACTCGGATG GTCCAGAAGG CCCTATTACT GCCAATAACT ACCCTATCAG TGACACGGAA 
GCCTGGAGTC TTCGCCAGCA GCTAAACTCT GAAAACACCC AGGCAGCCTA TGTCCTAGGA 
ACCCCAGCTG TGCTACCCTC ATTCTCTGAG AATGTCTTCT CCCAGGAGCA CTGCTCTAAT 
CCACTCTTTA CACCAGCCCT GGGGACTCCT AGAAGTGCCA GCTTCCCCAG GGCCCCTGAA 
CTAGGTGTGA TCTCAACATC AGAAGAGCTT GCCCAACCCT CCAAAGAACT GGACTTCAGT 
TACCTGCCAT TCCCTGCAAG GCCTGAGCCT TCCCTCCAAG CAGACTTGAG CAAGGATTTG 
GTGTGTACTC CACCTTACAC ACCCCACCAG CCAGGAGGCT GCGCCTTCCT CTTCAGCCTC 
CATGAACCCT TCCAGACTCA CTTGCCCCCT CCATCCAGCT CTCTCCAAGA ACAGCTGACG 
CCAAGCACGG TGACTTTCTC TGAACAGTTG ACACCAAGCA GTGCAACCTT CCCAGATCCA 
CTAACCAGTT CACTACAAGG ACAGTTGACT GAAAGCTCAG CCAGAAGCTT TGAAGAACAA 
TTGACTCCGT GCACCTCTAC CTTCCCTGAC CAGCTGCTTC CCAGCACTGC CACGTTCCCA 
GAACCTCTGG GTAGCCCCAC CCATGAGCAG CTGACTCCTC CCAGCACAGC ATTCCAAGCA 
CATCTGAACA GTCCTAGCCA AACCTTCCCA GAGCAACTGA GCCCTAATCC TACCAAGACT 
TACTTCGCCC AGGAGGGATG CAGTTTTCTC TATGAGAAGT TGCCCCCAAG TCCTAGCAGC 
CCTGGTAATG GGGACTGTAC ACTCTTGGCC CTAGCTCAAC TCCGGGGTCC CCTCTCTGTG 
GACGTCCCCC TGGTGCCTGA AGGCCTGCTC ACACCTGAGG CCTCTCCAGT CAAGCAAAGT 
TTCTTCCACT ATACAGAGAA AGAGCAGAAT GAGATAGATC GTCTCATCCA GCAGATCAGC 
CAGTTGGCTC AGGGCATGGA CAGGCCCTTC TCAGCTGAGG CTGGCACTGG GGGGCTGGAG 
CCACTTGGAG GGCTGGAGCC CCTGAACCCC AACCTGTCCC TGTCAGGGGC TGGACCCCCT 
GTGCTTAGCC TGGATCTTAA ACCCTGGAAA TGCCAGGAGC TGGACTTCTT GGTTGACCCT 
GATAATTTAT TCCTGGAAGA GACGCCAGTG GAAGACATCT TCATGGATCT TTCTACTCCA 
GACCCCAATG GGGAATGGGG TTCAGGGGAT CCTGAGGCAG AGGTCCCAGG AGGGACCCTG 
TCACCTTGCA ACAACCTGTC CCCAGAAGAT CACAGCTTCC TGGAGGACTT GGCCACCTAT 
GAAACCGCCT TTGAGACAGG TGTCTCAACA TTCCCCTATG AAGGGTTTGC TGATGAGTTG 
CATCAACTCC AGAGCCAAGT TCAAGACAGC TTCCATGAAG ATGGAAGTGG AGGGGAACCA 
ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Npas4 ( XM_017588841.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444330.1 Rattus norvegicus neuronal PAS domain protein 4 (Npas4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa03105
Clone ID Related Accession (Same CDS sequence)	NM_153626.1 , XM_017588841.1
Accession Version	XM_017588841.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neuronal PAS domain-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACCGAT CCACCAAGGG CGCCTCCAAG GCGCGCCGCG ACCAGATCAA CGCCGAGATT 
CGGAACCTCA AGGAACTGCT GCCGTTGGCT GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GTCTTGCCTG CATCTACACT CGCAAGGGTG TCTTCTTTGC TGGAGGCACT 
CCTTTGGCTG GCCCCACGGG GCTTCTCTCT GCTCAAGAGC TTGAAGACAT AGTGGCAGCA 
CTACCTGGAT TTCTACTTGT GTTCACAGCT GAGGGGAAGT TGCTATACCT GTCGGAGAGT 
GTGAGCGAGC ATCTGGGCCA TTCTATGGTG GATCTGGTTG CCCAGGGTGA CAGTATTTAC 
GACATCATTG ACCCTGCTGA CCATCTCACT GTGCGCCAGC AGCTCACCAT GCCCTCTGCT 
CTGGATGCTG ATCGCCTTTT CCGTTGTCGA TTTAACACAT CCAAGTCCCT CCGGCGCCAG 
AGTGCAGGCA ACAAACTGGT GCTTATTCGA GGTCGATTCC ATGCTCACCC ACCTGGGGCC 
TACTGGGCAG GAAACCCCGT GTTCACAGCT TTCTGTGCCC CACTGGAGCC AAGACCCCGT 
CCCGGCCCTG GCCCTGGCCC TGGCCCTGGT CCTGCCTCTC TCTTCCTGGC CATGTTCCAG 
AGCCGGCATG CTAAGGACCT AGCCCTACTG GACATTTCTG AAAGTGTCCT AATCTACCTG 
GGCTTTGAGC GCAGCGAACT GCTCTGTAAA TCATGGTATG GACTGCTACA CCCCGAGGAC 
CTGGCCCACG CTTCTTCTCA ACACTACCGC CTGTTGGCTG AAAATGGAGA TATTCAGGCT 
GAAATGGTGG TGAGACTTCA AGCCAAGCAT GGAGGCTGGA CATGGATTTA CTGCATGCTA 
TACTCGGATG GTCCAGAAGG CCCTATTACT GCCAATAACT ACCCTATCAG TGACACGGAA 
GCCTGGAGTC TTCGCCAGCA GCTAAACTCT GAAAACACCC AGGCAGCCTA TGTCCTAGGA 
ACCCCAGCTG TGCTACCCTC ATTCTCTGAG AATGTCTTCT CCCAGGAGCA CTGCTCTAAT 
CCACTCTTTA CACCAGCCCT GGGGACTCCT AGAAGTGCCA GCTTCCCCAG GGCCCCTGAA 
CTAGGTGTGA TCTCAACATC AGAAGAGCTT GCCCAACCCT CCAAAGAACT GGACTTCAGT 
TACCTGCCAT TCCCTGCAAG GCCTGAGCCT TCCCTCCAAG CAGACTTGAG CAAGGATTTG 
GTGTGTACTC CACCTTACAC ACCCCACCAG CCAGGAGGCT GCGCCTTCCT CTTCAGCCTC 
CATGAACCCT TCCAGACTCA CTTGCCCCCT CCATCCAGCT CTCTCCAAGA ACAGCTGACG 
CCAAGCACGG TGACTTTCTC TGAACAGTTG ACACCAAGCA GTGCAACCTT CCCAGATCCA 
CTAACCAGTT CACTACAAGG ACAGTTGACT GAAAGCTCAG CCAGAAGCTT TGAAGAACAA 
TTGACTCCGT GCACCTCTAC CTTCCCTGAC CAGCTGCTTC CCAGCACTGC CACGTTCCCA 
GAACCTCTGG GTAGCCCCAC CCATGAGCAG CTGACTCCTC CCAGCACAGC ATTCCAAGCA 
CATCTGAACA GTCCTAGCCA AACCTTCCCA GAGCAACTGA GCCCTAATCC TACCAAGACT 
TACTTCGCCC AGGAGGGATG CAGTTTTCTC TATGAGAAGT TGCCCCCAAG TCCTAGCAGC 
CCTGGTAATG GGGACTGTAC ACTCTTGGCC CTAGCTCAAC TCCGGGGTCC CCTCTCTGTG 
GACGTCCCCC TGGTGCCTGA AGGCCTGCTC ACACCTGAGG CCTCTCCAGT CAAGCAAAGT 
TTCTTCCACT ATACAGAGAA AGAGCAGAAT GAGATAGATC GTCTCATCCA GCAGATCAGC 
CAGTTGGCTC AGGGCATGGA CAGGCCCTTC TCAGCTGAGG CTGGCACTGG GGGGCTGGAG 
CCACTTGGAG GGCTGGAGCC CCTGAACCCC AACCTGTCCC TGTCAGGGGC TGGACCCCCT 
GTGCTTAGCC TGGATCTTAA ACCCTGGAAA TGCCAGGAGC TGGACTTCTT GGTTGACCCT 
GATAATTTAT TCCTGGAAGA GACGCCAGTG GAAGACATCT TCATGGATCT TTCTACTCCA 
GACCCCAATG GGGAATGGGG TTCAGGGGAT CCTGAGGCAG AGGTCCCAGG AGGGACCCTG 
TCACCTTGCA ACAACCTGTC CCCAGAAGAT CACAGCTTCC TGGAGGACTT GGCCACCTAT 
GAAACCGCCT TTGAGACAGG TGTCTCAACA TTCCCCTATG AAGGGTTTGC TGATGAGTTG 
CATCAACTCC AGAGCCAAGT TCAAGACAGC TTCCATGAAG ATGGAAGTGG AGGGGAACCA 
ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444330.1
CDS	2198..4606
Translation	MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTMPSALDADRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASSQHYRLLAENGDIQAEMVVRLQAKHGGWTWIYCMLYSDGPEGPITANNYPISDTEAWSLRQQLNSENTQAAYVLGTPAVLPSFSENVFSQEHCSNPLFTPALGTPRSASFPRAPELGVISTSEELAQPSKELDFSYLPFPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPPPSSSLQEQLTPSTVTFSEQLTPSSATFPDPLTSSLQGQLTESSARSFEEQLTPCTSTFPDQLLPSTATFPEPLGSPTHEQLTPPSTAFQAHLNSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYTEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLNPNLSLSGAGPPVLSLDLKPWKCQELDFLVDPDNLFLEETPVEDIFMDLSTPDPNGEWGSGDPEAEVPGGTLSPCNNLSPEDHSFLEDLATYETAFETGVSTFPYEGFADELHQLQSQVQDSFHEDGSGGEPTF

Target ORF information:

RefSeq Version	XM_017588841.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuronal PAS domain protein 4 (Npas4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017588841.1

ORF Insert Sequence:

ATGTACCGAT CCACCAAGGG CGCCTCCAAG GCGCGCCGCG ACCAGATCAA CGCCGAGATT 
CGGAACCTCA AGGAACTGCT GCCGTTGGCT GAAGCGGACA AGGTCCGGCT GTCCTACCTG 
CACATCATGA GTCTTGCCTG CATCTACACT CGCAAGGGTG TCTTCTTTGC TGGAGGCACT 
CCTTTGGCTG GCCCCACGGG GCTTCTCTCT GCTCAAGAGC TTGAAGACAT AGTGGCAGCA 
CTACCTGGAT TTCTACTTGT GTTCACAGCT GAGGGGAAGT TGCTATACCT GTCGGAGAGT 
GTGAGCGAGC ATCTGGGCCA TTCTATGGTG GATCTGGTTG CCCAGGGTGA CAGTATTTAC 
GACATCATTG ACCCTGCTGA CCATCTCACT GTGCGCCAGC AGCTCACCAT GCCCTCTGCT 
CTGGATGCTG ATCGCCTTTT CCGTTGTCGA TTTAACACAT CCAAGTCCCT CCGGCGCCAG 
AGTGCAGGCA ACAAACTGGT GCTTATTCGA GGTCGATTCC ATGCTCACCC ACCTGGGGCC 
TACTGGGCAG GAAACCCCGT GTTCACAGCT TTCTGTGCCC CACTGGAGCC AAGACCCCGT 
CCCGGCCCTG GCCCTGGCCC TGGCCCTGGT CCTGCCTCTC TCTTCCTGGC CATGTTCCAG 
AGCCGGCATG CTAAGGACCT AGCCCTACTG GACATTTCTG AAAGTGTCCT AATCTACCTG 
GGCTTTGAGC GCAGCGAACT GCTCTGTAAA TCATGGTATG GACTGCTACA CCCCGAGGAC 
CTGGCCCACG CTTCTTCTCA ACACTACCGC CTGTTGGCTG AAAATGGAGA TATTCAGGCT 
GAAATGGTGG TGAGACTTCA AGCCAAGCAT GGAGGCTGGA CATGGATTTA CTGCATGCTA 
TACTCGGATG GTCCAGAAGG CCCTATTACT GCCAATAACT ACCCTATCAG TGACACGGAA 
GCCTGGAGTC TTCGCCAGCA GCTAAACTCT GAAAACACCC AGGCAGCCTA TGTCCTAGGA 
ACCCCAGCTG TGCTACCCTC ATTCTCTGAG AATGTCTTCT CCCAGGAGCA CTGCTCTAAT 
CCACTCTTTA CACCAGCCCT GGGGACTCCT AGAAGTGCCA GCTTCCCCAG GGCCCCTGAA 
CTAGGTGTGA TCTCAACATC AGAAGAGCTT GCCCAACCCT CCAAAGAACT GGACTTCAGT 
TACCTGCCAT TCCCTGCAAG GCCTGAGCCT TCCCTCCAAG CAGACTTGAG CAAGGATTTG 
GTGTGTACTC CACCTTACAC ACCCCACCAG CCAGGAGGCT GCGCCTTCCT CTTCAGCCTC 
CATGAACCCT TCCAGACTCA CTTGCCCCCT CCATCCAGCT CTCTCCAAGA ACAGCTGACG 
CCAAGCACGG TGACTTTCTC TGAACAGTTG ACACCAAGCA GTGCAACCTT CCCAGATCCA 
CTAACCAGTT CACTACAAGG ACAGTTGACT GAAAGCTCAG CCAGAAGCTT TGAAGAACAA 
TTGACTCCGT GCACCTCTAC CTTCCCTGAC CAGCTGCTTC CCAGCACTGC CACGTTCCCA 
GAACCTCTGG GTAGCCCCAC CCATGAGCAG CTGACTCCTC CCAGCACAGC ATTCCAAGCA 
CATCTGAACA GTCCTAGCCA AACCTTCCCA GAGCAACTGA GCCCTAATCC TACCAAGACT 
TACTTCGCCC AGGAGGGATG CAGTTTTCTC TATGAGAAGT TGCCCCCAAG TCCTAGCAGC 
CCTGGTAATG GGGACTGTAC ACTCTTGGCC CTAGCTCAAC TCCGGGGTCC CCTCTCTGTG 
GACGTCCCCC TGGTGCCTGA AGGCCTGCTC ACACCTGAGG CCTCTCCAGT CAAGCAAAGT 
TTCTTCCACT ATACAGAGAA AGAGCAGAAT GAGATAGATC GTCTCATCCA GCAGATCAGC 
CAGTTGGCTC AGGGCATGGA CAGGCCCTTC TCAGCTGAGG CTGGCACTGG GGGGCTGGAG 
CCACTTGGAG GGCTGGAGCC CCTGAACCCC AACCTGTCCC TGTCAGGGGC TGGACCCCCT 
GTGCTTAGCC TGGATCTTAA ACCCTGGAAA TGCCAGGAGC TGGACTTCTT GGTTGACCCT 
GATAATTTAT TCCTGGAAGA GACGCCAGTG GAAGACATCT TCATGGATCT TTCTACTCCA 
GACCCCAATG GGGAATGGGG TTCAGGGGAT CCTGAGGCAG AGGTCCCAGG AGGGACCCTG 
TCACCTTGCA ACAACCTGTC CCCAGAAGAT CACAGCTTCC TGGAGGACTT GGCCACCTAT 
GAAACCGCCT TTGAGACAGG TGTCTCAACA TTCCCCTATG AAGGGTTTGC TGATGAGTTG 
CATCAACTCC AGAGCCAAGT TCAAGACAGC TTCCATGAAG ATGGAAGTGG AGGGGAACCA 
ACGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stress-induced hippocampus Npas4 mRNA expression relates to specific psychophysiological patterns of stress response.
Brain research167975-83(2018 Jan)
Drouet JB,Peinnequin A,Faure P,Denis J,Fidier N,Maury R,Buguet A,Cespuglio R,Canini F

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.
Neuron96(1)130-144.e6(2017 Sep)
Taniguchi M,Carreira MB,Cooper YA,Bobadilla AC,Heinsbroek JA,Koike N,Larson EB,Balmuth EA,Hughes BW,Penrod RD,Kumar J,Smith LN,Guzman D,Takahashi JS,Kim TK,Kalivas PW,Self DW,Lin Y,Cowan CW

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
eLife5(2016 10)
Wu D,Su X,Potluri N,Kim Y,Rastinejad F

NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons.
Journal of molecular neuroscience : MN58(4)401-10(2016 Apr)
Fan W,Long Y,Lai Y,Wang X,Chen G,Zhu B

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Npas4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報