Alox15b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Alox15b
Entrez Gene ID	266604
Full Name	arachidonate 15-lipoxygenase, type B
General protein information	Preferred Names arachidonate 15-lipoxygenase, type B Names arachidonate 15-lipoxygenase B 15-LOX-2 15-LOX-B 15-lipoxygenase 2 arachidonate 15-lipoxygenase type II arachidonate 15-lipoxygenase, second type linoleate 13-lipoxygenase 15-LOb
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	human homolog is an epidermis-type lipoxygenase and member of the multigene family of mammalian lipoxygenases [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008767779.2	XP_008766001.1	arachidonate 15-lipoxygenase B isoform X1
NM_153301.2	NP_695213.1	arachidonate 15-lipoxygenase B

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ALOX15B	XP_511865.2
Gallus gallus (chicken)	ALOXE3	XP_423676.4
Rattus norvegicus (Norway rat)	Alox15b	NP_695213.1
	ALOX15B	XP_001111890.1
Canis lupus familiaris (dog)	ALOX15B	XP_546603.1
Bos taurus (cattle)	ALOX15B	NP_001192632.1
Mus musculus (house mouse)	Alox8	NP_033791.1
Homo sapiens (human)	ALOX15B	NP_001132.2

Gene Ontology
Bibliography

Related articles in PubMed

Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.
Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Igarashi Y, Kihara A
Journal of dermatological science85(3)186-196(2017 Mar)

The structure of human 15-lipoxygenase-2 with a substrate mimic.
Kobe MJ, Neau DB, Mitchell CE, Bartlett SG, Newcomer ME
The Journal of biological chemistry289(12)8562-9(2014 Mar)

Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.
Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(5)1939-49(2013 May)

Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
Shen T, Ma J, Zhang L, Yu X, Liu M, Hou Y, Wang Y, Ma C, Li S, Zhu D
PloS one8(12)e83132(2013)

Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.
Magnusson LU, Lundqvist A, Karlsson MN, Sk?l?n K, Levin M, Wiklund O, Bor?n J, Hult?n LM
PloS one7(8)e43142(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Consistent with the decreases in the 15-LOX metabolites, expression levels of the genes that encode the 15-LOXs, Alox15 and Alox15b, were largely reduced in Olmsted syndrome model rats.
Title: Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.

Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension.
Title: Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.

Hypoxia promotes pulmonary artery smooth muscle cell proliferation and survival, contributing to pulmonary vascular medial hypertrophy, which is likely to be mediated via the PDGF-BB/15-LO-2/15-HETE pathway.
Title: Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition.

12/15-LO activation has roles in macrophage and vascular smooth muscle cell oxidant stress and inflammation
Title: Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.

The following Alox15b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alox15b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02966	NM_153301.2 Latest version!	Rattus norvegicus arachidonate 15-lipoxygenase, type B (Alox15b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
ORa44498	XM_008767779.2 Latest version!	Rattus norvegicus arachidonate 15-lipoxygenase, type B (Alox15b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Alox15b ( NM_153301.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_695213.1 Rattus norvegicus arachidonate 15-lipoxygenase, type B (Alox15b), mRNA.

Price & Availability↑

CloneID	ORa02966
Clone ID Related Accession (Same CDS sequence)	NM_153301.2
Accession Version	NM_153301.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2034bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	arachidonate 15-lipoxygenase B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF415240.1. On May 4, 2007 this sequence version replaced NM_153301.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF415240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642720, SAMN02642782 [ECO:0000348] ##Evidence-Data-END##

ATGGCTAAAT TCAGGGTGAG AGTATCCACC GGGGAGGCCT GTGGGGCAGG CACATGGGAC 
AAAGTGTCTG TCAGCATCGT GGGAACCCAT GGAGAGAGCC CCTTAGTACC TCTGGACCAT 
CTGGGCAAGG AGTTCAGCGC TGGAGCTGAA GAAGACTTCG AGGTGACGCT TCCCCAGGAC 
GTTGGCACTG TGCTGATGCT GCGAATACAC AAGGCACCCC CGGAGGCACC CCTCCCACTT 
CTGTCTTTCC CACCTGATGC CTGGTACTGC CGCTGGTTTG AGCTGGAGTG GCTGCCGGGG 
GCTGCACTTC GCTTCCCCTG TTATCAGTGG CTGGAAGGGG CAGGGGAGCT GGTGCTGAGA 
GAGGGAGCAG CCAAGGTGTC CTGGCAAGAC CACCACCGTA CGCTGCAGGA TCAGCGCCAG 
AAGGAGCTGG AGTCCAGGAA GGACATGTAC AGCTGGAAGA CTTACATTGA AGGTTGGCCT 
CACTGCCTTG ACCATGAGAC CGTGAAAGAC TTGGACCTCA ACATCAAGTA CTCTGCAATG 
AAGAACGCCA AATTCTTCTT TAAAGCCCAG TCTGCGTTTA CAGAGCTGAA ATTCAAAGGG 
CTCCTGGACC GCACAGGACT CTGGAGGAGT CTGAGGGAGA TGAAAAGGAT GTTTAACTTC 
CACAACACTC CAGCAGCAGA GTATGTGTTT GCACACTGGC AGGAAGATGC CTTCTTCGCC 
TCCCAGTTCC TAAATGGCCT CAACCCAGTT CTGATTCGCC GCTGTCGCAG ACTCCCAGAG 
AACTTCCCAG TCACTGATGA AATGGTGGCT CCAGTGCTGG GCCCTGGGAC CAGTCTGCAG 
GCTGAGTTAG AGAAGGGCTC CCTGTTCTTG GTGGACCATG GAATTCTTTC TGGAGTGCAA 
ACCAATGTCA TCAATGGAAA GCCTCAGTTC TCAGCAGCCC CGATGACCCT ATTATACCAG 
AGTCCAGGGT CCGGACCCCT GCTTCCCATC GCCATACAGC TCAAACAGAC TCCCGGGCCA 
GACAACCCCA TCTTCCTGCC CAGCGATGAC AAGTGGGACT GGCTACTGGC CAAGACCTGG 
GTGCGCAACG CTGAGTTTTC CATCCACGAG GCTCTCACGC ATCTGCTGCA TGCCCACCTG 
ATTCCAGAAG TCTTTGCCTT GGCCACACTG CGCCAGCTGC CCCACTGTCA CCCTCTCTTC 
AAGCTGCTGA TTCCTCACAC TCGGTACACA CTGCACATCA ACACACTCGC CCGTGAGCTG 
CTCATTGCCC CTGGGAAGGT GGTGGACAAG TCCACAGGCC TTGGCATTGG GGGATTCTCT 
GACCTGATAA AGAGAAACAT GGAGCAGCTG AGCTATTCTG TCCTGTGTCT CCCTGAAGAT 
ATCCGAGCCC GAGATGTGGG AGACCTCCCA GGATACTATT ACCGAGATGA TGGGATGCAG 
ATCTGGAGTG CAATAAGGAG CTTCGTCTCT GAGATAGTTG ACATCTATTA CCCAAGTGAC 
GCATCTGTCC GAGATGACCA AGAGCTCCAG GCCTGGGTGG GGGAGATCTT CTCTGAGGGC 
TTCCTCAGCC AAGAAAGCTC AGGTATGCCC TCCTTGTTGG ATACCCAGGA AGCCCTGGTC 
CAATATGTTA CCATGGTGAT ATTCACCTGC TCAGCCAAGC ATGCAGCTGT CAGTGCAAGC 
CAGTTTGACT CGTGTGTTTG GATGCCCAAT CTGCCACCTT CCATGCAGCT ACCACCACCT 
ACTTCCAAAG GCCAGGCAAG CCCTGAGGGT TTCATAGCCA CACTCCCAGC AGTCAATGCC 
ACATGTGATG TCATCATCGC CCTCTGGCTG CTAAGCAAGG AGCCAGGGGA CCGTAGGCCC 
CTGGGCCACT ATCCAGATGA GCACTTCACA GAGGAGGTCC CACGGCGGAG CATCGCGGCC 
TTCCAGAGAA AGCTGATCCA GATATCCAGT GGCATCAGGA AGAGGAACCA AAGCCTGGCA 
CTGCCCTACA CCTACCTGGA TCCTCCCCTC ATCGAGAACA GTGTCTCCAT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_695213.1
CDS	29..2062
Translation	MAKFRVRVSTGEACGAGTWDKVSVSIVGTHGESPLVPLDHLGKEFSAGAEEDFEVTLPQDVGTVLMLRIHKAPPEAPLPLLSFPPDAWYCRWFELEWLPGAALRFPCYQWLEGAGELVLREGAAKVSWQDHHRTLQDQRQKELESRKDMYSWKTYIEGWPHCLDHETVKDLDLNIKYSAMKNAKFFFKAQSAFTELKFKGLLDRTGLWRSLREMKRMFNFHNTPAAEYVFAHWQEDAFFASQFLNGLNPVLIRRCRRLPENFPVTDEMVAPVLGPGTSLQAELEKGSLFLVDHGILSGVQTNVINGKPQFSAAPMTLLYQSPGSGPLLPIAIQLKQTPGPDNPIFLPSDDKWDWLLAKTWVRNAEFSIHEALTHLLHAHLIPEVFALATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIAPGKVVDKSTGLGIGGFSDLIKRNMEQLSYSVLCLPEDIRARDVGDLPGYYYRDDGMQIWSAIRSFVSEIVDIYYPSDASVRDDQELQAWVGEIFSEGFLSQESSGMPSLLDTQEALVQYVTMVIFTCSAKHAAVSASQFDSCVWMPNLPPSMQLPPPTSKGQASPEGFIATLPAVNATCDVIIALWLLSKEPGDRRPLGHYPDEHFTEEVPRRSIAAFQRKLIQISSGIRKRNQSLALPYTYLDPPLIENSVSI

Target ORF information:

RefSeq Version	NM_153301.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arachidonate 15-lipoxygenase, type B (Alox15b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153301.2

ORF Insert Sequence:

ATGGCTAAAT TCAGGGTGAG AGTATCCACC GGGGAGGCCT GTGGGGCAGG CACATGGGAC 
AAAGTGTCTG TCAGCATCGT GGGAACCCAT GGAGAGAGCC CCTTAGTACC TCTGGACCAT 
CTGGGCAAGG AGTTCAGCGC TGGAGCTGAA GAAGACTTCG AGGTGACGCT TCCCCAGGAC 
GTTGGCACTG TGCTGATGCT GCGAATACAC AAGGCACCCC CGGAGGCACC CCTCCCACTT 
CTGTCTTTCC CACCTGATGC CTGGTACTGC CGCTGGTTTG AGCTGGAGTG GCTGCCGGGG 
GCTGCACTTC GCTTCCCCTG TTATCAGTGG CTGGAAGGGG CAGGGGAGCT GGTGCTGAGA 
GAGGGAGCAG CCAAGGTGTC CTGGCAAGAC CACCACCGTA CGCTGCAGGA TCAGCGCCAG 
AAGGAGCTGG AGTCCAGGAA GGACATGTAC AGCTGGAAGA CTTACATTGA AGGTTGGCCT 
CACTGCCTTG ACCATGAGAC CGTGAAAGAC TTGGACCTCA ACATCAAGTA CTCTGCAATG 
AAGAACGCCA AATTCTTCTT TAAAGCCCAG TCTGCGTTTA CAGAGCTGAA ATTCAAAGGG 
CTCCTGGACC GCACAGGACT CTGGAGGAGT CTGAGGGAGA TGAAAAGGAT GTTTAACTTC 
CACAACACTC CAGCAGCAGA GTATGTGTTT GCACACTGGC AGGAAGATGC CTTCTTCGCC 
TCCCAGTTCC TAAATGGCCT CAACCCAGTT CTGATTCGCC GCTGTCGCAG ACTCCCAGAG 
AACTTCCCAG TCACTGATGA AATGGTGGCT CCAGTGCTGG GCCCTGGGAC CAGTCTGCAG 
GCTGAGTTAG AGAAGGGCTC CCTGTTCTTG GTGGACCATG GAATTCTTTC TGGAGTGCAA 
ACCAATGTCA TCAATGGAAA GCCTCAGTTC TCAGCAGCCC CGATGACCCT ATTATACCAG 
AGTCCAGGGT CCGGACCCCT GCTTCCCATC GCCATACAGC TCAAACAGAC TCCCGGGCCA 
GACAACCCCA TCTTCCTGCC CAGCGATGAC AAGTGGGACT GGCTACTGGC CAAGACCTGG 
GTGCGCAACG CTGAGTTTTC CATCCACGAG GCTCTCACGC ATCTGCTGCA TGCCCACCTG 
ATTCCAGAAG TCTTTGCCTT GGCCACACTG CGCCAGCTGC CCCACTGTCA CCCTCTCTTC 
AAGCTGCTGA TTCCTCACAC TCGGTACACA CTGCACATCA ACACACTCGC CCGTGAGCTG 
CTCATTGCCC CTGGGAAGGT GGTGGACAAG TCCACAGGCC TTGGCATTGG GGGATTCTCT 
GACCTGATAA AGAGAAACAT GGAGCAGCTG AGCTATTCTG TCCTGTGTCT CCCTGAAGAT 
ATCCGAGCCC GAGATGTGGG AGACCTCCCA GGATACTATT ACCGAGATGA TGGGATGCAG 
ATCTGGAGTG CAATAAGGAG CTTCGTCTCT GAGATAGTTG ACATCTATTA CCCAAGTGAC 
GCATCTGTCC GAGATGACCA AGAGCTCCAG GCCTGGGTGG GGGAGATCTT CTCTGAGGGC 
TTCCTCAGCC AAGAAAGCTC AGGTATGCCC TCCTTGTTGG ATACCCAGGA AGCCCTGGTC 
CAATATGTTA CCATGGTGAT ATTCACCTGC TCAGCCAAGC ATGCAGCTGT CAGTGCAAGC 
CAGTTTGACT CGTGTGTTTG GATGCCCAAT CTGCCACCTT CCATGCAGCT ACCACCACCT 
ACTTCCAAAG GCCAGGCAAG CCCTGAGGGT TTCATAGCCA CACTCCCAGC AGTCAATGCC 
ACATGTGATG TCATCATCGC CCTCTGGCTG CTAAGCAAGG AGCCAGGGGA CCGTAGGCCC 
CTGGGCCACT ATCCAGATGA GCACTTCACA GAGGAGGTCC CACGGCGGAG CATCGCGGCC 
TTCCAGAGAA AGCTGATCCA GATATCCAGT GGCATCAGGA AGAGGAACCA AAGCCTGGCA 
CTGCCCTACA CCTACCTGGA TCCTCCCCTC ATCGAGAACA GTGTCTCCAT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Alox15b ( XM_008767779.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766001.1 Rattus norvegicus arachidonate 15-lipoxygenase, type B (Alox15b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44498
Clone ID Related Accession (Same CDS sequence)	XM_008767779.2
Accession Version	XM_008767779.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	arachidonate 15-lipoxygenase B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767779.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTAAAT TCAGGGTGAG AGTATCCACC GGGGAGGCCT GTGGGGCAGG CACATGGGAC 
AAAGTGTCTG TCAGCATCGT GGGAACCCAT GGAGAGAGCC CCTTAGTACC TCTGGACCAT 
CTGGGCAAGG AGTTCAGCGC TGGAGCTGAA GAAGACTTCG AGGTGACGCT TCCCCAGGAC 
GTTGGCACTG TGCTGATGCT GCGAATACAC AAGGCACCCC CGGAGGCACC CCTCCCACTT 
CTGTCTTTCC CACCTGATGC CTGGTACTGC CGCTGGTTTG AGCTGGAGTG GCTGCCGGGG 
GCTGCACTTC GCTTCCCCTG TTATCAGTGG CTGGAAGGGG CAGGGGAGCT GGTGCTGAGA 
GAGGGAGCAG CCAAGGTGTC CTGGCAAGAC CACCACCGTA CGCTGCAGGA TCAGCGCCAG 
AAGGAGCTGG AGTCCAGGAA GGACATGTAC AGGTTTACAG AGCTGAAATT CAAAGGGCTC 
CTGGACCGCA CAGGACTCTG GAGGAGTCTG AGGGAGATGA AAAGGATGTT TAACTTCCAC 
AACACTCCAG CAGCAGAGTA TGTGTTTGCA CACTGGCAGG AAGATGCCTT CTTCGCCTCC 
CAGTTCCTAA ATGGCCTCAA CCCAGTTCTG ATTCGCCGCT GTCGCAGACT CCCAGAGAAC 
TTCCCAGTCA CTGATGAAAT GGTGGCTCCA GTGCTGGGCC CTGGGACCAG TCTGCAGGCT 
GAGTTAGAGA AGGGCTCCCT GTTCTTGGTG GACCATGGAA TTCTTTCTGG AGTGCAAACC 
AATGTCATCA ATGGAAAGCC TCAGTTCTCA GCAGCCCCGA TGACCCTATT ATACCAGAGT 
CCAGGGTCCG GACCCCTGCT TCCCATCGCC ATACAGCTCA AACAGACTCC CGGGCCAGAC 
AACCCCATCT TCCTGCCCAG CGATGACAAG TGGGACTGGC TACTGGCCAA GACCTGGGTG 
CGCAACGCTG AGTTTTCCAT CCACGAGGCT CTCACGCATC TGCTGCATGC CCACCTGATT 
CCAGAAGTCT TTGCCTTGGC CACACTGCGC CAGCTGCCCC ACTGTCACCC TCTCTTCAAG 
CTGCTGATTC CTCACACTCG GTACACACTG CACATCAACA CGCTCGCCCG TGAGCTGCTC 
ATTGCCCCTG GGAAGGTGGT GGACAAGTCC ACAGGCCTTG GCATTGGGGG ATTCTCTGAC 
CTGATAAAGA GAAACATGGA GCAGCTGAGC TATTCTGTCC TGTGTCTCCC TGAAGATATC 
CGAGCCCGAG ATGTGGGAGA CCTCCCAGGA TACTATTACC GAGATGATGG GATGCAGATC 
TGGAGTGCAA TAAGGAGCTT CGTCTCTGAG ATAGTTGACA TCTATTACCC AAGTGACGCA 
TCTGTCCGAG ATGACCAAGA GCTCCAGGCC TGGGTGGGGG AGATCTTCTC TGAGGGCTTC 
CTCAGCCAAG AAAGCTCAGG TATGCCCTCT TTGTTGGATA CCCAGGAAGC CCTGGTCCAA 
TATGTTACCA TGGTGATATT CACCTGCTCA GCCAAGCATG CAGCTGTCAG TGCAAGCCAG 
TTTGACTCGT GTGTTTGGAT GCCCAATCTG CCACCTTCCA TGCAGCTACC ACCACCTACT 
TCCAAAGGCC AGGCAAGCCC TGAGGGTTTC ATAGCCACAC TCCCAGCAGT CAATGCCACA 
TGTGATGTCA TCATCGCCCT CTGGCTGCTA AGCAAGGAGC CAGGGGACCG TAGGCCCCTG 
GGCCACTATC CAGATGAGCA CTTCACAGAG GAGGCCCCAC GGCGGAGCAT CGCGGCCTTC 
CAGAGAAAGC TGATCCAGAT ATCCAGTGGC ATTAGGAAGA GGAACCAAAG CCTGGCACTG 
CCCTACACCT ACCTGGATCC TCCCCTCATC GAGAACAGTG TCTCCATCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766001.1
CDS	13..1923
Translation	MAKFRVRVSTGEACGAGTWDKVSVSIVGTHGESPLVPLDHLGKEFSAGAEEDFEVTLPQDVGTVLMLRIHKAPPEAPLPLLSFPPDAWYCRWFELEWLPGAALRFPCYQWLEGAGELVLREGAAKVSWQDHHRTLQDQRQKELESRKDMYRFTELKFKGLLDRTGLWRSLREMKRMFNFHNTPAAEYVFAHWQEDAFFASQFLNGLNPVLIRRCRRLPENFPVTDEMVAPVLGPGTSLQAELEKGSLFLVDHGILSGVQTNVINGKPQFSAAPMTLLYQSPGSGPLLPIAIQLKQTPGPDNPIFLPSDDKWDWLLAKTWVRNAEFSIHEALTHLLHAHLIPEVFALATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIAPGKVVDKSTGLGIGGFSDLIKRNMEQLSYSVLCLPEDIRARDVGDLPGYYYRDDGMQIWSAIRSFVSEIVDIYYPSDASVRDDQELQAWVGEIFSEGFLSQESSGMPSLLDTQEALVQYVTMVIFTCSAKHAAVSASQFDSCVWMPNLPPSMQLPPPTSKGQASPEGFIATLPAVNATCDVIIALWLLSKEPGDRRPLGHYPDEHFTEEAPRRSIAAFQRKLIQISSGIRKRNQSLALPYTYLDPPLIENSVSI

Target ORF information:

RefSeq Version	XM_008767779.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arachidonate 15-lipoxygenase, type B (Alox15b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767779.2

ORF Insert Sequence:

ATGGCTAAAT TCAGGGTGAG AGTATCCACC GGGGAGGCCT GTGGGGCAGG CACATGGGAC 
AAAGTGTCTG TCAGCATCGT GGGAACCCAT GGAGAGAGCC CCTTAGTACC TCTGGACCAT 
CTGGGCAAGG AGTTCAGCGC TGGAGCTGAA GAAGACTTCG AGGTGACGCT TCCCCAGGAC 
GTTGGCACTG TGCTGATGCT GCGAATACAC AAGGCACCCC CGGAGGCACC CCTCCCACTT 
CTGTCTTTCC CACCTGATGC CTGGTACTGC CGCTGGTTTG AGCTGGAGTG GCTGCCGGGG 
GCTGCACTTC GCTTCCCCTG TTATCAGTGG CTGGAAGGGG CAGGGGAGCT GGTGCTGAGA 
GAGGGAGCAG CCAAGGTGTC CTGGCAAGAC CACCACCGTA CGCTGCAGGA TCAGCGCCAG 
AAGGAGCTGG AGTCCAGGAA GGACATGTAC AGGTTTACAG AGCTGAAATT CAAAGGGCTC 
CTGGACCGCA CAGGACTCTG GAGGAGTCTG AGGGAGATGA AAAGGATGTT TAACTTCCAC 
AACACTCCAG CAGCAGAGTA TGTGTTTGCA CACTGGCAGG AAGATGCCTT CTTCGCCTCC 
CAGTTCCTAA ATGGCCTCAA CCCAGTTCTG ATTCGCCGCT GTCGCAGACT CCCAGAGAAC 
TTCCCAGTCA CTGATGAAAT GGTGGCTCCA GTGCTGGGCC CTGGGACCAG TCTGCAGGCT 
GAGTTAGAGA AGGGCTCCCT GTTCTTGGTG GACCATGGAA TTCTTTCTGG AGTGCAAACC 
AATGTCATCA ATGGAAAGCC TCAGTTCTCA GCAGCCCCGA TGACCCTATT ATACCAGAGT 
CCAGGGTCCG GACCCCTGCT TCCCATCGCC ATACAGCTCA AACAGACTCC CGGGCCAGAC 
AACCCCATCT TCCTGCCCAG CGATGACAAG TGGGACTGGC TACTGGCCAA GACCTGGGTG 
CGCAACGCTG AGTTTTCCAT CCACGAGGCT CTCACGCATC TGCTGCATGC CCACCTGATT 
CCAGAAGTCT TTGCCTTGGC CACACTGCGC CAGCTGCCCC ACTGTCACCC TCTCTTCAAG 
CTGCTGATTC CTCACACTCG GTACACACTG CACATCAACA CGCTCGCCCG TGAGCTGCTC 
ATTGCCCCTG GGAAGGTGGT GGACAAGTCC ACAGGCCTTG GCATTGGGGG ATTCTCTGAC 
CTGATAAAGA GAAACATGGA GCAGCTGAGC TATTCTGTCC TGTGTCTCCC TGAAGATATC 
CGAGCCCGAG ATGTGGGAGA CCTCCCAGGA TACTATTACC GAGATGATGG GATGCAGATC 
TGGAGTGCAA TAAGGAGCTT CGTCTCTGAG ATAGTTGACA TCTATTACCC AAGTGACGCA 
TCTGTCCGAG ATGACCAAGA GCTCCAGGCC TGGGTGGGGG AGATCTTCTC TGAGGGCTTC 
CTCAGCCAAG AAAGCTCAGG TATGCCCTCT TTGTTGGATA CCCAGGAAGC CCTGGTCCAA 
TATGTTACCA TGGTGATATT CACCTGCTCA GCCAAGCATG CAGCTGTCAG TGCAAGCCAG 
TTTGACTCGT GTGTTTGGAT GCCCAATCTG CCACCTTCCA TGCAGCTACC ACCACCTACT 
TCCAAAGGCC AGGCAAGCCC TGAGGGTTTC ATAGCCACAC TCCCAGCAGT CAATGCCACA 
TGTGATGTCA TCATCGCCCT CTGGCTGCTA AGCAAGGAGC CAGGGGACCG TAGGCCCCTG 
GGCCACTATC CAGATGAGCA CTTCACAGAG GAGGCCCCAC GGCGGAGCAT CGCGGCCTTC 
CAGAGAAAGC TGATCCAGAT ATCCAGTGGC ATTAGGAAGA GGAACCAAAG CCTGGCACTG 
CCCTACACCT ACCTGGATCC TCCCCTCATC GAGAACAGTG TCTCCATCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.
Journal of dermatological science85(3)186-196(2017 Mar)
Wakabayashi M,Yoshioka T,Higashino K,Numata Y,Igarashi Y,Kihara A

The structure of human 15-lipoxygenase-2 with a substrate mimic.
The Journal of biological chemistry289(12)8562-9(2014 Mar)
Kobe MJ,Neau DB,Mitchell CE,Bartlett SG,Newcomer ME

Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(5)1939-49(2013 May)
Gregus AM,Dumlao DS,Wei SC,Norris PC,Catella LC,Meyerstein FG,Buczynski MW,Steinauer JJ,Fitzsimmons BL,Yaksh TL,Dennis EA

Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
PloS one8(12)e83132(2013)
Shen T,Ma J,Zhang L,Yu X,Liu M,Hou Y,Wang Y,Ma C,Li S,Zhu D

Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.
PloS one7(8)e43142(2012)
Magnusson LU,Lundqvist A,Karlsson MN,Sk?l?n K,Levin M,Wiklund O,Bor?n J,Hult?n LM

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Alox15b cDNA ORF clone, Rattus norvegicus(Norway rat)

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