Casc3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casc3
Entrez Gene ID	259170
Full Name	cancer susceptibility 3
Synonyms	Btz,Mln51
General protein information	Preferred Names cancer susceptibility 3 Names protein CASC3 barentsz protein cancer susceptibility candidate 3 cancer susceptibility candidate gene 3 protein homolog metastatic lymph node 51 protein barentsz
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	nucleocytoplasmic shuttling protein, component of the dendritic mRNA transport particles in hippocampal neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_147144.1	NP_671485.1	protein CASC3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CASC3	XP_511470.3
Bos taurus (cattle)	CASC3	NP_001091538.1
Homo sapiens (human)	CASC3	NP_031385.2
Mus musculus (house mouse)	Casc3	NP_619601.2
Rattus norvegicus (Norway rat)	Casc3	NP_671485.1
	CASC3	XP_001096548.1
Gallus gallus (chicken)	CASC3	XP_423806.4
Canis lupus familiaris (dog)	CASC3	XP_537649.2
Xenopus tropicalis (tropical clawed frog)	casc3	NP_001012670.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure of a human catalytic step I spliceosome.
Zhan X, Yan C, Zhang X, Lei J, Shi Y
Science (New York, N.Y.)(2018 Jan)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud GA, Schirle M, Shi X, Hild M, Bauer A, Myer VE, Finan PM, Porter JA, Huang SM, Cong F
Nature cell biology13(5)623-9(2011 May)

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
Kunz JB, Neu-Yilik G, Hentze MW, Kulozik AE, Gehring NH
RNA (New York, N.Y.)12(6)1015-22(2006 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that the mRNA transport machinery is conserved during evolution, and that mammalian Btz is an additional component of the dendritic ribonucleoprotein particles in hippocampal neurons
Title: Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.

The following Casc3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casc3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02815	NM_147144.1 Latest version!	Rattus norvegicus CASC3 exon junction complex subunit (Casc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$412.30 $589.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casc3 ( NM_147144.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_671485.1 Rattus norvegicus CASC3 exon junction complex subunit (Casc3), mRNA.

Price & Availability↑

CloneID	ORa02815
Clone ID Related Accession (Same CDS sequence)	NM_147144.1
Accession Version	NM_147144.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2100bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	protein CASC3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF525467.1. ##Evidence-Data-START## Transcript exon combination :: AF525467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGACC GGCGGCGGCA GCGCGCTTCC CAGGACACTG AGGACGAAGA ATCTGGTGCT 
TCGGGTTCCG ACAGCGGCTC TCCCGCACGG GGCGGCGGCA GCTGCAGCGG GAGCGCCGGA 
GGCGGCGGCA GTGGCTCGCT GCCTTCTCAG CGCGGCGGCC GCGGCGGGGG CCTTCATCTG 
CGACGGGTGG AGAGCGGGGG CGCCAAGAGC GCAGAGGAGT CTGAGTGTGA GAGTGAAGAT 
GGCATGGAAG GAGATGCTGT TCTCTCCGAT TATGAAAGTG CAGAAGATTC AGAAGGTGAA 
GAAGAATACA GTGAAGAGGA GAATTCCAAG GTAGAGCTGA AATCAGAAGC TAATGATGCT 
GCTGATTCCT CTGCAAAAGA GAAGGGAGAA GAAAAGCCGG AATCTAAAGG CACCGTGACG 
GGGGAGAGGC AAAGTGGGGA TGGACAGGAG AGCACAGAGC CTGTGGAGAA CAAAGTGGGT 
AAAAAAGGCC CTAAGCATTT GGATGATGAT GAAGATCGGA AAAACCCAGC GTATATTCCC 
AGGAAAGGGC TCTTCTTTGA GCATGATCTT CGAGGACAGA CTCAGGAAGA GGAAGTCCGA 
CCCAAGGGAC GGCAGCGAAA ACTATGGAAA GATGAGGGTC GCTGGGAGCA TGATAAGTTC 
CGTGAGGATG AACAGGCTCC AAAATCTCGA CAGGAGCTAA TTGCACTTTA TGGCTATGAC 
ATTCGGTCTG CTCATAATCC TGATGACATC AAACCCCGAA GAATCCGGAA ACCTCGATTT 
GGAAGTCCCC CACAAAGAGA TCCAAACTGG ATTGGTGACC GATCAAGCAA ATCCCATCGC 
CACCAGGGTC CTGGGGGCAA CCTACCACCT AGGACATTTA TTAACAGGAA TGCAGCAGGT 
ACTGGCCGCA TGTCTACATC CAGGAATTAT TCTCGATCTG GGGGCTTCAA GGAAGGTCGT 
ACTAGTTTTA GGCCTGTGGA GGTTGGTGGG CAGCATGGTG CCCGGTCTGG TGAGACTCTT 
AAGCATGAAG CTAATTACCG GTCACGGCGT CTGGAGCAGA CTCCTATGAG GGATCCATCT 
CCAGAACCAG ATGCTCCATT GCTTGGAAGT CCTGAGAAAG AAGAGGTGGC CTCAGAGACA 
CCAGCTGCTG TACCTGACAT CACACCGCCA GCTCCTGACA GACCTATTGA GAAGAAATCC 
TATTCCCGGG CAAGAAGGAC CCGGACCAAA GTTGGGGATG CAGTCAAAGC AGCTGAAGAG 
GTTCCTCCTC CATCTGAAGG GCTCACTTCA GCAGCCACGG TCCCAGAATC TACTCCTCCA 
GCTGCTAAGA CTGGGAACTG GGAGGCTCCA GTGGATTCTA CCACAGGTGG ACTTGAGCAA 
GATGTGGCAC AGCTAAATAT AGCAGAACAA AATTGGAGTC CAGGACAGCC TTCATTCCTG 
CAGCCACGGG AACTTCGAGG TATGCCTAAC CACATCCATA TGGGAGCAGG ACCTCCACCT 
CAGTTTAACC GGATGGAAGA AATGGGTGTG CAGAGTGGTC GAGCTAAGCG TTACTCTTCC 
CAGCGGCAGC GGCCTGTGCC AGAGCCCCCT GCTCCTCCTG TGCATATCAG TATCATGGAG 
GGACATTACT ATGATCCATT GCAGTTCCAG GGACCAATCT ATACCCATGG TGACAGCCCT 
GCCCCACTGC CCCCACAGGG CATGATTGTA CAGCCAGAAA TGCACCTTCC TCACCCAGGT 
TTACACCCCC ACCAGTCACC AGCACCTCTG CCCAATCCGG GTCTCTACCC ACCACCAGTG 
TCCATGTCCC CAGGACAGCC ACCGCCCCAG CAGTTGCTTG CTCCCACCTA CTTTTCTGCT 
CCGGGTGTCA TGAATTTTGG TAACCCTAGT TACCCTTATG CTCCGGGAGC ACTGCCTCCT 
CCTCCACCTC CTCATCTGTA TCCTAATACA CAGGCTCCAT CACAGGTGTA TGGAGGAGTG 
ACTTACTATA ACCCTGCCCA GCAGCAGGTA CAGCCAAAGC CCTCTCCACC CCGGAGGACT 
CCCCAGCCAG TCTCCATCAA GCCCCCTCCA TCTGAGGTTG TAAGCAGAGG TTCCAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_671485.1
CDS	1..2100
Translation	MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEEYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSPPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNAAGTGRMSTSRNYSRSGGFKEGRTSFRPVEVGGQHGARSGETLKHEANYRSRRLEQTPMRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSEVVSRGSS

Target ORF information:

RefSeq Version	NM_147144.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CASC3 exon junction complex subunit (Casc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147144.1

ORF Insert Sequence:

ATGGCGGACC GGCGGCGGCA GCGCGCTTCC CAGGACACTG AGGACGAAGA ATCTGGTGCT 
TCGGGTTCCG ACAGCGGCTC TCCCGCACGG GGCGGCGGCA GCTGCAGCGG GAGCGCCGGA 
GGCGGCGGCA GTGGCTCGCT GCCTTCTCAG CGCGGCGGCC GCGGCGGGGG CCTTCATCTG 
CGACGGGTGG AGAGCGGGGG CGCCAAGAGC GCAGAGGAGT CTGAGTGTGA GAGTGAAGAT 
GGCATGGAAG GAGATGCTGT TCTCTCCGAT TATGAAAGTG CAGAAGATTC AGAAGGTGAA 
GAAGAATACA GTGAAGAGGA GAATTCCAAG GTAGAGCTGA AATCAGAAGC TAATGATGCT 
GCTGATTCCT CTGCAAAAGA GAAGGGAGAA GAAAAGCCGG AATCTAAAGG CACCGTGACG 
GGGGAGAGGC AAAGTGGGGA TGGACAGGAG AGCACAGAGC CTGTGGAGAA CAAAGTGGGT 
AAAAAAGGCC CTAAGCATTT GGATGATGAT GAAGATCGGA AAAACCCAGC GTATATTCCC 
AGGAAAGGGC TCTTCTTTGA GCATGATCTT CGAGGACAGA CTCAGGAAGA GGAAGTCCGA 
CCCAAGGGAC GGCAGCGAAA ACTATGGAAA GATGAGGGTC GCTGGGAGCA TGATAAGTTC 
CGTGAGGATG AACAGGCTCC AAAATCTCGA CAGGAGCTAA TTGCACTTTA TGGCTATGAC 
ATTCGGTCTG CTCATAATCC TGATGACATC AAACCCCGAA GAATCCGGAA ACCTCGATTT 
GGAAGTCCCC CACAAAGAGA TCCAAACTGG ATTGGTGACC GATCAAGCAA ATCCCATCGC 
CACCAGGGTC CTGGGGGCAA CCTACCACCT AGGACATTTA TTAACAGGAA TGCAGCAGGT 
ACTGGCCGCA TGTCTACATC CAGGAATTAT TCTCGATCTG GGGGCTTCAA GGAAGGTCGT 
ACTAGTTTTA GGCCTGTGGA GGTTGGTGGG CAGCATGGTG CCCGGTCTGG TGAGACTCTT 
AAGCATGAAG CTAATTACCG GTCACGGCGT CTGGAGCAGA CTCCTATGAG GGATCCATCT 
CCAGAACCAG ATGCTCCATT GCTTGGAAGT CCTGAGAAAG AAGAGGTGGC CTCAGAGACA 
CCAGCTGCTG TACCTGACAT CACACCGCCA GCTCCTGACA GACCTATTGA GAAGAAATCC 
TATTCCCGGG CAAGAAGGAC CCGGACCAAA GTTGGGGATG CAGTCAAAGC AGCTGAAGAG 
GTTCCTCCTC CATCTGAAGG GCTCACTTCA GCAGCCACGG TCCCAGAATC TACTCCTCCA 
GCTGCTAAGA CTGGGAACTG GGAGGCTCCA GTGGATTCTA CCACAGGTGG ACTTGAGCAA 
GATGTGGCAC AGCTAAATAT AGCAGAACAA AATTGGAGTC CAGGACAGCC TTCATTCCTG 
CAGCCACGGG AACTTCGAGG TATGCCTAAC CACATCCATA TGGGAGCAGG ACCTCCACCT 
CAGTTTAACC GGATGGAAGA AATGGGTGTG CAGAGTGGTC GAGCTAAGCG TTACTCTTCC 
CAGCGGCAGC GGCCTGTGCC AGAGCCCCCT GCTCCTCCTG TGCATATCAG TATCATGGAG 
GGACATTACT ATGATCCATT GCAGTTCCAG GGACCAATCT ATACCCATGG TGACAGCCCT 
GCCCCACTGC CCCCACAGGG CATGATTGTA CAGCCAGAAA TGCACCTTCC TCACCCAGGT 
TTACACCCCC ACCAGTCACC AGCACCTCTG CCCAATCCGG GTCTCTACCC ACCACCAGTG 
TCCATGTCCC CAGGACAGCC ACCGCCCCAG CAGTTGCTTG CTCCCACCTA CTTTTCTGCT 
CCGGGTGTCA TGAATTTTGG TAACCCTAGT TACCCTTATG CTCCGGGAGC ACTGCCTCCT 
CCTCCACCTC CTCATCTGTA TCCTAATACA CAGGCTCCAT CACAGGTGTA TGGAGGAGTG 
ACTTACTATA ACCCTGCCCA GCAGCAGGTA CAGCCAAAGC CCTCTCCACC CCGGAGGACT 
CCCCAGCCAG TCTCCATCAA GCCCCCTCCA TCTGAGGTTG TAAGCAGAGG TTCCAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of a human catalytic step I spliceosome.
Science (New York, N.Y.)(2018 Jan)
Zhan X,Yan C,Zhang X,Lei J,Shi Y

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Nature cell biology13(5)623-9(2011 May)
Zhang Y,Liu S,Mickanin C,Feng Y,Charlat O,Michaud GA,Schirle M,Shi X,Hild M,Bauer A,Myer VE,Finan PM,Porter JA,Huang SM,Cong F

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
RNA (New York, N.Y.)12(6)1015-22(2006 Jun)
Kunz JB,Neu-Yilik G,Hentze MW,Kulozik AE,Gehring NH

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Casc3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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