Cckbr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cckbr
Entrez Gene ID	25706
Full Name	cholecystokinin B receptor
Synonyms	Cck2r,Cholrec
General protein information	Preferred Names cholecystokinin B receptor Names gastrin/cholecystokinin type B receptor CCK-B receptor CCK-BR CCK2 receptor CCK2-R cholecystokinin-2 receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32
Summary	Cholecystokinin was one of the first gastrointestinal peptides discovered in the mammalian brain. Cholecystokinin receptors are members of the G protein-coupled receptor superfamily, stimulating phosphatidylinositol turnover and intracellular calcium mobilization. This gene encodes a cholecystokinin receptor of the B subtype. These receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013165.2	NP_037297.1	gastrin/cholecystokinin type B receptor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCKBR	XP_521813.2
Mus musculus (house mouse)	Cckbr	NP_031653.1
Gallus gallus (chicken)	CCKBR	NP_001001742.1
Danio rerio (zebrafish)	si:dkey-1h24.2	NP_001108186.2
Bos taurus (cattle)	CCKBR	NP_776687.2
Drosophila melanogaster (fruit fly)	CCKLR-17D1	NP_001097021.1
Rattus norvegicus (Norway rat)	Cckbr	NP_037297.1
	LOC712939	XP_001102094.1
Homo sapiens (human)	CCKBR	NP_795344.1
Danio rerio (zebrafish)	LOC100331465	XP_002663361.2

Gene Ontology
Bibliography

Related articles in PubMed

Expression of cholecystokinin2-receptor in rat and human L cells and the stimulation of glucagon-like peptide-1 secretion by gastrin treatment.
Cao Y, Cao X, Liu XM
Acta histochemica117(2)205-10(2015 Mar)

Modulation of acetylcholine release by cholecystokinin in striatum: receptor specificity; role of dopaminergic neuronal activity.
Petkova-Kirova P, Giovannini MG, Kalfin R, Rakovska A
Brain research bulletin89(5-6)177-84(2012 Dec)

CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.
Berna MJ, Seiz O, Nast JF, Benten D, Bl?ker M, Koch J, Lohse AW, Pace A
The Journal of biological chemistry285(50)38905-14(2010 Dec)

Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.
El-Kouhen K, Morisset J
Pancreas39(2)127-34(2010 Mar)

Cholecystokinin action on layer 6b neurons in somatosensory cortex.
Chung L, Moore SD, Cox CL
Brain research128210-9(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

treatment with gastrin, a CCK2R agonist, stimulated the secretion of GLP-1, and that this effect was likely due to increased expression of proglucagon and PCSK1 (also known as prohormone convertase 3 (PC3 gene)).
Title: Expression of cholecystokinin2-receptor in rat and human L cells and the stimulation of glucagon-like peptide-1 secretion by gastrin treatment.

CCK-B receptors mediate acetylcholine release through cell bodies of cholinergic interneurons in the corpus striatum.
Title: Modulation of acetylcholine release by cholecystokinin in striatum: receptor specificity; role of dopaminergic neuronal activity.

CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production
Title: CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.

Pancreatic islet CCK1/2 receptors initiate somatosatin secretion through constitutive secretion controlled at the level of protein synthesis.
Title: Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.

Our data indicate that CCK, acting via CCK(B) receptors, produces a long-lasting excitation of layer 6b neocortical neurons, and this action may play a critical role in modulation of corticothalamic circuit activity.
Title: Cholecystokinin action on layer 6b neurons in somatosensory cortex.

The following Cckbr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cckbr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02186	NM_013165.2 Latest version!	Rattus norvegicus cholecystokinin B receptor (Cckbr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cckbr ( NM_013165.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037297.1 Rattus norvegicus cholecystokinin B receptor (Cckbr), mRNA.

Price & Availability↑

CloneID	ORa02186
Clone ID Related Accession (Same CDS sequence)	NM_013165.2
Accession Version	NM_013165.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	gastrin/cholecystokinin type B receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M99418.1. On Feb 4, 2002 this sequence version replaced NM_013165.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M99418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTGC TCAAGCTGAA CCGCAGCGTG CAGGGACCAG GACCCGGGTC GGGGTCTTCT 
TTGTGCCGCC CGGGTGTCTC CCTTCTCAAC AGCAGTAGTG CCGGGAACCT CAGCTGTGAC 
CCCCCTCGTA TCCGCGGAAC CGGGACCAGA GAATTGGAGA TGGCGATTAG AATCACCCTT 
TATGCAGTGA TCTTTCTGAT GAGTGTTGGC GGAAACGTGC TCATCATCGT GGTCCTGGGA 
CTGAGCCGAC GCCTAAGAAC GGTCACCAAC GCCTTCCTGC TCTCCCTGGC AGTCAGCGAC 
CTCCTGCTGG CCGTGGCTTG CATGCCCTTC ACACTCCTGC CCAACCTCAT GGGCACATTC 
ATCTTCGGCA CAGTCATCTG CAAGGCCATT TCCTACCTCA TGGGGGTATC AGTGAGTGTA 
TCCACTCTAA ATCTCGTGGC CATAGCCCTG GAGCGATACA GCGCCATCTG CCGACCACTG 
CAAGCACGAG TATGGCAAAC ACGCTCCCAC GCAGCTCGGG TGATCTTAGC CACGTGGCTG 
CTGTCTGGAC TGCTTATGGT ACCCTACCCT GTGTACACCA TGGTACAGCC AGTGGGACCT 
CGAGTGCTGC AGTGCATGCA TCGCTGGCCC AGTGCACGTG TCCAACAAAC CTGGTCCGTG 
CTACTGCTAC TGCTTTTGTT CTTCATCCCG GGTGTGGTTA TTGCGGTGGC CTATGGACTC 
ATCTCCCGCG AACTCTACCT AGGACTCCAC TTTGATGGTG AAAATGACAG CGAGACCCAA 
AGCCGGGCCC GAAACCAAGG GGGCCTGCCG GGTGGGGCAG CACCAGGGCC TGTCCACCAG 
AACGGGGGCT GCCGGCCTGT AACCAGCGTA GCTGGGGAAG ACAGTGATGG CTGCTGTGTG 
CAACTTCCGC GTTCCCGACT GGAGATGACA ACGCTAACCA CACCCACTCC TGGGCCAGTC 
CCTGGCCCTC GGCCCAACCA GGCCAAGCTG CTGGCTAAGA AGCGGGTGGT GCGAATGCTG 
CTAGTGATTG TTTTGCTTTT CTTCCTGTGT TGGCTGCCAG TGTACAGCGT CAACACGTGG 
CGCGCCTTCG ATGGCCCAGG CGCACAACGA GCACTCTCAG GGGCCCCTAT CTCTTTCATC 
CACTTGCTGA GCTACGTCTC TGCTTGTGTC AACCCCCTGG TCTACTGTTT CATGCACCGC 
CGCTTCCGCC AGGCCTGCCT GGACACATGT GCCCGCTGTT GCCCACGCCC TCCACGAGCT 
CGCCCACAGC CTCTTCCAGA TGAGGATCCT CCTACCCCCT CCATCGCTTC GCTGTCCAGG 
CTAAGCTATA CCACCATCAG CACACTGGGG CCTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037297.1
CDS	45..1403
Translation	MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLGPG

Target ORF information:

RefSeq Version	NM_013165.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cholecystokinin B receptor (Cckbr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013165.2

ORF Insert Sequence:

ATGGAGCTGC TCAAGCTGAA CCGCAGCGTG CAGGGACCAG GACCCGGGTC GGGGTCTTCT 
TTGTGCCGCC CGGGTGTCTC CCTTCTCAAC AGCAGTAGTG CCGGGAACCT CAGCTGTGAC 
CCCCCTCGTA TCCGCGGAAC CGGGACCAGA GAATTGGAGA TGGCGATTAG AATCACCCTT 
TATGCAGTGA TCTTTCTGAT GAGTGTTGGC GGAAACGTGC TCATCATCGT GGTCCTGGGA 
CTGAGCCGAC GCCTAAGAAC GGTCACCAAC GCCTTCCTGC TCTCCCTGGC AGTCAGCGAC 
CTCCTGCTGG CCGTGGCTTG CATGCCCTTC ACACTCCTGC CCAACCTCAT GGGCACATTC 
ATCTTCGGCA CAGTCATCTG CAAGGCCATT TCCTACCTCA TGGGGGTATC AGTGAGTGTA 
TCCACTCTAA ATCTCGTGGC CATAGCCCTG GAGCGATACA GCGCCATCTG CCGACCACTG 
CAAGCACGAG TATGGCAAAC ACGCTCCCAC GCAGCTCGGG TGATCTTAGC CACGTGGCTG 
CTGTCTGGAC TGCTTATGGT ACCCTACCCT GTGTACACCA TGGTACAGCC AGTGGGACCT 
CGAGTGCTGC AGTGCATGCA TCGCTGGCCC AGTGCACGTG TCCAACAAAC CTGGTCCGTG 
CTACTGCTAC TGCTTTTGTT CTTCATCCCG GGTGTGGTTA TTGCGGTGGC CTATGGACTC 
ATCTCCCGCG AACTCTACCT AGGACTCCAC TTTGATGGTG AAAATGACAG CGAGACCCAA 
AGCCGGGCCC GAAACCAAGG GGGCCTGCCG GGTGGGGCAG CACCAGGGCC TGTCCACCAG 
AACGGGGGCT GCCGGCCTGT AACCAGCGTA GCTGGGGAAG ACAGTGATGG CTGCTGTGTG 
CAACTTCCGC GTTCCCGACT GGAGATGACA ACGCTAACCA CACCCACTCC TGGGCCAGTC 
CCTGGCCCTC GGCCCAACCA GGCCAAGCTG CTGGCTAAGA AGCGGGTGGT GCGAATGCTG 
CTAGTGATTG TTTTGCTTTT CTTCCTGTGT TGGCTGCCAG TGTACAGCGT CAACACGTGG 
CGCGCCTTCG ATGGCCCAGG CGCACAACGA GCACTCTCAG GGGCCCCTAT CTCTTTCATC 
CACTTGCTGA GCTACGTCTC TGCTTGTGTC AACCCCCTGG TCTACTGTTT CATGCACCGC 
CGCTTCCGCC AGGCCTGCCT GGACACATGT GCCCGCTGTT GCCCACGCCC TCCACGAGCT 
CGCCCACAGC CTCTTCCAGA TGAGGATCCT CCTACCCCCT CCATCGCTTC GCTGTCCAGG 
CTAAGCTATA CCACCATCAG CACACTGGGG CCTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of cholecystokinin2-receptor in rat and human L cells and the stimulation of glucagon-like peptide-1 secretion by gastrin treatment.
Acta histochemica117(2)205-10(2015 Mar)
Cao Y,Cao X,Liu XM

Modulation of acetylcholine release by cholecystokinin in striatum: receptor specificity; role of dopaminergic neuronal activity.
Brain research bulletin89(5-6)177-84(2012 Dec)
Petkova-Kirova P,Giovannini MG,Kalfin R,Rakovska A

CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.
The Journal of biological chemistry285(50)38905-14(2010 Dec)
Berna MJ,Seiz O,Nast JF,Benten D,Bl?ker M,Koch J,Lohse AW,Pace A

Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.
Pancreas39(2)127-34(2010 Mar)
El-Kouhen K,Morisset J

Cholecystokinin action on layer 6b neurons in somatosensory cortex.
Brain research128210-9(2009 Jul)
Chung L,Moore SD,Cox CL

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Cckbr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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