Slc7a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc7a1
Entrez Gene ID	25648
Full Name	solute carrier family 7 member 1
Synonyms	Atrc1,CAT1,Cat-1,EcoR
General protein information	Preferred Names solute carrier family 7 member 1 Names high affinity cationic amino acid transporter 1 ERR Solute carrier family 7 member A1 (amino acid transporter cationic 1) cationic amino acid transporter, y+ system cationinc amino acid transporter 1 ecotropic retroviral leukemia receptor ecotropic retrovirus receptor solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 system Y+ basic amino acid transporter
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p11
Summary	acts as a cationic amino acid transporter and as an ecotropic retrovirus receptor; plays a role in the Na+-independent y+ cationic amino acid transport system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013111.3	NP_037243.2	high affinity cationic amino acid transporter 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SLC7A1	NP_001129264.1
Rattus norvegicus (Norway rat)	Slc7a1	NP_037243.1
Pan troglodytes (chimpanzee)	SLC7A1	XP_001139004.1
Danio rerio (zebrafish)	slc7a1	XP_005155334.1
Homo sapiens (human)	SLC7A1	NP_003036.1
	SLC7A1	XP_002800751.1
Gallus gallus (chicken)	SLC7A1	NP_001138962.1
Drosophila melanogaster (fruit fly)	slif	NP_649428.1
Xenopus tropicalis (tropical clawed frog)	slc7a1	XP_002934074.1
Drosophila melanogaster (fruit fly)	CG5535	NP_730312.1
Canis lupus familiaris (dog)	SLC7A1	XP_005635552.1
Mus musculus (house mouse)	Slc7a1	NP_031539.3
Arabidopsis thaliana (thale cress)	CAT4	NP_187022.5

Gene Ontology
Bibliography

Related articles in PubMed

Effects of simvastatin on CAT-1-mediated arginine transport and NO level under high glucose conditions in conditionally immortalized rat inner blood-retinal barrier cell lines (TR-iBRB).
Tun T, Kang YS
Microvascular research11160-66(2017 May)

ZMPSTE24 defends against influenza and other pathogenic viruses.
Fu B, Wang L, Li S, Dorf ME
The Journal of experimental medicine214(4)919-929(2017 Apr)

Involvement of cationic amino acid transporter 1 in L-arginine transport in rat retinal pericytes.
Zakoji N, Akanuma S, Tachikawa M, Hosoya K
Biological & pharmaceutical bulletin38(2)257-62(2015)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.
Yaman I, Fernandez J, Liu H, Caprara M, Komar AA, Koromilas AE, Zhou L, Snider MD, Scheuner D, Kaufman RJ, Hatzoglou M
Cell113(4)519-31(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the presence of high-glucose levels, increased l-arginine uptake due to simvastatin treatment was associated with increased CAT-1 and eNOS mRNA levels, leading to higher NO production in immortalized rat inner blood-retinal barrier cell lines.
Title: Effects of simvastatin on CAT-1-mediated arginine transport and NO level under high glucose conditions in conditionally immortalized rat inner blood-retinal barrier cell lines (TR-iBRB).

CAT1 is involved in L-Arg uptake by retinal pericytes and this is expected to play an important role in the relaxation of retinal pericytes, thereby modulating the microcirculatory hemodynamics in the retina
Title: Involvement of cationic amino acid transporter 1 in L-arginine transport in rat retinal pericytes.

Aortic arginine transport by CAT-1 is attenuated in old male rats through upregulation of PKCalpha.
Title: Aortic arginine transport is attenuated, through post-translational modulation of CAT-1 by PKCalpha, in old male rats.

analysis of how a bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha)
Title: A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha).

Attenuated glomerular arginine transport by CAT-1 contributes to the age-dependent, NO-deficient state in old male rats through upregulation of PKCalpha.
Title: Sexual dimorphism in glomerular arginine transport affects nitric oxide generation in old male rats.

The following Slc7a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc7a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa43186	NM_013111.3 Latest version!	Rattus norvegicus solute carrier family 7 member 1 (Slc7a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc7a1 ( NM_013111.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037243.2 Rattus norvegicus solute carrier family 7 member 1 (Slc7a1), mRNA.

Price & Availability↑

CloneID	ORa43186
Clone ID Related Accession (Same CDS sequence)	NM_013111.3
Accession Version	NM_013111.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	high affinity cationic amino acid transporter 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07035232.1, AF245000.1 and AABR07035237.1. On Aug 21, 2014 this sequence version replaced NM_013111.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF245000.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 12757712 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCTGCA AAAACCTGTT GAGCCTGGGT CAGCAGACGC TGCGCCGGAA AGTGGTGGAC 
TGCAGCCGGG AGGAGAGCCG GCTGTCCCGC TGCCTCAACA CCTATGATCT GGTAGCTCTT 
GGGGTGGGCA GCACCTTGGG CGCTGGTGTC TACGTCCTAG CCGGTGCAGT GGCCCGTGAG 
AATGCTGGTC CTGCCATCGT CATCTCCTTC CTGATCGCTG CTCTTGCCTC AGTGCTGGCC 
GGCCTGTGCT ATGGCGAGTT TGGTGCCCGT GTCCCCAAGA CGGGCTCAGC CTACCTCTAC 
AGCTATGTGA CAGTGGGGGA GCTCTGGGCC TTCATCACTG GCTGGAACCT GATTCTCTCC 
TACATCATCG GTACATCCAG CGTGGCAAGA GCCTGGAGTG CAACTTTTGA CGAGCTGATA 
GGCAAACCCA TCGGAGAGTT CTCGCGTCAA CACATGGCCC TGAACGCCCC TGGGGTGCTG 
GCCCAAACCC CGGATATATT TGCTGTGATT ATAATTATCA TCCTGACAGG ACTGTTAACT 
CTCGGTGTGA AAGAATCAGC CATGGTCAAC AAAATCTTCA CCTGTATCAA TGTCCTGGTC 
TTGTGCTTCA TCATGGTGTC GGGATTCGTG AAAGGCTCCA TTGAGAACTG GCAGCTCACG 
GAGAATAAAT CCAGTCCTCT CTGTGGGAAC AATGACACAA ACGTGAAATA CGGTGAGGGA 
GGGTTCATGC CCTTTGGATT CTCTGGTGTC CTGTCAGGGG CAGCGACCTG CTTTTATGCC 
TTCGTGGGCT TTGACTGCAT CGCCACCACA GGGGAAGAAG TCAAGAACCC CCAGAAGGCC 
ATTCCTGTGG GCATTGTGGC GTCCCTCCTC ATTTGCTTCA TAGCTTACTT TGGGGTGTCC 
GCTGCTCTCA CCCTCATGAT GCCCTACTTC TGCCTGGACA CTGACAGCCC ACTGCCTGGC 
GCCTTCAAGT ACAGGGGCTG GGAAGAAGCT AAGTATGCAG TGGCCGTGGG CTCCCTCTGC 
GCACTCTCCA CCAGTCTCCT AGGTTCCATG TTCCCCATGC CCCGAGTTAT CTATGCCATG 
GCTGAAGATG GACTACTGTT TAAATTTTTG GCCAAAATCA ACGATAGGAC CAAAACACCA 
ATAATCGCTA CTGTGACCTC AGGCGCCATC GCTGCTGTGA TGGCCTTCCT CTTTGAACTG 
AAGGATCTGG TGGACCTCAT GTCCATTGGT ACTCTCCTGG CTTACTCTTT GGTGGCTGCC 
TGTGTTTTGG TCTTACGGTA CCAGCCAGAA CAACCTAATC TGGTATACCA GATGGCCAGA 
ACCACCGATG AGCTAGACCA GGTAGACCAG AATGAGATGG TCAGTGCCAG TGAGTCCCAG 
ACAGGCTTTT TACCAGCAGC CGAGAAGTTT TCTCTGAAAA CCATACTCTC ACCCAAGAAC 
ATGGAGCCGT CCAAATTCTC AGGGCTAATT GTGAACATTT CAGCCGGCCT CCTAGCCGTT 
CTTATCATCA CCGTGTGCAT TGTGGCCGTG CTTGGAAGAG AGGCCCTGGC TGAAGGGACG 
CTGTGGGCAG TCTTTGTAAT GACAGGGTCA GTCCTCCTCT GCATGCTGGT GACGGGCATC 
ATCTGGAGGC AGCCTGAGAG CAAGACCAAG CTCTCGTTTA AGGTACCCTT TGTCCCCGTA 
CTTCCTGTCT TAAGCATCTT TGTGAACATC TATCTCATGA TGCAACTGGA CCAGGGCACG 
TGGGTCCGGT TCGCAGTGTG GATGCTGATA GGCTTTGCCA TCTACTTTGG CTATGGGGCC 
TGGCACAGTG AGGAAGCATC CCTGGCTGCT GGCCAGGCAA AGACTCCTGA TAGCAACTTG 
GACCAGTGCA AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037243.2
CDS	271..2145
Translation	MGCKNLLSLGQQTLRRKVVDCSREESRLSRCLNTYDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGKPIGEFSRQHMALNAPGVLAQTPDIFAVIIIIILTGLLTLGVKESAMVNKIFTCINVLVLCFIMVSGFVKGSIENWQLTENKSSPLCGNNDTNVKYGEGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDTDSPLPGAFKYRGWEEAKYAVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLAKINDRTKTPIIATVTSGAIAAVMAFLFELKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMARTTDELDQVDQNEMVSASESQTGFLPAAEKFSLKTILSPKNMEPSKFSGLIVNISAGLLAVLIITVCIVAVLGREALAEGTLWAVFVMTGSVLLCMLVTGIIWRQPESKTKLSFKVPFVPVLPVLSIFVNIYLMMQLDQGTWVRFAVWMLIGFAIYFGYGAWHSEEASLAAGQAKTPDSNLDQCK

Target ORF information:

RefSeq Version	NM_013111.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 7 member 1 (Slc7a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013111.3

ORF Insert Sequence:

ATGGGCTGCA AAAACCTGTT GAGCCTGGGT CAGCAGACGC TGCGCCGGAA AGTGGTGGAC 
TGCAGCCGGG AGGAGAGCCG GCTGTCCCGC TGCCTCAACA CCTATGATCT GGTAGCTCTT 
GGGGTGGGCA GCACCTTGGG CGCTGGTGTC TACGTCCTAG CCGGTGCAGT GGCCCGTGAG 
AATGCTGGTC CTGCCATCGT CATCTCCTTC CTGATCGCTG CTCTTGCCTC AGTGCTGGCC 
GGCCTGTGCT ATGGCGAGTT TGGTGCCCGT GTCCCCAAGA CGGGCTCAGC CTACCTCTAC 
AGCTATGTGA CAGTGGGGGA GCTCTGGGCC TTCATCACTG GCTGGAACCT GATTCTCTCC 
TACATCATCG GTACATCCAG CGTGGCAAGA GCCTGGAGTG CAACTTTTGA CGAGCTGATA 
GGCAAACCCA TCGGAGAGTT CTCGCGTCAA CACATGGCCC TGAACGCCCC TGGGGTGCTG 
GCCCAAACCC CGGATATATT TGCTGTGATT ATAATTATCA TCCTGACAGG ACTGTTAACT 
CTCGGTGTGA AAGAATCAGC CATGGTCAAC AAAATCTTCA CCTGTATCAA TGTCCTGGTC 
TTGTGCTTCA TCATGGTGTC GGGATTCGTG AAAGGCTCCA TTGAGAACTG GCAGCTCACG 
GAGAATAAAT CCAGTCCTCT CTGTGGGAAC AATGACACAA ACGTGAAATA CGGTGAGGGA 
GGGTTCATGC CCTTTGGATT CTCTGGTGTC CTGTCAGGGG CAGCGACCTG CTTTTATGCC 
TTCGTGGGCT TTGACTGCAT CGCCACCACA GGGGAAGAAG TCAAGAACCC CCAGAAGGCC 
ATTCCTGTGG GCATTGTGGC GTCCCTCCTC ATTTGCTTCA TAGCTTACTT TGGGGTGTCC 
GCTGCTCTCA CCCTCATGAT GCCCTACTTC TGCCTGGACA CTGACAGCCC ACTGCCTGGC 
GCCTTCAAGT ACAGGGGCTG GGAAGAAGCT AAGTATGCAG TGGCCGTGGG CTCCCTCTGC 
GCACTCTCCA CCAGTCTCCT AGGTTCCATG TTCCCCATGC CCCGAGTTAT CTATGCCATG 
GCTGAAGATG GACTACTGTT TAAATTTTTG GCCAAAATCA ACGATAGGAC CAAAACACCA 
ATAATCGCTA CTGTGACCTC AGGCGCCATC GCTGCTGTGA TGGCCTTCCT CTTTGAACTG 
AAGGATCTGG TGGACCTCAT GTCCATTGGT ACTCTCCTGG CTTACTCTTT GGTGGCTGCC 
TGTGTTTTGG TCTTACGGTA CCAGCCAGAA CAACCTAATC TGGTATACCA GATGGCCAGA 
ACCACCGATG AGCTAGACCA GGTAGACCAG AATGAGATGG TCAGTGCCAG TGAGTCCCAG 
ACAGGCTTTT TACCAGCAGC CGAGAAGTTT TCTCTGAAAA CCATACTCTC ACCCAAGAAC 
ATGGAGCCGT CCAAATTCTC AGGGCTAATT GTGAACATTT CAGCCGGCCT CCTAGCCGTT 
CTTATCATCA CCGTGTGCAT TGTGGCCGTG CTTGGAAGAG AGGCCCTGGC TGAAGGGACG 
CTGTGGGCAG TCTTTGTAAT GACAGGGTCA GTCCTCCTCT GCATGCTGGT GACGGGCATC 
ATCTGGAGGC AGCCTGAGAG CAAGACCAAG CTCTCGTTTA AGGTACCCTT TGTCCCCGTA 
CTTCCTGTCT TAAGCATCTT TGTGAACATC TATCTCATGA TGCAACTGGA CCAGGGCACG 
TGGGTCCGGT TCGCAGTGTG GATGCTGATA GGCTTTGCCA TCTACTTTGG CTATGGGGCC 
TGGCACAGTG AGGAAGCATC CCTGGCTGCT GGCCAGGCAA AGACTCCTGA TAGCAACTTG 
GACCAGTGCA AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of simvastatin on CAT-1-mediated arginine transport and NO level under high glucose conditions in conditionally immortalized rat inner blood-retinal barrier cell lines (TR-iBRB).
Microvascular research11160-66(2017 May)
Tun T,Kang YS

ZMPSTE24 defends against influenza and other pathogenic viruses.
The Journal of experimental medicine214(4)919-929(2017 Apr)
Fu B,Wang L,Li S,Dorf ME

Involvement of cationic amino acid transporter 1 in L-arginine transport in rat retinal pericytes.
Biological & pharmaceutical bulletin38(2)257-62(2015)
Zakoji N,Akanuma S,Tachikawa M,Hosoya K

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.
Cell113(4)519-31(2003 May)
Yaman I,Fernandez J,Liu H,Caprara M,Komar AA,Koromilas AE,Zhou L,Snider MD,Scheuner D,Kaufman RJ,Hatzoglou M

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Slc7a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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