Plau cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plau
Entrez Gene ID	25619
Full Name	plasminogen activator, urokinase
Synonyms	UPAM
General protein information	Preferred Names plasminogen activator, urokinase Names urokinase-type plasminogen activator U-plasminogen activator Urinary plasminogen activator, urokinase uPA urokinase plasminogen activator
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p16
Summary	displays a post-transcriptional increase in enzyme levels in chemically induced mammary carcinoma; may play a role in tumor invasion and metastasis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013085.3	NP_037217.3	urokinase-type plasminogen activator precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PLAU	XP_003312680.1
Danio rerio (zebrafish)	plaua	NP_001165872.1
Homo sapiens (human)	PLAU	NP_002649.1
	PLAU	XP_001099459.1
Bos taurus (cattle)	PLAU	NP_776572.1
Mus musculus (house mouse)	Plau	NP_032899.1
Rattus norvegicus (Norway rat)	Plau	NP_037217.3
Gallus gallus (chicken)	PLAU	NP_990774.2
Danio rerio (zebrafish)	plaub	NP_001239279.1
Canis lupus familiaris (dog)	PLAU	NP_001181881.1

Gene Ontology
Bibliography

Related articles in PubMed

Autophagy inhibits endothelial progenitor cells migration via the regulation of MMP2, MMP9 and uPA under normoxia condition.
Li WD, Hu N, Lei FR, Wei S, Rong JJ, Zhuang H, Li XQ
Biochemical and biophysical research communications466(3)376-80(2015 Oct)

Basic mechanisms and regulation of fibrinolysis.
Longstaff C, Kolev K
Journal of thrombosis and haemostasis : JTH13 Suppl 1S98-105(2015 Jun)

Subunits of the Pyruvate Dehydrogenase Cluster of Mycoplasma pneumoniae Are Surface-Displayed Proteins that Bind and Activate Human Plasminogen.
Gr?ndel A, Friedrich K, Pfeiffer M, Jacobs E, Dumke R
PloS one10(5)e0126600(2015)

SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator.
Swamynathan S, Swamynathan SK
Investigative ophthalmology & visual science55(10)6251-61(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

autophagy could regulate the EPCs migration through mTOR-P70 S6K pathway, and MMP2, MMP9 and uPA may also involve in the regulation mechanism
Title: Autophagy inhibits endothelial progenitor cells migration via the regulation of MMP2, MMP9 and uPA under normoxia condition.

The effects of UPA/UPAR on migration of lipid-loaded cells occurred through the binding to LRP-1.
Title: UPA promotes lipid-loaded vascular smooth muscle cell migration through LRP-1.

uPA and uPAR expressions were significantly increased both at transcriptional and protein level during early phase post myocardial infarct period
Title: uPA, uPAR and TGF?? expression during early and late post myocardial infarction period in rat myocardium.

Data show that Huangqi is able to stimulate expression of cyclin D1 and excite ERK and P38 MAPK signaling pathways to promote cell proliferation and stimulates the FGF-2-UPA-MMP 9 migration pathway and cell migration.
Title: The proliferation and migration effects of huangqi on RSC96 Schwann cells.

Expression of u-PA/PAI-1 mRNA and protein increased during the early stage of hyperoxic exposure and decreased during the middle and late stage.
Title: [Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen].

The following Plau gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plau cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42687	NM_013085.3 Latest version!	Rattus norvegicus plasminogen activator, urokinase (Plau), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plau ( NM_013085.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037217.3 Rattus norvegicus plasminogen activator, urokinase (Plau), mRNA.

Price & Availability↑

CloneID	ORa42687
Clone ID Related Accession (Same CDS sequence)	NM_013085.3
Accession Version	NM_013085.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	urokinase-type plasminogen activator precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105859.1. On Apr 13, 2007 this sequence version replaced NM_013085.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC105859.1 [ECO:0000332] ##Evidence-Data-END##

ATGAGAGTCT GGCTTGCGAG CCTGTTCCTC TGCGCCTTGG TGGCGCACTC TGAAGGTGGC 
AGTGAACTTG GAGCTTCTGA TGAATCAAAC TGTGGCTGTC AGAACGGAGG AGTATGTGTG 
TCCTACAAGT ACTTCTCCAG CATTCGAAGA TGCAGCTGCC CAAAGAAATT CAAAGGGGAG 
CACTGTGAGA TAGATACATC AAAAACCTGC TATCATGGAA ATGGTCAATC TTACCGAGGA 
AAGGCCAATA CTGACACCAA AGGCCGGCCC TGCCTGGCCT GGAATTCACC CGCTGTCCTT 
CAGCAAACCT ACAATGCTCA CAGATCCGAT GCTCTTAGCC TAGGCCTGGG GAAACACAAT 
TACTGCAGGA ACCCCGACAA CCAGAGGCGA CCCTGGTGCT ATGTGCAAAT TGGCCTAAAG 
CAGTTTGTCC AAGAATGCAT GGTGCAGGAC TGCTCTCTCA GCAAAAAGCC TTCTTCTACT 
GTAGACCAAC AAGGGTTCCA GTGTGGCCAG AAGGCTCTAA GGCCCCGCTT CAAGATCGTT 
GGGGGAGAAT TCACTGTCGT TGAGAACCAG CCCTGGTTTG CAGCCATCTA CCTGAAGAAT 
AAGGGAGGAA GCCCTCCCTC CTTTAAATGT GGTGGGAGCC TCATCAGTCC TTGCTGGGTG 
GCCAGCGCCA CACACTGCTT CGTGAATCAG CCAAAGAAGG AAGAGTACGT TGTCTACCTG 
GGTCAGTCGA AGCGGAACTC CTATAACCCC GGAGAGATGA AGTTTGAGGT GGAGCAGCTC 
ATCTTGCACG AAGACTTCAG CGACGAAACT CTGGCCTTCC ATAATGACAT AGCCTTGCTG 
AAGATACGTA CCAGCACGGG CCAATGCGCA CAGCCATCCA GGACCATACA GACCATCTGC 
CTGCCCCCGA GGTTTGGTGA TGCTCCGTTT GGTTCAGACT GTGAGATCAC TGGCTTCGGA 
CAAGAGAGTG CCACTGACTA TTTCTATCCG AAGGACCTGA AAATGTCAGT TGTAAAGATT 
ATTTCTCACG AACAGTGCAA GCAGCCTCAC TACTATGGCT CTGAAATTAA TTATAAAATG 
CTGTGTGCTG CTGACCCAGA GTGGAAAACA GATTCCTGCT CGGGAGATTC AGGAGGACCT 
CTTATCTGTA ACATCGATGG CCGCCCAACT CTGAGCGGGA TTGTGAGCTG GGGCAGTGGA 
TGTGCAGAGA AAAACAAGCC TGGTGTCTAC ACGAGGGTCT CATACTTCCT GAACTGGATT 
CAGTCCCACA TTGGAGAAGA GAATGGCCTA GCCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037217.3
CDS	63..1361
Translation	MRVWLASLFLCALVAHSEGGSELGASDESNCGCQNGGVCVSYKYFSSIRRCSCPKKFKGEHCEIDTSKTCYHGNGQSYRGKANTDTKGRPCLAWNSPAVLQQTYNAHRSDALSLGLGKHNYCRNPDNQRRPWCYVQIGLKQFVQECMVQDCSLSKKPSSTVDQQGFQCGQKALRPRFKIVGGEFTVVENQPWFAAIYLKNKGGSPPSFKCGGSLISPCWVASATHCFVNQPKKEEYVVYLGQSKRNSYNPGEMKFEVEQLILHEDFSDETLAFHNDIALLKIRTSTGQCAQPSRTIQTICLPPRFGDAPFGSDCEITGFGQESATDYFYPKDLKMSVVKIISHEQCKQPHYYGSEINYKMLCAADPEWKTDSCSGDSGGPLICNIDGRPTLSGIVSWGSGCAEKNKPGVYTRVSYFLNWIQSHIGEENGLAF

Target ORF information:

RefSeq Version	NM_013085.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus plasminogen activator, urokinase (Plau), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013085.3

ORF Insert Sequence:

ATGAGAGTCT GGCTTGCGAG CCTGTTCCTC TGCGCCTTGG TGGCGCACTC TGAAGGTGGC 
AGTGAACTTG GAGCTTCTGA TGAATCAAAC TGTGGCTGTC AGAACGGAGG AGTATGTGTG 
TCCTACAAGT ACTTCTCCAG CATTCGAAGA TGCAGCTGCC CAAAGAAATT CAAAGGGGAG 
CACTGTGAGA TAGATACATC AAAAACCTGC TATCATGGAA ATGGTCAATC TTACCGAGGA 
AAGGCCAATA CTGACACCAA AGGCCGGCCC TGCCTGGCCT GGAATTCACC CGCTGTCCTT 
CAGCAAACCT ACAATGCTCA CAGATCCGAT GCTCTTAGCC TAGGCCTGGG GAAACACAAT 
TACTGCAGGA ACCCCGACAA CCAGAGGCGA CCCTGGTGCT ATGTGCAAAT TGGCCTAAAG 
CAGTTTGTCC AAGAATGCAT GGTGCAGGAC TGCTCTCTCA GCAAAAAGCC TTCTTCTACT 
GTAGACCAAC AAGGGTTCCA GTGTGGCCAG AAGGCTCTAA GGCCCCGCTT CAAGATCGTT 
GGGGGAGAAT TCACTGTCGT TGAGAACCAG CCCTGGTTTG CAGCCATCTA CCTGAAGAAT 
AAGGGAGGAA GCCCTCCCTC CTTTAAATGT GGTGGGAGCC TCATCAGTCC TTGCTGGGTG 
GCCAGCGCCA CACACTGCTT CGTGAATCAG CCAAAGAAGG AAGAGTACGT TGTCTACCTG 
GGTCAGTCGA AGCGGAACTC CTATAACCCC GGAGAGATGA AGTTTGAGGT GGAGCAGCTC 
ATCTTGCACG AAGACTTCAG CGACGAAACT CTGGCCTTCC ATAATGACAT AGCCTTGCTG 
AAGATACGTA CCAGCACGGG CCAATGCGCA CAGCCATCCA GGACCATACA GACCATCTGC 
CTGCCCCCGA GGTTTGGTGA TGCTCCGTTT GGTTCAGACT GTGAGATCAC TGGCTTCGGA 
CAAGAGAGTG CCACTGACTA TTTCTATCCG AAGGACCTGA AAATGTCAGT TGTAAAGATT 
ATTTCTCACG AACAGTGCAA GCAGCCTCAC TACTATGGCT CTGAAATTAA TTATAAAATG 
CTGTGTGCTG CTGACCCAGA GTGGAAAACA GATTCCTGCT CGGGAGATTC AGGAGGACCT 
CTTATCTGTA ACATCGATGG CCGCCCAACT CTGAGCGGGA TTGTGAGCTG GGGCAGTGGA 
TGTGCAGAGA AAAACAAGCC TGGTGTCTAC ACGAGGGTCT CATACTTCCT GAACTGGATT 
CAGTCCCACA TTGGAGAAGA GAATGGCCTA GCCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autophagy inhibits endothelial progenitor cells migration via the regulation of MMP2, MMP9 and uPA under normoxia condition.
Biochemical and biophysical research communications466(3)376-80(2015 Oct)
Li WD,Hu N,Lei FR,Wei S,Rong JJ,Zhuang H,Li XQ

Basic mechanisms and regulation of fibrinolysis.
Journal of thrombosis and haemostasis : JTH13 Suppl 1S98-105(2015 Jun)
Longstaff C,Kolev K

Subunits of the Pyruvate Dehydrogenase Cluster of Mycoplasma pneumoniae Are Surface-Displayed Proteins that Bind and Activate Human Plasminogen.
PloS one10(5)e0126600(2015)
Gr?ndel A,Friedrich K,Pfeiffer M,Jacobs E,Dumke R

SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator.
Investigative ophthalmology & visual science55(10)6251-61(2014 Aug)
Swamynathan S,Swamynathan SK

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Plau cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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