Hcrtr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hcrtr2
Entrez Gene ID	25605
Full Name	hypocretin receptor 2
General protein information	Preferred Names hypocretin receptor 2 Names orexin receptor type 2 hypocretin (orexin) receptor 2 hypocretin receptor type 2 ox-2-R ox2-R ox2r
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	G-protein coupled receptor that binds orexin neuropeptides; involved in regulation of feeding behavior [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013074.1	NP_037206.1	orexin receptor type 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	HCRTR2	NP_001517.2
	HCRTR2	XP_001109616.1
Xenopus tropicalis (tropical clawed frog)	hcrtr2	XP_002934896.2
Caenorhabditis elegans (roundworm)	npr-2	NP_501701.2
Pan troglodytes (chimpanzee)	HCRTR2	XP_518552.2
Bos taurus (cattle)	HCRTR2	NP_001179606.1
Mus musculus (house mouse)	Hcrtr2	NP_945200.1
Gallus gallus (chicken)	HCRTR2	NP_001019755.1
Canis lupus familiaris (dog)	HCRTR2	NP_001002933.1
Rattus norvegicus (Norway rat)	Hcrtr2	NP_037206.1
Danio rerio (zebrafish)	hcrtr2	NP_001073337.1
Caenorhabditis elegans (roundworm)	npr-1	NP_508816.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats.
Sahafzadeh M, Karimi-Haghighi S, Mousavi Z, Haghparast A
Brain research bulletin137217-224(2017 Dec)

Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats.
Alizamini MM, Farzinpour Z, Ezzatpanah S, Haghparast A
Neuroscience letters6601-5(2017 Nov)

Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats.
J?hren O, Neidert SJ, Kummer M, Dendorfer A, Dominiak P
Endocrinology142(8)3324-31(2001 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study suggests that the orexin-1 and orexin-2 receptor mediated projections from the lateral hypothalamus to dentate gyrus are involved in the development, expression and extinction of conditioned place preference induced by lateral hypothalamus stimulation
Title: Involvement of orexin-1 and orexin-2 receptors within the dentate gyrus of the hippocampus in the acquisition, expression and extinction of lateral hypothalamic-induced conditioned place preference in the rats.

Study using specific orexin receptor antagonists suggests that the orexin 2 receptor has a dominant role in the observed effects of orexin A/hypocretin-1 . To our knowledge, this article is the first to show orexinergic modulation of the ventrolateral geniculate nucleus .
Title: Orexins excite ventrolateral geniculate nucleus neurons predominantly via OX2 receptors.

Activation of orexin perifornical hypothalamus-rostral ventrolateral medulla (RVLM) neurons and orexin type 2 receptors in the RVLM facilitates epinephrine release by increasing sympathetic drive to adrenal chromaffin cells during hypoglycemia.
Title: Activation of Medulla-Projecting Perifornical Neurons Modulates the Adrenal Sympathetic Response to Hypoglycemia: Involvement of Orexin Type 2 (OX2-R) Receptors.

the OX2 receptor has a critical role in modulating reward circuit in the Ventral Tegmental Area and Nucleus Accumbens
Title: Functional interaction between OX2 and CB1 receptors in the ventral tegmental area and the nucleus accumbens in response to place preference induced by chemical stimulation of the lateral hypothalamus.

Study reveals a direct excitatory action of orexin on inferior vestibular nucleus neurons via co-activation of both postsynaptic OX1 and OX2 receptors
Title: Orexin excites rat inferior vestibular nuclear neurons via co-activation of OX1 and OX 2 receptors.

The following Hcrtr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hcrtr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13329	NM_013074.1 Latest version!	Rattus norvegicus hypocretin receptor 2 (Hcrtr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hcrtr2 ( NM_013074.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037206.1 Rattus norvegicus hypocretin receptor 2 (Hcrtr2), mRNA.

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CloneID	ORa13329
Clone ID Related Accession (Same CDS sequence)	NM_013074.1
Accession Version	NM_013074.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	orexin receptor type 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF041246.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF041246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMN02642595 [ECO:0000348] ##Evidence-Data-END##

ATGTCCAGCA CCAAATTGGA GGATTCCCTC CCTCGTCGCA ACTGGTCATC TGCTTCGGAG 
CTGAATGAAA CTCAAGAGCC GTTTTTAAAC CCCACAGACT ATGACGACGA GGAATTCCTG 
CGGTACCTGT GGAGGGAATA CCTACACCCG AAAGAATATG AGTGGGTCCT GATCGCAGGG 
TATATCATCG TGTTCGTCGT GGCTCTCATC GGGAACGTCC TGGTCTGCGT GGCAGTGTGG 
AAGAACCACC ACATGAGGAC AGTCACCAAC TACTTCATAG TCAACCTCTC CCTGGCTGAT 
GTGCTTGTGA CCATCACCTG CCTTCCAGCC ACCCTTGTTG TTGACATCAC CGAGACTTGG 
TTCTTTGGAC AGTCCCTCTG TAAGGTCATC CCTTATTTAC AGACTGTGTC AGTGTCTGTG 
TCTGTTCTTA CATTGAGCTG CATTGCCTTG GACCGATGGT ACGCCATTTG TCACCCTTTG 
ATGTTCAAGA GCACAGCCAA ACGGGCTCGA AACAGCATCG TTGTCATCTG GATCGTCTCC 
TGCATCATAA TGATTCCTCA AGCCATTGTC ATGGAGCGCA GCAGCATGCT CCCTGGCCTA 
GCCAATAAGA CCACCCTCTT TACAGTCTGC GATGAACGCT GGGGAGGTGA AGTTTACCCA 
AAGATGTACC ACATCTGCTT CTTTCTGGTG ACGTACATGG CACCCCTGTG TCTTATGGTA 
TTGGCTTATC TCCAAATATT CCGTAAACTC TGGTGCAGAC AGATTCCCGG AACTTCTTCT 
GTGGTTCAGA GAAAATGGAA GCAGCCGCAG CCGGTTTCTC AGCCCCGGGG GTCCGGACAG 
CAGAGCAAGG CCCGGATTAG CGCTGTCGCT GCTGAGATAA AGCAGATCCG AGCACGAAGG 
AAAACAGCCC GGATGCTCAT GGTTGTACTT CTGGTCTTTG CAATTTGCTA TCTACCAATC 
AGCATCCTCA ATGTGCTAAA GAGAGTGTTC GGGATGTTCA CACACACCGA AGACAGAGAG 
ACTGTCTACG CCTGGTTCAC TTTTTCTCAT TGGCTTGTGT ATGCCAATAG TGCTGCAAAC 
CCAATTATTT ATAATTTTCT CAGTGGAAAA TTTCGAGAGG AATTTAAAGC TGCCTTTTCT 
TGCTGTCTTG GGGTTCATCG TCGTCAAGGA GATCGCCTCG CCAGGGGACG CACAAGTACA 
GAGAGCAGGA AGTCCCTGAC TACTCAGATC AGCAACTTTG ATAATGTATC AAAACTCTCA 
GAGCACGTGG CGCTCACCAG CATAAGCACA CTCCCAGCAG CCAACGGGGC AGGACCGCTT 
CAAAACTGGT ATCTACAACA GGGAGTGCCA TCTTCACTCC TGTCCACCTG GCTGGAGGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037206.1
CDS	60..1442
Translation	MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV

Target ORF information:

RefSeq Version	NM_013074.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hypocretin receptor 2 (Hcrtr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013074.1

ORF Insert Sequence:

ATGTCCAGCA CCAAATTGGA GGATTCCCTC CCTCGTCGCA ACTGGTCATC TGCTTCGGAG 
CTGAATGAAA CTCAAGAGCC GTTTTTAAAC CCCACAGACT ATGACGACGA GGAATTCCTG 
CGGTACCTGT GGAGGGAATA CCTACACCCG AAAGAATATG AGTGGGTCCT GATCGCAGGG 
TATATCATCG TGTTCGTCGT GGCTCTCATC GGGAACGTCC TGGTCTGCGT GGCAGTGTGG 
AAGAACCACC ACATGAGGAC AGTCACCAAC TACTTCATAG TCAACCTCTC CCTGGCTGAT 
GTGCTTGTGA CCATCACCTG CCTTCCAGCC ACCCTTGTTG TTGACATCAC CGAGACTTGG 
TTCTTTGGAC AGTCCCTCTG TAAGGTCATC CCTTATTTAC AGACTGTGTC AGTGTCTGTG 
TCTGTTCTTA CATTGAGCTG CATTGCCTTG GACCGATGGT ACGCCATTTG TCACCCTTTG 
ATGTTCAAGA GCACAGCCAA ACGGGCTCGA AACAGCATCG TTGTCATCTG GATCGTCTCC 
TGCATCATAA TGATTCCTCA AGCCATTGTC ATGGAGCGCA GCAGCATGCT CCCTGGCCTA 
GCCAATAAGA CCACCCTCTT TACAGTCTGC GATGAACGCT GGGGAGGTGA AGTTTACCCA 
AAGATGTACC ACATCTGCTT CTTTCTGGTG ACGTACATGG CACCCCTGTG TCTTATGGTA 
TTGGCTTATC TCCAAATATT CCGTAAACTC TGGTGCAGAC AGATTCCCGG AACTTCTTCT 
GTGGTTCAGA GAAAATGGAA GCAGCCGCAG CCGGTTTCTC AGCCCCGGGG GTCCGGACAG 
CAGAGCAAGG CCCGGATTAG CGCTGTCGCT GCTGAGATAA AGCAGATCCG AGCACGAAGG 
AAAACAGCCC GGATGCTCAT GGTTGTACTT CTGGTCTTTG CAATTTGCTA TCTACCAATC 
AGCATCCTCA ATGTGCTAAA GAGAGTGTTC GGGATGTTCA CACACACCGA AGACAGAGAG 
ACTGTCTACG CCTGGTTCAC TTTTTCTCAT TGGCTTGTGT ATGCCAATAG TGCTGCAAAC 
CCAATTATTT ATAATTTTCT CAGTGGAAAA TTTCGAGAGG AATTTAAAGC TGCCTTTTCT 
TGCTGTCTTG GGGTTCATCG TCGTCAAGGA GATCGCCTCG CCAGGGGACG CACAAGTACA 
GAGAGCAGGA AGTCCCTGAC TACTCAGATC AGCAACTTTG ATAATGTATC AAAACTCTCA 
GAGCACGTGG CGCTCACCAG CATAAGCACA CTCCCAGCAG CCAACGGGGC AGGACCGCTT 
CAAAACTGGT ATCTACAACA GGGAGTGCCA TCTTCACTCC TGTCCACCTG GCTGGAGGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats.
Brain research bulletin137217-224(2017 Dec)
Sahafzadeh M,Karimi-Haghighi S,Mousavi Z,Haghparast A

Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats.
Neuroscience letters6601-5(2017 Nov)
Alizamini MM,Farzinpour Z,Ezzatpanah S,Haghparast A

Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats.
Endocrinology142(8)3324-31(2001 Aug)
J?hren O,Neidert SJ,Kummer M,Dendorfer A,Dominiak P

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Hcrtr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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