Fabp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fabp2
Entrez Gene ID	25598
Full Name	fatty acid binding protein 2
Synonyms	FABP
General protein information	Preferred Names fatty acid binding protein 2 Names fatty acid-binding protein, intestinal FABPI I-FABP fatty acid binding protein 1 fatty acid binding protein 2, intestinal intestinal fatty acid binding protein intestinal-type fatty acid-binding protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q42
Summary	may play roles in fatty acid transport and compartmentalization [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013068.1	NP_037200.1	fatty acid-binding protein, intestinal

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FABP2	XP_001149448.1
	FABP2	XP_001099243.1
Canis lupus familiaris (dog)	FABP2	XP_545047.1
Mus musculus (house mouse)	Fabp2	NP_032006.1
Rattus norvegicus (Norway rat)	Fabp2	NP_037200.1
Gallus gallus (chicken)	FABP2	NP_001007924.1
Danio rerio (zebrafish)	fabp2	NP_571506.1
Homo sapiens (human)	FABP2	NP_000125.2
Bos taurus (cattle)	FABP2	NP_001020503.1
Xenopus tropicalis (tropical clawed frog)	fabp2	NP_001106373.1

Gene Ontology
Bibliography

Related articles in PubMed

Time Scales of Conformational Gating in a Lipid-Binding Protein.
Kaieda S, Halle B
The journal of physical chemistry. B119(25)7957-67(2015 Jun)

Characterization of fatty acid binding and transfer from ?98?, a functional all-? abridged form of IFABP.
Sawicki LR, Guerbi MX, Falomir Lockhart LJ, Curto LM, Delfino JM, C?rsico B, Franchini GR
Biochimica et biophysica acta1841(12)1733-40(2014 Dec)

IFABP portal region insertion during membrane interaction depends on phospholipid composition.
de Ger?nimo E, Rodriguez Sawicki L, Bottasso Arias N, Franchini GR, Zamarre?o F, Costabel MD, C?rsico B, Falomir Lockhart LJ
Biochimica et biophysica acta1841(1)141-50(2014 Jan)

N-3 PUFAs attenuate ischemia/reperfusion induced intestinal barrier injury by?activating I-FABP-PPAR? pathway.
Wang X, Pan L, Lu J, Li N, Li J
Clinical nutrition (Edinburgh, Scotland)31(6)951-7(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study characterized internal-water exchange and associated conformational dynamics in rIFABP by recording the water 2H and 17O MRD profiles for the apo and palmitate-bound forms
Title: Time Scales of Conformational Gating in a Lipid-Binding Protein.

This work highlights the importance of the beta-barrel of IFABP for its specific functions.
Title: Characterization of fatty acid binding and transfer from ?98?, a functional all-? abridged form of IFABP.

the portal region of IFABP penetrates deeply into the phospholipid bilayer, especially when CL-containing vesicles are employed. The orientation of the protein and the degree of penetration were highly dependent on the lipid composition
Title: IFABP portal region insertion during membrane interaction depends on phospholipid composition.

n-3 PUFAs protect the intestinal barrier by modifying intracellular I-FABP, activating the PPARgamma pathway, and then upregulating tight junction protein expression.
Title: N-3 PUFAs attenuate ischemia/reperfusion induced intestinal barrier injury by?activating I-FABP-PPAR? pathway.

Delta 78 Delta beta-barrel motif retains substantial beta-sheet content and preserves tertiary interactions, displaying cooperative unfolding and binding activity. Most strikingly, this construct adopts a remarkably stable dimeric structure in solution.
Title: Dissection of a beta-barrel motif leads to a functional dimer: the case of the intestinal fatty acid binding protein.

The following Fabp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fabp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01844	NM_013068.1 Latest version!	Rattus norvegicus fatty acid binding protein 2 (Fabp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fabp2 ( NM_013068.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037200.1 Rattus norvegicus fatty acid binding protein 2 (Fabp2), mRNA.

Price & Availability↑

CloneID	ORa01844
Clone ID Related Accession (Same CDS sequence)	NM_013068.1
Accession Version	NM_013068.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	fatty acid-binding protein, intestinal
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M35992.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: K01180.1, M35992.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689598, SAMN00632251 [ECO:0000350] ##Evidence-Data-END##

ATGGCATTTG ATGGCACTTG GAAAGTAGAC CGGAATGAGA ACTATGAAAA GTTCATGGAG 
AAAATGGGCA TTAACGTGGT GAAGAGGAAG CTTGGAGCTC ATGACAACTT GAAACTGACG 
ATCACACAGG AAGGAAATAA ATTCACAGTC AAAGAATCAA GCAACTTCCG AAACATTGAT 
GTTGTGTTTG AACTCGGCGT CGACTTTGCC TATAGTCTAG CAGATGGAAC AGAACTCACT 
GGGACCTGGA CCATGGAGGG AAATAAACTT GTTGGAAAAT TCAAACGTGT AGACAATGGA 
AAGGAGCTGA TTGCTGTCCG AGAGATTTCT GGTAACGAAC TAATCCAAAC CTACACATAT 
GAAGGAGTGG AGGCCAAGCG GATCTTTAAG AAGGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037200.1
CDS	13..411
Translation	MAFDGTWKVDRNENYEKFMEKMGINVVKRKLGAHDNLKLTITQEGNKFTVKESSNFRNIDVVFELGVDFAYSLADGTELTGTWTMEGNKLVGKFKRVDNGKELIAVREISGNELIQTYTYEGVEAKRIFKKE

Target ORF information:

RefSeq Version	NM_013068.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fatty acid binding protein 2 (Fabp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013068.1

ORF Insert Sequence:

ATGGCATTTG ATGGCACTTG GAAAGTAGAC CGGAATGAGA ACTATGAAAA GTTCATGGAG 
AAAATGGGCA TTAACGTGGT GAAGAGGAAG CTTGGAGCTC ATGACAACTT GAAACTGACG 
ATCACACAGG AAGGAAATAA ATTCACAGTC AAAGAATCAA GCAACTTCCG AAACATTGAT 
GTTGTGTTTG AACTCGGCGT CGACTTTGCC TATAGTCTAG CAGATGGAAC AGAACTCACT 
GGGACCTGGA CCATGGAGGG AAATAAACTT GTTGGAAAAT TCAAACGTGT AGACAATGGA 
AAGGAGCTGA TTGCTGTCCG AGAGATTTCT GGTAACGAAC TAATCCAAAC CTACACATAT 
GAAGGAGTGG AGGCCAAGCG GATCTTTAAG AAGGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Time Scales of Conformational Gating in a Lipid-Binding Protein.
The journal of physical chemistry. B119(25)7957-67(2015 Jun)
Kaieda S,Halle B

Characterization of fatty acid binding and transfer from ?98?, a functional all-? abridged form of IFABP.
Biochimica et biophysica acta1841(12)1733-40(2014 Dec)
Sawicki LR,Guerbi MX,Falomir Lockhart LJ,Curto LM,Delfino JM,C?rsico B,Franchini GR

IFABP portal region insertion during membrane interaction depends on phospholipid composition.
Biochimica et biophysica acta1841(1)141-50(2014 Jan)
de Ger?nimo E,Rodriguez Sawicki L,Bottasso Arias N,Franchini GR,Zamarre?o F,Costabel MD,C?rsico B,Falomir Lockhart LJ

N-3 PUFAs attenuate ischemia/reperfusion induced intestinal barrier injury by?activating I-FABP-PPAR? pathway.
Clinical nutrition (Edinburgh, Scotland)31(6)951-7(2012 Dec)
Wang X,Pan L,Lu J,Li N,Li J

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Fabp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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