Slc34a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc34a1
Entrez Gene ID	25548
Full Name	solute carrier family 34 member 1
Synonyms	NaPi-2,NaPi2A,Npt2,Slc17a2
General protein information	Preferred Names solute carrier family 34 member 1 Names sodium-dependent phosphate transport protein 2A Na(+)-dependent phosphate cotransporter 2A Na(+)/Pi cotransporter 2A naPi-2a sodium-phosphate co-transporter type II sodium-phosphate transport protein 2A sodium/phosphate cotransporter 2A solute carrier family 17 (sodium/hydrogen exchanger) member 2 solute carrier family 34 (sodium phosphate), member 1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p14
Summary	membrane carrier protein that may be involved with active transport of phosphate into cells via sodium cotransport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013030.1	NP_037162.1	sodium-dependent phosphate transport protein 2A

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC34A1	NP_003043.3
	SLC34A1	XP_001089538.1
Pan troglodytes (chimpanzee)	SLC34A1	XP_001142298.2
Gallus gallus (chicken)	SLC34A1	XP_425204.4
Danio rerio (zebrafish)	slc34a1a	XP_002664304.2
Rattus norvegicus (Norway rat)	Slc34a1	NP_037162.1
Caenorhabditis elegans (roundworm)	ZK563.2	NP_508581.2
Canis lupus familiaris (dog)	SLC34A1	XP_852242.1
Bos taurus (cattle)	SLC34A1	NP_001096693.1
Mus musculus (house mouse)	Slc34a1	NP_035522.2

Gene Ontology
Bibliography

Related articles in PubMed

Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia.
Schlingmann KP, Ruminska J, Kaufmann M, Dursun I, Patti M, Kranz B, Pronicka E, Ciara E, Akcay T, Bulus D, Cornelissen EA, Gawlik A, Sikora P, Patzer L, Galiano M, Boyadzhiev V, Dumic M, Vivante A, Kleta R, Dekel B, Levtchenko E, Bindels RJ, Rust S, Forster IC, Hernando N, Jones G, Wagner CA, Konrad M
Journal of the American Society of Nephrology : JASN27(2)604-14(2016 Feb)

Effect of hyperphosphatemia on gene expression of the Na-Pi cotransporter in rats.
Zhang C, Shi LM, Li Y, Zhu QG, Jin CL, Wang HP, Zhou L, Hu XP, Zhang L, Wang H, Yuan GJ, Xu L, Zhao YK, Chou Y
Genetics and molecular research : GMR14(4)19404-10(2016 Jan)

Vitamin B?? deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a.
Shiga T, Kimira Y, Mano H, Kawata T, Tadokoro T, Suzuki T, Yamamoto Y
Bioscience, biotechnology, and biochemistry80(3)510-3(2016)

Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ER? and ER?) in rat kidney proximal tubule.
Burris D, Webster R, Sheriff S, Faroqui R, Levi M, Hawse JR, Amlal H
American journal of physiology. Renal physiology308(6)F522-34(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NaPi-IIa mRNA expression is affected by hyperphosphatemia.
Title: Effect of hyperphosphatemia on gene expression of the Na-Pi cotransporter in rats.

Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B12 deficiency suggests that vitamin B12 plays an important role in Pi homeostasis
Title: Vitamin B?? deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a.

Estrogen induces phosphaturia by directly and specifically targeting NaPi-IIa in the proximal tubule cells.
Title: Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ER? and ER?) in rat kidney proximal tubule.

Downregulation of renal Npt2a expression through induction of plasma iPTH levels alters Pi homeostasis during LPS-induced acute inflammation.
Title: Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation.

Magnesium deficiency induces downregulation of 1alpha(OH)ase and type IIa and IIc Na/Pi cotransporters, and upregulation of 24(OH)ase in the kidney.
Title: Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats.

The following Slc34a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc34a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01701	NM_013030.1 Latest version!	Rattus norvegicus solute carrier family 34 member 1 (Slc34a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc34a1 ( NM_013030.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037162.1 Rattus norvegicus solute carrier family 34 member 1 (Slc34a1), mRNA.

Price & Availability↑

CloneID	ORa01701
Clone ID Related Accession (Same CDS sequence)	NM_013030.1
Accession Version	NM_013030.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1914bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	sodium-dependent phosphate transport protein 2A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L13257.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L13257.1, BC078876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642782 [ECO:0000348] ##Evidence-Data-END##

ATGATGTCCT ACAGCGAGAG ATTGGGGGGA CCGGCTGTCT CCCCACTTCC AGTCCGTGGG 
AGACACATGG TGCATGGGGC AGCCTTTGCT TATGTCCCCA GCCCACAAGT CCTGCACAGG 
ATTCCTGGGA CAACCACCTA TGCCATCTCC AGTCTGAGCC CGGTAGCCCT CACAGAGCAC 
AGCTGTCCCT ATGGGGAGGT CCTGGAATGT CATGACCCGC TCCCTGCCAA GCTGGCCCAG 
GAAGAGGAGC AAAAGCCAGA GCCCAGGCTG TCCCAGAAGC TTGCCCAGGT TGGCACAAAG 
CTCCTGAAGG TGCCGTTGAT GCTAGGCTTC CTTTACCTCT TTGTCTGCTC CCTGGACGTG 
CTCAGCTCTG CCTTCCAACT GGCCGGAGGG AAAGTGGCTG GGGACATCTT CAAGGACAAT 
GCCATCCTGT CCAACCCAGT GGCAGGGCTG GTGGTGGGAA TCCTGGTGAC AGTTCTGGTG 
CAGAGCTCCA GCACCTCGAC ATCCATCATT GTCAGCATGG TCTCCTCTGG CTTGTTGGAG 
GTGAGCTCCG CCATTCCGAT AATCATGGGC TCCAACATCG GGACCTCTGT CACCAACACC 
ATTGTGGCCC TGATGCAGGC GGGGGACAGG ACTGACTTCA GGCGGGCTTT TGCAGGGGCA 
ACAGTGCATG ACTGCTTTAA CTGGCTGTCT GTTCTGGTCC TGCTGCCCCT GGAGGCTGCC 
ACGGGCTACC TGCACCACGT CACCGGGCTT GTGGTTGCCT CCTTCAACAT CCGTGGTGGC 
CGTGATGCCC CTGACCTTCT CAAGGTTATC ACAGAGCCCT TCACAAAGCT TATCATCCAG 
CTGGACAAGT CTGTGATTAC CAGCATTGCC GTGGGGGATG AGTCCCTGAG GAATCACAGT 
CTCATTCGGA TTTGGTGTCA ACCAGAGACA AAAGAGGCTT CCACTTCTAT GTCCAGGGTA 
GAGGCCATTG GCAGCCTTGC AAACACCACC ATGGAGAAAT GCAACCATAT CTTCGTGGAT 
ACTGGGCTGC CCGACCTGGC CGTGGGGCTC ATTCTGCTGG CGGGCTCCCT GGTGGTCCTG 
TGCACTTGTC TTATCCTCCT CGTCAAGATG CTCAACTCTC TGCTGAAGGG CCAAGTGGCC 
AATGTCATCC AGAAGGTCAT CAACACAGAC TTCCCAGCCC CCTTCACTTG GGTCACAGGC 
TACTTTGCCA TGGTGGTGGG CGCCAGCATG ACGTTTGTTG TCCAGAGCAG TTCCGTGTTC 
ACCTCAGCCA TCACTCCGCT CATTGGCCTG GGTGTGATCA GTATTGAGCG GGCCTACCCT 
CTCACCCTGG GCTCCAACAT TGGTACCACC ACTACAGCCA TCCTGGCAGC ACTGGCCAGC 
CCCAGGGAGA AGCTCTCCAG CTCCTTTCAG ATTGCCCTCT GCCACTTCTT CTTCAACATC 
TCGGGCATCC TCCTGTGGTA CCCGCTGCCC TGCACACGTC TGCCCATCCG CATGGCCAAG 
GCACTGGGCA AACGCACTGC CAAGTACCGC TGGTTTGCCG TCCTCTACCT CCTCGTGTGC 
TTCCTGCTCC TGCCCTCACT GGTGTTTGGC ATTTCTATGG CAGGCTGGCA GGCTATGGTC 
GGTGTGGGCA CACCCTTTGG GGCCCTGCTC GCCTTCGTGG TGCTTGTTAA CGTCCTGCAG 
AGTCGAAGTC CCGGGCACCT CCCCAAGTGG CTGCAGACAT GGGACTTCCT ACCCCGCTGG 
ATGCACTCTC TGCAGCCCCT GGATGGCCTT ATCACAAGAG CCACCTTGTG CTATGCCAGG 
CCCGAGCCCC GTTCACCCCA ACTTCCCCCC AGAGTCTTCC TGGAGGAGCT TCCTCCTGCC 
ACGCCCTCTC CCCGCCTGGC ACTGCCCGCT CACCACAATG CCACCCGGCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037162.1
CDS	54..1967
Translation	MMSYSERLGGPAVSPLPVRGRHMVHGAAFAYVPSPQVLHRIPGTTTYAISSLSPVALTEHSCPYGEVLECHDPLPAKLAQEEEQKPEPRLSQKLAQVGTKLLKVPLMLGFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTKLIIQLDKSVITSIAVGDESLRNHSLIRIWCQPETKEASTSMSRVEAIGSLANTTMEKCNHIFVDTGLPDLAVGLILLAGSLVVLCTCLILLVKMLNSLLKGQVANVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQSRSPGHLPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSPRLALPAHHNATRL

Target ORF information:

RefSeq Version	NM_013030.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 34 member 1 (Slc34a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013030.1

ORF Insert Sequence:

ATGATGTCCT ACAGCGAGAG ATTGGGGGGA CCGGCTGTCT CCCCACTTCC AGTCCGTGGG 
AGACACATGG TGCATGGGGC AGCCTTTGCT TATGTCCCCA GCCCACAAGT CCTGCACAGG 
ATTCCTGGGA CAACCACCTA TGCCATCTCC AGTCTGAGCC CGGTAGCCCT CACAGAGCAC 
AGCTGTCCCT ATGGGGAGGT CCTGGAATGT CATGACCCGC TCCCTGCCAA GCTGGCCCAG 
GAAGAGGAGC AAAAGCCAGA GCCCAGGCTG TCCCAGAAGC TTGCCCAGGT TGGCACAAAG 
CTCCTGAAGG TGCCGTTGAT GCTAGGCTTC CTTTACCTCT TTGTCTGCTC CCTGGACGTG 
CTCAGCTCTG CCTTCCAACT GGCCGGAGGG AAAGTGGCTG GGGACATCTT CAAGGACAAT 
GCCATCCTGT CCAACCCAGT GGCAGGGCTG GTGGTGGGAA TCCTGGTGAC AGTTCTGGTG 
CAGAGCTCCA GCACCTCGAC ATCCATCATT GTCAGCATGG TCTCCTCTGG CTTGTTGGAG 
GTGAGCTCCG CCATTCCGAT AATCATGGGC TCCAACATCG GGACCTCTGT CACCAACACC 
ATTGTGGCCC TGATGCAGGC GGGGGACAGG ACTGACTTCA GGCGGGCTTT TGCAGGGGCA 
ACAGTGCATG ACTGCTTTAA CTGGCTGTCT GTTCTGGTCC TGCTGCCCCT GGAGGCTGCC 
ACGGGCTACC TGCACCACGT CACCGGGCTT GTGGTTGCCT CCTTCAACAT CCGTGGTGGC 
CGTGATGCCC CTGACCTTCT CAAGGTTATC ACAGAGCCCT TCACAAAGCT TATCATCCAG 
CTGGACAAGT CTGTGATTAC CAGCATTGCC GTGGGGGATG AGTCCCTGAG GAATCACAGT 
CTCATTCGGA TTTGGTGTCA ACCAGAGACA AAAGAGGCTT CCACTTCTAT GTCCAGGGTA 
GAGGCCATTG GCAGCCTTGC AAACACCACC ATGGAGAAAT GCAACCATAT CTTCGTGGAT 
ACTGGGCTGC CCGACCTGGC CGTGGGGCTC ATTCTGCTGG CGGGCTCCCT GGTGGTCCTG 
TGCACTTGTC TTATCCTCCT CGTCAAGATG CTCAACTCTC TGCTGAAGGG CCAAGTGGCC 
AATGTCATCC AGAAGGTCAT CAACACAGAC TTCCCAGCCC CCTTCACTTG GGTCACAGGC 
TACTTTGCCA TGGTGGTGGG CGCCAGCATG ACGTTTGTTG TCCAGAGCAG TTCCGTGTTC 
ACCTCAGCCA TCACTCCGCT CATTGGCCTG GGTGTGATCA GTATTGAGCG GGCCTACCCT 
CTCACCCTGG GCTCCAACAT TGGTACCACC ACTACAGCCA TCCTGGCAGC ACTGGCCAGC 
CCCAGGGAGA AGCTCTCCAG CTCCTTTCAG ATTGCCCTCT GCCACTTCTT CTTCAACATC 
TCGGGCATCC TCCTGTGGTA CCCGCTGCCC TGCACACGTC TGCCCATCCG CATGGCCAAG 
GCACTGGGCA AACGCACTGC CAAGTACCGC TGGTTTGCCG TCCTCTACCT CCTCGTGTGC 
TTCCTGCTCC TGCCCTCACT GGTGTTTGGC ATTTCTATGG CAGGCTGGCA GGCTATGGTC 
GGTGTGGGCA CACCCTTTGG GGCCCTGCTC GCCTTCGTGG TGCTTGTTAA CGTCCTGCAG 
AGTCGAAGTC CCGGGCACCT CCCCAAGTGG CTGCAGACAT GGGACTTCCT ACCCCGCTGG 
ATGCACTCTC TGCAGCCCCT GGATGGCCTT ATCACAAGAG CCACCTTGTG CTATGCCAGG 
CCCGAGCCCC GTTCACCCCA ACTTCCCCCC AGAGTCTTCC TGGAGGAGCT TCCTCCTGCC 
ACGCCCTCTC CCCGCCTGGC ACTGCCCGCT CACCACAATG CCACCCGGCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia.
Journal of the American Society of Nephrology : JASN27(2)604-14(2016 Feb)
Schlingmann KP,Ruminska J,Kaufmann M,Dursun I,Patti M,Kranz B,Pronicka E,Ciara E,Akcay T,Bulus D,Cornelissen EA,Gawlik A,Sikora P,Patzer L,Galiano M,Boyadzhiev V,Dumic M,Vivante A,Kleta R,Dekel B,Levtchenko E,Bindels RJ,Rust S,Forster IC,Hernando N,Jones G,Wagner CA,Konrad M

Effect of hyperphosphatemia on gene expression of the Na-Pi cotransporter in rats.
Genetics and molecular research : GMR14(4)19404-10(2016 Jan)
Zhang C,Shi LM,Li Y,Zhu QG,Jin CL,Wang HP,Zhou L,Hu XP,Zhang L,Wang H,Yuan GJ,Xu L,Zhao YK,Chou Y

Vitamin B?? deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a.
Bioscience, biotechnology, and biochemistry80(3)510-3(2016)
Shiga T,Kimira Y,Mano H,Kawata T,Tadokoro T,Suzuki T,Yamamoto Y

Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ER? and ER?) in rat kidney proximal tubule.
American journal of physiology. Renal physiology308(6)F522-34(2015 Mar)
Burris D,Webster R,Sheriff S,Faroqui R,Levi M,Hawse JR,Amlal H

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Slc34a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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