Ppia cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppia
Entrez Gene ID	25518
Full Name	peptidylprolyl isomerase A (cyclophilin A)
Synonyms	CYCA,CyP-A
General protein information	Preferred Names peptidylprolyl isomerase A (cyclophilin A) Names peptidyl-prolyl cis-trans isomerase A PPIase A cyclophilin A cyclosporin A-binding protein p1B15 p31 rotamase A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	may play a role in protein folding or intracellular protein transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017101.1	NP_058797.1	peptidyl-prolyl cis-trans isomerase A
XM_017599085.1	XP_017454574.1	peptidyl-prolyl cis-trans isomerase A isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC100337215	XP_002690561.1
Mus musculus (house mouse)	Ppia	NP_032933.1
Rattus norvegicus (Norway rat)	LOC100360977	XP_006250863.1
Caenorhabditis elegans (roundworm)	cyn-1	NP_506561.1
Kluyveromyces lactis	KLLA0B04565g	XP_451736.1
Arabidopsis thaliana (thale cress)	ROC2	NP_191166.1
Xenopus tropicalis (tropical clawed frog)	LOC100496569	XP_002932593.1
Homo sapiens (human)	PPIA	NP_066953.1
Pan troglodytes (chimpanzee)	PPIA	XP_003951049.1
Rattus norvegicus (Norway rat)	Ppia	NP_058797.1
Oryza sativa (rice)	Os09g0571400	NP_001063993.1
Canis lupus familiaris (dog)	PPIA	XP_532723.2
Eremothecium gossypii	AGOS_AER156C	NP_985014.1
	PPIA	NP_001027981.1
Rattus norvegicus (Norway rat)	LOC100911252	XP_006236184.1
Gallus gallus (chicken)	PPIA	NP_001159798.1
Danio rerio (zebrafish)	ppiaa	NP_997923.1
Saccharomyces cerevisiae (baker's yeast)	CPR3	NP_013633.1

Gene Ontology
Bibliography

Related articles in PubMed

Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain.
Su Z, Lin R, Chen Y, Shu X, Zhang H, Liang S, Nie R, Wang J, Xie S
Journal of vascular research53(3-4)206-215(2016)

Diet induced obesity in rats reduces NHE3 and Na(+) /K(+) -ATPase expression in the kidney.
Briffa JF, Grinfeld E, Jenkin KA, Mathai ML, Poronnik P, McAinch AJ, Hryciw DH
Clinical and experimental pharmacology & physiology42(10)1118-26(2015 Oct)

Pancreatic acinar cells-derived cyclophilin A promotes pancreatic damage by activating NF-?B pathway in experimental pancreatitis.
Yu G, Wan R, Hu Y, Ni J, Yin G, Xing M, Shen J, Tang M, Chen C, Fan Y, Xiao W, Zhao Y, Wang X, Hu G
Biochemical and biophysical research communications444(1)75-80(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of myosin light chains in vascular smooth muscle cells.
Title: Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain.

CypA promotes pancreatic damage by upregulating expression of inflammatory cytokines of acinar cells via the NF-kappaB pathway.
Title: Pancreatic acinar cells-derived cyclophilin A promotes pancreatic damage by activating NF-?B pathway in experimental pancreatitis.

CyPA is an important regulator for AngII-induced ROS generation in VSMC through interaction with p47phox and cell cytoskeleton, which enhances the translocation of p47phox to caveolae.
Title: Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells.

Cyclophilin-A and EMMPRIN play roles in the maturation of dental hard tissue and the formation of a molar eruption pathway.
Title: Differential expression of cyclophilin A and EMMPRIN in developing molars of rats.

CyPA is required for Ang II-mediated cardiac hypertrophy by directly potentiating ROS production, stimulating the proliferation and migration of cardiac fibroblasts, and promoting cardiac myocyte hypertrophy.
Title: Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.

The following Ppia gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppia cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12898	NM_017101.1 Latest version!	Rattus norvegicus peptidylprolyl isomerase A (Ppia), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa58229	XM_017599085.1 Latest version!	Rattus norvegicus peptidylprolyl isomerase A (cyclophilin A) (Ppia), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppia ( NM_017101.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058797.1 Rattus norvegicus peptidylprolyl isomerase A (Ppia), mRNA.

Price & Availability↑

CloneID	ORa12898
Clone ID Related Accession (Same CDS sequence)	NM_017101.1
Accession Version	NM_017101.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M19533.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M19533.1, FQ241390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTCAACC CCACCGTGTT CTTCGACATC ACGGCTGATG GCGAGCCCTT GGGTCGCGTC 
TGCTTCGAGC TGTTTGCAGA CAAAGTTCCA AAGACAGCAG AAAACTTTCG TGCTCTGAGC 
ACTGGGGAGA AAGGATTTGG CTATAAGGGT TCCTCCTTTC ACAGAATTAT TCCAGGATTC 
ATGTGCCAGG GTGGTGACTT CACACGCCAT AATGGCACTG GTGGCAAGTC CATCTACGGA 
GAGAAATTTG AGGATGAGAA CTTCATCCTG AAGCATACAG GTCCTGGCAT CTTGTCCATG 
GCAAATGCTG GACCAAACAC AAATGGTTCC CAGTTTTTTA TCTGCACTGC CAAGACTGAG 
TGGCTGGATG GCAAGCATGT GGTCTTTGGG AAGGTGAAAG AAGGCATGAG CATTGTGGAA 
GCCATGGAGC GTTTTGGGTC CAGGAATGGC AAGACCAGCA AGAAGATCAC CATCTCCGAC 
TGTGGACAAC TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058797.1
CDS	43..537
Translation	MVNPTVFFDITADGEPLGRVCFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMSIVEAMERFGSRNGKTSKKITISDCGQL

Target ORF information:

RefSeq Version	NM_017101.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus peptidylprolyl isomerase A (Ppia), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017101.1

ORF Insert Sequence:

ATGGTCAACC CCACCGTGTT CTTCGACATC ACGGCTGATG GCGAGCCCTT GGGTCGCGTC 
TGCTTCGAGC TGTTTGCAGA CAAAGTTCCA AAGACAGCAG AAAACTTTCG TGCTCTGAGC 
ACTGGGGAGA AAGGATTTGG CTATAAGGGT TCCTCCTTTC ACAGAATTAT TCCAGGATTC 
ATGTGCCAGG GTGGTGACTT CACACGCCAT AATGGCACTG GTGGCAAGTC CATCTACGGA 
GAGAAATTTG AGGATGAGAA CTTCATCCTG AAGCATACAG GTCCTGGCAT CTTGTCCATG 
GCAAATGCTG GACCAAACAC AAATGGTTCC CAGTTTTTTA TCTGCACTGC CAAGACTGAG 
TGGCTGGATG GCAAGCATGT GGTCTTTGGG AAGGTGAAAG AAGGCATGAG CATTGTGGAA 
GCCATGGAGC GTTTTGGGTC CAGGAATGGC AAGACCAGCA AGAAGATCAC CATCTCCGAC 
TGTGGACAAC TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppia ( XM_017599085.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454574.1 Rattus norvegicus peptidylprolyl isomerase A (cyclophilin A) (Ppia), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa58229
Clone ID Related Accession (Same CDS sequence)	XM_017599085.1
Accession Version	XM_017599085.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCCAGG GTGGTGACTT CACACGCCAT AATGGCACTG GTGGCAAGTC CATCTACGGA 
GAGAAATTTG AGGATGAGAA CTTCATCCTG AAGCATACAG GTCCTGGCAT CTTGTCCATG 
GCAAATGCTG GACCAAACAC AAATGGTTCC CAGTTTTTTA TCTGCACTGC CAAGACTGAG 
TGGCTGGATG GCAAGCATGT GGTCTTTGGG AAGGTGAAAG AAGGCATGAG CATTGTGGAA 
GCCATGGAGC GTTTTGGGTC CAGGAATGGC AAGACCAGCA AGAAGATCAC CATCTCCGAC 
TGTGGACAAC TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454574.1
CDS	192..506
Translation	MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMSIVEAMERFGSRNGKTSKKITISDCGQL

Target ORF information:

RefSeq Version	XM_017599085.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus peptidylprolyl isomerase A (cyclophilin A) (Ppia), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599085.1

ORF Insert Sequence:

ATGTGCCAGG GTGGTGACTT CACACGCCAT AATGGCACTG GTGGCAAGTC CATCTACGGA 
GAGAAATTTG AGGATGAGAA CTTCATCCTG AAGCATACAG GTCCTGGCAT CTTGTCCATG 
GCAAATGCTG GACCAAACAC AAATGGTTCC CAGTTTTTTA TCTGCACTGC CAAGACTGAG 
TGGCTGGATG GCAAGCATGT GGTCTTTGGG AAGGTGAAAG AAGGCATGAG CATTGTGGAA 
GCCATGGAGC GTTTTGGGTC CAGGAATGGC AAGACCAGCA AGAAGATCAC CATCTCCGAC 
TGTGGACAAC TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain.
Journal of vascular research53(3-4)206-215(2016)
Su Z,Lin R,Chen Y,Shu X,Zhang H,Liang S,Nie R,Wang J,Xie S

Diet induced obesity in rats reduces NHE3 and Na(+) /K(+) -ATPase expression in the kidney.
Clinical and experimental pharmacology & physiology42(10)1118-26(2015 Oct)
Briffa JF,Grinfeld E,Jenkin KA,Mathai ML,Poronnik P,McAinch AJ,Hryciw DH

Pancreatic acinar cells-derived cyclophilin A promotes pancreatic damage by activating NF-?B pathway in experimental pancreatitis.
Biochemical and biophysical research communications444(1)75-80(2014 Jan)
Yu G,Wan R,Hu Y,Ni J,Yin G,Xing M,Shen J,Tang M,Chen C,Fan Y,Xiao W,Zhao Y,Wang X,Hu G

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Ppia cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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