Fcer1g cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fcer1g
Entrez Gene ID	25441
Full Name	Fc fragment of IgE receptor Ig
General protein information	Preferred Names Fc fragment of IgE receptor Ig Names high affinity immunoglobulin epsilon receptor subunit gamma Fc fragment of IgE, high affinity I, receptor for Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide Fc receptor gamma-chain Fc receptor, IgE, high affinity I, gamma polypeptide fc-epsilon RI-gamma fcRgamma fceRI gamma gamma polypeptide igE Fc receptor subunit gamma
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q24
Summary	subunit of high-affinity receptor for immunoglobulin E; mediates the release of mediators responsible for allergic symptoms [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001131001.1	NP_001124473.1	high affinity immunoglobulin epsilon receptor subunit gamma precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FCER1G	NP_001003171.1
Mus musculus (house mouse)	Fcer1g	NP_034315.1
Rattus norvegicus (Norway rat)	Fcer1g	NP_001124473.1
Bos taurus (cattle)	FCER1G	NP_776962.1
Homo sapiens (human)	FCER1G	NP_004097.1
Pan troglodytes (chimpanzee)	FCER1G	XP_003949670.1
	FCER1G	XP_001115585.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of C-Type Lectin Mincle with Fc?RI?? Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.
Honjoh C, Chihara K, Yoshiki H, Yamauchi S, Takeuchi K, Kato Y, Hida Y, Ishizuka T, Sada K
Scientific reports746064(2017 Apr)

Gene expression profile changes in rat dorsal horn after sciatic nerve injury.
Wang J, Ma SH, Tao R, Xia LJ, Liu L, Jiang YH
Neurological research39(2)176-182(2017 Feb)

Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and Fc?RI-?.
Lobato-Pascual A, Saether PC, Fossum S, Dissen E, Daws MR
European journal of immunology43(12)3167-74(2013 Dec)

C-type lectin MCL is an FcR?-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.
Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S
Immunity38(5)1050-62(2013 May)

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.
Heit B, Kim H, Cos?o G, Casta?o D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S
Developmental cell24(4)372-83(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study showed that CCL2, NF-kappaB1, RAC2, FCER1G and C1Q may contribute to the generation of neuropathic pain after sciatic nerve injury via immune and defense pathways.
Title: Gene expression profile changes in rat dorsal horn after sciatic nerve injury.

The results presented in this paper suggest that the Mincle/MCL/FcepsilonRI-gamma complex is the functionally optimal form for these C-type lectin receptors on the surface of myeloid cells.
Title: Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and Fc?RI-?.

substitution of FcR-gamma T22 with non-polar amino acids does not interfere with surface expression of the FcvarepsilonRI and its signaling capacity
Title: Fc receptor-? subunits with both polar or non-polar amino acids at position of T22 are capable of restoring surface expression of the high-affinity IgE receptor and degranulation in ? subunit-deficient rat basophilic leukemia cells.

Among the proteins that bind to phosphorylated beta ITAM of the FcepsilonRI-beta are Syk, Grb2, Shc, SHIP, and SHP-1, and binding does not depend on previous cell activation.
Title: Analysis of proteins binding to the ITAM motif of the beta-subunit of the high-affinity receptor for IgE (FcepsilonRI).

Phospholipase D1 activity by regulating phosphatidic acid formation controls the early signals initiated by FcepsilonRI aggregation that lead to mast cell degranulation.
Title: Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation.

The following Fcer1g gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fcer1g cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12567	NM_001131001.1 Latest version!	Rattus norvegicus Fc fragment of IgE receptor Ig (Fcer1g), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fcer1g ( NM_001131001.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001124473.1 Rattus norvegicus Fc fragment of IgE receptor Ig (Fcer1g), mRNA.

Price & Availability↑

CloneID	ORa12567
Clone ID Related Accession (Same CDS sequence)	NM_001131001.1
Accession Version	NM_001131001.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 261bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	high affinity immunoglobulin epsilon receptor subunit gamma precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC160864.1. On Jan 9, 2009 this sequence version replaced XM_001053627.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC160864.1, DV727874.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGATCCCAG CGGTGATCTT GTTCTTGCTC CTTTTGGTGG AAGAAGCAGC TGCCCTAGGA 
GAGCCGCAGC TCTGCTATAT CCTGGATGCC ATCCTGTTTT TGTATGGTAT TGTCCTTACC 
CTGCTCTACT GTCGACTCAA GATCCAGGTC CGAAAGGCAG ACATAGCCAG CCGTGAGAAA 
TCAGATGCTG TCTACACGGG CCTGAACACC CGGAACCAGG AGACATATGA GACTCTGAAA 
CATGAGAAAC CACCCCAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124473.1
CDS	82..342
Translation	MIPAVILFLLLLVEEAAALGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKADIASREKSDAVYTGLNTRNQETYETLKHEKPPQ

Target ORF information:

RefSeq Version	NM_001131001.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Fc fragment of IgE receptor Ig (Fcer1g), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001131001.1

ORF Insert Sequence:

ATGATCCCAG CGGTGATCTT GTTCTTGCTC CTTTTGGTGG AAGAAGCAGC TGCCCTAGGA 
GAGCCGCAGC TCTGCTATAT CCTGGATGCC ATCCTGTTTT TGTATGGTAT TGTCCTTACC 
CTGCTCTACT GTCGACTCAA GATCCAGGTC CGAAAGGCAG ACATAGCCAG CCGTGAGAAA 
TCAGATGCTG TCTACACGGG CCTGAACACC CGGAACCAGG AGACATATGA GACTCTGAAA 
CATGAGAAAC CACCCCAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of C-Type Lectin Mincle with Fc?RI?? Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.
Scientific reports746064(2017 Apr)
Honjoh C,Chihara K,Yoshiki H,Yamauchi S,Takeuchi K,Kato Y,Hida Y,Ishizuka T,Sada K

Gene expression profile changes in rat dorsal horn after sciatic nerve injury.
Neurological research39(2)176-182(2017 Feb)
Wang J,Ma SH,Tao R,Xia LJ,Liu L,Jiang YH

Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and Fc?RI-?.
European journal of immunology43(12)3167-74(2013 Dec)
Lobato-Pascual A,Saether PC,Fossum S,Dissen E,Daws MR

C-type lectin MCL is an FcR?-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.
Immunity38(5)1050-62(2013 May)
Miyake Y,Toyonaga K,Mori D,Kakuta S,Hoshino Y,Oyamada A,Yamada H,Ono K,Suyama M,Iwakura Y,Yoshikai Y,Yamasaki S

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.
Developmental cell24(4)372-83(2013 Feb)
Heit B,Kim H,Cos?o G,Casta?o D,Collins R,Lowell CA,Kain KC,Trimble WS,Grinstein S

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Fcer1g cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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