Ctsh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctsh
Entrez Gene ID	25425
Full Name	cathepsin H
General protein information	Preferred Names cathepsin H Names pro-cathepsin H cathepsin B3 cathepsin BA
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q31
Summary	lysosomal protease that plays a role in protein metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008766440.2	XP_008764662.1	pro-cathepsin H isoform X1
NM_012939.2	NP_037071.1	pro-cathepsin H precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CTSH	XP_001153217.1
Danio rerio (zebrafish)	ctsh	NP_997853.1
	CTSH	XP_001108862.1
Mus musculus (house mouse)	Ctsh	NP_031827.2
Arabidopsis thaliana (thale cress)	ALP	NP_568921.1
Oryza sativa (rice)	Os09g0442300	NP_001063289.1
Bos taurus (cattle)	CTSH	NP_001029557.1
Arabidopsis thaliana (thale cress)	AT3G45310	NP_566880.1
Canis lupus familiaris (dog)	CTSH	XP_536212.3
Homo sapiens (human)	CTSH	NP_004381.2
Rattus norvegicus (Norway rat)	Ctsh	NP_037071.1
Gallus gallus (chicken)	CTSH	XP_001232765.3

Gene Ontology
Bibliography

Related articles in PubMed

Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.
Oda K, Luo Y, Yoshihara A, Ishido Y, Sekihata K, Usukura K, Sue M, Hiroi N, Hirose T, Suzuki K
Biochemical and biophysical research communications483(1)541-546(2017 01)

CTSH regulates ?-cell function and disease progression in newly diagnosed type 1 diabetes patients.
Fl?yel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, St?rling J, Pociot F
Proceedings of the National Academy of Sciences of the United States of America111(28)10305-10(2014 Jul)

Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
Irwin LN, Byers DM
Brain research14891-7(2012 Dec)

Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells.
Wu SM, Huang YH, Yeh CT, Tsai MM, Liao CH, Cheng WL, Chen WJ, Lin KH
Oncogene30(17)2057-69(2011 Apr)

Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer.
Gocheva V, Chen X, Peters C, Reinheckel T, Joyce JA
Biological chemistry391(8)937-45(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cathepsin H is an active participant in lysosome-mediated pre-hormone degradation, and follicular Tg stimulates mobilization of pre-hormones by activating cathepsin H-associated proteolysis pathways
Title: Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.

The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D
Title: CTSH regulates ?-cell function and disease progression in newly diagnosed type 1 diabetes patients.

In the amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only.
Title: Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.

CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression.
Title: Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells.

involvement in processing of hydrophobic surfactant-associated protein C in type II pneumocytes
Title: Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes.

The following Ctsh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctsh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01381	NM_012939.2 Latest version!	Rattus norvegicus cathepsin H (Ctsh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa01381	XM_008766440.2 Latest version!	Rattus norvegicus cathepsin H (Ctsh), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctsh ( NM_012939.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037071.1 Rattus norvegicus cathepsin H (Ctsh), mRNA.

Price & Availability↑

CloneID	ORa01381
Clone ID Related Accession (Same CDS sequence)	XM_008766440.2 , NM_012939.2
Accession Version	NM_012939.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Rattus norvegicus(Norway rat)
Product	pro-cathepsin H precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07071029.1, FM059929.1, FN800263.1 and FM135658.1. On Mar 9, 2017 this sequence version replaced NM_012939.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ228686.1, FQ227275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGACTG CGCTGCCCCT GCTGTGCGCT GGGGCCTGGC TGCTGAGTGC TGGGGCCACC 
GCTGAGCTGA CCGTGAATGC CATAGAAAAG TTTCACTTTA CGTCATGGAT GAAACAGCAT 
CAAAAGACGT ACAGCTCGAG GGAGTACAGC CACAGGCTGC AGGTGTTTGC CAACAACTGG 
AGGAAGATTC AAGCCCACAA CCAGAGGAAC CACACATTTA AAATGGGATT GAACCAGTTT 
TCAGATATGA GCTTTGCCGA AATAAAACAC AAATACCTCT GGTCAGAGCC TCAGAATTGC 
TCAGCCACCA AAAGTAACTA CCTCCGTGGT ACTGGCCCCT ACCCATCCTC CATGGACTGG 
AGGAAGAAAG GAAATGTCGT TTCACCAGTG AAGAACCAGG GGGCCTGTGG CAGCTGCTGG 
ACTTTCTCAA CCACTGGGGC CCTAGAGTCA GCTGTGGCTA TTGCCAGTGG GAAAATGATG 
ACCTTGGCTG AGCAGCAGCT GGTGGATTGT GCCCAGAACT TCAACAATCA TGGCTGCCAA 
GGAGGTCTCC CCAGCCAGGC CTTCGAGTAC ATCCTGTACA ACAAGGGCAT CATGGGAGAG 
GACAGCTACC CTTACATAGG CAAGAATGGT CAGTGCAAAT TCAACCCAGA AAAGGCCGTC 
GCGTTCGTCA AGAATGTTGT CAACATCACA CTCAATGATG AGGCTGCAAT GGTAGAGGCT 
GTGGCCCTAT ACAATCCTGT GAGCTTTGCC TTTGAGGTGA CTGAAGATTT TATGATGTAT 
AAAAGTGGTG TCTACTCCAG TAACTCCTGT CATAAAACTC CAGATAAAGT AAACCATGCA 
GTCCTGGCTG TTGGCTATGG AGAACAGAAT GGATTACTCT ACTGGATTGT GAAAAACTCT 
TGGGGCTCCA ACTGGGGGAA CAATGGGTAC TTCCTCATTG AGCGTGGAAA GAACATGTGT 
GGCCTGGCTG CCTGTGCCTC CTACCCCATC CCTCAGGTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037071.1
CDS	139..1140
Translation	MWTALPLLCAGAWLLSAGATAELTVNAIEKFHFTSWMKQHQKTYSSREYSHRLQVFANNWRKIQAHNQRNHTFKMGLNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKMMTLAEQQLVDCAQNFNNHGCQGGLPSQAFEYILYNKGIMGEDSYPYIGKNGQCKFNPEKAVAFVKNVVNITLNDEAAMVEAVALYNPVSFAFEVTEDFMMYKSGVYSSNSCHKTPDKVNHAVLAVGYGEQNGLLYWIVKNSWGSNWGNNGYFLIERGKNMCGLAACASYPIPQV

Target ORF information:

RefSeq Version	NM_012939.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cathepsin H (Ctsh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012939.2

ORF Insert Sequence:

ATGTGGACTG CGCTGCCCCT GCTGTGCGCT GGGGCCTGGC TGCTGAGTGC TGGGGCCACC 
GCTGAGCTGA CCGTGAATGC CATAGAAAAG TTTCACTTTA CGTCATGGAT GAAACAGCAT 
CAAAAGACGT ACAGCTCGAG GGAGTACAGC CACAGGCTGC AGGTGTTTGC CAACAACTGG 
AGGAAGATTC AAGCCCACAA CCAGAGGAAC CACACATTTA AAATGGGATT GAACCAGTTT 
TCAGATATGA GCTTTGCCGA AATAAAACAC AAATACCTCT GGTCAGAGCC TCAGAATTGC 
TCAGCCACCA AAAGTAACTA CCTCCGTGGT ACTGGCCCCT ACCCATCCTC CATGGACTGG 
AGGAAGAAAG GAAATGTCGT TTCACCAGTG AAGAACCAGG GGGCCTGTGG CAGCTGCTGG 
ACTTTCTCAA CCACTGGGGC CCTAGAGTCA GCTGTGGCTA TTGCCAGTGG GAAAATGATG 
ACCTTGGCTG AGCAGCAGCT GGTGGATTGT GCCCAGAACT TCAACAATCA TGGCTGCCAA 
GGAGGTCTCC CCAGCCAGGC CTTCGAGTAC ATCCTGTACA ACAAGGGCAT CATGGGAGAG 
GACAGCTACC CTTACATAGG CAAGAATGGT CAGTGCAAAT TCAACCCAGA AAAGGCCGTC 
GCGTTCGTCA AGAATGTTGT CAACATCACA CTCAATGATG AGGCTGCAAT GGTAGAGGCT 
GTGGCCCTAT ACAATCCTGT GAGCTTTGCC TTTGAGGTGA CTGAAGATTT TATGATGTAT 
AAAAGTGGTG TCTACTCCAG TAACTCCTGT CATAAAACTC CAGATAAAGT AAACCATGCA 
GTCCTGGCTG TTGGCTATGG AGAACAGAAT GGATTACTCT ACTGGATTGT GAAAAACTCT 
TGGGGCTCCA ACTGGGGGAA CAATGGGTAC TTCCTCATTG AGCGTGGAAA GAACATGTGT 
GGCCTGGCTG CCTGTGCCTC CTACCCCATC CCTCAGGTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ctsh ( XM_008766440.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008764662.1 Rattus norvegicus cathepsin H (Ctsh), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa01381
Clone ID Related Accession (Same CDS sequence)	XM_008766440.2 , NM_012939.2
Accession Version	XM_008766440.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	pro-cathepsin H isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008766440.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGACTG CGCTGCCCCT GCTGTGCGCT GGGGCCTGGC TGCTGAGTGC TGGGGCCACC 
GCTGAGCTGA CCGTGAATGC CATAGAAAAG TTTCACTTTA CGTCATGGAT GAAACAGCAT 
CAAAAGACGT ACAGCTCGAG GGAGTACAGC CACAGGCTGC AGGTGTTTGC CAACAACTGG 
AGGAAGATTC AAGCCCACAA CCAGAGGAAC CACACATTTA AAATGGGATT GAACCAGTTT 
TCAGATATGA GCTTTGCCGA AATAAAACAC AAATACCTCT GGTCAGAGCC TCAGAATTGC 
TCAGCCACCA AAAGTAACTA CCTCCGTGGT ACTGGCCCCT ACCCATCCTC CATGGACTGG 
AGGAAGAAAG GAAATGTCGT TTCACCAGTG AAGAACCAGG GGGCCTGTGG CAGCTGCTGG 
ACTTTCTCAA CCACTGGGGC CCTAGAGTCA GCTGTGGCTA TTGCCAGTGG GAAAATGATG 
ACCTTGGCTG AGCAGCAGCT GGTGGATTGT GCCCAGAACT TCAACAATCA TGGCTGCCAA 
GGAGGTCTCC CCAGCCAGGC CTTCGAGTAC ATCCTGTACA ACAAGGGCAT CATGGGAGAG 
GACAGCTACC CTTACATAGG CAAGAATGGT CAGTGCAAAT TCAACCCAGA AAAGGCCGTC 
GCGTTCGTCA AGAATGTTGT CAACATCACA CTCAATGATG AGGCTGCAAT GGTAGAGGCT 
GTGGCCCTAT ACAATCCTGT GAGCTTTGCC TTTGAGGTGA CTGAAGATTT TATGATGTAT 
AAAAGTGGTG TCTACTCCAG TAACTCCTGT CATAAAACTC CAGATAAAGT AAACCATGCA 
GTCCTGGCTG TTGGCTATGG AGAACAGAAT GGATTACTCT ACTGGATTGT GAAAAACTCT 
TGGGGCTCCA ACTGGGGGAA CAATGGGTAC TTCCTCATTG AGCGTGGAAA GAACATGTGT 
GGCCTGGCTG CCTGTGCCTC CTACCCCATC CCTCAGGTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008764662.1
CDS	53..1054
Translation	MWTALPLLCAGAWLLSAGATAELTVNAIEKFHFTSWMKQHQKTYSSREYSHRLQVFANNWRKIQAHNQRNHTFKMGLNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKMMTLAEQQLVDCAQNFNNHGCQGGLPSQAFEYILYNKGIMGEDSYPYIGKNGQCKFNPEKAVAFVKNVVNITLNDEAAMVEAVALYNPVSFAFEVTEDFMMYKSGVYSSNSCHKTPDKVNHAVLAVGYGEQNGLLYWIVKNSWGSNWGNNGYFLIERGKNMCGLAACASYPIPQV

Target ORF information:

RefSeq Version	XM_008766440.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cathepsin H (Ctsh), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008766440.2

ORF Insert Sequence:

ATGTGGACTG CGCTGCCCCT GCTGTGCGCT GGGGCCTGGC TGCTGAGTGC TGGGGCCACC 
GCTGAGCTGA CCGTGAATGC CATAGAAAAG TTTCACTTTA CGTCATGGAT GAAACAGCAT 
CAAAAGACGT ACAGCTCGAG GGAGTACAGC CACAGGCTGC AGGTGTTTGC CAACAACTGG 
AGGAAGATTC AAGCCCACAA CCAGAGGAAC CACACATTTA AAATGGGATT GAACCAGTTT 
TCAGATATGA GCTTTGCCGA AATAAAACAC AAATACCTCT GGTCAGAGCC TCAGAATTGC 
TCAGCCACCA AAAGTAACTA CCTCCGTGGT ACTGGCCCCT ACCCATCCTC CATGGACTGG 
AGGAAGAAAG GAAATGTCGT TTCACCAGTG AAGAACCAGG GGGCCTGTGG CAGCTGCTGG 
ACTTTCTCAA CCACTGGGGC CCTAGAGTCA GCTGTGGCTA TTGCCAGTGG GAAAATGATG 
ACCTTGGCTG AGCAGCAGCT GGTGGATTGT GCCCAGAACT TCAACAATCA TGGCTGCCAA 
GGAGGTCTCC CCAGCCAGGC CTTCGAGTAC ATCCTGTACA ACAAGGGCAT CATGGGAGAG 
GACAGCTACC CTTACATAGG CAAGAATGGT CAGTGCAAAT TCAACCCAGA AAAGGCCGTC 
GCGTTCGTCA AGAATGTTGT CAACATCACA CTCAATGATG AGGCTGCAAT GGTAGAGGCT 
GTGGCCCTAT ACAATCCTGT GAGCTTTGCC TTTGAGGTGA CTGAAGATTT TATGATGTAT 
AAAAGTGGTG TCTACTCCAG TAACTCCTGT CATAAAACTC CAGATAAAGT AAACCATGCA 
GTCCTGGCTG TTGGCTATGG AGAACAGAAT GGATTACTCT ACTGGATTGT GAAAAACTCT 
TGGGGCTCCA ACTGGGGGAA CAATGGGTAC TTCCTCATTG AGCGTGGAAA GAACATGTGT 
GGCCTGGCTG CCTGTGCCTC CTACCCCATC CCTCAGGTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.
Biochemical and biophysical research communications483(1)541-546(2017 01)
Oda K,Luo Y,Yoshihara A,Ishido Y,Sekihata K,Usukura K,Sue M,Hiroi N,Hirose T,Suzuki K

CTSH regulates ?-cell function and disease progression in newly diagnosed type 1 diabetes patients.
Proceedings of the National Academy of Sciences of the United States of America111(28)10305-10(2014 Jul)
Fl?yel T,Brorsson C,Nielsen LB,Miani M,Bang-Berthelsen CH,Friedrichsen M,Overgaard AJ,Berchtold LA,Wiberg A,Poulsen P,Hansen L,Rosinger S,Boehm BO,Ram R,Nguyen Q,Mehta M,Morahan G,Concannon P,Bergholdt R,Nielsen JH,Reinheckel T,von Herrath M,Vaag A,Eizirik DL,Mortensen HB,St?rling J,Pociot F

Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
Brain research14891-7(2012 Dec)
Irwin LN,Byers DM

Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells.
Oncogene30(17)2057-69(2011 Apr)
Wu SM,Huang YH,Yeh CT,Tsai MM,Liao CH,Cheng WL,Chen WJ,Lin KH

Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer.
Biological chemistry391(8)937-45(2010 Aug)
Gocheva V,Chen X,Peters C,Reinheckel T,Joyce JA

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Ctsh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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