Grk3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grk3
Entrez Gene ID	25372
Full Name	G protein-coupled receptor kinase 3
Synonyms	Adrbk2
General protein information	Preferred Names G protein-coupled receptor kinase 3 Names beta-adrenergic receptor kinase 2 adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase) adrenergic, beta, receptor kinase 2 beta ARK2 beta-ARK-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	catalzyes phosphorylation of the beta-adrenergic receptor; may mediate desensitizaton of synaptic receptors; may regulate bone formation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017598272.1	XP_017453761.1	beta-adrenergic receptor kinase 2 isoform X1
NM_012897.2	NP_037029.1	beta-adrenergic receptor kinase 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADRBK2	NP_005151.2
Caenorhabditis elegans (roundworm)	grk-2	NP_497235.2
Pan troglodytes (chimpanzee)	ADRBK2	XP_003317197.1
Mus musculus (house mouse)	Adrbk2	NP_796052.2
Canis lupus familiaris (dog)	ADRBK2	XP_543453.3
Drosophila melanogaster (fruit fly)	Gprk1	NP_001163051.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012026	XP_320502.4
Xenopus tropicalis (tropical clawed frog)	adrbk2	XP_002932117.2
	ADRBK2	XP_001104308.1
Bos taurus (cattle)	ADRBK2	NP_776925.1
Rattus norvegicus (Norway rat)	Adrbk2	NP_037029.1
Gallus gallus (chicken)	ADRBK2	XP_415195.4
Danio rerio (zebrafish)	adrbk2	NP_001128197.1

Gene Ontology
Bibliography

Related articles in PubMed

Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of ?-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex.
Hejnova L, Skrabalova J, Novotny J
Journal of molecular neuroscience : MN63(3-4)364-376(2017 Dec)

?2- and ?1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.
Mont? F, Oliver E, Vicente D, Buend?a F, Rueda J, Ag?ero J, Almenar L, Valldecabres C, Rovira E, Muedra V, Noguera MA, Ivorra MD, D?Ocon P
Journal of cardiovascular pharmacology66(5)478-86(2015 Nov)

GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain.
Ahmed MR, Bychkov E, Li L, Gurevich VV, Gurevich EV
Scientific reports510920(2015 Jun)

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
Tarrant TK, Billard MJ, Timoshchenko RG, McGinnis MW, Serafin DS, Foreman O, Esserman DA, Chao NJ, Lento WE, Lee DM, Patel D, Siderovski DP
Journal of leukocyte biology94(6)1243-51(2013 Dec)

Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents.
?lvaro-Bartolom? M, Garc?a-Sevilla JA
Neuroscience247294-308(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings reveal a novel mechanism of GRK3 control of the dopamine receptor signaling and the role of Gq in LID.
Title: GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain.

the loss of GRK3-mediated regulation of CXCL12/CXCR4 signaling contributes to some, but not all, of the complete WHIM phenotype and that GRK3 inhibition may be beneficial in the treatment of inflammatory arthritis.
Title: G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.

We suggest that reduced stress resilience after TSS may be related to oxidative stress, depletion of GRK3 and impaired regulation of alpha(2A)-AR and CRF(1)-R in LC.
Title: Differential effects of inescapable stress on locus coeruleus GRK3, alpha2-adrenoceptor and CRF1 receptor levels in learned helpless and non-helpless rats: a potential link to stress resilience.

Substrate specificity of Grk3 at cardiac myocyte receptors provides basis for distinct role in regulation of myocardial function.
Title: Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function.

CRF selectively up-regulates GRK3 expression via an ERK1/2-mediated mechanism accompanied by the activation of Sp-1 and Ap-2 transcription factors.
Title: Activation of the CRF(1) receptor causes ERK1/2 mediated increase in GRK3 expression in CATH.a cells.

The following Grk3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grk3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42825	NM_012897.2 Latest version!	Rattus norvegicus G protein-coupled receptor kinase 3 (Grk3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$405.30 $579.00
ORa57783	XM_017598272.1 Latest version!	Rattus norvegicus G protein-coupled receptor kinase 3 (Grk3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grk3 ( NM_012897.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037029.1 Rattus norvegicus G protein-coupled receptor kinase 3 (Grk3), mRNA.

Price & Availability↑

CloneID	ORa42825
Clone ID Related Accession (Same CDS sequence)	NM_012897.2
Accession Version	NM_012897.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	beta-adrenergic receptor kinase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M87855.1. On Apr 12, 2007 this sequence version replaced NM_012897.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGACC TGGAGGCCGT GCTGGCCGAC GTCAGCTACC TGATGGCCAT GGAGAAGAGC 
AAGGCGACGC CGGCCGCGCG CGCCAGCAAG AAGGTCGTCC TGCCGGAGCC CAGTATCCGG 
AGTGTGATGC AGAGGTATCT GGCAGAAAGA AACGAAATAA CCTTTGACAA GATTTTCAAT 
CAGAAAATCG GCTTCCTGCT ATTTAAAGAT TTCTGCTTGA ATGAAATCGG TGAAGCGGTG 
CCTCAGGTGA AATTTTATGA AGAGATAAAG GAATACGAGA AACTGGACAA CGAAGAAGAC 
CGGCTGCACC GGAGTCGGCA GATGTACGAC GCCTACATCA TGAGGGAGCT TCTGTCCAGC 
ACACACCAAT TCTCAAAGCA AGCTGTAGAA CATGTCCAGA GCCATCTCTC CAAGAAGCAG 
GTGACGCCTA CCCTTTTTCA GCCGTACATA GAAGAAATCT GCGAAAGCCT TCGAGGCGAC 
ATCTTCCAAA AGTTTATGGA AAGCGAAAAA TTCACTAGAT TCTGTCAGTG GAAGAATGTG 
GAATTGAATA TTCATCTGAG CATGAACGAC TTCAGTGTGC ACAGGATCAT CGGCCGAGGA 
GGGTTTGGGG AAGTTTACGG CTGCAGGAAA GCAGACACCG GGAAAATGTA TGCCATGAAG 
TGCTTAGACA AGAAGAGAGT GAAGATGAAA CAGGGAGAGA CACTGGCTTT GAACGAGAGG 
ATCATGTTGT CTCTCGTCAG CACTGGGGAC TGTCCCTTCA TTGTCTGCAT GACCTATGCC 
TTCCACACAC CAGACAAACT CTGCTTCATC CTGGACCTGA TGAACGGGGG CGACATGCAC 
TACCACCTCT CCCAGCACGG GGTGTTCTCT GAGAAGGAGA TGCGATTTTA TGCCAGCGAG 
ATCATCCTGG GCCTCGAGCA CATGCACACC TGCTTTGTAG TCTACAGAGA CCTGAAGCCT 
GCGAACATCC TCCTGGATGA ATATGGGCAT GTGAGGATAT CGGATCTTGG CCTGGCCTGC 
GATTTCTCTA AAAAGAAGCC TCACGCCAGT GTGGGCACCC ATGGGTACAT GGCTCCCGAG 
GTGTTGCAGA AGGGGACATG CTACGACAGC AGCGCCGACT GGTTCTCCCT GGGCTGCATG 
CTCTTCAAGC TCCTGCGGGG CCACAGCCCT TTCAGGCAGC ATAAAACCAA AGACAAGCAT 
GAGATAGACC GCATGACCCT GACCGTGAAC GTGCAGCTTC CAGATGCCTT CTCCCCTGAG 
CTGAGGTCCC TCTTGGAGGG TTTGCTCCAG CGGGATGTGA GCCAGCGACT GGGCTGCTAC 
GGAGGAGGGG CACGAGAGTT GAAGGAGCAC ATCTTCTTCA AGGGCATCGA CTGGCAGTAT 
GTGTACTTAC GGAAGTACCC GCCACCCCTA ATCCCTCCTC GGGGAGAGGT CAATGCCGCA 
GACGCCTTTG ATATTGGCTC GTTTGATGAA GAAGATACCA AAGGCATTAA GCTGTTGGAC 
TGCGACCAGG ACCTCTATAA GAACTTCCCG CTGATGATTT CTGAGCGCTG GCAGCAGGAA 
GTAGTGGAGA CCATCTACGA CGCCGTCAAT GCCGAAACTG ATAAAATTGA GGCCAGGAAG 
AAGGCTAAAA ATAAACAGCT TTGTCAAGAA GAAGATTATG CCATGGGGAA GGACTGCATC 
ATGCACGGAT ACATGCTGAA GCTGGGGAAC CCCTTTCTCA CACAGTGGCA AAGACGTTAT 
TTTTACCTGT TTCCCAACAG ACTGGAGTGG AGAGGAGAGG GCGAGTCTCG GCAAAATCTA 
CTGACCATGG AACAGATCAT GTCTGTGGAG GAGACCCAAA TTAAAGACAG AAAATGCATT 
TTACTCAGGG TAAAAGGAGG GAAGCAGTTT GTTTTGCAAT GTGAGAGTGA CCCCGAGTTT 
GCACAGTGGC TGAAAGAGCT GACGTGCACC TTCAACGAGG CCCAGAGACT GCTGCGCCGC 
GCCCCCAAGT TCCTCAACAA ACCACGTGCC GCCATCCTGG AGTTCTCCAA GCCACCGCTG 
TGTCACAGAA ATAGCAGCGG CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037029.1
CDS	4..2070
Translation	MADLEAVLADVSYLMAMEKSKATPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFNQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLHRSRQMYDAYIMRELLSSTHQFSKQAVEHVQSHLSKKQVTPTLFQPYIEEICESLRGDIFQKFMESEKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCYGGGARELKEHIFFKGIDWQYVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLMISERWQQEVVETIYDAVNAETDKIEARKKAKNKQLCQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQIMSVEETQIKDRKCILLRVKGGKQFVLQCESDPEFAQWLKELTCTFNEAQRLLRRAPKFLNKPRAAILEFSKPPLCHRNSSGL

Target ORF information:

RefSeq Version	NM_012897.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor kinase 3 (Grk3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012897.2

ORF Insert Sequence:

ATGGCGGACC TGGAGGCCGT GCTGGCCGAC GTCAGCTACC TGATGGCCAT GGAGAAGAGC 
AAGGCGACGC CGGCCGCGCG CGCCAGCAAG AAGGTCGTCC TGCCGGAGCC CAGTATCCGG 
AGTGTGATGC AGAGGTATCT GGCAGAAAGA AACGAAATAA CCTTTGACAA GATTTTCAAT 
CAGAAAATCG GCTTCCTGCT ATTTAAAGAT TTCTGCTTGA ATGAAATCGG TGAAGCGGTG 
CCTCAGGTGA AATTTTATGA AGAGATAAAG GAATACGAGA AACTGGACAA CGAAGAAGAC 
CGGCTGCACC GGAGTCGGCA GATGTACGAC GCCTACATCA TGAGGGAGCT TCTGTCCAGC 
ACACACCAAT TCTCAAAGCA AGCTGTAGAA CATGTCCAGA GCCATCTCTC CAAGAAGCAG 
GTGACGCCTA CCCTTTTTCA GCCGTACATA GAAGAAATCT GCGAAAGCCT TCGAGGCGAC 
ATCTTCCAAA AGTTTATGGA AAGCGAAAAA TTCACTAGAT TCTGTCAGTG GAAGAATGTG 
GAATTGAATA TTCATCTGAG CATGAACGAC TTCAGTGTGC ACAGGATCAT CGGCCGAGGA 
GGGTTTGGGG AAGTTTACGG CTGCAGGAAA GCAGACACCG GGAAAATGTA TGCCATGAAG 
TGCTTAGACA AGAAGAGAGT GAAGATGAAA CAGGGAGAGA CACTGGCTTT GAACGAGAGG 
ATCATGTTGT CTCTCGTCAG CACTGGGGAC TGTCCCTTCA TTGTCTGCAT GACCTATGCC 
TTCCACACAC CAGACAAACT CTGCTTCATC CTGGACCTGA TGAACGGGGG CGACATGCAC 
TACCACCTCT CCCAGCACGG GGTGTTCTCT GAGAAGGAGA TGCGATTTTA TGCCAGCGAG 
ATCATCCTGG GCCTCGAGCA CATGCACACC TGCTTTGTAG TCTACAGAGA CCTGAAGCCT 
GCGAACATCC TCCTGGATGA ATATGGGCAT GTGAGGATAT CGGATCTTGG CCTGGCCTGC 
GATTTCTCTA AAAAGAAGCC TCACGCCAGT GTGGGCACCC ATGGGTACAT GGCTCCCGAG 
GTGTTGCAGA AGGGGACATG CTACGACAGC AGCGCCGACT GGTTCTCCCT GGGCTGCATG 
CTCTTCAAGC TCCTGCGGGG CCACAGCCCT TTCAGGCAGC ATAAAACCAA AGACAAGCAT 
GAGATAGACC GCATGACCCT GACCGTGAAC GTGCAGCTTC CAGATGCCTT CTCCCCTGAG 
CTGAGGTCCC TCTTGGAGGG TTTGCTCCAG CGGGATGTGA GCCAGCGACT GGGCTGCTAC 
GGAGGAGGGG CACGAGAGTT GAAGGAGCAC ATCTTCTTCA AGGGCATCGA CTGGCAGTAT 
GTGTACTTAC GGAAGTACCC GCCACCCCTA ATCCCTCCTC GGGGAGAGGT CAATGCCGCA 
GACGCCTTTG ATATTGGCTC GTTTGATGAA GAAGATACCA AAGGCATTAA GCTGTTGGAC 
TGCGACCAGG ACCTCTATAA GAACTTCCCG CTGATGATTT CTGAGCGCTG GCAGCAGGAA 
GTAGTGGAGA CCATCTACGA CGCCGTCAAT GCCGAAACTG ATAAAATTGA GGCCAGGAAG 
AAGGCTAAAA ATAAACAGCT TTGTCAAGAA GAAGATTATG CCATGGGGAA GGACTGCATC 
ATGCACGGAT ACATGCTGAA GCTGGGGAAC CCCTTTCTCA CACAGTGGCA AAGACGTTAT 
TTTTACCTGT TTCCCAACAG ACTGGAGTGG AGAGGAGAGG GCGAGTCTCG GCAAAATCTA 
CTGACCATGG AACAGATCAT GTCTGTGGAG GAGACCCAAA TTAAAGACAG AAAATGCATT 
TTACTCAGGG TAAAAGGAGG GAAGCAGTTT GTTTTGCAAT GTGAGAGTGA CCCCGAGTTT 
GCACAGTGGC TGAAAGAGCT GACGTGCACC TTCAACGAGG CCCAGAGACT GCTGCGCCGC 
GCCCCCAAGT TCCTCAACAA ACCACGTGCC GCCATCCTGG AGTTCTCCAA GCCACCGCTG 
TGTCACAGAA ATAGCAGCGG CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Grk3 ( XM_017598272.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453761.1 Rattus norvegicus G protein-coupled receptor kinase 3 (Grk3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57783
Clone ID Related Accession (Same CDS sequence)	XM_017598272.1
Accession Version	XM_017598272.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	beta-adrenergic receptor kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACGACG CCTACATCAT GAGGGAGCTT CTGTCCAGCA CACACCAATT CTCAAAGCAA 
GCTGTAGAAC ATGTCCAGAG CCATCTCTCC AAGAAGCAGG TGACGCCTAC CCTTTTTCAG 
CCGTACATAG AAGAAATCTG CGAAAGCCTT CGAGGCGACA TCTTCCAAAA GTTTATGGAA 
AGCGAAAAAT TCACTAGATT CTGTCAGTGG AAGAATGTGG AATTGAATAT TCACCTGAGC 
ATGAACGACT TCAGTGTGCA CAGGATCATC GGCCGAGGAG GGTTTGGGGA AGTTTACGGC 
TGCAGGAAAG CAGACACCGG GAAAATGTAT GCCATGAAGT GCTTAGACAA GAAGAGAGTG 
AAGATGAAAC AGGGAGAGAC ACTGGCTTTG AACGAGAGGA TCATGTTGTC TCTCGTCAGC 
ACTGGGGACT GTCCCTTCAT TGTCTGCATG ACCTATGCCT TCCACACACC AGACAAACTC 
TGCTTCATCC TGGACCTGAT GAACGGGGGC GACATGCACT ACCACCTCTC CCAGCACGGG 
GTGTTCTCTG AGAAGGAGAT GCGATTTTAT GCCAGCGAGA TCATCCTGGG CCTCGAGCAC 
ATGCACACCT GCTTTGTAGT CTACAGAGAC CTGAAGCCTG CGAACATCCT CCTGGATGAA 
TATGGGCATG TGAGGATATC GGATCTTGGC CTGGCCTGCG ATTTCTCTAA AAAGAAGCCT 
CACGCCAGTG TGGGCACCCA TGGGTACATG GCTCCCGAGG TGTTGCAGAA GGGGACATGC 
TACGACAGCA GCGCCGACTG GTTCTCCCTG GGCTGCATGC TCTTCAAGCT CCTGCGGGGC 
CACAGCCCTT TCAGGCAGCA TAAAACCAAA GACAAGCATG AGATAGACCG CATGACCCTG 
ACCGTGAACG TGCAGCTTCC AGATGCCTTC TCCCCTGAGC TGAGGTCCCT CTTGGAGGGT 
TTGCTCCAGC GGGATGTGAG CCAGCGACTG GGCTGCTGCG GAGGAGGGGC ACGAGAGTTG 
AAGGAGCACA TCTTCTTCAA GGGCATCGAC TGGCAGTATG TGTACTTACG GAAGTACCCG 
CCACCCCTAA TCCCTCCTCG GGGAGAGGTC AATGCCGCAG ACGCCTTTGA TATTGGCTCG 
TTTGATGAAG AAGATACCAA AGGCATTAAG CTGTTGGACT GCGACCAGGA CCTCTATAAG 
AACTTCCCGC TGGTGATTTC TGAGCGCTGG CAGCAGGAAG TAGTGGAGAC CATCTACGAC 
GCCGTCAATG CCGAAACTGA TAAAATTGAG GCCAGGAAGA AGGCTAAAAA TAAACAGCTT 
TGTCAAGAAG AAGATTATGC CATGGGGAAG GACTGCATCA TGCACGGATA CATGCTGAAG 
CTGGGGAACC CCTTTCTCAC ACAGTGGCAA AGACGTTATT TTTACCTGTT TCCCAACAGA 
CTGGAGTGGA GAGGAGAGGG CGAGTCTCGG CAAAATCTAC TGACCATGGA ACAGATCATG 
TCTGTGGAGG AGACCCAAAT TAAAGACAGA AAATGCATTT TACTCAGGGT AAAAGGAGGG 
AAGCAGTTTG TTTTGCAATG TGAGAGTGAC CCCGAGTTTG CACAGTGGCT GAAAGAGCTG 
ACGTGCACCT TCAACGAGGC CCAGAGACTG CTGCGCCGCG CCCCCAAGTT CCTCAACAAA 
CCACGTGCCG CCATCCTGGA GTTCTCCAAG CCACCGCTGT GTCACAGAAA TAGCAGCGGC 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453761.1
CDS	134..1879
Translation	MYDAYIMRELLSSTHQFSKQAVEHVQSHLSKKQVTPTLFQPYIEEICESLRGDIFQKFMESEKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCCGGGARELKEHIFFKGIDWQYVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLVISERWQQEVVETIYDAVNAETDKIEARKKAKNKQLCQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQIMSVEETQIKDRKCILLRVKGGKQFVLQCESDPEFAQWLKELTCTFNEAQRLLRRAPKFLNKPRAAILEFSKPPLCHRNSSGL

Target ORF information:

RefSeq Version	XM_017598272.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor kinase 3 (Grk3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598272.1

ORF Insert Sequence:

ATGTACGACG CCTACATCAT GAGGGAGCTT CTGTCCAGCA CACACCAATT CTCAAAGCAA 
GCTGTAGAAC ATGTCCAGAG CCATCTCTCC AAGAAGCAGG TGACGCCTAC CCTTTTTCAG 
CCGTACATAG AAGAAATCTG CGAAAGCCTT CGAGGCGACA TCTTCCAAAA GTTTATGGAA 
AGCGAAAAAT TCACTAGATT CTGTCAGTGG AAGAATGTGG AATTGAATAT TCACCTGAGC 
ATGAACGACT TCAGTGTGCA CAGGATCATC GGCCGAGGAG GGTTTGGGGA AGTTTACGGC 
TGCAGGAAAG CAGACACCGG GAAAATGTAT GCCATGAAGT GCTTAGACAA GAAGAGAGTG 
AAGATGAAAC AGGGAGAGAC ACTGGCTTTG AACGAGAGGA TCATGTTGTC TCTCGTCAGC 
ACTGGGGACT GTCCCTTCAT TGTCTGCATG ACCTATGCCT TCCACACACC AGACAAACTC 
TGCTTCATCC TGGACCTGAT GAACGGGGGC GACATGCACT ACCACCTCTC CCAGCACGGG 
GTGTTCTCTG AGAAGGAGAT GCGATTTTAT GCCAGCGAGA TCATCCTGGG CCTCGAGCAC 
ATGCACACCT GCTTTGTAGT CTACAGAGAC CTGAAGCCTG CGAACATCCT CCTGGATGAA 
TATGGGCATG TGAGGATATC GGATCTTGGC CTGGCCTGCG ATTTCTCTAA AAAGAAGCCT 
CACGCCAGTG TGGGCACCCA TGGGTACATG GCTCCCGAGG TGTTGCAGAA GGGGACATGC 
TACGACAGCA GCGCCGACTG GTTCTCCCTG GGCTGCATGC TCTTCAAGCT CCTGCGGGGC 
CACAGCCCTT TCAGGCAGCA TAAAACCAAA GACAAGCATG AGATAGACCG CATGACCCTG 
ACCGTGAACG TGCAGCTTCC AGATGCCTTC TCCCCTGAGC TGAGGTCCCT CTTGGAGGGT 
TTGCTCCAGC GGGATGTGAG CCAGCGACTG GGCTGCTGCG GAGGAGGGGC ACGAGAGTTG 
AAGGAGCACA TCTTCTTCAA GGGCATCGAC TGGCAGTATG TGTACTTACG GAAGTACCCG 
CCACCCCTAA TCCCTCCTCG GGGAGAGGTC AATGCCGCAG ACGCCTTTGA TATTGGCTCG 
TTTGATGAAG AAGATACCAA AGGCATTAAG CTGTTGGACT GCGACCAGGA CCTCTATAAG 
AACTTCCCGC TGGTGATTTC TGAGCGCTGG CAGCAGGAAG TAGTGGAGAC CATCTACGAC 
GCCGTCAATG CCGAAACTGA TAAAATTGAG GCCAGGAAGA AGGCTAAAAA TAAACAGCTT 
TGTCAAGAAG AAGATTATGC CATGGGGAAG GACTGCATCA TGCACGGATA CATGCTGAAG 
CTGGGGAACC CCTTTCTCAC ACAGTGGCAA AGACGTTATT TTTACCTGTT TCCCAACAGA 
CTGGAGTGGA GAGGAGAGGG CGAGTCTCGG CAAAATCTAC TGACCATGGA ACAGATCATG 
TCTGTGGAGG AGACCCAAAT TAAAGACAGA AAATGCATTT TACTCAGGGT AAAAGGAGGG 
AAGCAGTTTG TTTTGCAATG TGAGAGTGAC CCCGAGTTTG CACAGTGGCT GAAAGAGCTG 
ACGTGCACCT TCAACGAGGC CCAGAGACTG CTGCGCCGCG CCCCCAAGTT CCTCAACAAA 
CCACGTGCCG CCATCCTGGA GTTCTCCAAG CCACCGCTGT GTCACAGAAA TAGCAGCGGC 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of ?-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex.
Journal of molecular neuroscience : MN63(3-4)364-376(2017 Dec)
Hejnova L,Skrabalova J,Novotny J

?2- and ?1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.
Journal of cardiovascular pharmacology66(5)478-86(2015 Nov)
Mont? F,Oliver E,Vicente D,Buend?a F,Rueda J,Ag?ero J,Almenar L,Valldecabres C,Rovira E,Muedra V,Noguera MA,Ivorra MD,D?Ocon P

GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain.
Scientific reports510920(2015 Jun)
Ahmed MR,Bychkov E,Li L,Gurevich VV,Gurevich EV

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
Journal of leukocyte biology94(6)1243-51(2013 Dec)
Tarrant TK,Billard MJ,Timoshchenko RG,McGinnis MW,Serafin DS,Foreman O,Esserman DA,Chao NJ,Lento WE,Lee DM,Patel D,Siderovski DP

Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents.
Neuroscience247294-308(2013 Sep)
?lvaro-Bartolom? M,Garc?a-Sevilla JA

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Grk3 cDNA ORF clone, Rattus norvegicus(Norway rat)

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ORF Insert Sequence:

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