Asic2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Asic2
Entrez Gene ID	25364
Full Name	acid sensing ion channel subunit 2
Synonyms	Accn1,BNC1k,BNaC1,MDEG,MDEG1,MDEG2
General protein information	Preferred Names acid sensing ion channel subunit 2 Names acid-sensing ion channel 2 BNC1 acid-sensing (proton-gated) ion channel 2 acid-sensing proton-gated ion channel 2 short variant MDEG2 amiloride-sensitive brain sodium channel 2 amiloride-sensitive cation channel 1, neuronal brain sodium channel 1 degenerin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26
Summary	member of the degenerin/epithelial Na(+) channel superfamily; permeable for Na(+), K(+) and Li(+); mutations may lead to a form of hereditary neurodegeneration; may be important for pain sensation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012892.2	NP_037024.2	acid-sensing ion channel 2 isoform MDEG2
NM_001034014.1	NP_001029186.1	acid-sensing ion channel 2 isoform MDEG1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ASIC2	NP_899233.1
Canis lupus familiaris (dog)	ASIC2	XP_548270.2
Mus musculus (house mouse)	Asic2	NP_031410.1
Rattus norvegicus (Norway rat)	Asic2	NP_037024.2

Gene Ontology
Bibliography

Related articles in PubMed

Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
Zhang H, Gao G, Zhang Y, Sun Y, Li H, Dong S, Ma W, Liu B, Wang W, Wu H, Zhang H
Scientific reports7(1)5870(2017 Jul)

Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures.
Wu H, Wang C, Liu B, Li H, Zhang Y, Dong S, Gao G, Zhang H
Molecular neurobiology53(3)1782-1793(2016 Apr)

Structural domains underlying the activation of acid-sensing ion channel 2a.
Schuhmacher LN, Srivats S, Smith ES
Molecular pharmacology87(4)561-71(2015 Apr)

Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia.
Yu XW, Hu ZL, Ni M, Fang P, Zhang PW, Shu Q, Fan H, Zhou HY, Ni L, Zhu LQ, Chen JG, Wang F
Glia63(3)483-96(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ASICs may enhance susceptibility to epileptogenesis in the piriform cortex.
Title: Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures.

identified domains of ASIC2 that are crucial to channel function and may be important for the function of other members of the ASIC family.
Title: Structural domains underlying the activation of acid-sensing ion channel 2a.

identified the expression and localization of different ASIC subunits in the rest and activated microglia and further elucidated the role of ASICs in microglia activation and inflammatory response
Title: Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia.

These results uncover a new mechanism of caspase-8-mediated apoptosis induced by intracellular calcium overload that is dependent on the autophagy-related proteins LC3 and p62 upon hyperactivation of DEG/ENaC channels.
Title: Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis.

Acid-sensing ion channels contribute to chemosensitivity of breathing-related neurons of the nucleus of the solitary tract
Title: Acid-sensing ion channels contribute to chemosensitivity of breathing-related neurons of the nucleus of the solitary tract.

The following Asic2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Asic2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01230	NM_012892.2 Latest version!	Rattus norvegicus acid sensing ion channel subunit 2 (Asic2), transcript variant MDEG2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
ORa08826	NM_001034014.1 Latest version!	Rattus norvegicus acid sensing ion channel subunit 2 (Asic2), transcript variant MDEG1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$300.30 $429.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Asic2 ( NM_012892.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037024.2 Rattus norvegicus acid sensing ion channel subunit 2 (Asic2), transcript variant MDEG2, mRNA.

Price & Availability↑

CloneID	ORa01230
Clone ID Related Accession (Same CDS sequence)	NM_012892.2
Accession Version	NM_012892.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1692bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Rattus norvegicus(Norway rat)
Product	acid-sensing ion channel 2 isoform MDEG2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y14635.1. On Sep 26, 2003 this sequence version replaced NM_012892.1. Transcript Variant: The variant (MDEG2) encodes the longer protein (isoform MDEG2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y14635.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGCCGGA GCGGCGGAGC CCGGCTGCCC GCGACCGCGC TCAGCGGCCC GGGACGCTTC 
CGTATGGCCC GCGAGCAGCC GGCGCCCGTG GCGGTGGCGG CAGCTAGGCA GCCCGGAGGA 
GACCGGAGCG GCGATCCGGC GCTGCAGGGG CCAGGGGTCG CCCGCAGGGG GCGGCCGTCC 
CTGAGTCGCA CTAAATTGCA CGGGCTGCGG CACATGTGCG CGGGGCGCAC GGCGGCGGGA 
GGCTCTTTCC AGCGACGGGC GCTGTGGGTG CTGGCCTTCT GCACGTCCCT CGGCTTGCTG 
CTGTCCTGGT CCTCGAACCG CCTGCTCTAC TGGCTCAGCT TCCCGTCACA CACACGAGTG 
CACCGTGAGT GGAGCCGCCA GCTGCCGTTC CCCGCCGTCA CCGTGTGCAA CAACAACCCC 
CTGCGCTTCC CGCGCCTCTC CAAGGGGGAC CTCTACTACG CGGGCCACTG GCTAGGGCTG 
CTGCTTCCCA ACCGCACCGC GCGCCCGCTG GTCAGCGAGC TGCTGCGGGG CGACGAGCCG 
CGCCGCCAGT GGTTCCGCAA ACTGGCCGAC TTCCGCCTCT TCCTGCCGCC GCGCCACTTC 
GAGGGCATCA GCGCTGCCTT CATGGACCGT TTGGGCCACC AGCTGGAGGA TATGCTGCTC 
TCCTGCAAGT ACCGGGGCGA GCTCTGTGGC CCGCACAACT TCTCCTCAGT GTTTACAAAA 
TACGGGAAGT GTTACATGTT TAACTCAGGC GAGGATGGCA AGCCGCTGCT CACCACGGTC 
AAGGGGGGGA CGGGCAACGG GCTGGAGATC ATGCTGGACA TTCAGCAAGA TGAGTACCTG 
CCCATCTGGG GAGAGACAGA GGAAACAACG TTTGAAGCAG GAGTGAAGGT TCAGATCCAC 
AGTCAGTCTG AGCCGCCTTT CATCCAAGAG CTGGGCTTTG GGGTGGCTCC GGGGTTCCAG 
ACCTTCGTGG CCACACAAGA GCAGAGGCTC ACATATCTGC CCCCACCATG GGGGGAGTGC 
CGGTCCTCAG AGATGGGACT CGACTTCTTT CCTGTTTACA GCATCACAGC CTGTCGGATT 
GACTGTGAGA CCCGCTACAT CGTGGAGAAC TGTAACTGCC GCATGGTCCA CATGCCAGGG 
GACGCCCCTT TCTGCACCCC TGAGCAGCAC AAGGAGTGTG CAGAGCCTGC CCTCGGTCTA 
CTGGCAGAAA AGGACAGCAA TTACTGTCTC TGCAGGACAC CCTGCAACCT GACACGCTAC 
AACAAAGAGC TCTCCATGGT GAAGATCCCC AGCAAGACGT CAGCCAAGTA CTTAGAGAAG 
AAATTTAACA AATCGGAAAA ATATATCTCA GAGAACATTC TTGTTCTGGA CATATTTTTT 
GAGGCGCTCA ATTACGAAAC AATTGAACAG AAGAAGGCGT ATGAAGTTGC TGCCTTACTT 
GGTGACATCG GTGGTCAGAT GGGACTGTTC ATTGGTGCTA GTCTCCTCAC AATACTAGAG 
CTCTTTGATT ATATTTATGA GCTGATCAAA GAGAAGCTAT TAGACCTGCT TGGCAAAGAA 
GAAGAGGAAG GGAGCCACGA TGAGAACATG AGCACCTGTG ACACAATGCC AAACCACTCT 
GAAACCATCA GCCACACTGT GAACGTGCCC CTGCAGACAG CTTTGGGCAC CCTGGAGGAG 
ATTGCCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037024.2
CDS	16..1707
Translation	MSRSGGARLPATALSGPGRFRMAREQPAPVAVAAARQPGGDRSGDPALQGPGVARRGRPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC

Target ORF information:

RefSeq Version	NM_012892.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus acid sensing ion channel subunit 2 (Asic2), transcript variant MDEG2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012892.2

ORF Insert Sequence:

ATGAGCCGGA GCGGCGGAGC CCGGCTGCCC GCGACCGCGC TCAGCGGCCC GGGACGCTTC 
CGTATGGCCC GCGAGCAGCC GGCGCCCGTG GCGGTGGCGG CAGCTAGGCA GCCCGGAGGA 
GACCGGAGCG GCGATCCGGC GCTGCAGGGG CCAGGGGTCG CCCGCAGGGG GCGGCCGTCC 
CTGAGTCGCA CTAAATTGCA CGGGCTGCGG CACATGTGCG CGGGGCGCAC GGCGGCGGGA 
GGCTCTTTCC AGCGACGGGC GCTGTGGGTG CTGGCCTTCT GCACGTCCCT CGGCTTGCTG 
CTGTCCTGGT CCTCGAACCG CCTGCTCTAC TGGCTCAGCT TCCCGTCACA CACACGAGTG 
CACCGTGAGT GGAGCCGCCA GCTGCCGTTC CCCGCCGTCA CCGTGTGCAA CAACAACCCC 
CTGCGCTTCC CGCGCCTCTC CAAGGGGGAC CTCTACTACG CGGGCCACTG GCTAGGGCTG 
CTGCTTCCCA ACCGCACCGC GCGCCCGCTG GTCAGCGAGC TGCTGCGGGG CGACGAGCCG 
CGCCGCCAGT GGTTCCGCAA ACTGGCCGAC TTCCGCCTCT TCCTGCCGCC GCGCCACTTC 
GAGGGCATCA GCGCTGCCTT CATGGACCGT TTGGGCCACC AGCTGGAGGA TATGCTGCTC 
TCCTGCAAGT ACCGGGGCGA GCTCTGTGGC CCGCACAACT TCTCCTCAGT GTTTACAAAA 
TACGGGAAGT GTTACATGTT TAACTCAGGC GAGGATGGCA AGCCGCTGCT CACCACGGTC 
AAGGGGGGGA CGGGCAACGG GCTGGAGATC ATGCTGGACA TTCAGCAAGA TGAGTACCTG 
CCCATCTGGG GAGAGACAGA GGAAACAACG TTTGAAGCAG GAGTGAAGGT TCAGATCCAC 
AGTCAGTCTG AGCCGCCTTT CATCCAAGAG CTGGGCTTTG GGGTGGCTCC GGGGTTCCAG 
ACCTTCGTGG CCACACAAGA GCAGAGGCTC ACATATCTGC CCCCACCATG GGGGGAGTGC 
CGGTCCTCAG AGATGGGACT CGACTTCTTT CCTGTTTACA GCATCACAGC CTGTCGGATT 
GACTGTGAGA CCCGCTACAT CGTGGAGAAC TGTAACTGCC GCATGGTCCA CATGCCAGGG 
GACGCCCCTT TCTGCACCCC TGAGCAGCAC AAGGAGTGTG CAGAGCCTGC CCTCGGTCTA 
CTGGCAGAAA AGGACAGCAA TTACTGTCTC TGCAGGACAC CCTGCAACCT GACACGCTAC 
AACAAAGAGC TCTCCATGGT GAAGATCCCC AGCAAGACGT CAGCCAAGTA CTTAGAGAAG 
AAATTTAACA AATCGGAAAA ATATATCTCA GAGAACATTC TTGTTCTGGA CATATTTTTT 
GAGGCGCTCA ATTACGAAAC AATTGAACAG AAGAAGGCGT ATGAAGTTGC TGCCTTACTT 
GGTGACATCG GTGGTCAGAT GGGACTGTTC ATTGGTGCTA GTCTCCTCAC AATACTAGAG 
CTCTTTGATT ATATTTATGA GCTGATCAAA GAGAAGCTAT TAGACCTGCT TGGCAAAGAA 
GAAGAGGAAG GGAGCCACGA TGAGAACATG AGCACCTGTG ACACAATGCC AAACCACTCT 
GAAACCATCA GCCACACTGT GAACGTGCCC CTGCAGACAG CTTTGGGCAC CCTGGAGGAG 
ATTGCCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Asic2 ( NM_001034014.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029186.1 Rattus norvegicus acid sensing ion channel subunit 2 (Asic2), transcript variant MDEG1, mRNA.

Price & Availability↑

CloneID	ORa08826
Clone ID Related Accession (Same CDS sequence)	NM_001034014.1
Accession Version	NM_001034014.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Rattus norvegicus(Norway rat)
Product	acid-sensing ion channel 2 isoform MDEG1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U53211.1. Transcript Variant: This variant (MDEG1) uses an alternate 5' terminal exon compared to variant MDEG2. The resulting protein (isoform MDGEG1) is shorter and has a distinct N-terminus compared to isoform MDEG2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U53211.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGACCTCA AGGAGAGCCC CAGTGAGGGC AGCCTGCAAC CTTCCAGTAT CCAGATCTTC 
GCCAATACCT CCACTCTCCA TGGCATCCGC CACATCTTCG TGTATGGGCC GCTGACCATC 
CGGCGTGTGC TTTGGGCAGT GGCCTTCGTC GGATCCCTGG GCCTGCTGCT GGTGGAGAGC 
TCGGAGAGGG TGTCCTACTA TTTCTCTTAT CAGCATGTTA CCAAGGTGGA TGAAGTGGTG 
GCCCAGAGCC TGGTCTTCCC AGCTGTGACC CTCTGCAACC TCAATGGCTT CCGGTTCTCC 
AGGCTTACCA CCAACGACTT GTACCACGCT GGGGAGTTGC TGGCCCTGCT GGATGTCAAC 
CTACAGATTC CCGACCCGCA TCTGGCAGAC CCCACGGTGC TGGAGGCCCT CCGACAGAAG 
GCCAACTTCA AACACTACAA ACCGAAGCAG TTCAGCATGC TGGAGTTCCT GCACCGGGTA 
GGCCATGACC TGAAGGATAT GATGCTCTAC TGCAAGTTCA AGGGGCAGGA GTGTGGGCAT 
CAAGACTTCA CCACAGTGTT TACAAAATAC GGGAAGTGTT ACATGTTTAA CTCAGGCGAG 
GATGGCAAGC CGCTGCTCAC CACGGTCAAG GGGGGGACGG GCAACGGGCT GGAGATCATG 
CTGGACATTC AGCAAGATGA GTACCTGCCC ATCTGGGGAG AGACAGAGGA AACAACGTTT 
GAAGCAGGAG TGAAGGTTCA GATCCACAGT CAGTCTGAGC CGCCTTTCAT CCAAGAGCTG 
GGCTTTGGGG TGGCTCCGGG GTTCCAGACC TTCGTGGCCA CACAAGAGCA GAGGCTCACA 
TATCTGCCCC CACCATGGGG GGAGTGCCGG TCCTCAGAGA TGGGACTCGA CTTCTTTCCT 
GTTTACAGCA TCACAGCCTG TCGGATTGAC TGTGAGACCC GCTACATCGT GGAGAACTGT 
AACTGCCGCA TGGTCCACAT GCCAGGGGAC GCCCCTTTCT GCACCCCTGA GCAGCACAAG 
GAGTGTGCAG AGCCTGCCCT CGGTCTACTG GCAGAAAAGG ACAGCAATTA CTGTCTCTGC 
AGGACACCCT GCAACCTGAC ACGCTACAAC AAAGAGCTCT CCATGGTGAA GATCCCCAGC 
AAGACGTCAG CCAAGTACTT AGAGAAGAAA TTTAACAAAT CGGAAAAATA TATCTCAGAG 
AACATTCTTG TTCTGGACAT ATTTTTTGAG GCGCTCAATT ACGAAACAAT TGAACAGAAG 
AAGGCGTATG AAGTTGCTGC CTTACTTGGT GACATCGGTG GTCAGATGGG ACTGTTCATT 
GGTGCTAGTC TCCTCACAAT ACTAGAGCTC TTTGATTATA TTTATGAGCT GATCAAAGAG 
AAGCTATTAG ACCTGCTTGG CAAAGAAGAA GAGGAAGGGA GCCACGATGA GAACATGAGC 
ACCTGTGACA CAATGCCAAA CCACTCTGAA ACCATCAGCC ACACTGTGAA CGTGCCCCTG 
CAGACAGCTT TGGGCACCCT GGAGGAGATT GCCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029186.1
CDS	154..1692
Translation	MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC

Target ORF information:

RefSeq Version	NM_001034014.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus acid sensing ion channel subunit 2 (Asic2), transcript variant MDEG1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034014.1

ORF Insert Sequence:

ATGGACCTCA AGGAGAGCCC CAGTGAGGGC AGCCTGCAAC CTTCCAGTAT CCAGATCTTC 
GCCAATACCT CCACTCTCCA TGGCATCCGC CACATCTTCG TGTATGGGCC GCTGACCATC 
CGGCGTGTGC TTTGGGCAGT GGCCTTCGTC GGATCCCTGG GCCTGCTGCT GGTGGAGAGC 
TCGGAGAGGG TGTCCTACTA TTTCTCTTAT CAGCATGTTA CCAAGGTGGA TGAAGTGGTG 
GCCCAGAGCC TGGTCTTCCC AGCTGTGACC CTCTGCAACC TCAATGGCTT CCGGTTCTCC 
AGGCTTACCA CCAACGACTT GTACCACGCT GGGGAGTTGC TGGCCCTGCT GGATGTCAAC 
CTACAGATTC CCGACCCGCA TCTGGCAGAC CCCACGGTGC TGGAGGCCCT CCGACAGAAG 
GCCAACTTCA AACACTACAA ACCGAAGCAG TTCAGCATGC TGGAGTTCCT GCACCGGGTA 
GGCCATGACC TGAAGGATAT GATGCTCTAC TGCAAGTTCA AGGGGCAGGA GTGTGGGCAT 
CAAGACTTCA CCACAGTGTT TACAAAATAC GGGAAGTGTT ACATGTTTAA CTCAGGCGAG 
GATGGCAAGC CGCTGCTCAC CACGGTCAAG GGGGGGACGG GCAACGGGCT GGAGATCATG 
CTGGACATTC AGCAAGATGA GTACCTGCCC ATCTGGGGAG AGACAGAGGA AACAACGTTT 
GAAGCAGGAG TGAAGGTTCA GATCCACAGT CAGTCTGAGC CGCCTTTCAT CCAAGAGCTG 
GGCTTTGGGG TGGCTCCGGG GTTCCAGACC TTCGTGGCCA CACAAGAGCA GAGGCTCACA 
TATCTGCCCC CACCATGGGG GGAGTGCCGG TCCTCAGAGA TGGGACTCGA CTTCTTTCCT 
GTTTACAGCA TCACAGCCTG TCGGATTGAC TGTGAGACCC GCTACATCGT GGAGAACTGT 
AACTGCCGCA TGGTCCACAT GCCAGGGGAC GCCCCTTTCT GCACCCCTGA GCAGCACAAG 
GAGTGTGCAG AGCCTGCCCT CGGTCTACTG GCAGAAAAGG ACAGCAATTA CTGTCTCTGC 
AGGACACCCT GCAACCTGAC ACGCTACAAC AAAGAGCTCT CCATGGTGAA GATCCCCAGC 
AAGACGTCAG CCAAGTACTT AGAGAAGAAA TTTAACAAAT CGGAAAAATA TATCTCAGAG 
AACATTCTTG TTCTGGACAT ATTTTTTGAG GCGCTCAATT ACGAAACAAT TGAACAGAAG 
AAGGCGTATG AAGTTGCTGC CTTACTTGGT GACATCGGTG GTCAGATGGG ACTGTTCATT 
GGTGCTAGTC TCCTCACAAT ACTAGAGCTC TTTGATTATA TTTATGAGCT GATCAAAGAG 
AAGCTATTAG ACCTGCTTGG CAAAGAAGAA GAGGAAGGGA GCCACGATGA GAACATGAGC 
ACCTGTGACA CAATGCCAAA CCACTCTGAA ACCATCAGCC ACACTGTGAA CGTGCCCCTG 
CAGACAGCTT TGGGCACCCT GGAGGAGATT GCCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
Scientific reports7(1)5870(2017 Jul)
Zhang H,Gao G,Zhang Y,Sun Y,Li H,Dong S,Ma W,Liu B,Wang W,Wu H,Zhang H

Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures.
Molecular neurobiology53(3)1782-1793(2016 Apr)
Wu H,Wang C,Liu B,Li H,Zhang Y,Dong S,Gao G,Zhang H

Structural domains underlying the activation of acid-sensing ion channel 2a.
Molecular pharmacology87(4)561-71(2015 Apr)
Schuhmacher LN,Srivats S,Smith ES

Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia.
Glia63(3)483-96(2015 Mar)
Yu XW,Hu ZL,Ni M,Fang P,Zhang PW,Shu Q,Fan H,Zhou HY,Ni L,Zhu LQ,Chen JG,Wang F

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Asic2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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