Vcam1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vcam1
Entrez Gene ID	25361
Full Name	vascular cell adhesion molecule 1
Synonyms	VCAM1B
General protein information	Preferred Names vascular cell adhesion molecule 1 Names vascular cell adhesion protein 1 V-CAM 1 VCAM-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q41
Summary	binds integrin very late antigen (VLA4); plays a role in cell adhesion [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012889.1	NP_037021.1	vascular cell adhesion protein 1 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	vcam1	NP_001077304.1
Homo sapiens (human)	VCAM1	NP_001069.1
	VCAM1	XP_001107924.1
Bos taurus (cattle)	LOC534578	NP_001094628.1
Mus musculus (house mouse)	Vcam1	NP_035823.3
Rattus norvegicus (Norway rat)	Vcam1	NP_037021.1
Canis lupus familiaris (dog)	VCAM1	NP_001003298.1
Bos taurus (cattle)	VCAM1	NP_776909.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibiting adhesion events by Panax notoginseng saponins and Ginsenoside Rb1 protecting arteries via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway.
Fan J, Liu D, He C, Li X, He F
Journal of ethnopharmacology192423-430(2016 Nov)

Renoprotective effects of berberine and its potential effect on the expression of ?-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in streptozocin-diabetic nephropathy rats.
Tang LQ, Ni WJ, Cai M, Ding HH, Liu S, Zhang ST
Journal of diabetes8(5)693-700(2016 Sep)

Dendritic cell vaccination enhances antiangiogenesis induced by endostatin in rat glioma.
Zhou X, Liao Y, Li H, Zhao Z, Liu Q
Journal of cancer research and therapeutics12(1)198-203(2016 Jan-Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Panax notoginseng saponins and Ginsenoside protect aorta form atherosclerosis via Rb1 via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway.
Title: Inhibiting adhesion events by Panax notoginseng saponins and Ginsenoside Rb1 protecting arteries via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway.

Berberine exhibited renoprotective effects in diabetic nephropathy (DN), and the underlying molecular mechanisms may be associated with changes in the levels and regulation of beta-arrestin 1/2 expression, as well as intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) levels in the kidney.
Title: Renoprotective effects of berberine and its potential effect on the expression of ?-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in streptozocin-diabetic nephropathy rats.

The combination of DC vaccination and antiangionesis inhibited the rats with malignant glioma by stimulating immune response, supressing the expression of angiogenesis-related proteins VEGF, VCAM, and ICAM-1
Title: Dendritic cell vaccination enhances antiangiogenesis induced by endostatin in rat glioma.

Activation of Wnt/beta-catenin signaling in AECs attenuated intercellular adhesion molecule 1 (ICAM-1)/vascular cell adhesion molecule 1 (VCAM-1)-mediated adhesion of both macrophages and neutrophils to AECs.
Title: Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1-mediated neutrophilic acute lung inflammation.

VCAM1 was strikingly increased in neurons after intracerebral hemorrhage.
Title: Up-regulation of VCAM1 Relates to Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.

The following Vcam1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vcam1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13527	NM_012889.1 Latest version!	Rattus norvegicus vascular cell adhesion molecule 1 (Vcam1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vcam1 ( NM_012889.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037021.1 Rattus norvegicus vascular cell adhesion molecule 1 (Vcam1), mRNA.

Price & Availability↑

CloneID	ORa13527
Clone ID Related Accession (Same CDS sequence)	NM_012889.1
Accession Version	NM_012889.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2220bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Rattus norvegicus(Norway rat)
Product	vascular cell adhesion protein 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M84488.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M84488.1, BC089812.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCTGTGA AGATGGTCGC GATCTTCGGA GCCTCAACGG TACTTTGGAT ACTGTTTGCA 
GTCTCTCAAG CTTTTAAAAT CGAGATCTCC CCTGAATACA AAACGCTCGC TCAGATTGGA 
GACTCCATGC TCCTGACTTG CAGCACCACA GGCTGTGAGT CGCCATCATT CTCTTGGAGA 
ACCCAGATAG ACAGTCCACT AAATGGGAAG GTGAAGACAG AGGGGGCCAA GTCCGTTCTG 
ACCATGGACC CTGTCAGCTT TGAGAATGAA CACTCTTACC TGTGCACAGC AACATGTAAC 
TCTGGGAAAC TGGAAAGAGG AATCCAAGTG GACATCTACT CATTCCCTAA GGATCCAGAG 
ATTCAATTCA GTGGCCCCCT GGAGGTTGGG AAGCCGGTCA TGGTCAAGTG TTTGGCTCCT 
GATGTTTACC CAATTGACAG ACTGGAGATA GAACTGTTCA AGGGTGACCG TCTCATGAAG 
AAACAGGATT TTGTAGATGA GATGGCAAAG AAGTCTCTGG AAACCAAGAG TTTGGAAGTC 
ATCTTTACTC CTGTCATTGA GGATATTGAA AAGGCTCTTG TTTGCCGAGC TAAATTATAC 
ATTGACCAAA CTGATTCTAT TCCCAAAGAA AGGGAGACTG TCAGAGAACT ACAAGTCTAC 
ACCTCCCCCA AGAATACAGA GATCTCTGTA CATCCCTCCA CAAGGCTACA TGAGGGTGCT 
GCTGTGACGA TGACATGTGC CAGCGAGGGT CTACCAGCTC CTGAGATTTT CTGGAGCAAG 
AAATTAGATA ATGGAGTTCT ACAGCTCCTC TCGGGAAATG CCACCCTCAC CTTAATTGCT 
ATGAGGATGG AAGATTCTGG AATCTATGTG TGTGAAGGAG TGAATCTGGT TGGGAGAGAC 
AAAACAGAAG TGGAATTAAT TGTTCAAGAG AAACCATTTA CTGTTGACAT CTCCCCTGGA 
TCTCAGGTGG CTGCACAGGT TGGGGATTCC GTTGTTCTGA CATGTGCTGC TGTTGGCTGT 
GACTCTCCCT CCTTTTCTTG GAGAACCCAG ACAGACAGTC CCCTCAATGG GGAGGTGAGG 
GATGAAGGGG CTACATCCAC ACTGACGCTG AGCCCTGTGG GTGTTGAGGA TGAGCACTCT 
TACCTGTGCA CTGTGACCTG TCAGCGAAGG AAACTGGAGA AGACAATCCA AGTGGAGGTC 
TACTCATTCC CTGAAGACCC AGAAATTGAA ATAAGTGGAC CACTTGTACA CGGGAGACCT 
GTCACTGTCA ACTGCACGGT CCCTAATGTG TACCCCTTTG ACCATCTGGA GATTGAACTA 
CTGAAGGGGG AGACAACACT GTTGAATAAA TTTTTAAGGG AGGAAATTGG CACAAAGTCT 
CTAGAGACCA AAAGTTTGGA AATGACCTTC ATCCCCACCG CTGAAGACAC CGGGAAAGCT 
CTTGTTTGCC TCGCTAAGTT ACACAGCAGT CAAATGGAGT CTGAACCCAA ACAAAGGCAG 
AGTACACAGA CTCTTTATGT CAACGTTGCT CCGAAAGAAC CCACCATCTG GGTTAGCCCC 
TCTCCTGTCC CAGAGGAGGG CAGTCCTGTG AACCTGACCT GCTCAAGTGA TGGTTTTCCA 
ACTCCCAAAA TCCTGTGGAG CAGACAGCTA AAGAACGGGG AACTGCAGCC TCTTTCTCAA 
AATACAACAC TCTCCTTCAT GGCTACAAAA ATGGAAGATT CCGGCATTTA TGTATGTGAA 
GGGATTAATG AGGCTGGAAT TAGCAAAAAA TCAGTTGAAC TGATTATCCA AGGCTCTTCG 
AAGGACATAC AGCTTACAGT CTTCCCATCT AAGAGCGTCA AAGAGGGAGA CACTGTCATT 
ATCTCCTGTA CTTGTGGAAG TGTGCCCGAA ATATGGATAA TTCTGAAAAA GAAAGCCAAG 
ACAGGAGACA TGGTGCTAAA GTCTGTTAAT GGCTCGTACA CCATCCGCAA GGCACAGCTG 
CAGGATGCCG GAGTATACGA GTGTGAATCG AAAACCGAAG TCGGCTCGCA GTTGCGAAGT 
TTAACACTTG ATGTGAAAGG AAAAGAAAAT AACAAGGACT ATTTTTCCCC TGAACTCCTT 
GCACTCTACT TTGCATCCTC CTTGGTAATA CCCGCCATTG GGATGATCAT TTACTTTGCA 
AGAAAAGCCA ACATGAAAGG ATCGTACAGT CTGGTGGAGG CACAGAAGTC AAAAGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037021.1
CDS	58..2277
Translation	MPVKMVAIFGASTVLWILFAVSQAFKIEISPEYKTLAQIGDSMLLTCSTTGCESPSFSWRTQIDSPLNGKVKTEGAKSVLTMDPVSFENEHSYLCTATCNSGKLERGIQVDIYSFPKDPEIQFSGPLEVGKPVMVKCLAPDVYPIDRLEIELFKGDRLMKKQDFVDEMAKKSLETKSLEVIFTPVIEDIEKALVCRAKLYIDQTDSIPKERETVRELQVYTSPKNTEISVHPSTRLHEGAAVTMTCASEGLPAPEIFWSKKLDNGVLQLLSGNATLTLIAMRMEDSGIYVCEGVNLVGRDKTEVELIVQEKPFTVDISPGSQVAAQVGDSVVLTCAAVGCDSPSFSWRTQTDSPLNGEVRDEGATSTLTLSPVGVEDEHSYLCTVTCQRRKLEKTIQVEVYSFPEDPEIEISGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLLNKFLREEIGTKSLETKSLEMTFIPTAEDTGKALVCLAKLHSSQMESEPKQRQSTQTLYVNVAPKEPTIWVSPSPVPEEGSPVNLTCSSDGFPTPKILWSRQLKNGELQPLSQNTTLSFMATKMEDSGIYVCEGINEAGISKKSVELIIQGSSKDIQLTVFPSKSVKEGDTVIISCTCGSVPEIWIILKKKAKTGDMVLKSVNGSYTIRKAQLQDAGVYECESKTEVGSQLRSLTLDVKGKENNKDYFSPELLALYFASSLVIPAIGMIIYFARKANMKGSYSLVEAQKSKV

Target ORF information:

RefSeq Version	NM_012889.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vascular cell adhesion molecule 1 (Vcam1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012889.1

ORF Insert Sequence:

ATGCCTGTGA AGATGGTCGC GATCTTCGGA GCCTCAACGG TACTTTGGAT ACTGTTTGCA 
GTCTCTCAAG CTTTTAAAAT CGAGATCTCC CCTGAATACA AAACGCTCGC TCAGATTGGA 
GACTCCATGC TCCTGACTTG CAGCACCACA GGCTGTGAGT CGCCATCATT CTCTTGGAGA 
ACCCAGATAG ACAGTCCACT AAATGGGAAG GTGAAGACAG AGGGGGCCAA GTCCGTTCTG 
ACCATGGACC CTGTCAGCTT TGAGAATGAA CACTCTTACC TGTGCACAGC AACATGTAAC 
TCTGGGAAAC TGGAAAGAGG AATCCAAGTG GACATCTACT CATTCCCTAA GGATCCAGAG 
ATTCAATTCA GTGGCCCCCT GGAGGTTGGG AAGCCGGTCA TGGTCAAGTG TTTGGCTCCT 
GATGTTTACC CAATTGACAG ACTGGAGATA GAACTGTTCA AGGGTGACCG TCTCATGAAG 
AAACAGGATT TTGTAGATGA GATGGCAAAG AAGTCTCTGG AAACCAAGAG TTTGGAAGTC 
ATCTTTACTC CTGTCATTGA GGATATTGAA AAGGCTCTTG TTTGCCGAGC TAAATTATAC 
ATTGACCAAA CTGATTCTAT TCCCAAAGAA AGGGAGACTG TCAGAGAACT ACAAGTCTAC 
ACCTCCCCCA AGAATACAGA GATCTCTGTA CATCCCTCCA CAAGGCTACA TGAGGGTGCT 
GCTGTGACGA TGACATGTGC CAGCGAGGGT CTACCAGCTC CTGAGATTTT CTGGAGCAAG 
AAATTAGATA ATGGAGTTCT ACAGCTCCTC TCGGGAAATG CCACCCTCAC CTTAATTGCT 
ATGAGGATGG AAGATTCTGG AATCTATGTG TGTGAAGGAG TGAATCTGGT TGGGAGAGAC 
AAAACAGAAG TGGAATTAAT TGTTCAAGAG AAACCATTTA CTGTTGACAT CTCCCCTGGA 
TCTCAGGTGG CTGCACAGGT TGGGGATTCC GTTGTTCTGA CATGTGCTGC TGTTGGCTGT 
GACTCTCCCT CCTTTTCTTG GAGAACCCAG ACAGACAGTC CCCTCAATGG GGAGGTGAGG 
GATGAAGGGG CTACATCCAC ACTGACGCTG AGCCCTGTGG GTGTTGAGGA TGAGCACTCT 
TACCTGTGCA CTGTGACCTG TCAGCGAAGG AAACTGGAGA AGACAATCCA AGTGGAGGTC 
TACTCATTCC CTGAAGACCC AGAAATTGAA ATAAGTGGAC CACTTGTACA CGGGAGACCT 
GTCACTGTCA ACTGCACGGT CCCTAATGTG TACCCCTTTG ACCATCTGGA GATTGAACTA 
CTGAAGGGGG AGACAACACT GTTGAATAAA TTTTTAAGGG AGGAAATTGG CACAAAGTCT 
CTAGAGACCA AAAGTTTGGA AATGACCTTC ATCCCCACCG CTGAAGACAC CGGGAAAGCT 
CTTGTTTGCC TCGCTAAGTT ACACAGCAGT CAAATGGAGT CTGAACCCAA ACAAAGGCAG 
AGTACACAGA CTCTTTATGT CAACGTTGCT CCGAAAGAAC CCACCATCTG GGTTAGCCCC 
TCTCCTGTCC CAGAGGAGGG CAGTCCTGTG AACCTGACCT GCTCAAGTGA TGGTTTTCCA 
ACTCCCAAAA TCCTGTGGAG CAGACAGCTA AAGAACGGGG AACTGCAGCC TCTTTCTCAA 
AATACAACAC TCTCCTTCAT GGCTACAAAA ATGGAAGATT CCGGCATTTA TGTATGTGAA 
GGGATTAATG AGGCTGGAAT TAGCAAAAAA TCAGTTGAAC TGATTATCCA AGGCTCTTCG 
AAGGACATAC AGCTTACAGT CTTCCCATCT AAGAGCGTCA AAGAGGGAGA CACTGTCATT 
ATCTCCTGTA CTTGTGGAAG TGTGCCCGAA ATATGGATAA TTCTGAAAAA GAAAGCCAAG 
ACAGGAGACA TGGTGCTAAA GTCTGTTAAT GGCTCGTACA CCATCCGCAA GGCACAGCTG 
CAGGATGCCG GAGTATACGA GTGTGAATCG AAAACCGAAG TCGGCTCGCA GTTGCGAAGT 
TTAACACTTG ATGTGAAAGG AAAAGAAAAT AACAAGGACT ATTTTTCCCC TGAACTCCTT 
GCACTCTACT TTGCATCCTC CTTGGTAATA CCCGCCATTG GGATGATCAT TTACTTTGCA 
AGAAAAGCCA ACATGAAAGG ATCGTACAGT CTGGTGGAGG CACAGAAGTC AAAAGTGTAG