Rab38 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rab38
Entrez Gene ID	252916
Full Name	RAB38, member RAS oncogene family
Synonyms	R,Ruby
General protein information	Preferred Names RAB38, member RAS oncogene family Names ras-related protein Rab-38 Rab38, member of RAS oncogene family red eyed dilution ruby or red eyed dilution small GTP binding protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32
Summary	a small G protein that is involved in intracellular vesicle transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145774.2	NP_665717.1	ras-related protein Rab-38

Pathways from BioSystems

Homologies

Homo sapiens (human)	RAB38	NP_071732.1
Mus musculus (house mouse)	Rab38	NP_082514.4
Gallus gallus (chicken)	RAB38	XP_425653.3
Danio rerio (zebrafish)	rab38a	XP_001342875.3
Xenopus tropicalis (tropical clawed frog)	rab38	XP_002936591.1
Canis lupus familiaris (dog)	RAB38	XP_850212.2
Rattus norvegicus (Norway rat)	Rab38	NP_665717.1
Danio rerio (zebrafish)	LOC100007788	XP_003199402.1
Pan troglodytes (chimpanzee)	RAB38	XP_508683.2
	RAB38	XP_001104269.1
Bos taurus (cattle)	RAB38	XP_002699093.2

Gene Ontology
Bibliography

Related articles in PubMed

Exogenous gene transfer of Rab
Osanai K, Nakase K, Sakuma T, Nishiki K, Nojiri M, Kato R, Saito M, Fujimoto Y, Mizuno S, Toga H
Respiratory research18(1)70(2017 Apr)

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY, Li M, Li Y, Mijatovic V, Ko YA, Taliun D, Luciani A, Chen MH, Yang Q, Foster MC, Olden M, Hiraki LT, Tayo BO, Fuchsberger C, Dieffenbach AK, Shuldiner AR, Smith AV, Zappa AM, Lupo A, Kollerits B, Ponte B, Stengel B, Kr?mer BK, Paulweber B, Mitchell BD, Hayward C, Helmer C, Meisinger C, Gieger C, Shaffer CM, M?ller C, Langenberg C, Ackermann D, Siscovick D, , Boerwinkle E, Kronenberg F, Ehret GB, Homuth G, Waeber G, Navis G, Gambaro G, Malerba G, Eiriksdottir G, Li G, Wichmann HE, Grallert H, Wallaschofski H, V?lzke H, Brenner H, Kramer H, Mateo Leach I, Rudan I, Hillege HL, Beckmann JS, Lambert JC, Luan J, Zhao JH, Chalmers J, Coresh J, Denny JC, Butterbach K, Launer LJ, Ferrucci L, Kedenko L, Haun M, Metzger M, Woodward M, Hoffman MJ, Nauck M, Waldenberger M, Pruijm M, Bochud M, Rheinberger M, Verweij N, Wareham NJ, Endlich N, Soranzo N, Polasek O, van der Harst P, Pramstaller PP, Vollenweider P, Wild PS, Gansevoort RT, Rettig R, Biffar R, Carroll RJ, Katz R, Loos RJ, Hwang SJ, Coassin S, Bergmann S, Rosas SE, Stracke S, Harris TB, Corre T, Zeller T, Illig T, Aspelund T, Tanaka T, Lendeckel U, V?lker U, Gudnason V, Chouraki V, Koenig W, Kutalik Z, O'Connell JR, Parsa A, Heid IM, Paterson AD, de Boer IH, Devuyst O, Lazar J, Endlich K, Susztak K, Tremblay J, Hamet P, Jacob HJ, B?ger CA, Fox CS, Pattaro C, K?ttgen A
Diabetes65(3)803-17(2016 Mar)

RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.
Marubashi S, Shimada H, Fukuda M, Ohbayashi N
The Journal of biological chemistry291(3)1427-40(2016 Jan)

Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins.
Ortiz-Sandoval CG, Hughes SC, Dacks JB, Simmen T
Cellular logistics4(4)e986399(2014 Oct-Dec)

Rab38 modulates proteinuria in model of hypertension-associated renal disease.
Rangel-Filho A, Lazar J, Moreno C, Geurts A, Jacob HJ
Journal of the American Society of Nephrology : JASN24(2)283-92(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In an experimental diabetes model, Rab38 knockout rats showed higher urinary albumin concentrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface compared to control rats.
Title: Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

Rab38 affects urinary protein excretion via effects in the proximal tubule.
Title: Rab38 modulates proteinuria in model of hypertension-associated renal disease.

Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.
Title: Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.

Data show that Rab38-deficient type II cells appear to carry abnormality in lung surfactant secretion but not in synthesis or uptake.
Title: Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome.

Rab38 may play a role in the development of dense granules in the megakaryocytes and platelets
Title: The role of Rab38 in platelet dense granule defects.

The following Rab38 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rab38 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02677	NM_145774.2 Latest version!	Rattus norvegicus RAB38, member RAS oncogene family (Rab38), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rab38 ( NM_145774.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_665717.1 Rattus norvegicus RAB38, member RAS oncogene family (Rab38), mRNA.

Price & Availability↑

CloneID	ORa02677
Clone ID Related Accession (Same CDS sequence)	NM_145774.2
Accession Version	NM_145774.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-12
Organism	Rattus norvegicus(Norway rat)
Product	ras-related protein Rab-38
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M94043.1. On Aug 30, 2012 this sequence version replaced NM_145774.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M94043.1, BC070513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGCAGACAC CGCACAAGGA GCACCTGTAT AAGCTGCTGG TAATCGGCGA CCTAGGTGTA 
GGCAAGACCA GCATCATCAA GCGCTACGTG CACCAAAACT TCTCCTCCCA CTACCGGGCC 
ACCATTGGTG TGGACTTCGC GCTGAAGGTG CTCCACTGGG ACCCAGAGAC GGTGGTGCGC 
CTGCAGCTCT GGGACATCGC AGGTCAAGAA AGATTTGGTA ACATGACAAG AGTCTATTAC 
CGAGAAGCTA TGGGAGCATT TATTGTTTTT GATGTCACCA GACCAGCCAC ATTTGAAGCA 
GTGGCAAAAT GGAAAAATGA TTTGGACTCA AAGTTAACTC TCCCTAATGG TAAGCCAGTA 
TCAGTGGTTT TGTTGGCCAA CAAATGTGAC CAAGGGAAGG ATGTGCTTGT GAACAATGGA 
CTCAAGATGG ACCAGTTCTG CAAGGAGCAT GGTTTCGTAG GATGGTTTGA AACATCAGCC 
AAGGAAAATA TAAACATTGA TGAAGCGTCA AGATGCCTGG TCAAGCACAT ACTTGCAAAT 
GAGTGCGACT TCATAGAGTC TATAGAACCG GACATTGTGA AGCCCCACCT CACATCACCC 
AAGGTTGTCA GCTGCTCTGG CTGTGCCAAA TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665717.1
CDS	47..682
Translation	MQTPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFALKVLHWDPETVVRLQLWDIAGQERFGNMTRVYYREAMGAFIVFDVTRPATFEAVAKWKNDLDSKLTLPNGKPVSVVLLANKCDQGKDVLVNNGLKMDQFCKEHGFVGWFETSAKENINIDEASRCLVKHILANECDFIESIEPDIVKPHLTSPKVVSCSGCAKS

Target ORF information:

RefSeq Version	NM_145774.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RAB38, member RAS oncogene family (Rab38), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145774.2

ORF Insert Sequence:

ATGCAGACAC CGCACAAGGA GCACCTGTAT AAGCTGCTGG TAATCGGCGA CCTAGGTGTA 
GGCAAGACCA GCATCATCAA GCGCTACGTG CACCAAAACT TCTCCTCCCA CTACCGGGCC 
ACCATTGGTG TGGACTTCGC GCTGAAGGTG CTCCACTGGG ACCCAGAGAC GGTGGTGCGC 
CTGCAGCTCT GGGACATCGC AGGTCAAGAA AGATTTGGTA ACATGACAAG AGTCTATTAC 
CGAGAAGCTA TGGGAGCATT TATTGTTTTT GATGTCACCA GACCAGCCAC ATTTGAAGCA 
GTGGCAAAAT GGAAAAATGA TTTGGACTCA AAGTTAACTC TCCCTAATGG TAAGCCAGTA 
TCAGTGGTTT TGTTGGCCAA CAAATGTGAC CAAGGGAAGG ATGTGCTTGT GAACAATGGA 
CTCAAGATGG ACCAGTTCTG CAAGGAGCAT GGTTTCGTAG GATGGTTTGA AACATCAGCC 
AAGGAAAATA TAAACATTGA TGAAGCGTCA AGATGCCTGG TCAAGCACAT ACTTGCAAAT 
GAGTGCGACT TCATAGAGTC TATAGAACCG GACATTGTGA AGCCCCACCT CACATCACCC 
AAGGTTGTCA GCTGCTCTGG CTGTGCCAAA TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exogenous gene transfer of Rab
Respiratory research18(1)70(2017 Apr)
Osanai K,Nakase K,Sakuma T,Nishiki K,Nojiri M,Kato R,Saito M,Fujimoto Y,Mizuno S,Toga H

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Diabetes65(3)803-17(2016 Mar)
Teumer A,Tin A,Sorice R,Gorski M,Yeo NC,Chu AY,Li M,Li Y,Mijatovic V,Ko YA,Taliun D,Luciani A,Chen MH,Yang Q,Foster MC,Olden M,Hiraki LT,Tayo BO,Fuchsberger C,Dieffenbach AK,Shuldiner AR,Smith AV,Zappa AM,Lupo A,Kollerits B,Ponte B,Stengel B,Kr?mer BK,Paulweber B,Mitchell BD,Hayward C,Helmer C,Meisinger C,Gieger C,Shaffer CM,M?ller C,Langenberg C,Ackermann D,Siscovick D,,Boerwinkle E,Kronenberg F,Ehret GB,Homuth G,Waeber G,Navis G,Gambaro G,Malerba G,Eiriksdottir G,Li G,Wichmann HE,Grallert H,Wallaschofski H,V?lzke H,Brenner H,Kramer H,Mateo Leach I,Rudan I,Hillege HL,Beckmann JS,Lambert JC,Luan J,Zhao JH,Chalmers J,Coresh J,Denny JC,Butterbach K,Launer LJ,Ferrucci L,Kedenko L,Haun M,Metzger M,Woodward M,Hoffman MJ,Nauck M,Waldenberger M,Pruijm M,Bochud M,Rheinberger M,Verweij N,Wareham NJ,Endlich N,Soranzo N,Polasek O,van der Harst P,Pramstaller PP,Vollenweider P,Wild PS,Gansevoort RT,Rettig R,Biffar R,Carroll RJ,Katz R,Loos RJ,Hwang SJ,Coassin S,Bergmann S,Rosas SE,Stracke S,Harris TB,Corre T,Zeller T,Illig T,Aspelund T,Tanaka T,Lendeckel U,V?lker U,Gudnason V,Chouraki V,Koenig W,Kutalik Z,O'Connell JR,Parsa A,Heid IM,Paterson AD,de Boer IH,Devuyst O,Lazar J,Endlich K,Susztak K,Tremblay J,Hamet P,Jacob HJ,B?ger CA,Fox CS,Pattaro C,K?ttgen A

RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.
The Journal of biological chemistry291(3)1427-40(2016 Jan)
Marubashi S,Shimada H,Fukuda M,Ohbayashi N

Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins.
Cellular logistics4(4)e986399(2014 Oct-Dec)
Ortiz-Sandoval CG,Hughes SC,Dacks JB,Simmen T

Rab38 modulates proteinuria in model of hypertension-associated renal disease.
Journal of the American Society of Nephrology : JASN24(2)283-92(2013 Feb)
Rangel-Filho A,Lazar J,Moreno C,Geurts A,Jacob HJ

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Rab38 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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