Sycp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sycp1
Entrez Gene ID	25276
Full Name	synaptonemal complex protein 1
Synonyms	SCP1
General protein information	Preferred Names synaptonemal complex protein 1 Names synaptonemal complex protein 1 A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes SCP-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	component of the transverse filaments of synaptonemal complexes (SCs) that are formed between homologous chromosomes during meiotic prophase; may be involved in chromosome pairing and recombination [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012810.1	NP_036942.1	synaptonemal complex protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SYCP1	NP_001269470.1
Canis lupus familiaris (dog)	SYCP1	XP_857086.1
Rattus norvegicus (Norway rat)	Sycp1	NP_036942.1
Xenopus tropicalis (tropical clawed frog)	sycp1	XP_004911444.1
Pan troglodytes (chimpanzee)	SYCP1	XP_513674.3
Gallus gallus (chicken)	SYCP1	XP_004935063.1
Danio rerio (zebrafish)	sycp1	NP_001112366.1
	SYCP1	XP_001111808.1
Bos taurus (cattle)	SYCP1	XP_003585895.1
Mus musculus (house mouse)	Sycp1	NP_035646.2

Gene Ontology
Bibliography

Related articles in PubMed

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.
Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, H?rault Y, Guillou F, Bourc'his D
Science (New York, N.Y.)354(6314)909-912(2016 11)

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein.
Finsterbusch F, Ravindranathan R, Dereli I, Stanzione M, Tr?nkner D, T?th A
PLoS genetics12(10)e1006393(2016 Oct)

Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells.
Inoue H, Ogonuki N, Hirose M, Hatanaka Y, Matoba S, Chuma S, Kobayashi K, Wakana S, Noguchi J, Inoue K, Tanemura K, Ogura A
Biochemical and biophysical research communications478(2)592-8(2016 09)

FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Sun X, Brie?o-Enr?quez MA, Cornelius A, Modzelewski AJ, Maley TT, Campbell-Peterson KM, Holloway JK, Cohen PE
Chromosoma125(2)237-52(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SCP1 has the potential to induce cardiac hypertrophy; however, the effect is suppressed by intronic miR-26b in cardiomyocytes. miR-26b has an antagonistic effect on its host gene SCP1.
Title: MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene.

Premature loss of SCP1 resulted in more oocytes reaching diplotene stage, evidenced by decrease in number of oocytes containing germ cell nuclear antigen-1 and increase in number of oocytes expressing MSY2(expressed in oocytes arrested in diplotene).
Title: Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary.

SCP1 is a primary determinant of SC assembly that plays a key role in synapsis of homologous chromosomes
Title: Mammalian protein SCP1 forms synaptonemal complex-like structures in the absence of meiotic chromosomes.

The following Sycp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sycp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42560	NM_012810.1 Latest version!	Rattus norvegicus synaptonemal complex protein 1 (Sycp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sycp1 ( NM_012810.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036942.1 Rattus norvegicus synaptonemal complex protein 1 (Sycp1), mRNA.

Price & Availability↑

CloneID	ORa42560
Clone ID Related Accession (Same CDS sequence)	NM_012810.1
Accession Version	NM_012810.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2841bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	synaptonemal complex protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X67805.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X67805.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689601, SAMEA2689602 [ECO:0000350] ##Evidence-Data-END##

ATGTCCAGTC TATCAAAAAA TCGGGAAAAC ATTGATACAG ATCCCGCTTT TCAAAAACTT 
AGCATTTTGC CCATGCTTGA ACAGGTTGCA AATTCTGGCA GTTGCCACTA TCAGGAAGGA 
GTAAATGACT CTGATTTTGA GAATTCAGAG CCAATGAGCA GACTGTACTC AAAGCTGTAT 
AAAGAGGCTG AAAAGATAAA AAAGTGGAAA GTGAGCATAG AGTCTGAACT GAAGCAGAAA 
GAAAATAAGT TGCAAGAAAA CAGAAAGATA ATTGAAGCCC AGCGAAAAGC CATTCAGGAA 
CTTCAGTTTG AAAATGAAAA AGTAAGCTTG AAATTAGAAG AAGAAATTCA AGAAAATAAA 
GATTTAATCA AGGAGAATAA TGCTACAAGA CATTGGTGTA ATTTACTCAA GGAAACCTGT 
GCTAGATCTG CAGAAAAGAC AAGTAAATAT GAATATGAGC GAGAAGAAAC CAGACAAGTT 
TATGTGGATC TAAATAATAA CATTGAGAAA ATGATACTAG CTTTTGAGGA ACTTCGTGTG 
CAAGCTGAGA ATGCCAGGCT GGAAATGCAC TTTAAGTTAA AGGAAGATCA TGAAAAAATC 
CAACATCTTG AAGAAGAATA TCAGAAGGAA GTAAACAACA AGGAAAACCA GGTATCACTA 
CTATTGATCC AAAGTACTGA GAAAGAAAAT AAAATGAAAG ATTTAACATT TCTGCTAGAG 
GAATCCAGAG ATAAAGCTAA TCAATTAGAG GAAAAAACAA AATTACAAGA TGAAAACTTA 
AAAGAATTAA ATGAAAAGAA GGATCATTTA ACATCAGAAC TTGAAGATAT TAAAATGTCC 
ATGCAAAGAA GTATGAGCAC TCAGAAGACT TTAGAGGAAG ATTTACAGAT AGCAACAAAA 
ACGATTTATC AGCTCACTGA AGAAAAAGAA GCTCAAATGG AAGAACTCAA CAAAGCTAAA 
ACTACTCACT CACTTGTGGT GACTGAACTT AAAGCCACTA CATGTACCTT GGAGGAATTA 
CTGAGAACAG AACAGCAAAG ATTGGAAAAT AATGAGGATC AACTGAAACT GATTACTATG 
GAGCTCCAGA AGAAATCAAG TGAACTAGAA GAGATGACTA AATTTAAAAA TAACAAAGAA 
GTGGAACTTG AAGAATTAAA AACCATATTG GCAGAAGACC AAAAACTTTT AGATGAAAAG 
AAACAAGTTG AGAAGCTTGC TGAAGAATTA CAAGGGAAAG AACAAGAACT AACTTTCCTT 
TTGCAAACCA GAGAGAAAGA AATCCATGAT TTGGAAGTAC AAGTAACTGT CACTAAAACA 
AGTGAAGAAC ATTATTTAAA ACAGGTTGAA GAAATGAAAA CTGAGCTTGA AAAAGAGAAA 
CTTAAGAATA TTGAATTAAC TGCAAACTCT GACATGCTTT TGCTTGAGAA CAAAAAATTG 
GTACAAGAAG CAAGTGATAT GGTCCTAGAA CTCAAGAAAC ATCAAGAAGA TATCATTAAT 
TGCAAAAAGC AAGAAGAAAG GATGTTGAAA CAAATAGAAA CTTTGGAAGA AAAAGAAATG 
AATTTAAGGG ATGAACTGGA ATCAGTAAGA AAAGAGTTCA TACAGCAAGG AGATGAAGTT 
AAATGTAAAT TGGACAAGAG TGAAGAAAAT GCTCGAAGCA TTGAATATGA AGTTTTAAAG 
AAAGAAAAGC AGATGAAGAT ATTAGAAAAT AAGTGTAATA ATTTAAAGAA ACAAATCGAA 
AATAAAAGCA AGAATATTGA AGAGCTTCAC CAGGAGAATA AAGCCTTGAA AAAAAAAAGT 
TCAGCAGAAA ACAAACAACT GAATGCATAT GAGATAAAGG TCAATAAATT AGAGTTGGAA 
TTAGCAAGTA CCAAGCAAAA ATTTGAAGAA ATGATTAACA ACTACCAGAA AGAAATTGAG 
ATAAAAAAGA TTTCAGAAGA AAAGCTTTTG GGAGAGGTTG AGAAAGCCAA AGCAACAGTT 
GATGAAGCCG TAAAGTTACA GAAAGAAATT GATTTACGAT GCCAACATAA AATAGCTGAG 
ATGGTAGCAC TTATGGAAAA ACATAAGCAC CAATATGATA AGATTGTTGA AGAAAGAGAC 
TCAGAATTAG GACTTTATAA AAACAGAGAA CAGGAACAGT CTTCAGCAAA GGTTGCTTTG 
GAGACTGAAT TATCTAATAT CAGAAACGAA CTTGTATCCC TTAAGAAGCA ACTTGAAGTA 
GAAAAAGAAG AAAAAGAGAA ATTAAAAATG GAACAAGAAA ACACAGCTAT TCTCACAGAT 
AAAAAAGACA AGAAAATACA GGCATCTTTG CTGGAATCAC CTGAAGCCAC TAGTTGGAAA 
TTTGATTCTA AAACAACTCC CTCACAAAAT ATATCTCGGC TTTCCTCATC AATGGATAGT 
GGCAAATCCA AAGATAACAG AGATAGTCTG CGGGCATCTG CCAAAAGCAT TTTATCTACA 
ACAGTTACAA AGGAATATAC AGTGAAGACA CCAACTAAAA AGAGCATATA TCAAAGAGAA 
AACAAGTATT TACCTACTGG AGGAAGTAAT AAAAAGAGAA AAACTGTCTT TGAATTTGAT 
GTTAATTCAG ATAGTTCAGA AACTACTGAT CTTTTGAGCT TGGTTTCAGA GGAAGATATA 
TCAAACAGGA TTTATAATAA TAATACACCA GATTCTCATC TATTAGTCAA AACTCCCAAA 
CAGACTCCTT TATCTTTATC AACTCCTGCA TCTTTTACGA AGTTTGGAAG TCTGAAAAAA 
ATGAGAGAAG ACCGTTGGGC AACGATTGCT AAAATTGATA GGAAAAGAAG ACTAAAGGAA 
GCAGAAAAGT TATTTACTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036942.1
CDS	262..3102
Translation	MSSLSKNRENIDTDPAFQKLSILPMLEQVANSGSCHYQEGVNDSDFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHWCNLLKETCARSAEKTSKYEYEREETRQVYVDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYQKEVNNKENQVSLLLIQSTEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELNEKKDHLTSELEDIKMSMQRSMSTQKTLEEDLQIATKTIYQLTEEKEAQMEELNKAKTTHSLVVTELKATTCTLEELLRTEQQRLENNEDQLKLITMELQKKSSELEEMTKFKNNKEVELEELKTILAEDQKLLDEKKQVEKLAEELQGKEQELTFLLQTREKEIHDLEVQVTVTKTSEEHYLKQVEEMKTELEKEKLKNIELTANSDMLLLENKKLVQEASDMVLELKKHQEDIINCKKQEERMLKQIETLEEKEMNLRDELESVRKEFIQQGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKSKNIEELHQENKALKKKSSAENKQLNAYEIKVNKLELELASTKQKFEEMINNYQKEIEIKKISEEKLLGEVEKAKATVDEAVKLQKEIDLRCQHKIAEMVALMEKHKHQYDKIVEERDSELGLYKNREQEQSSAKVALETELSNIRNELVSLKKQLEVEKEEKEKLKMEQENTAILTDKKDKKIQASLLESPEATSWKFDSKTTPSQNISRLSSSMDSGKSKDNRDSLRASAKSILSTTVTKEYTVKTPTKKSIYQRENKYLPTGGSNKKRKTVFEFDVNSDSSETTDLLSLVSEEDISNRIYNNNTPDSHLLVKTPKQTPLSLSTPASFTKFGSLKKMREDRWATIAKIDRKRRLKEAEKLFT

Target ORF information:

RefSeq Version	NM_012810.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptonemal complex protein 1 (Sycp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012810.1

ORF Insert Sequence:

ATGTCCAGTC TATCAAAAAA TCGGGAAAAC ATTGATACAG ATCCCGCTTT TCAAAAACTT 
AGCATTTTGC CCATGCTTGA ACAGGTTGCA AATTCTGGCA GTTGCCACTA TCAGGAAGGA 
GTAAATGACT CTGATTTTGA GAATTCAGAG CCAATGAGCA GACTGTACTC AAAGCTGTAT 
AAAGAGGCTG AAAAGATAAA AAAGTGGAAA GTGAGCATAG AGTCTGAACT GAAGCAGAAA 
GAAAATAAGT TGCAAGAAAA CAGAAAGATA ATTGAAGCCC AGCGAAAAGC CATTCAGGAA 
CTTCAGTTTG AAAATGAAAA AGTAAGCTTG AAATTAGAAG AAGAAATTCA AGAAAATAAA 
GATTTAATCA AGGAGAATAA TGCTACAAGA CATTGGTGTA ATTTACTCAA GGAAACCTGT 
GCTAGATCTG CAGAAAAGAC AAGTAAATAT GAATATGAGC GAGAAGAAAC CAGACAAGTT 
TATGTGGATC TAAATAATAA CATTGAGAAA ATGATACTAG CTTTTGAGGA ACTTCGTGTG 
CAAGCTGAGA ATGCCAGGCT GGAAATGCAC TTTAAGTTAA AGGAAGATCA TGAAAAAATC 
CAACATCTTG AAGAAGAATA TCAGAAGGAA GTAAACAACA AGGAAAACCA GGTATCACTA 
CTATTGATCC AAAGTACTGA GAAAGAAAAT AAAATGAAAG ATTTAACATT TCTGCTAGAG 
GAATCCAGAG ATAAAGCTAA TCAATTAGAG GAAAAAACAA AATTACAAGA TGAAAACTTA 
AAAGAATTAA ATGAAAAGAA GGATCATTTA ACATCAGAAC TTGAAGATAT TAAAATGTCC 
ATGCAAAGAA GTATGAGCAC TCAGAAGACT TTAGAGGAAG ATTTACAGAT AGCAACAAAA 
ACGATTTATC AGCTCACTGA AGAAAAAGAA GCTCAAATGG AAGAACTCAA CAAAGCTAAA 
ACTACTCACT CACTTGTGGT GACTGAACTT AAAGCCACTA CATGTACCTT GGAGGAATTA 
CTGAGAACAG AACAGCAAAG ATTGGAAAAT AATGAGGATC AACTGAAACT GATTACTATG 
GAGCTCCAGA AGAAATCAAG TGAACTAGAA GAGATGACTA AATTTAAAAA TAACAAAGAA 
GTGGAACTTG AAGAATTAAA AACCATATTG GCAGAAGACC AAAAACTTTT AGATGAAAAG 
AAACAAGTTG AGAAGCTTGC TGAAGAATTA CAAGGGAAAG AACAAGAACT AACTTTCCTT 
TTGCAAACCA GAGAGAAAGA AATCCATGAT TTGGAAGTAC AAGTAACTGT CACTAAAACA 
AGTGAAGAAC ATTATTTAAA ACAGGTTGAA GAAATGAAAA CTGAGCTTGA AAAAGAGAAA 
CTTAAGAATA TTGAATTAAC TGCAAACTCT GACATGCTTT TGCTTGAGAA CAAAAAATTG 
GTACAAGAAG CAAGTGATAT GGTCCTAGAA CTCAAGAAAC ATCAAGAAGA TATCATTAAT 
TGCAAAAAGC AAGAAGAAAG GATGTTGAAA CAAATAGAAA CTTTGGAAGA AAAAGAAATG 
AATTTAAGGG ATGAACTGGA ATCAGTAAGA AAAGAGTTCA TACAGCAAGG AGATGAAGTT 
AAATGTAAAT TGGACAAGAG TGAAGAAAAT GCTCGAAGCA TTGAATATGA AGTTTTAAAG 
AAAGAAAAGC AGATGAAGAT ATTAGAAAAT AAGTGTAATA ATTTAAAGAA ACAAATCGAA 
AATAAAAGCA AGAATATTGA AGAGCTTCAC CAGGAGAATA AAGCCTTGAA AAAAAAAAGT 
TCAGCAGAAA ACAAACAACT GAATGCATAT GAGATAAAGG TCAATAAATT AGAGTTGGAA 
TTAGCAAGTA CCAAGCAAAA ATTTGAAGAA ATGATTAACA ACTACCAGAA AGAAATTGAG 
ATAAAAAAGA TTTCAGAAGA AAAGCTTTTG GGAGAGGTTG AGAAAGCCAA AGCAACAGTT 
GATGAAGCCG TAAAGTTACA GAAAGAAATT GATTTACGAT GCCAACATAA AATAGCTGAG 
ATGGTAGCAC TTATGGAAAA ACATAAGCAC CAATATGATA AGATTGTTGA AGAAAGAGAC 
TCAGAATTAG GACTTTATAA AAACAGAGAA CAGGAACAGT CTTCAGCAAA GGTTGCTTTG 
GAGACTGAAT TATCTAATAT CAGAAACGAA CTTGTATCCC TTAAGAAGCA ACTTGAAGTA 
GAAAAAGAAG AAAAAGAGAA ATTAAAAATG GAACAAGAAA ACACAGCTAT TCTCACAGAT 
AAAAAAGACA AGAAAATACA GGCATCTTTG CTGGAATCAC CTGAAGCCAC TAGTTGGAAA 
TTTGATTCTA AAACAACTCC CTCACAAAAT ATATCTCGGC TTTCCTCATC AATGGATAGT 
GGCAAATCCA AAGATAACAG AGATAGTCTG CGGGCATCTG CCAAAAGCAT TTTATCTACA 
ACAGTTACAA AGGAATATAC AGTGAAGACA CCAACTAAAA AGAGCATATA TCAAAGAGAA 
AACAAGTATT TACCTACTGG AGGAAGTAAT AAAAAGAGAA AAACTGTCTT TGAATTTGAT 
GTTAATTCAG ATAGTTCAGA AACTACTGAT CTTTTGAGCT TGGTTTCAGA GGAAGATATA 
TCAAACAGGA TTTATAATAA TAATACACCA GATTCTCATC TATTAGTCAA AACTCCCAAA 
CAGACTCCTT TATCTTTATC AACTCCTGCA TCTTTTACGA AGTTTGGAAG TCTGAAAAAA 
ATGAGAGAAG ACCGTTGGGC AACGATTGCT AAAATTGATA GGAAAAGAAG ACTAAAGGAA 
GCAGAAAAGT TATTTACTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.
Science (New York, N.Y.)354(6314)909-912(2016 11)
Barau J,Teissandier A,Zamudio N,Roy S,Nalesso V,H?rault Y,Guillou F,Bourc'his D

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein.
PLoS genetics12(10)e1006393(2016 Oct)
Finsterbusch F,Ravindranathan R,Dereli I,Stanzione M,Tr?nkner D,T?th A

Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells.
Biochemical and biophysical research communications478(2)592-8(2016 09)
Inoue H,Ogonuki N,Hirose M,Hatanaka Y,Matoba S,Chuma S,Kobayashi K,Wakana S,Noguchi J,Inoue K,Tanemura K,Ogura A

FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Chromosoma125(2)237-52(2016 Jun)
Sun X,Brie?o-Enr?quez MA,Cornelius A,Modzelewski AJ,Maley TT,Campbell-Peterson KM,Holloway JK,Cohen PE