Abcd3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcd3
Entrez Gene ID	25270
Full Name	ATP binding cassette subfamily D member 3
Synonyms	PMP70,Pxmp1
General protein information	Preferred Names ATP binding cassette subfamily D member 3 Names ATP-binding cassette sub-family D member 3 70-kDa peroxisomal membrane protein ATP-binding cassette, sub-family D (ALD), member 3 ATP-binding cassette, subfamily D (ALD), member 3 Peroxisomal membrane protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q41
Summary	may form an ATP binding channel; may play a role in active transport in peroxisomes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012804.1	NP_036936.1	ATP-binding cassette sub-family D member 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Abcd3	NP_033017.2
Rattus norvegicus (Norway rat)	Abcd3	NP_036936.1
Arabidopsis thaliana (thale cress)	PXA1	NP_568072.1
Xenopus tropicalis (tropical clawed frog)	abcd3	XP_002933838.2
Homo sapiens (human)	ABCD3	NP_002849.1
Canis lupus familiaris (dog)	ABCD3	XP_537064.4
Danio rerio (zebrafish)	abcd3a	NP_998647.1
Oryza sativa (rice)	Os05g0107600	NP_001054425.1
	ABCD3	XP_002808274.1
Drosophila melanogaster (fruit fly)	Pmp70	NP_001259732.1
Caenorhabditis elegans (roundworm)	pmp-1	NP_495407.1
Caenorhabditis elegans (roundworm)	pmp-2	NP_495408.1
Bos taurus (cattle)	ABCD3	NP_001098866.1
Gallus gallus (chicken)	ABCD3	NP_001012615.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000440	XP_310656.2

Gene Ontology
Bibliography

Related articles in PubMed

A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3.
Ferdinandusse S, Jimenez-Sanchez G, Koster J, Denis S, Van Roermund CW, Silva-Zolezzi I, Moser AB, Visser WF, Gulluoglu M, Durmaz O, Demirkol M, Waterham HR, G?kcay G, Wanders RJ, Valle D
Human molecular genetics24(2)361-70(2015 Jan)

Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice.
Kaczmarek K, Studencka M, Meinhardt A, Wieczerzak K, Thoms S, Engel W, Grzmil P
Molecular biology of the cell22(10)1766-79(2011 May)

PEX14 is required for microtubule-based peroxisome motility in human cells.
Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, Herrmann C, Meyer HE, Wiese S, Warscheid B, Theiss C, Erdmann R
Journal of cell science124(Pt 10)1759-68(2011 May)

Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP70.
Iwashita S, Tsuchida M, Tsukuda M, Yamashita Y, Emi Y, Kida Y, Komori M, Kashiwayama Y, Imanaka T, Sakaguchi M
Journal of biochemistry147(4)581-90(2010 Apr)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knock-down of PMP70 in rat glial cells recall the oxidative and inflammatory status observed in human X-linked adrenoleukodystrophy and reinforce the possibility of its involvement in this disease.
Title: PMP70 knock-down generates oxidative stress and pro-inflammatory cytokine production in C6 glial cells.

Considered as a whole, our results indicate that the abcd3kd cell line is a valuable tool to further study the function of PMP70 and eventually its role in X-linked adrenoleukodystrophy.
Title: RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function.

ATP binding/hydrolysis by and phosphorylation of PMP70 and ALDP are involved in the regulation of fatty acid transport into peroxisomes.
Title: ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1).

PMP70 exists as a dimer on the peroxisomal membranes and the binding and hydrolysis of ATP induce conformational changes.
Title: Nucleotide-induced conformational changes of PMP70, an ATP binding cassette transporter on rat liver peroxisomal membranes.

The following Abcd3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcd3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00986	NM_012804.1 Latest version!	Rattus norvegicus ATP binding cassette subfamily D member 3 (Abcd3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcd3 ( NM_012804.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036936.1 Rattus norvegicus ATP binding cassette subfamily D member 3 (Abcd3), mRNA.

Price & Availability↑

CloneID	ORa00986
Clone ID Related Accession (Same CDS sequence)	NM_012804.1
Accession Version	NM_012804.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1980bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	ATP-binding cassette sub-family D member 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D90038.1. On Jan 12, 2005 this sequence version replaced XM_346639.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D90038.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCCT TCAGCAAGTA CTTGACGGCG CGGAACTCCT CGCTGGCGGG GGCCGCGTTC 
CTGCTGTTCT GCCTGCTCCA CAAGCGGCGT CGCGCCCTCG GCCTGCACGG TAAGAAAAGT 
GGAAAACCGC CATTACAGAA TAATGAGAAA GAAGGAAAGA AAGAGCGAGC TGTGGTGGAC 
AAAGTGTTTT TATCAAGGCT CTCACAGATC CTAAAAATTA TGGTCCCTAG AACATTTTGT 
AAAGAGACAG GGTACTTGAT ACTTATTGCT GTTATGCTGG TATCTCGAAC ATACTGTGAT 
GTTTGGATGA TTCAAAATGG CACACTGATT GAAAGTGGCA TCATTGGTCG TAGCAGTAAA 
GATTTCAAGA GATACTTATT CAACTTCATC GCTGCCATGC CTCTTATCTC TCTGGTTAAT 
AACTTCTTGA AGTATGGGTT AAATGAGCTC AAACTGTGCT TCCGTGTGCG GCTCACTAGA 
TACCTCTATG AGGAGTATCT CCAAGCCTTC ACCTACTATA AAATGGGCAA CCTGGATAAC 
AGAATAGCAA ACCCAGACCA GCTGCTTACA CAAGATGTAG AAAAGTTTTG TAACAGTGTA 
GTTGATCTTT ATTCGAATCT TAGTAAGCCA TTTTTAGACA TAGTTTTGTA TATTTTCAAG 
TTAACAAGTG CAATTGGAGC TCAGGGCCCG GCAAGCATGA TGGCCTACTT GCTTGTTTCT 
GGGCTATTCC TAACTCGACT CAGAAGACCC ATCGGTAAAA TGACGATTAT GGAGCAGAAG 
TATGAAGGAG AATATAGATT CGTTAATTCA CGGCTTATCA CTAATAGTGA AGAAATTGCC 
TTTTACAATG GGAATAAACG AGAAAAGCAG ACAATCCACT CTGTCTTCCG AAAACTGGTG 
GAACACCTAC ATAATTTCAT TTTCTTCCGG TTTTCTATGG GTTTCATTGA TAGCATCATT 
GCCAAATATA TTGCCACTGT AGTTGGGTAC CTGGTTGTCA GTCGCCCGTT CCTAGACCTG 
GCGCATCCGC GACACCTTCA CAGCACCCAC TCAGAGCTGC TGGAGGATTA CTACCAAAGT 
GGAAGAATGC TTTTGAGAAT GTCTCAAGCT TTGGGGCGGA TAGTTTTGGC TGGGCGTGAA 
ATGACTAGAT TGGCTGGTTT TACGGCTCGG ATTACGGAAT TAATGCAAGT ACTAAAGGAT 
TTAAATCATG GCAAATATGA ACGTACAATG GTGTCACAAC AGGATAAGGG TATTGAAGGA 
GCACAAGCTA GTCCCTTGAT ACCTGGTGCT GGAGAAATCA TCAATGCAGA CAACATTATA 
AAGTTTGATC ATGTTCCTTT AGCAACACCA AATGGAGATA TCTTGATCCA AGACCTTAGT 
TTTGAAGTTC GATCTGGGGC CAACGTTCTC ATTTGTGGTC CAAATGGCTG TGGAAAGAGC 
TCCCTCTTCC GTGTTCTTGG TGAATTATGG CCTCTCTTTG GAGGACATCT TACTAAACCT 
GAGAGAGGAA AGTTATTTTA TGTTCCTCAG CGACCCTATA TGACCCTGGG AACACTGAGA 
GACCAAGTAA TATATCCAGA TGGAAAGGAG GATCAGAAGA AGAAGGGGAT ATCTGACCAA 
GTGCTGAAGG GGTACTTGGA CAATGTACAG TTGGGCCATA TCCTTGAGCG GGAAGGAGGC 
TGGGACAGTG TTCAGGACTG GATGGATGTA CTCAGCGGAG GAGAAAAACA AAGAATGGCG 
ATGGCAAGAT TGTTTTATCA TAAACCCCAG TTTGCCATTC TGGATGAGTG CACAAGTGCA 
GTTAGTGTGG ATGTGGAAGA CTACATTTAC AGCCACTGTC GGAAGGTTGG CATCACCCTC 
TTCACTGTCT CACACAGGAA ATCCCTTTGG AAACACCACG AGTACTACCT GCACATGGAT 
GGCAGAGGCA ATTATGAATT CAAAAAGATC ACAGAAGACA CAGTTGAGTT CGGATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036936.1
CDS	36..2015
Translation	MAAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS

Target ORF information:

RefSeq Version	NM_012804.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily D member 3 (Abcd3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012804.1

ORF Insert Sequence:

ATGGCGGCCT TCAGCAAGTA CTTGACGGCG CGGAACTCCT CGCTGGCGGG GGCCGCGTTC 
CTGCTGTTCT GCCTGCTCCA CAAGCGGCGT CGCGCCCTCG GCCTGCACGG TAAGAAAAGT 
GGAAAACCGC CATTACAGAA TAATGAGAAA GAAGGAAAGA AAGAGCGAGC TGTGGTGGAC 
AAAGTGTTTT TATCAAGGCT CTCACAGATC CTAAAAATTA TGGTCCCTAG AACATTTTGT 
AAAGAGACAG GGTACTTGAT ACTTATTGCT GTTATGCTGG TATCTCGAAC ATACTGTGAT 
GTTTGGATGA TTCAAAATGG CACACTGATT GAAAGTGGCA TCATTGGTCG TAGCAGTAAA 
GATTTCAAGA GATACTTATT CAACTTCATC GCTGCCATGC CTCTTATCTC TCTGGTTAAT 
AACTTCTTGA AGTATGGGTT AAATGAGCTC AAACTGTGCT TCCGTGTGCG GCTCACTAGA 
TACCTCTATG AGGAGTATCT CCAAGCCTTC ACCTACTATA AAATGGGCAA CCTGGATAAC 
AGAATAGCAA ACCCAGACCA GCTGCTTACA CAAGATGTAG AAAAGTTTTG TAACAGTGTA 
GTTGATCTTT ATTCGAATCT TAGTAAGCCA TTTTTAGACA TAGTTTTGTA TATTTTCAAG 
TTAACAAGTG CAATTGGAGC TCAGGGCCCG GCAAGCATGA TGGCCTACTT GCTTGTTTCT 
GGGCTATTCC TAACTCGACT CAGAAGACCC ATCGGTAAAA TGACGATTAT GGAGCAGAAG 
TATGAAGGAG AATATAGATT CGTTAATTCA CGGCTTATCA CTAATAGTGA AGAAATTGCC 
TTTTACAATG GGAATAAACG AGAAAAGCAG ACAATCCACT CTGTCTTCCG AAAACTGGTG 
GAACACCTAC ATAATTTCAT TTTCTTCCGG TTTTCTATGG GTTTCATTGA TAGCATCATT 
GCCAAATATA TTGCCACTGT AGTTGGGTAC CTGGTTGTCA GTCGCCCGTT CCTAGACCTG 
GCGCATCCGC GACACCTTCA CAGCACCCAC TCAGAGCTGC TGGAGGATTA CTACCAAAGT 
GGAAGAATGC TTTTGAGAAT GTCTCAAGCT TTGGGGCGGA TAGTTTTGGC TGGGCGTGAA 
ATGACTAGAT TGGCTGGTTT TACGGCTCGG ATTACGGAAT TAATGCAAGT ACTAAAGGAT 
TTAAATCATG GCAAATATGA ACGTACAATG GTGTCACAAC AGGATAAGGG TATTGAAGGA 
GCACAAGCTA GTCCCTTGAT ACCTGGTGCT GGAGAAATCA TCAATGCAGA CAACATTATA 
AAGTTTGATC ATGTTCCTTT AGCAACACCA AATGGAGATA TCTTGATCCA AGACCTTAGT 
TTTGAAGTTC GATCTGGGGC CAACGTTCTC ATTTGTGGTC CAAATGGCTG TGGAAAGAGC 
TCCCTCTTCC GTGTTCTTGG TGAATTATGG CCTCTCTTTG GAGGACATCT TACTAAACCT 
GAGAGAGGAA AGTTATTTTA TGTTCCTCAG CGACCCTATA TGACCCTGGG AACACTGAGA 
GACCAAGTAA TATATCCAGA TGGAAAGGAG GATCAGAAGA AGAAGGGGAT ATCTGACCAA 
GTGCTGAAGG GGTACTTGGA CAATGTACAG TTGGGCCATA TCCTTGAGCG GGAAGGAGGC 
TGGGACAGTG TTCAGGACTG GATGGATGTA CTCAGCGGAG GAGAAAAACA AAGAATGGCG 
ATGGCAAGAT TGTTTTATCA TAAACCCCAG TTTGCCATTC TGGATGAGTG CACAAGTGCA 
GTTAGTGTGG ATGTGGAAGA CTACATTTAC AGCCACTGTC GGAAGGTTGG CATCACCCTC 
TTCACTGTCT CACACAGGAA ATCCCTTTGG AAACACCACG AGTACTACCT GCACATGGAT 
GGCAGAGGCA ATTATGAATT CAAAAAGATC ACAGAAGACA CAGTTGAGTT CGGATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3.
Human molecular genetics24(2)361-70(2015 Jan)
Ferdinandusse S,Jimenez-Sanchez G,Koster J,Denis S,Van Roermund CW,Silva-Zolezzi I,Moser AB,Visser WF,Gulluoglu M,Durmaz O,Demirkol M,Waterham HR,G?kcay G,Wanders RJ,Valle D

Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice.
Molecular biology of the cell22(10)1766-79(2011 May)
Kaczmarek K,Studencka M,Meinhardt A,Wieczerzak K,Thoms S,Engel W,Grzmil P

PEX14 is required for microtubule-based peroxisome motility in human cells.
Journal of cell science124(Pt 10)1759-68(2011 May)
Bharti P,Schliebs W,Schievelbusch T,Neuhaus A,David C,Kock K,Herrmann C,Meyer HE,Wiese S,Warscheid B,Theiss C,Erdmann R

Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP70.
Journal of biochemistry147(4)581-90(2010 Apr)
Iwashita S,Tsuchida M,Tsukuda M,Yamashita Y,Emi Y,Kida Y,Komori M,Kashiwayama Y,Imanaka T,Sakaguchi M

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

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Abcd3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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