Proc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Proc
Entrez Gene ID	25268
Full Name	protein C, inactivator of coagulation factors Va and VIIIa
General protein information	Preferred Names protein C, inactivator of coagulation factors Va and VIIIa Names vitamin K-dependent protein C anticoagulant protein C autoprothrombin IIA blood coagulation factor XIV protein C
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p12
Summary	vitamin K-dependent zymogen that acts as a serine protease upon activation; catalyzes the inactivation of blood coagulation cofactors Va and VIIIa [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008772018.2	XP_008770240.2	vitamin K-dependent protein C isoform X1
NM_012803.1	NP_036935.1	vitamin K-dependent protein C precursor
XM_006254526.2	XP_006254588.1	vitamin K-dependent protein C isoform X2
XM_006254527.2	XP_006254589.1	vitamin K-dependent protein C isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PROC	NP_000303.1
Xenopus tropicalis (tropical clawed frog)	proc	NP_001015759.1
Mus musculus (house mouse)	Proc	NP_032960.3
Rattus norvegicus (Norway rat)	Proc	NP_036935.1
Gallus gallus (chicken)	PROC	NP_989772.1
	PROC	XP_001087196.2
Pan troglodytes (chimpanzee)	PROC	XP_515775.3
Canis lupus familiaris (dog)	LOC476104	NP_001013871.1
Bos taurus (cattle)	PROC	NP_001159984.1
Danio rerio (zebrafish)	proca	NP_956650.1

Gene Ontology
Bibliography

Related articles in PubMed

Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial.
de Boer JD, Berger M, Majoor CJ, Kager LM, Meijers JC, Terpstra S, Nieuwland R, Boing AN, Lutter R, Wouters D, van Mierlo GJ, Zeerleder SS, Bel EH, van't Veer C, de Vos AF, van der Zee JS, van der Poll T
The European respiratory journal46(6)1636-44(2015 Dec)

Compound heterozygous protein C deficiency in a family with venous thrombosis: Identification and in vitro study of p.Asp297His and p.Val420Leu mutations.
Liu H, Wang HF, Tang L, Yang Y, Wang QY, Zeng W, Wu YY, Cheng ZP, Hu B, Guo T, Hu Y
Gene563(1)35-40(2015 May)

The effect of plasma-derived activated protein C on leukocyte cell-death and vascular endothelial damage.
Iba T, Nagakari K
Thrombosis research135(5)963-9(2015 May)

Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays.
Ding Q, Yang L, Dinarvand P, Wang X, Rezaie AR
Blood125(15)2428-34(2015 Apr)

Anti-protein C antibodies are associated with resistance to endogenous protein C activation and a severe thrombotic phenotype in antiphospholipid syndrome.
Arachchillage DR, Efthymiou M, Mackie IJ, Lawrie AS, Machin SJ, Cohen H
Journal of thrombosis and haemostasis : JTH12(11)1801-9(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Vascular endothelial damage in Lipopolysaccharide-induced sepsis model is attenuated by activated protein C.
Title: The effect of plasma-derived activated protein C on leukocyte cell-death and vascular endothelial damage.

mutated Protein C did not appear to alter the levels of NFkB or fibrinogen in our model of hemorrhagic shock and resuscitation.
Title: Effect of protein C gene mutation on coagulation and inflammation in hemorrhagic shock.

APC treatment significantly improves pial microcirculation by reducing leukocyte adhesion and increasing functional capillary density
Title: Activated protein C improves pial microcirculation in experimental endotoxemia in rats.

activated protein C induces the reduction of the nuclear level of NF-kappaB p65 in hippocampal neurons at glutamate-induced excitotoxicity via binding to EPCR and subsequent PAR-1 activation and signaling
Title: Activated protein C prevents glutamate- and thrombin-induced activation of nuclear factor-kappaB in cultured hippocampal neurons.

Xuebijing could upregulate EPCR and PAR1 mRNA and protein expression of rat aortic endothelial cells after LPS challenge.
Title: [Effect of Xuebijing injection on expression of endothelial protein C receptor and protease activated receptor 1 mRNA and protein in endothelial cells induced by lipopolysaccharide].

The following Proc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Proc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa38264	XM_006254527.2 Latest version!	Rattus norvegicus protein C (Proc), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa38264	XM_008772018.2 Latest version!	Rattus norvegicus protein C (Proc), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa00983	NM_012803.1 Latest version!	Rattus norvegicus protein C, inactivator of coagulation factors Va and VIIIa (Proc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00
ORa38263	XM_006254526.2 Latest version!	Rattus norvegicus protein C (Proc), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Proc ( XM_008772018.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008770240.2 Rattus norvegicus protein C (Proc), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38264
Clone ID Related Accession (Same CDS sequence)	XM_008772018.2 , XM_006254527.2
Accession Version	XM_008772018.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	vitamin K-dependent protein C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772018.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCAGT TCAGAATCTT CCTGCTGTTC GCGTCCACCT GGGGGATTTC TGGCGTATCA 
GCCCATCCCG ACCCAGTGTT CTCCAGCAGC GAGGGTGCCC ACCAGGTGCT TCGGGTCAGA 
CGAGCCAACA GCTTCCTGGA GGAGGTGCGG GCAGGCAGCC TGGAGCGGGA GTGTATGGAG 
GAGATCTGTG ACTTCGAGGA GGCCCAGGAG ATTTTCCAGA ATGTGGAAGA CACACTGGCC 
TTTTGGATCA AGTACTTCGA TGGTGACCAG TGCTCAACTC CGCCCTTGGA CCACCAATGC 
GACAGCCCAT GCTGCGGCCA TGGCACATGC ATCGACGGCC TGGGCGGCTT CAGCTGCAGC 
TGCGATAAGG GCTGGGAGGG CAGGTTCTGT CAGCAGGAGA TGGGCTTCCA GGACTGTCGG 
GTGAAAAATG GCGGCTGCTA CCACTACTGC CTGGAGGAGA CCAGAGGGCG GCGCTGCGCT 
TGCGCCCCGG GCTATGAGCT GGCAGATGAC CACATGCACT GCAGGCCCAC CGTGAATTTT 
CCGTGTGGGA AACTGTGGAA GCGGACTGAC AAGAAACGCA AGAACTTCAA ACGGGACATA 
GACCCAGAAG ACGAAGAACT AGAACTAGGT CCAAGGATAG TCAATGGAAC ACTAACAAAG 
CAGGGTGACA GTCCCTGGCA GGCGATCCTT CTGGACTCCA AGAAGAAGCT AGCCTGTGGA 
GGGGTGCTCA TCCACACCTC CTGGGTGCTG ACGGCAGCCC ACTGTCTGGA GAGCAGCAAG 
AAGCTTACCG TGAGGCTTGG TGAGTATGAT CTGAGACGCA GGGACCCCTG GGAGTTGGAC 
CTGGACATCA AGGAGGTCCT CGTCCACCCT AACTACACCC GGAGCAACAG CGACAACGAC 
ATCGCCCTGC TCCGCCTGTC CCAGCCAGCC ACACTCTCTA AAACCATAGT GCCCATCTGT 
CTGCCGAACA GCGGCCTGGC GCAGGAGCTC AGTCAGGCTG GCCAGGAGAC GGTGGTGACA 
GGCTGGGGCT ATCAAAGCGA CAAAGTCAAG GATGGCAGAA GGAACCGCAC CTTTATTCTC 
ACCTTCATCC GCATCCCTTT GGCCGCTCGA AATGACTGCA TGCAGGTCAT GAACAACGTG 
GTCTCGGAGA ACATGCTCTG CGCCGGCATC ATTGGAGACA CGAGAGACGC CTGCGACGGC 
GACAGTGGGG GACCTATGGT GGTCTTCTTT CGGGGTACCT GGTTTCTGGT GGGCCTGGTG 
AGCTGGGGTG AGGGCTGTGG GCACCTCAAC AACTATGGCG TCTACACCAA AGTGGGTAGC 
TACCTCAAAT GGATCCACAG CTACATAGGG GAAAGGGATG TTTCCCTGAA GAGCCCGAAG 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008770240.2
CDS	39..1424
Translation	MWQFRIFLLFASTWGISGVSAHPDPVFSSSEGAHQVLRVRRANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCACAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL

Target ORF information:

RefSeq Version	XM_008772018.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein C (Proc), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008772018.2

ORF Insert Sequence:

ATGTGGCAGT TCAGAATCTT CCTGCTGTTC GCGTCCACCT GGGGGATTTC TGGCGTATCA 
GCCCATCCCG ACCCAGTGTT CTCCAGCAGC GAGGGTGCCC ACCAGGTGCT TCGGGTCAGA 
CGAGCCAACA GCTTCCTGGA GGAGGTGCGG GCAGGCAGCC TGGAGCGGGA GTGTATGGAG 
GAGATCTGTG ACTTCGAGGA GGCCCAGGAG ATTTTCCAGA ATGTGGAAGA CACACTGGCC 
TTTTGGATCA AGTACTTCGA TGGTGACCAG TGCTCAACTC CGCCCTTGGA CCACCAATGC 
GACAGCCCAT GCTGCGGCCA TGGCACATGC ATCGACGGCC TGGGCGGCTT CAGCTGCAGC 
TGCGATAAGG GCTGGGAGGG CAGGTTCTGT CAGCAGGAGA TGGGCTTCCA GGACTGTCGG 
GTGAAAAATG GCGGCTGCTA CCACTACTGC CTGGAGGAGA CCAGAGGGCG GCGCTGCGCT 
TGCGCCCCGG GCTATGAGCT GGCAGATGAC CACATGCACT GCAGGCCCAC CGTGAATTTT 
CCGTGTGGGA AACTGTGGAA GCGGACTGAC AAGAAACGCA AGAACTTCAA ACGGGACATA 
GACCCAGAAG ACGAAGAACT AGAACTAGGT CCAAGGATAG TCAATGGAAC ACTAACAAAG 
CAGGGTGACA GTCCCTGGCA GGCGATCCTT CTGGACTCCA AGAAGAAGCT AGCCTGTGGA 
GGGGTGCTCA TCCACACCTC CTGGGTGCTG ACGGCAGCCC ACTGTCTGGA GAGCAGCAAG 
AAGCTTACCG TGAGGCTTGG TGAGTATGAT CTGAGACGCA GGGACCCCTG GGAGTTGGAC 
CTGGACATCA AGGAGGTCCT CGTCCACCCT AACTACACCC GGAGCAACAG CGACAACGAC 
ATCGCCCTGC TCCGCCTGTC CCAGCCAGCC ACACTCTCTA AAACCATAGT GCCCATCTGT 
CTGCCGAACA GCGGCCTGGC GCAGGAGCTC AGTCAGGCTG GCCAGGAGAC GGTGGTGACA 
GGCTGGGGCT ATCAAAGCGA CAAAGTCAAG GATGGCAGAA GGAACCGCAC CTTTATTCTC 
ACCTTCATCC GCATCCCTTT GGCCGCTCGA AATGACTGCA TGCAGGTCAT GAACAACGTG 
GTCTCGGAGA ACATGCTCTG CGCCGGCATC ATTGGAGACA CGAGAGACGC CTGCGACGGC 
GACAGTGGGG GACCTATGGT GGTCTTCTTT CGGGGTACCT GGTTTCTGGT GGGCCTGGTG 
AGCTGGGGTG AGGGCTGTGG GCACCTCAAC AACTATGGCG TCTACACCAA AGTGGGTAGC 
TACCTCAAAT GGATCCACAG CTACATAGGG GAAAGGGATG TTTCCCTGAA GAGCCCGAAG 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Proc ( XM_006254527.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254589.1 Rattus norvegicus protein C (Proc), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa38264
Clone ID Related Accession (Same CDS sequence)	XM_008772018.2 , XM_006254527.2
Accession Version	XM_006254527.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	vitamin K-dependent protein C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006254527.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCAGT TCAGAATCTT CCTGCTGTTC GCGTCCACCT GGGGGATTTC TGGCGTATCA 
GCCCATCCCG ACCCAGTGTT CTCCAGCAGC GAGGGTGCCC ACCAGGTGCT TCGGGTCAGA 
CGAGCCAACA GCTTCCTGGA GGAGGTGCGG GCAGGCAGCC TGGAGCGGGA GTGTATGGAG 
GAGATCTGTG ACTTCGAGGA GGCCCAGGAG ATTTTCCAGA ATGTGGAAGA CACACTGGCC 
TTTTGGATCA AGTACTTCGA TGGTGACCAG TGCTCAACTC CGCCCTTGGA CCACCAATGC 
GACAGCCCAT GCTGCGGCCA TGGCACATGC ATCGACGGCC TGGGCGGCTT CAGCTGCAGC 
TGCGATAAGG GCTGGGAGGG CAGGTTCTGT CAGCAGGAGA TGGGCTTCCA GGACTGTCGG 
GTGAAAAATG GCGGCTGCTA CCACTACTGC CTGGAGGAGA CCAGAGGGCG GCGCTGCGCT 
TGCGCCCCGG GCTATGAGCT GGCAGATGAC CACATGCACT GCAGGCCCAC CGTGAATTTT 
CCGTGTGGGA AACTGTGGAA GCGGACTGAC AAGAAACGCA AGAACTTCAA ACGGGACATA 
GACCCAGAAG ACGAAGAACT AGAACTAGGT CCAAGGATAG TCAATGGAAC ACTAACAAAG 
CAGGGTGACA GTCCCTGGCA GGCGATCCTT CTGGACTCCA AGAAGAAGCT AGCCTGTGGA 
GGGGTGCTCA TCCACACCTC CTGGGTGCTG ACGGCAGCCC ACTGTCTGGA GAGCAGCAAG 
AAGCTTACCG TGAGGCTTGG TGAGTATGAT CTGAGACGCA GGGACCCCTG GGAGTTGGAC 
CTGGACATCA AGGAGGTCCT CGTCCACCCT AACTACACCC GGAGCAACAG CGACAACGAC 
ATCGCCCTGC TCCGCCTGTC CCAGCCAGCC ACACTCTCTA AAACCATAGT GCCCATCTGT 
CTGCCGAACA GCGGCCTGGC GCAGGAGCTC AGTCAGGCTG GCCAGGAGAC GGTGGTGACA 
GGCTGGGGCT ATCAAAGCGA CAAAGTCAAG GATGGCAGAA GGAACCGCAC CTTTATTCTC 
ACCTTCATCC GCATCCCTTT GGCCGCTCGA AATGACTGCA TGCAGGTCAT GAACAACGTG 
GTCTCGGAGA ACATGCTCTG CGCCGGCATC ATTGGAGACA CGAGAGACGC CTGCGACGGC 
GACAGTGGGG GACCTATGGT GGTCTTCTTT CGGGGTACCT GGTTTCTGGT GGGCCTGGTG 
AGCTGGGGTG AGGGCTGTGG GCACCTCAAC AACTATGGCG TCTACACCAA AGTGGGTAGC 
TACCTCAAAT GGATCCACAG CTACATAGGG GAAAGGGATG TTTCCCTGAA GAGCCCGAAG 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254589.1
CDS	128..1513
Translation	MWQFRIFLLFASTWGISGVSAHPDPVFSSSEGAHQVLRVRRANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCACAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL

Target ORF information:

RefSeq Version	XM_006254527.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein C (Proc), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254527.2

ORF Insert Sequence:

ATGTGGCAGT TCAGAATCTT CCTGCTGTTC GCGTCCACCT GGGGGATTTC TGGCGTATCA 
GCCCATCCCG ACCCAGTGTT CTCCAGCAGC GAGGGTGCCC ACCAGGTGCT TCGGGTCAGA 
CGAGCCAACA GCTTCCTGGA GGAGGTGCGG GCAGGCAGCC TGGAGCGGGA GTGTATGGAG 
GAGATCTGTG ACTTCGAGGA GGCCCAGGAG ATTTTCCAGA ATGTGGAAGA CACACTGGCC 
TTTTGGATCA AGTACTTCGA TGGTGACCAG TGCTCAACTC CGCCCTTGGA CCACCAATGC 
GACAGCCCAT GCTGCGGCCA TGGCACATGC ATCGACGGCC TGGGCGGCTT CAGCTGCAGC 
TGCGATAAGG GCTGGGAGGG CAGGTTCTGT CAGCAGGAGA TGGGCTTCCA GGACTGTCGG 
GTGAAAAATG GCGGCTGCTA CCACTACTGC CTGGAGGAGA CCAGAGGGCG GCGCTGCGCT 
TGCGCCCCGG GCTATGAGCT GGCAGATGAC CACATGCACT GCAGGCCCAC CGTGAATTTT 
CCGTGTGGGA AACTGTGGAA GCGGACTGAC AAGAAACGCA AGAACTTCAA ACGGGACATA 
GACCCAGAAG ACGAAGAACT AGAACTAGGT CCAAGGATAG TCAATGGAAC ACTAACAAAG 
CAGGGTGACA GTCCCTGGCA GGCGATCCTT CTGGACTCCA AGAAGAAGCT AGCCTGTGGA 
GGGGTGCTCA TCCACACCTC CTGGGTGCTG ACGGCAGCCC ACTGTCTGGA GAGCAGCAAG 
AAGCTTACCG TGAGGCTTGG TGAGTATGAT CTGAGACGCA GGGACCCCTG GGAGTTGGAC 
CTGGACATCA AGGAGGTCCT CGTCCACCCT AACTACACCC GGAGCAACAG CGACAACGAC 
ATCGCCCTGC TCCGCCTGTC CCAGCCAGCC ACACTCTCTA AAACCATAGT GCCCATCTGT 
CTGCCGAACA GCGGCCTGGC GCAGGAGCTC AGTCAGGCTG GCCAGGAGAC GGTGGTGACA 
GGCTGGGGCT ATCAAAGCGA CAAAGTCAAG GATGGCAGAA GGAACCGCAC CTTTATTCTC 
ACCTTCATCC GCATCCCTTT GGCCGCTCGA AATGACTGCA TGCAGGTCAT GAACAACGTG 
GTCTCGGAGA ACATGCTCTG CGCCGGCATC ATTGGAGACA CGAGAGACGC CTGCGACGGC 
GACAGTGGGG GACCTATGGT GGTCTTCTTT CGGGGTACCT GGTTTCTGGT GGGCCTGGTG 
AGCTGGGGTG AGGGCTGTGG GCACCTCAAC AACTATGGCG TCTACACCAA AGTGGGTAGC 
TACCTCAAAT GGATCCACAG CTACATAGGG GAAAGGGATG TTTCCCTGAA GAGCCCGAAG 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Proc ( NM_012803.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036935.1 Rattus norvegicus protein C, inactivator of coagulation factors Va and VIIIa (Proc), mRNA.

Price & Availability↑

CloneID	ORa00983
Clone ID Related Accession (Same CDS sequence)	NM_012803.1
Accession Version	NM_012803.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	vitamin K-dependent protein C precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X64336.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X64336.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689597, SAMEA2689598 [ECO:0000350] ##Evidence-Data-END##

ATGTGGCAGT TCAGAATCTT CCTGCTGTTC GCGTCCACCT GGGGGATTTC TGGCGTATCA 
GCCCATCCCG ACCCAGTGTT CTCCAGCAGC GAGGGTGCCC ACCAGGTGCT TCGGGTCAGA 
CGAGCCAACA GCTTCCTGGA GGAGGTGCGG GCAGGCAGCC TGGAGCGGGA GTGTATGGAG 
GAGATCTGTG ACTTCGAGGA GGCCCAGGAG ATTTTCCAGA ATGTGGAAGA CACACTGGCC 
TTTTGGATCA AGTACTTCGA TGGTGACCAG TGCTCAACTC CGCCCTTGGA CCACCAATGC 
GACAGCCCAT GCTGCGGCCA TGGCACATGC ATCGACGGCC TGGGCGGCTT CAGCTGCAGC 
TGCGATAAGG GCTGGGAGGG CAGGTTCTGT CAGCAGGAGA TGGGCTTCCA GGACTGTCGG 
GTGAAAAATG GCGGCTGCTA CCACTACTGC CTGGAGGAGA CCAGAGGGCG GCGCTGCCGT 
TGCGCCCCGG GCTATGAGCT GGCAGATGAC CACATGCACT GCAGGCCCAC CGTGAATTTT 
CCGTGTGGGA AACTGTGGAA GCGGACTGAC AAGAAACGCA AGAACTTCAA ACGGGACATA 
GACCCAGAAG ACGAAGAACT AGAACTAGGT CCAAGGATAG TCAATGGAAC ACTAACAAAG 
CAGGGTGACA GTCCCTGGCA GGCGATCCTT CTGGACTCCA AGAAGAAGCT AGCCTGTGGA 
GGGGTGCTCA TCCACACCTC CTGGGTGCTG ACGGCAGCCC ACTGTCTGGA GAGCAGCAAG 
AAGCTTACCG TGAGGCTTGG TGAGTATGAT CTGAGACGCA GGGACCCCTG GGAGTTGGAC 
CTGGACATCA AGGAGGTCCT CGTCCACCCT AACTACACCC GGAGCAACAG CGACAACGAC 
ATCGCCCTGC TCCGCCTGTC CCAGCCAGCC ACACTCTCTA AAACCATAGT GCCCATCTGT 
CTGCCGAACA GCGGCCTGGC GCAGGAGCTC AGTCAGGCTG GCCAGGAGAC GGTGGTGACA 
GGCTGGGGCT ATCAAAGCGA CAAAGTCAAG GATGGCAGAA GGAACCGCAC CTTTATTCTC 
ACCTTCATCC GCATCCCTTT GGCCGCTCGA AATGACTGCA TGCAGGTCAT GAACAACGTG 
GTCTCGGAGA ACATGCTCTG CGCCGGCATC ATTGGAGACA CGAGAGACGC CTGCGACGGC 
GACAGTGGGG GACCTATGGT GGTCTTCTTT CGGGGTACCT GGTTTCTGGT GGGCCTGGTG 
AGCTGGGGTG AGGGCTGTGG GCACCTCAAC AACTATGGCG TCTACACCAA AGTGGGTAGC 
TACCTCAAAT GGATCCACAG CTACATAGGG GAAAGGGATG TTTCCCTGAA GAGCCCGAAG 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036935.1
CDS	49..1434
Translation	MWQFRIFLLFASTWGISGVSAHPDPVFSSSEGAHQVLRVRRANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCRCAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL

Target ORF information:

RefSeq Version	NM_012803.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein C, inactivator of coagulation factors Va and VIIIa (Proc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012803.1

ORF Insert Sequence:

ATGTGGCAGT TCAGAATCTT CCTGCTGTTC GCGTCCACCT GGGGGATTTC TGGCGTATCA 
GCCCATCCCG ACCCAGTGTT CTCCAGCAGC GAGGGTGCCC ACCAGGTGCT TCGGGTCAGA 
CGAGCCAACA GCTTCCTGGA GGAGGTGCGG GCAGGCAGCC TGGAGCGGGA GTGTATGGAG 
GAGATCTGTG ACTTCGAGGA GGCCCAGGAG ATTTTCCAGA ATGTGGAAGA CACACTGGCC 
TTTTGGATCA AGTACTTCGA TGGTGACCAG TGCTCAACTC CGCCCTTGGA CCACCAATGC 
GACAGCCCAT GCTGCGGCCA TGGCACATGC ATCGACGGCC TGGGCGGCTT CAGCTGCAGC 
TGCGATAAGG GCTGGGAGGG CAGGTTCTGT CAGCAGGAGA TGGGCTTCCA GGACTGTCGG 
GTGAAAAATG GCGGCTGCTA CCACTACTGC CTGGAGGAGA CCAGAGGGCG GCGCTGCCGT 
TGCGCCCCGG GCTATGAGCT GGCAGATGAC CACATGCACT GCAGGCCCAC CGTGAATTTT 
CCGTGTGGGA AACTGTGGAA GCGGACTGAC AAGAAACGCA AGAACTTCAA ACGGGACATA 
GACCCAGAAG ACGAAGAACT AGAACTAGGT CCAAGGATAG TCAATGGAAC ACTAACAAAG 
CAGGGTGACA GTCCCTGGCA GGCGATCCTT CTGGACTCCA AGAAGAAGCT AGCCTGTGGA 
GGGGTGCTCA TCCACACCTC CTGGGTGCTG ACGGCAGCCC ACTGTCTGGA GAGCAGCAAG 
AAGCTTACCG TGAGGCTTGG TGAGTATGAT CTGAGACGCA GGGACCCCTG GGAGTTGGAC 
CTGGACATCA AGGAGGTCCT CGTCCACCCT AACTACACCC GGAGCAACAG CGACAACGAC 
ATCGCCCTGC TCCGCCTGTC CCAGCCAGCC ACACTCTCTA AAACCATAGT GCCCATCTGT 
CTGCCGAACA GCGGCCTGGC GCAGGAGCTC AGTCAGGCTG GCCAGGAGAC GGTGGTGACA 
GGCTGGGGCT ATCAAAGCGA CAAAGTCAAG GATGGCAGAA GGAACCGCAC CTTTATTCTC 
ACCTTCATCC GCATCCCTTT GGCCGCTCGA AATGACTGCA TGCAGGTCAT GAACAACGTG 
GTCTCGGAGA ACATGCTCTG CGCCGGCATC ATTGGAGACA CGAGAGACGC CTGCGACGGC 
GACAGTGGGG GACCTATGGT GGTCTTCTTT CGGGGTACCT GGTTTCTGGT GGGCCTGGTG 
AGCTGGGGTG AGGGCTGTGG GCACCTCAAC AACTATGGCG TCTACACCAA AGTGGGTAGC 
TACCTCAAAT GGATCCACAG CTACATAGGG GAAAGGGATG TTTCCCTGAA GAGCCCGAAG 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Proc ( XM_006254526.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254588.1 Rattus norvegicus protein C (Proc), transcript variant X2, mRNA.

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CloneID	ORa38263
Clone ID Related Accession (Same CDS sequence)	XM_006254526.2
Accession Version	XM_006254526.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	vitamin K-dependent protein C isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006254526.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGTAC CTGGACGAAA TTGCAGTTTC TCCTTGGCCC ACCCCTGTGT CAGCAGCTCC 
AGGATGTGGC AGTTCAGAAT CTTCCTGCTG TTCGCGTCCA CCTGGGGGAT TTCTGGCGTA 
TCAGCCCATC CCGACCCAGT GTTCTCCAGC AGCGAGGGTG CCCACCAGGT GCTTCGGGTC 
AGACGAGCCA ACAGCTTCCT GGAGGAGGTG CGGGCAGGCA GCCTGGAGCG GGAGTGTATG 
GAGGAGATCT GTGACTTCGA GGAGGCCCAG GAGATTTTCC AGAATGTGGA AGACACACTG 
GCCTTTTGGA TCAAGTACTT CGATGGTGAC CAGTGCTCAA CTCCGCCCTT GGACCACCAA 
TGCGACAGCC CATGCTGCGG CCATGGCACA TGCATCGACG GCCTGGGCGG CTTCAGCTGC 
AGCTGCGATA AGGGCTGGGA GGGCAGGTTC TGTCAGCAGG AGATGGGCTT CCAGGACTGT 
CGGGTGAAAA ATGGCGGCTG CTACCACTAC TGCCTGGAGG AGACCAGAGG GCGGCGCTGC 
GCTTGCGCCC CGGGCTATGA GCTGGCAGAT GACCACATGC ACTGCAGGCC CACCGTGAAT 
TTTCCGTGTG GGAAACTGTG GAAGCGGACT GACAAGAAAC GCAAGAACTT CAAACGGGAC 
ATAGACCCAG AAGACGAAGA ACTAGAACTA GGTCCAAGGA TAGTCAATGG AACACTAACA 
AAGCAGGGTG ACAGTCCCTG GCAGGCGATC CTTCTGGACT CCAAGAAGAA GCTAGCCTGT 
GGAGGGGTGC TCATCCACAC CTCCTGGGTG CTGACGGCAG CCCACTGTCT GGAGAGCAGC 
AAGAAGCTTA CCGTGAGGCT TGGTGAGTAT GATCTGAGAC GCAGGGACCC CTGGGAGTTG 
GACCTGGACA TCAAGGAGGT CCTCGTCCAC CCTAACTACA CCCGGAGCAA CAGCGACAAC 
GACATCGCCC TGCTCCGCCT GTCCCAGCCA GCCACACTCT CTAAAACCAT AGTGCCCATC 
TGTCTGCCGA ACAGCGGCCT GGCGCAGGAG CTCAGTCAGG CTGGCCAGGA GACGGTGGTG 
ACAGGCTGGG GCTATCAAAG CGACAAAGTC AAGGATGGCA GAAGGAACCG CACCTTTATT 
CTCACCTTCA TCCGCATCCC TTTGGCCGCT CGAAATGACT GCATGCAGGT CATGAACAAC 
GTGGTCTCGG AGAACATGCT CTGCGCCGGC ATCATTGGAG ACACGAGAGA CGCCTGCGAC 
GGCGACAGTG GGGGACCTAT GGTGGTCTTC TTTCGGGGTA CCTGGTTTCT GGTGGGCCTG 
GTGAGCTGGG GTGAGGGCTG TGGGCACCTC AACAACTATG GCGTCTACAC CAAAGTGGGT 
AGCTACCTCA AATGGATCCA CAGCTACATA GGGGAAAGGG ATGTTTCCCT GAAGAGCCCG 
AAGCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254588.1
CDS	58..1506
Translation	MAVPGRNCSFSLAHPCVSSSRMWQFRIFLLFASTWGISGVSAHPDPVFSSSEGAHQVLRVRRANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCACAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL

Target ORF information:

RefSeq Version	XM_006254526.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein C (Proc), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254526.2

ORF Insert Sequence:

ATGGCGGTAC CTGGACGAAA TTGCAGTTTC TCCTTGGCCC ACCCCTGTGT CAGCAGCTCC 
AGGATGTGGC AGTTCAGAAT CTTCCTGCTG TTCGCGTCCA CCTGGGGGAT TTCTGGCGTA 
TCAGCCCATC CCGACCCAGT GTTCTCCAGC AGCGAGGGTG CCCACCAGGT GCTTCGGGTC 
AGACGAGCCA ACAGCTTCCT GGAGGAGGTG CGGGCAGGCA GCCTGGAGCG GGAGTGTATG 
GAGGAGATCT GTGACTTCGA GGAGGCCCAG GAGATTTTCC AGAATGTGGA AGACACACTG 
GCCTTTTGGA TCAAGTACTT CGATGGTGAC CAGTGCTCAA CTCCGCCCTT GGACCACCAA 
TGCGACAGCC CATGCTGCGG CCATGGCACA TGCATCGACG GCCTGGGCGG CTTCAGCTGC 
AGCTGCGATA AGGGCTGGGA GGGCAGGTTC TGTCAGCAGG AGATGGGCTT CCAGGACTGT 
CGGGTGAAAA ATGGCGGCTG CTACCACTAC TGCCTGGAGG AGACCAGAGG GCGGCGCTGC 
GCTTGCGCCC CGGGCTATGA GCTGGCAGAT GACCACATGC ACTGCAGGCC CACCGTGAAT 
TTTCCGTGTG GGAAACTGTG GAAGCGGACT GACAAGAAAC GCAAGAACTT CAAACGGGAC 
ATAGACCCAG AAGACGAAGA ACTAGAACTA GGTCCAAGGA TAGTCAATGG AACACTAACA 
AAGCAGGGTG ACAGTCCCTG GCAGGCGATC CTTCTGGACT CCAAGAAGAA GCTAGCCTGT 
GGAGGGGTGC TCATCCACAC CTCCTGGGTG CTGACGGCAG CCCACTGTCT GGAGAGCAGC 
AAGAAGCTTA CCGTGAGGCT TGGTGAGTAT GATCTGAGAC GCAGGGACCC CTGGGAGTTG 
GACCTGGACA TCAAGGAGGT CCTCGTCCAC CCTAACTACA CCCGGAGCAA CAGCGACAAC 
GACATCGCCC TGCTCCGCCT GTCCCAGCCA GCCACACTCT CTAAAACCAT AGTGCCCATC 
TGTCTGCCGA ACAGCGGCCT GGCGCAGGAG CTCAGTCAGG CTGGCCAGGA GACGGTGGTG 
ACAGGCTGGG GCTATCAAAG CGACAAAGTC AAGGATGGCA GAAGGAACCG CACCTTTATT 
CTCACCTTCA TCCGCATCCC TTTGGCCGCT CGAAATGACT GCATGCAGGT CATGAACAAC 
GTGGTCTCGG AGAACATGCT CTGCGCCGGC ATCATTGGAG ACACGAGAGA CGCCTGCGAC 
GGCGACAGTG GGGGACCTAT GGTGGTCTTC TTTCGGGGTA CCTGGTTTCT GGTGGGCCTG 
GTGAGCTGGG GTGAGGGCTG TGGGCACCTC AACAACTATG GCGTCTACAC CAAAGTGGGT 
AGCTACCTCA AATGGATCCA CAGCTACATA GGGGAAAGGG ATGTTTCCCT GAAGAGCCCG 
AAGCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial.
The European respiratory journal46(6)1636-44(2015 Dec)
de Boer JD,Berger M,Majoor CJ,Kager LM,Meijers JC,Terpstra S,Nieuwland R,Boing AN,Lutter R,Wouters D,van Mierlo GJ,Zeerleder SS,Bel EH,van't Veer C,de Vos AF,van der Zee JS,van der Poll T

Compound heterozygous protein C deficiency in a family with venous thrombosis: Identification and in vitro study of p.Asp297His and p.Val420Leu mutations.
Gene563(1)35-40(2015 May)
Liu H,Wang HF,Tang L,Yang Y,Wang QY,Zeng W,Wu YY,Cheng ZP,Hu B,Guo T,Hu Y

The effect of plasma-derived activated protein C on leukocyte cell-death and vascular endothelial damage.
Thrombosis research135(5)963-9(2015 May)
Iba T,Nagakari K

Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays.
Blood125(15)2428-34(2015 Apr)
Ding Q,Yang L,Dinarvand P,Wang X,Rezaie AR

Anti-protein C antibodies are associated with resistance to endogenous protein C activation and a severe thrombotic phenotype in antiphospholipid syndrome.
Journal of thrombosis and haemostasis : JTH12(11)1801-9(2014 Nov)
Arachchillage DR,Efthymiou M,Mackie IJ,Lawrie AS,Machin SJ,Cohen H

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Proc cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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