Nppb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nppb
Entrez Gene ID	25105
Full Name	natriuretic peptide B
Synonyms	BNP,Bnf
General protein information	Preferred Names natriuretic peptide B Names natriuretic peptides B Brain natriuretic factor brain natriuretic peptide gamma-brain natriuretic peptide iso-ANP natriuretic peptide precursor B natriuretic peptide precursor type B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	hormone produced primarily by the atrium and ventricle of the heart [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006239376.1	XP_006239438.1	natriuretic peptides B isoform X1
NM_031545.1	NP_113733.1	natriuretic peptides B precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nppb	NP_032752.1
Rattus norvegicus (Norway rat)	Nppb	NP_113733.1

Gene Ontology
Bibliography

Related articles in PubMed

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in?a?rat?model of polycystic kidney disease.
Holditch SJ, Schreiber CA, Harris PC, LaRusso NF, Ramirez-Alvarado M, Cataliotti A, Torres VE, Ikeda Y
Kidney international92(3)657-668(2017 Sep)

Cardioprotective effects of rutin via alteration in TNF-?, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats.
Saklani R, Gupta SK, Mohanty IR, Kumar B, Srivastava S, Mathur R
Molecular and cellular biochemistry420(1-2)65-72(2016 Sep)

Arterial Remodeling in B-Type Natriuretic Peptide Knock-Out Females.
Holditch SJ, Schreiber CA, Burnett JC, Ikeda Y
Scientific reports625623(2016 May)

[ATRIAL AND BRAIN NATRIURETIC PEPTIDES OF CARDIAC MUSCLE CELLS IN POSTREPERFUSION PERIOD IN RATS].
Bugrova ML
Tsitologiia58(2)129-34(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cardioprotective effects of rutin via alteration in TNF-alpha, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats.
Title: Cardioprotective effects of rutin via alteration in TNF-?, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats.

NT-proBNP and BNP are potential early biomarkers for 2-DG-induced cardiac toxicity that can be useful to monitor 2-DG therapy in clinical trials.
Title: 2-Deoxy-d-Glucose (2-DG)-Induced Cardiac Toxicity in Rat: NT-proBNP and BNP as Potential Early Cardiac Safety Biomarkers.

This is due to the fact that ANP is the main hormone of the natriuretic peptide system involved in the regulation of blood pressure in normal conditions, while BNP is the principal regulator of pressure in cardiovascular pathology
Title: [ATRIAL AND BRAIN NATRIURETIC PEPTIDES OF CARDIAC MUSCLE CELLS IN POSTREPERFUSION PERIOD IN RATS].

Despite preserved LV structure and function, treatment with GYY increased the levels of the natriuretic peptides ANP and BNP in association with enhanced cyclic GMP levels, paralleled by higher cGMP-dependent protein kinase type I (cGKI) protein levels
Title: GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia.

Serum NT-proBNP levels significantly increased after 5 hours of the blunt chest trauma.
Title: N-terminal pro-B-type natriuretic peptide as a marker of blunt cardiac contusion in trauma.

The following Nppb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nppb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13482	NM_031545.1 Latest version!	Rattus norvegicus natriuretic peptide B (Nppb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa28888	XM_006239376.1 Latest version!	Rattus norvegicus natriuretic peptide B (Nppb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nppb ( NM_031545.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113733.1 Rattus norvegicus natriuretic peptide B (Nppb), mRNA.

Price & Availability↑

CloneID	ORa13482
Clone ID Related Accession (Same CDS sequence)	NM_031545.1
Accession Version	NM_031545.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Rattus norvegicus(Norway rat)
Product	natriuretic peptides B precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M25297.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M25297.1, FQ228997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689600 [ECO:0000348] ##Evidence-Data-END##

ATGGATCTCC AGAAGGTGCT GCCCCAGATG ATTCTGCTCC TGCTTTTCCT TAATCTGTCG 
CCGCTGGGAG GTCACTCCCA TCCCCTGGGA AGTCCTAGCC AGTCTCCAGA ACAATCCACG 
ATGCAGAAGC TGCTGGAGCT GATAAGAGAA AAGTCAGAGG AAATGGCTCA GAGACAGCTC 
TCAAAGGACC AAGGCCCTAC AAAAGAACTT CTAAAAAGAG TCCTTAGGTC TCAAGACAGC 
GCCTTCCGGA TCCAGGAGAG ACTTCGAAAT TCCAAGATGG CACATAGTTC AAGCTGCTTT 
GGGCAGAAGA TAGACCGGAT CGGCGCAGTC AGTCGCTTGG GCTGTGACGG GCTGAGGTTG 
TTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113733.1
CDS	58..423
Translation	MDLQKVLPQMILLLLFLNLSPLGGHSHPLGSPSQSPEQSTMQKLLELIREKSEEMAQRQLSKDQGPTKELLKRVLRSQDSAFRIQERLRNSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF

Target ORF information:

RefSeq Version	NM_031545.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus natriuretic peptide B (Nppb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031545.1

ORF Insert Sequence:

ATGGATCTCC AGAAGGTGCT GCCCCAGATG ATTCTGCTCC TGCTTTTCCT TAATCTGTCG 
CCGCTGGGAG GTCACTCCCA TCCCCTGGGA AGTCCTAGCC AGTCTCCAGA ACAATCCACG 
ATGCAGAAGC TGCTGGAGCT GATAAGAGAA AAGTCAGAGG AAATGGCTCA GAGACAGCTC 
TCAAAGGACC AAGGCCCTAC AAAAGAACTT CTAAAAAGAG TCCTTAGGTC TCAAGACAGC 
GCCTTCCGGA TCCAGGAGAG ACTTCGAAAT TCCAAGATGG CACATAGTTC AAGCTGCTTT 
GGGCAGAAGA TAGACCGGAT CGGCGCAGTC AGTCGCTTGG GCTGTGACGG GCTGAGGTTG 
TTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nppb ( XM_006239376.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239438.1 Rattus norvegicus natriuretic peptide B (Nppb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa28888
Clone ID Related Accession (Same CDS sequence)	XM_006239376.1
Accession Version	XM_006239376.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	natriuretic peptides B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCTCC AGAAGGTGCT GCCCCAGATG ATTCTGCTCC TGCTTTTCCT TAATCTGTCG 
CCGCTGGGAG GTCACTCCCA TCCCCTGGGA AGTCCTAGCC AGTCTCCAGA ACAATCCACG 
ATGCAGCTGC TGGAGCTGAT AAGAGAAAAG TCAGAGGAAA TGGCTCAGAG ACAGCTCTCA 
AAGGACCAAG GCCCTACAAA AGAACTTCTA AAAAGAGTCC TTAGGTCTCA AGACAGCGCC 
TTCCGGATCC AGGAGAGACT TCGAAATTCC AAGATGGCAC ATAGTTCAAG CTGCTTTGGG 
CAGAAGATAG ACCGGATTGG CGCAGTCAGT CGTTTGGGCT GTGACGGGCT GAGGTTGTTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239438.1
CDS	111..473
Translation	MDLQKVLPQMILLLLFLNLSPLGGHSHPLGSPSQSPEQSTMQLLELIREKSEEMAQRQLSKDQGPTKELLKRVLRSQDSAFRIQERLRNSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF

Target ORF information:

RefSeq Version	XM_006239376.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus natriuretic peptide B (Nppb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239376.1

ORF Insert Sequence:

ATGGATCTCC AGAAGGTGCT GCCCCAGATG ATTCTGCTCC TGCTTTTCCT TAATCTGTCG 
CCGCTGGGAG GTCACTCCCA TCCCCTGGGA AGTCCTAGCC AGTCTCCAGA ACAATCCACG 
ATGCAGCTGC TGGAGCTGAT AAGAGAAAAG TCAGAGGAAA TGGCTCAGAG ACAGCTCTCA 
AAGGACCAAG GCCCTACAAA AGAACTTCTA AAAAGAGTCC TTAGGTCTCA AGACAGCGCC 
TTCCGGATCC AGGAGAGACT TCGAAATTCC AAGATGGCAC ATAGTTCAAG CTGCTTTGGG 
CAGAAGATAG ACCGGATTGG CGCAGTCAGT CGTTTGGGCT GTGACGGGCT GAGGTTGTTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in?a?rat?model of polycystic kidney disease.
Kidney international92(3)657-668(2017 Sep)
Holditch SJ,Schreiber CA,Harris PC,LaRusso NF,Ramirez-Alvarado M,Cataliotti A,Torres VE,Ikeda Y

Cardioprotective effects of rutin via alteration in TNF-?, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats.
Molecular and cellular biochemistry420(1-2)65-72(2016 Sep)
Saklani R,Gupta SK,Mohanty IR,Kumar B,Srivastava S,Mathur R

Arterial Remodeling in B-Type Natriuretic Peptide Knock-Out Females.
Scientific reports625623(2016 May)
Holditch SJ,Schreiber CA,Burnett JC,Ikeda Y

[ATRIAL AND BRAIN NATRIURETIC PEPTIDES OF CARDIAC MUSCLE CELLS IN POSTREPERFUSION PERIOD IN RATS].
Tsitologiia58(2)129-34(2016)
Bugrova ML

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Nppb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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