Kpnb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kpnb1
Entrez Gene ID	24917
Full Name	karyopherin subunit beta 1
Synonyms	Impnb
General protein information	Preferred Names karyopherin subunit beta 1 Names importin subunit beta-1 Importin beta PTAC97 karyopherin (importin) beta 1 karyopherin,beta 1 nuclear factor P97 pore targeting complex 97 kDa subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	subunit of complex necessary for nuclear import [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017063.1	NP_058759.1	importin subunit beta-1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KPNB1	XP_004950071.1
Caenorhabditis elegans (roundworm)	imb-1	NP_491477.2
Kluyveromyces lactis	KLLA0B05665g	XP_451788.1
Homo sapiens (human)	KPNB1	NP_002256.2
Bos taurus (cattle)	KPNB1	NP_001180082.1
Mus musculus (house mouse)	Kpnb1	NP_032405.3
Drosophila melanogaster (fruit fly)	Fs(2)Ket	NP_001246109.1
Neurospora crassa	NCU02011	XP_964876.1
Oryza sativa (rice)	Os12g0568800	NP_001067068.1
Saccharomyces cerevisiae (baker's yeast)	KAP95	NP_013451.1
Schizosaccharomyces pombe (fission yeast)	kap95	NP_594233.1
Pan troglodytes (chimpanzee)	KPNB1	XP_003315429.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009921	XP_319040.3
Arabidopsis thaliana (thale cress)	AT5G53480	NP_200160.1
Xenopus tropicalis (tropical clawed frog)	kpnb1	XP_002940197.1
	KPNB1	XP_001082833.2
Canis lupus familiaris (dog)	KPNB1	XP_005624657.1
Rattus norvegicus (Norway rat)	Kpnb1	NP_058759.1
Danio rerio (zebrafish)	kpnb1	NP_001032791.2
Eremothecium gossypii	AGOS_ACL187W	NP_983217.2
Magnaporthe oryzae (rice blast fungus)	MGG_03668	XP_003716218.1

Gene Ontology
Bibliography

Related articles in PubMed

AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization.
Mahboubi H, Koromilas AE, Stochaj U
Molecular pharmacology90(4)460-8(2016 Oct)

RanGTP and CLASP1 cooperate to position the mitotic spindle.
Bird SL, Heald R, Weis K
Molecular biology of the cell24(16)2506-14(2013 Aug)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-?1.
Di Paola S, Micaroni M, Di Tullio G, Buccione R, Di Girolamo M
PloS one7(6)e37352(2012)

Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin ?.
Ohara R, Hata K, Yasuhara N, Mehmood R, Yoneda Y, Nakagawa M, Yamashita T
Biochemical and biophysical research communications405(4)697-702(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Importin beta, which was locally translated after axotomy, was associated with the dynein-importin alpha complex and was required for axonogenesis.
Title: Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin ?.

In response to acute hyperosmotic challenge, NK3R associates with importin ss-1 which enables the nuclear transport of NK3R.
Title: Expression of the nuclear transport protein importin ?-1 and its association with the neurokinin 3 receptor in the rat hypothalamus following acute hyperosmotic challenge.

data show a differential regulation of imp beta 1 expression after acute and chronic seizure activity in the hippocampus
Title: Seizures increase importin-beta1 expression in NG2+ cells in the rat hippocampus.

PTH1R forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta, and nuclear PTH1R is associated with the nucleoplasm
Title: Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta.

The following Kpnb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kpnb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02666	NM_017063.1 Latest version!	Rattus norvegicus karyopherin subunit beta 1 (Kpnb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$517.30 $739.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kpnb1 ( NM_017063.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058759.1 Rattus norvegicus karyopherin subunit beta 1 (Kpnb1), mRNA.

Price & Availability↑

CloneID	ORa02666
Clone ID Related Accession (Same CDS sequence)	NM_017063.1
Accession Version	NM_017063.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	importin subunit beta-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L38644.1. On Jun 25, 2006 this sequence version replaced XM_001081365.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L38644.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCTCA TAACCATCCT CGAGAAGACC GTGTCTCCGG ATCGGCTGGA GCTGGAAGCG 
GCGCAGAAGT TCCTTGAGCG TGCGGCTGTG GAGAATCTGC CCACGTTCCT GGTGGAACTG 
TCCAGAGTGC TGGCAAATCC CGGAAACAGT CAGGTTGCCA GAGTTGCAGC TGGTCTACAA 
ATTAGACTCT TGACATCGAA GGATCCAGAT ATCAAGGCAC AGTACCAGCA GAGGTGGCTT 
GCTATTGATG CTAATGCTCG GCGGGAAGTC AAGAACTATG TTTTGCAGAC TTTGGGCACA 
GAGACTTACC GGCCTAGTTC AGCCTCACAG TGTGTGGCTG GTATCGCTTG TGCAGAGATC 
CCAGTAAGCC AGTGGCCGGA ACTAATTCCT CAGCTGGTAG CCAATGTCAC CAACCCCAAC 
AGCACGGAGC ACATGAAAGA GTCCACACTG GAAGCCATCG GTTACATTTG CCAAGATATA 
GACCCGGAGC AGCTGCAGGA TAAATCCAAT GAGATCCTGA CTGCCATAAT CCAGGGCATG 
CGGAAGGAAG AGCCTAGTAA CAATGTGAAG CTGGCCGCTA CCAACGCGCT CCTGAACTCA 
CTGGAGTTCA CCAAAGCAAA CTTCGACAAA GAGTCTGAAC GGCACTTTAT CATGCAAGTG 
GTCTGTGAAG CCACACAGTG TCCAGATACA AGGGTAAGAG TGGCTGCTTT ACAGAATCTA 
GTGAAGATAA TGTCCTTGTA TTACCAGTAC ATGGAGACAT ACATGGGCCC TGCCCTCTTT 
GCAATCACAA TTGAAGCAAT GAAAAGTGAC ATTGATGAGG TAGCTCTCCA AGGGATAGAG 
TTCTGGTCCA ATGTCTGTGA TGAGGAAATG GATTTGGCCA TTGAGGCTTC AGAGGCAGCA 
GAACAAGGAC GGCCCCCGGA GCACACCAGC AAATTTTACG CCAAGGGAGC GCTGCAGTAC 
CTGGTGCCCA TCCTCACACA GACACTAACT AAACAGGATG AAAACGATGA CGACGATGAC 
TGGAACCCTT GCAAAGCAGC TGGGGTGTGC CTCATGCTCC TGTCTACCTG CTGTGAAGAT 
GACATTGTGC CACATGTCCT TCCCTTTATT AAAGAGCACA TCAAGAACCC TGACTGGCGG 
TACCGGGATG CAGCAGTGAT GGCTTTTGGC AGCATCTTGG AAGGACCAGA GCCTAACCAG 
CTTAAACCAT TAGTCATACA GGCTATGCCC ACCCTGATAG AATTAATGAA AGACCCCAGT 
GTAGTTGTTC GAGATACAAC AGCATGGACT GTGGGCAGGA TCTGTGAGCT GCTGCCTGAA 
GCTGCCATCA ATGATGTCTA CTTGGCACCC CTTTTACAGT GTCTGATTGA GGGTCTCAGT 
GCTGAACCCA GAGTGGCTTC AAATGTGTGC TGGGCTTTTT CCAGTCTGGC TGAAGCTGCT 
TACGAAGCTG CAGATGTAGC TGATGATCAG GAAGAACCAG CCACCTATTG CTTGTCTTCT 
TCCTTTGAAC TTATAGTTCA GAAGCTGCTG GAGACCACCG ACAGACCTGA TGGACACCAG 
AACAACCTGA GAAGTTCTGC ATATGAATCT CTAATGGAAA TTGTAAAAAA CAGTGCCAAG 
GATTGTTACC CTGCGGTGCA GAAGACCACC CTGGTCATTA TGGAACGGTT GCAGCAGGTG 
CTTCAGATGG AGTCCCACAT CCAGAGCACG TCGGACAGGA TCCAATTCAA TGACCTCCAG 
TCTCTACTCT GTGCAACTCT TCAGAATGTT CTCTGGAAAG TGCAGCATCA AGATGCTTTG 
CAGATCTCTG ATGTGGTCAT GGCCTCCCTG TTAAGGATGT TCCAAAGCAC AGCTGGGTCT 
GGCGGAGTGC AAGAAGACGC CCTGATGGCA GTCAGCACAC TGGTGGAAGT GTTGGGTGGT 
GAATTCCTCA AGTACATGGA GGCCTTTAAA CCATTCCTGG GCATTGGATT GAAAAATTAT 
GCTGAATGCC AGGTGTGTTT GGCAGCTGTT GGCTTAGTTG GAGACTTGTG CCGAGCCCTG 
CAGTCTAACA TCTTACCTTT CTGTGATGAG GTGATGCAGC TGCTCCTAGA GAACTTAGGG 
AATGAGAATG TCCACAGGTC TGTGAAACCA CAGATTCTGT CTGTGTTTGG TGACATTACT 
CTTGCCATTG GTGGAGAATT TAAGAAATAC TTGGAGGTTG TACTGAATAC ACTGCAGCAG 
GCCTCCCAAG CCCAAGTGGA CAAGTCAGAC TTTGACATGG TGGATTATCT GAATGAGCTA 
AGAGAAAGCT GCTTGGAAGC TTATACGGGA ATCGTCCAGG GATTGAAGGG AGACCAGGAA 
AACGTACACC CTGATGTAAT GCTGGTGCAA CCCAGAGTAG AATTTATTTT GTCTTTTATT 
GATCACATTG CTGGAGATGA GGATCATACG GATGGAGTGG TAGCTTGTGC TGCTGGACTG 
ATAGGGGACT TGTGTACAGC ATTTGGAAAG GATGTACTGA AATTAGTAGA AGCTAGGCCA 
ATGATCCATG AACTATTAAC TGAAGGGCGG AGATCGAAGA CTAACAAAGC AAAGACCCTT 
GCTACGTGGG CAACAAAGGA ACTGAGGAAA CTGAAGAACC AAGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058759.1
CDS	102..2729
Translation	MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIRLLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVSQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLSTCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLWKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAECQVCLAAVGLVGDLCRALQSNILPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDITLAIGGEFKKYLEVVLNTLQQASQAQVDKSDFDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA

Target ORF information:

RefSeq Version	NM_017063.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus karyopherin subunit beta 1 (Kpnb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017063.1

ORF Insert Sequence:

ATGGAGCTCA TAACCATCCT CGAGAAGACC GTGTCTCCGG ATCGGCTGGA GCTGGAAGCG 
GCGCAGAAGT TCCTTGAGCG TGCGGCTGTG GAGAATCTGC CCACGTTCCT GGTGGAACTG 
TCCAGAGTGC TGGCAAATCC CGGAAACAGT CAGGTTGCCA GAGTTGCAGC TGGTCTACAA 
ATTAGACTCT TGACATCGAA GGATCCAGAT ATCAAGGCAC AGTACCAGCA GAGGTGGCTT 
GCTATTGATG CTAATGCTCG GCGGGAAGTC AAGAACTATG TTTTGCAGAC TTTGGGCACA 
GAGACTTACC GGCCTAGTTC AGCCTCACAG TGTGTGGCTG GTATCGCTTG TGCAGAGATC 
CCAGTAAGCC AGTGGCCGGA ACTAATTCCT CAGCTGGTAG CCAATGTCAC CAACCCCAAC 
AGCACGGAGC ACATGAAAGA GTCCACACTG GAAGCCATCG GTTACATTTG CCAAGATATA 
GACCCGGAGC AGCTGCAGGA TAAATCCAAT GAGATCCTGA CTGCCATAAT CCAGGGCATG 
CGGAAGGAAG AGCCTAGTAA CAATGTGAAG CTGGCCGCTA CCAACGCGCT CCTGAACTCA 
CTGGAGTTCA CCAAAGCAAA CTTCGACAAA GAGTCTGAAC GGCACTTTAT CATGCAAGTG 
GTCTGTGAAG CCACACAGTG TCCAGATACA AGGGTAAGAG TGGCTGCTTT ACAGAATCTA 
GTGAAGATAA TGTCCTTGTA TTACCAGTAC ATGGAGACAT ACATGGGCCC TGCCCTCTTT 
GCAATCACAA TTGAAGCAAT GAAAAGTGAC ATTGATGAGG TAGCTCTCCA AGGGATAGAG 
TTCTGGTCCA ATGTCTGTGA TGAGGAAATG GATTTGGCCA TTGAGGCTTC AGAGGCAGCA 
GAACAAGGAC GGCCCCCGGA GCACACCAGC AAATTTTACG CCAAGGGAGC GCTGCAGTAC 
CTGGTGCCCA TCCTCACACA GACACTAACT AAACAGGATG AAAACGATGA CGACGATGAC 
TGGAACCCTT GCAAAGCAGC TGGGGTGTGC CTCATGCTCC TGTCTACCTG CTGTGAAGAT 
GACATTGTGC CACATGTCCT TCCCTTTATT AAAGAGCACA TCAAGAACCC TGACTGGCGG 
TACCGGGATG CAGCAGTGAT GGCTTTTGGC AGCATCTTGG AAGGACCAGA GCCTAACCAG 
CTTAAACCAT TAGTCATACA GGCTATGCCC ACCCTGATAG AATTAATGAA AGACCCCAGT 
GTAGTTGTTC GAGATACAAC AGCATGGACT GTGGGCAGGA TCTGTGAGCT GCTGCCTGAA 
GCTGCCATCA ATGATGTCTA CTTGGCACCC CTTTTACAGT GTCTGATTGA GGGTCTCAGT 
GCTGAACCCA GAGTGGCTTC AAATGTGTGC TGGGCTTTTT CCAGTCTGGC TGAAGCTGCT 
TACGAAGCTG CAGATGTAGC TGATGATCAG GAAGAACCAG CCACCTATTG CTTGTCTTCT 
TCCTTTGAAC TTATAGTTCA GAAGCTGCTG GAGACCACCG ACAGACCTGA TGGACACCAG 
AACAACCTGA GAAGTTCTGC ATATGAATCT CTAATGGAAA TTGTAAAAAA CAGTGCCAAG 
GATTGTTACC CTGCGGTGCA GAAGACCACC CTGGTCATTA TGGAACGGTT GCAGCAGGTG 
CTTCAGATGG AGTCCCACAT CCAGAGCACG TCGGACAGGA TCCAATTCAA TGACCTCCAG 
TCTCTACTCT GTGCAACTCT TCAGAATGTT CTCTGGAAAG TGCAGCATCA AGATGCTTTG 
CAGATCTCTG ATGTGGTCAT GGCCTCCCTG TTAAGGATGT TCCAAAGCAC AGCTGGGTCT 
GGCGGAGTGC AAGAAGACGC CCTGATGGCA GTCAGCACAC TGGTGGAAGT GTTGGGTGGT 
GAATTCCTCA AGTACATGGA GGCCTTTAAA CCATTCCTGG GCATTGGATT GAAAAATTAT 
GCTGAATGCC AGGTGTGTTT GGCAGCTGTT GGCTTAGTTG GAGACTTGTG CCGAGCCCTG 
CAGTCTAACA TCTTACCTTT CTGTGATGAG GTGATGCAGC TGCTCCTAGA GAACTTAGGG 
AATGAGAATG TCCACAGGTC TGTGAAACCA CAGATTCTGT CTGTGTTTGG TGACATTACT 
CTTGCCATTG GTGGAGAATT TAAGAAATAC TTGGAGGTTG TACTGAATAC ACTGCAGCAG 
GCCTCCCAAG CCCAAGTGGA CAAGTCAGAC TTTGACATGG TGGATTATCT GAATGAGCTA 
AGAGAAAGCT GCTTGGAAGC TTATACGGGA ATCGTCCAGG GATTGAAGGG AGACCAGGAA 
AACGTACACC CTGATGTAAT GCTGGTGCAA CCCAGAGTAG AATTTATTTT GTCTTTTATT 
GATCACATTG CTGGAGATGA GGATCATACG GATGGAGTGG TAGCTTGTGC TGCTGGACTG 
ATAGGGGACT TGTGTACAGC ATTTGGAAAG GATGTACTGA AATTAGTAGA AGCTAGGCCA 
ATGATCCATG AACTATTAAC TGAAGGGCGG AGATCGAAGA CTAACAAAGC AAAGACCCTT 
GCTACGTGGG CAACAAAGGA ACTGAGGAAA CTGAAGAACC AAGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization.
Molecular pharmacology90(4)460-8(2016 Oct)
Mahboubi H,Koromilas AE,Stochaj U

RanGTP and CLASP1 cooperate to position the mitotic spindle.
Molecular biology of the cell24(16)2506-14(2013 Aug)
Bird SL,Heald R,Weis K

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-?1.
PloS one7(6)e37352(2012)
Di Paola S,Micaroni M,Di Tullio G,Buccione R,Di Girolamo M

Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin ?.
Biochemical and biophysical research communications405(4)697-702(2011 Feb)
Ohara R,Hata K,Yasuhara N,Mehmood R,Yoneda Y,Nakagawa M,Yamashita T

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Kpnb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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