Lox cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lox
Entrez Gene ID	24914
Full Name	lysyl oxidase
Synonyms	H-rev142,Rrg1
General protein information	Preferred Names lysyl oxidase Names protein-lysine 6-oxidase Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q11
Summary	enzyme involved in the catalysis of the reaction required for cross-linking of collagen and elastin fibers [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006254713.3	XP_006254775.1	protein-lysine 6-oxidase isoform X1
XM_006254715.3	XP_006254777.1	protein-lysine 6-oxidase isoform X2
XM_006254714.3	XP_006254776.1	protein-lysine 6-oxidase isoform X1
NM_017061.2	NP_058757.1	protein-lysine 6-oxidase precursor

Pathways from BioSystems

Homologies

	LOX	XP_001089079.1
Gallus gallus (chicken)	LOX	NP_990812.1
Xenopus tropicalis (tropical clawed frog)	lox	NP_001072611.1
Homo sapiens (human)	LOX	NP_002308.2
Pan troglodytes (chimpanzee)	LOX	XP_001153015.1
Rattus norvegicus (Norway rat)	Lox	NP_058757.1
Danio rerio (zebrafish)	lox	NP_996972.1
Bos taurus (cattle)	LOX	NP_776357.2
Canis lupus familiaris (dog)	LOX	XP_005626496.1
Mus musculus (house mouse)	Lox	NP_001273111.1

Gene Ontology
Bibliography

Related articles in PubMed

LOX-related collagen crosslink changes act as an initiator of bone fragility in a ZDF rats model.
Xiao X, Ren J, Chen J, Liu Z, Tian Y, Nabar NR, Wang M, Hao L
Biochemical and biophysical research communications495(1)821-827(2018 01)

Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism.
Gao L, Wu C, Fu F, You X, Ma X, Qin F, Li T, Wang R, Yuan J
Journal of cellular and molecular medicine(2017 Dec)

Targeting lysyl oxidase reduces peritoneal fibrosis.
Harlow CR, Wu X, van Deemter M, Gardiner F, Poland C, Green R, Sarvi S, Brown P, Kadler KE, Lu Y, Mason JI, Critchley HOD, Hillier SG
PloS one12(8)e0183013(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Together, these findings suggest that bone fragility in DM2 is initiated in the matrix phase and that the LOX family may play a critical part in the pathogenesis of DM2 mediated bone fragility.
Title: LOX-related collagen crosslink changes act as an initiator of bone fragility in a ZDF rats model.

The interaction of alpha2beta1 integrin to collagen I in the cellular microenvironment can regulate expression of LOX.
Title: Lysyl oxidase expression in cardiac fibroblasts is regulated by ?2?1 integrin interactions with the cellular microenvironment.

The reduction of leptin levels by BAPN in vivo and the ability of this compound to inhibit leptin-induced profibrotic mediators and ROS production in cardiac and vascular cells suggest that interactions between leptin and LOX regulate downstream events responsible for myocardial and vascular fibrosis in obesity.
Title: The lysyl oxidase inhibitor (?-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.

In transgenic mice expressing rat LOX in wild-type megakaryocytes and platelets, higher affinity of Pf4-Lox(tg/tg) platelets to the collagen sequence GFOGER implies that the collagen receptor integrin alpha2beta1 is affected by LOX.
Title: Lysyl oxidase is associated with increased thrombosis and platelet reactivity.

Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue
Title: Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer.

The following Lox gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lox cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13282	NM_017061.2 Latest version!	Rattus norvegicus lysyl oxidase (Lox), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
ORa13282	XM_006254713.3 Latest version!	Rattus norvegicus lysyl oxidase (Lox), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
ORa13282	XM_006254714.3 Latest version!	Rattus norvegicus lysyl oxidase (Lox), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
ORa38381	XM_006254715.3 Latest version!	Rattus norvegicus lysyl oxidase (Lox), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lox ( NM_017061.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058757.1 Rattus norvegicus lysyl oxidase (Lox), mRNA.

Price & Availability↑

CloneID	ORa13282
Clone ID Related Accession (Same CDS sequence)	XM_006254713.3 , XM_006254714.3 , NM_017061.2
Accession Version	NM_017061.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	protein-lysine 6-oxidase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078861.1. On Jun 10, 2007 this sequence version replaced NM_017061.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078861.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCGTTTCG CCTGGACCGT GCTCTTTCTG GGACAGCTGC AGTTCTGTCC CCTTCTCCGC 
TGCGCCCCGC AGGCCCCGCG CGAGCCTCCC GCCGCCCCCG GTGCCTGGCG CCAGACAATC 
CAATGGGAGA ACAACGGGCA GGTGTTCAGT CTGTTGAGCC TGGGGGCGCA GTACCAGCCT 
CAGCGACGCC GCGACTCCAG CGCCACTGCC CCGAGAGCCG ACGGCAACGC TGCAGCACAG 
CCACGCACGC CCATTCTGCT GCTGCGTGAC AACCGCACTG CCTCTGCCCG TGCGAGGACT 
CCAAGCCCAT CTGGGGTCGC CGCGGGTCGT CCCCGGCCCG CAGCCCGCCA CTGGTTCCAA 
GTTGGTTTCT CGCCGTCGGG GGCCGGCGAT GGAGCCTCAA GGCGCGCAGC GAACCGGACT 
GCGTCGCCAC AGCCTCCGCA GCTCAGTAAT CTGAGGCCAC CCAGCCACGT AGATCGCATG 
GTGGGCGACG ACCCCTACAA TCCCTACAAG TACTCCGACG ACAACCCCTA TTATAACTAC 
TATGACACTT ATGAGAGACC CCGGTCCGGG AGCAGGCACC GACCTGGATA TGGCACCGGT 
TACTTCCAGT ACGGTCTCCC GGACCTGGTA CCCGATCCCT ACTACATCCA GGCATCCACG 
TACGTACAAA AGATGTCTAT GTACAACCTG AGATGCGCTG CGGAAGAAAA CTGCCTGGCC 
AGTTCAGCAT ATAGGGCGGA TGTCAGAGAC TATGACCACA GGGTACTGCT ACGATTTCCT 
CAGAGAGTGA AAAACCAAGG GACGTCTGAC TTCTTACCAA GCCGCCCCCG CTACTCCTGG 
GAGTGGCACA GCTGCCACCA ACATTACCAC AGCATGGATG AATTCAGCCA CTACGACCTG 
CTGGATGCCA GCACACAGAG GAGAGTGGCC GAGGGCCACA AAGCAAGCTT CTGTCTGGAG 
GACACTTCCT GTGATTATGG GTACCACAGA CGATTTGCCT GTACTGCACA CACACAGGGG 
TTGAGTCCCG GATGTTATGA TACTTATGCA GCAGACATAG ACTGCCAGTG GATTGATATT 
ACAGATGTAC AACCCGGAAA TTACATTCTA AAGGTCAGTG TAAACCCCAG CTACCTGGTG 
CCTGAATCAG ACTACAGTAA CAATGTCGTA CGCTGTGAAA TTCGCTACAC AGGACATCAC 
GCCTATGCCT CAGGCTGCAC CATTTCACCG TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058757.1
CDS	319..1554
Translation	MRFAWTVLFLGQLQFCPLLRCAPQAPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDSSATAPRADGNAAAQPRTPILLLRDNRTASARARTPSPSGVAAGRPRPAARHWFQVGFSPSGAGDGASRRAANRTASPQPPQLSNLRPPSHVDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRSGSRHRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY

Target ORF information:

RefSeq Version	NM_017061.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysyl oxidase (Lox), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017061.2

ORF Insert Sequence:

ATGCGTTTCG CCTGGACCGT GCTCTTTCTG GGACAGCTGC AGTTCTGTCC CCTTCTCCGC 
TGCGCCCCGC AGGCCCCGCG CGAGCCTCCC GCCGCCCCCG GTGCCTGGCG CCAGACAATC 
CAATGGGAGA ACAACGGGCA GGTGTTCAGT CTGTTGAGCC TGGGGGCGCA GTACCAGCCT 
CAGCGACGCC GCGACTCCAG CGCCACTGCC CCGAGAGCCG ACGGCAACGC TGCAGCACAG 
CCACGCACGC CCATTCTGCT GCTGCGTGAC AACCGCACTG CCTCTGCCCG TGCGAGGACT 
CCAAGCCCAT CTGGGGTCGC CGCGGGTCGT CCCCGGCCCG CAGCCCGCCA CTGGTTCCAA 
GTTGGTTTCT CGCCGTCGGG GGCCGGCGAT GGAGCCTCAA GGCGCGCAGC GAACCGGACT 
GCGTCGCCAC AGCCTCCGCA GCTCAGTAAT CTGAGGCCAC CCAGCCACGT AGATCGCATG 
GTGGGCGACG ACCCCTACAA TCCCTACAAG TACTCCGACG ACAACCCCTA TTATAACTAC 
TATGACACTT ATGAGAGACC CCGGTCCGGG AGCAGGCACC GACCTGGATA TGGCACCGGT 
TACTTCCAGT ACGGTCTCCC GGACCTGGTA CCCGATCCCT ACTACATCCA GGCATCCACG 
TACGTACAAA AGATGTCTAT GTACAACCTG AGATGCGCTG CGGAAGAAAA CTGCCTGGCC 
AGTTCAGCAT ATAGGGCGGA TGTCAGAGAC TATGACCACA GGGTACTGCT ACGATTTCCT 
CAGAGAGTGA AAAACCAAGG GACGTCTGAC TTCTTACCAA GCCGCCCCCG CTACTCCTGG 
GAGTGGCACA GCTGCCACCA ACATTACCAC AGCATGGATG AATTCAGCCA CTACGACCTG 
CTGGATGCCA GCACACAGAG GAGAGTGGCC GAGGGCCACA AAGCAAGCTT CTGTCTGGAG 
GACACTTCCT GTGATTATGG GTACCACAGA CGATTTGCCT GTACTGCACA CACACAGGGG 
TTGAGTCCCG GATGTTATGA TACTTATGCA GCAGACATAG ACTGCCAGTG GATTGATATT 
ACAGATGTAC AACCCGGAAA TTACATTCTA AAGGTCAGTG TAAACCCCAG CTACCTGGTG 
CCTGAATCAG ACTACAGTAA CAATGTCGTA CGCTGTGAAA TTCGCTACAC AGGACATCAC 
GCCTATGCCT CAGGCTGCAC CATTTCACCG TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lox ( XM_006254713.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254775.1 Rattus norvegicus lysyl oxidase (Lox), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13282
Clone ID Related Accession (Same CDS sequence)	XM_006254713.3 , XM_006254714.3 , NM_017061.2
Accession Version	XM_006254713.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	protein-lysine 6-oxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254713.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGTTTCG CCTGGACCGT GCTCTTTCTG GGACAGCTGC AGTTCTGTCC CCTTCTCCGC 
TGCGCCCCGC AGGCCCCGCG CGAGCCTCCC GCCGCCCCCG GTGCCTGGCG CCAGACAATC 
CAATGGGAGA ACAACGGGCA GGTGTTCAGT CTGTTGAGCC TGGGGGCGCA GTACCAGCCT 
CAGCGACGCC GCGACTCCAG CGCCACTGCC CCGAGAGCCG ACGGCAACGC TGCAGCACAG 
CCACGCACGC CCATTCTGCT GCTGCGTGAC AACCGCACTG CCTCTGCCCG TGCGAGGACT 
CCAAGCCCAT CTGGGGTCGC CGCGGGTCGT CCCCGGCCCG CAGCCCGCCA CTGGTTCCAA 
GTTGGTTTCT CGCCGTCGGG GGCCGGCGAT GGAGCCTCAA GGCGCGCAGC GAACCGGACT 
GCGTCGCCAC AGCCTCCGCA GCTCAGTAAT CTGAGGCCAC CCAGCCACGT AGATCGCATG 
GTGGGCGACG ACCCCTACAA TCCCTACAAG TACTCCGACG ACAACCCCTA TTATAACTAC 
TATGACACTT ATGAGAGACC CCGGTCCGGG AGCAGGCACC GACCTGGATA TGGCACCGGT 
TACTTCCAGT ACGGTCTCCC GGACCTGGTA CCCGATCCCT ACTACATCCA GGCATCCACG 
TACGTACAAA AGATGTCTAT GTACAACCTG AGATGCGCTG CGGAAGAAAA CTGCCTGGCC 
AGTTCAGCAT ATAGGGCGGA TGTCAGAGAC TATGACCACA GGGTACTGCT ACGATTTCCT 
CAGAGAGTGA AAAACCAAGG GACGTCTGAC TTCTTACCAA GCCGCCCCCG CTACTCCTGG 
GAGTGGCACA GCTGCCACCA ACATTACCAC AGCATGGATG AATTCAGCCA CTACGACCTG 
CTGGATGCCA GCACACAGAG GAGAGTGGCC GAGGGCCACA AAGCAAGCTT CTGTCTGGAG 
GACACTTCCT GTGATTATGG GTACCACAGA CGATTTGCCT GTACTGCACA CACACAGGGG 
TTGAGTCCCG GATGTTATGA TACTTATGCA GCAGACATAG ACTGCCAGTG GATTGATATT 
ACAGATGTAC AACCCGGAAA TTACATTCTA AAGGTCAGTG TAAACCCCAG CTACCTGGTG 
CCTGAATCAG ACTACAGTAA CAATGTCGTA CGCTGTGAAA TTCGCTACAC AGGACATCAC 
GCCTATGCCT CAGGCTGCAC CATTTCACCG TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254775.1
CDS	399..1634
Translation	MRFAWTVLFLGQLQFCPLLRCAPQAPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDSSATAPRADGNAAAQPRTPILLLRDNRTASARARTPSPSGVAAGRPRPAARHWFQVGFSPSGAGDGASRRAANRTASPQPPQLSNLRPPSHVDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRSGSRHRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY

Target ORF information:

RefSeq Version	XM_006254713.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysyl oxidase (Lox), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254713.3

ORF Insert Sequence:

ATGCGTTTCG CCTGGACCGT GCTCTTTCTG GGACAGCTGC AGTTCTGTCC CCTTCTCCGC 
TGCGCCCCGC AGGCCCCGCG CGAGCCTCCC GCCGCCCCCG GTGCCTGGCG CCAGACAATC 
CAATGGGAGA ACAACGGGCA GGTGTTCAGT CTGTTGAGCC TGGGGGCGCA GTACCAGCCT 
CAGCGACGCC GCGACTCCAG CGCCACTGCC CCGAGAGCCG ACGGCAACGC TGCAGCACAG 
CCACGCACGC CCATTCTGCT GCTGCGTGAC AACCGCACTG CCTCTGCCCG TGCGAGGACT 
CCAAGCCCAT CTGGGGTCGC CGCGGGTCGT CCCCGGCCCG CAGCCCGCCA CTGGTTCCAA 
GTTGGTTTCT CGCCGTCGGG GGCCGGCGAT GGAGCCTCAA GGCGCGCAGC GAACCGGACT 
GCGTCGCCAC AGCCTCCGCA GCTCAGTAAT CTGAGGCCAC CCAGCCACGT AGATCGCATG 
GTGGGCGACG ACCCCTACAA TCCCTACAAG TACTCCGACG ACAACCCCTA TTATAACTAC 
TATGACACTT ATGAGAGACC CCGGTCCGGG AGCAGGCACC GACCTGGATA TGGCACCGGT 
TACTTCCAGT ACGGTCTCCC GGACCTGGTA CCCGATCCCT ACTACATCCA GGCATCCACG 
TACGTACAAA AGATGTCTAT GTACAACCTG AGATGCGCTG CGGAAGAAAA CTGCCTGGCC 
AGTTCAGCAT ATAGGGCGGA TGTCAGAGAC TATGACCACA GGGTACTGCT ACGATTTCCT 
CAGAGAGTGA AAAACCAAGG GACGTCTGAC TTCTTACCAA GCCGCCCCCG CTACTCCTGG 
GAGTGGCACA GCTGCCACCA ACATTACCAC AGCATGGATG AATTCAGCCA CTACGACCTG 
CTGGATGCCA GCACACAGAG GAGAGTGGCC GAGGGCCACA AAGCAAGCTT CTGTCTGGAG 
GACACTTCCT GTGATTATGG GTACCACAGA CGATTTGCCT GTACTGCACA CACACAGGGG 
TTGAGTCCCG GATGTTATGA TACTTATGCA GCAGACATAG ACTGCCAGTG GATTGATATT 
ACAGATGTAC AACCCGGAAA TTACATTCTA AAGGTCAGTG TAAACCCCAG CTACCTGGTG 
CCTGAATCAG ACTACAGTAA CAATGTCGTA CGCTGTGAAA TTCGCTACAC AGGACATCAC 
GCCTATGCCT CAGGCTGCAC CATTTCACCG TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lox ( XM_006254714.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254776.1 Rattus norvegicus lysyl oxidase (Lox), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa13282
Clone ID Related Accession (Same CDS sequence)	XM_006254713.3 , XM_006254714.3 , NM_017061.2
Accession Version	XM_006254714.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	protein-lysine 6-oxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254714.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGTTTCG CCTGGACCGT GCTCTTTCTG GGACAGCTGC AGTTCTGTCC CCTTCTCCGC 
TGCGCCCCGC AGGCCCCGCG CGAGCCTCCC GCCGCCCCCG GTGCCTGGCG CCAGACAATC 
CAATGGGAGA ACAACGGGCA GGTGTTCAGT CTGTTGAGCC TGGGGGCGCA GTACCAGCCT 
CAGCGACGCC GCGACTCCAG CGCCACTGCC CCGAGAGCCG ACGGCAACGC TGCAGCACAG 
CCACGCACGC CCATTCTGCT GCTGCGTGAC AACCGCACTG CCTCTGCCCG TGCGAGGACT 
CCAAGCCCAT CTGGGGTCGC CGCGGGTCGT CCCCGGCCCG CAGCCCGCCA CTGGTTCCAA 
GTTGGTTTCT CGCCGTCGGG GGCCGGCGAT GGAGCCTCAA GGCGCGCAGC GAACCGGACT 
GCGTCGCCAC AGCCTCCGCA GCTCAGTAAT CTGAGGCCAC CCAGCCACGT AGATCGCATG 
GTGGGCGACG ACCCCTACAA TCCCTACAAG TACTCCGACG ACAACCCCTA TTATAACTAC 
TATGACACTT ATGAGAGACC CCGGTCCGGG AGCAGGCACC GACCTGGATA TGGCACCGGT 
TACTTCCAGT ACGGTCTCCC GGACCTGGTA CCCGATCCCT ACTACATCCA GGCATCCACG 
TACGTACAAA AGATGTCTAT GTACAACCTG AGATGCGCTG CGGAAGAAAA CTGCCTGGCC 
AGTTCAGCAT ATAGGGCGGA TGTCAGAGAC TATGACCACA GGGTACTGCT ACGATTTCCT 
CAGAGAGTGA AAAACCAAGG GACGTCTGAC TTCTTACCAA GCCGCCCCCG CTACTCCTGG 
GAGTGGCACA GCTGCCACCA ACATTACCAC AGCATGGATG AATTCAGCCA CTACGACCTG 
CTGGATGCCA GCACACAGAG GAGAGTGGCC GAGGGCCACA AAGCAAGCTT CTGTCTGGAG 
GACACTTCCT GTGATTATGG GTACCACAGA CGATTTGCCT GTACTGCACA CACACAGGGG 
TTGAGTCCCG GATGTTATGA TACTTATGCA GCAGACATAG ACTGCCAGTG GATTGATATT 
ACAGATGTAC AACCCGGAAA TTACATTCTA AAGGTCAGTG TAAACCCCAG CTACCTGGTG 
CCTGAATCAG ACTACAGTAA CAATGTCGTA CGCTGTGAAA TTCGCTACAC AGGACATCAC 
GCCTATGCCT CAGGCTGCAC CATTTCACCG TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254776.1
CDS	345..1580
Translation	MRFAWTVLFLGQLQFCPLLRCAPQAPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDSSATAPRADGNAAAQPRTPILLLRDNRTASARARTPSPSGVAAGRPRPAARHWFQVGFSPSGAGDGASRRAANRTASPQPPQLSNLRPPSHVDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRSGSRHRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY

Target ORF information:

RefSeq Version	XM_006254714.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysyl oxidase (Lox), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254714.3

ORF Insert Sequence:

ATGCGTTTCG CCTGGACCGT GCTCTTTCTG GGACAGCTGC AGTTCTGTCC CCTTCTCCGC 
TGCGCCCCGC AGGCCCCGCG CGAGCCTCCC GCCGCCCCCG GTGCCTGGCG CCAGACAATC 
CAATGGGAGA ACAACGGGCA GGTGTTCAGT CTGTTGAGCC TGGGGGCGCA GTACCAGCCT 
CAGCGACGCC GCGACTCCAG CGCCACTGCC CCGAGAGCCG ACGGCAACGC TGCAGCACAG 
CCACGCACGC CCATTCTGCT GCTGCGTGAC AACCGCACTG CCTCTGCCCG TGCGAGGACT 
CCAAGCCCAT CTGGGGTCGC CGCGGGTCGT CCCCGGCCCG CAGCCCGCCA CTGGTTCCAA 
GTTGGTTTCT CGCCGTCGGG GGCCGGCGAT GGAGCCTCAA GGCGCGCAGC GAACCGGACT 
GCGTCGCCAC AGCCTCCGCA GCTCAGTAAT CTGAGGCCAC CCAGCCACGT AGATCGCATG 
GTGGGCGACG ACCCCTACAA TCCCTACAAG TACTCCGACG ACAACCCCTA TTATAACTAC 
TATGACACTT ATGAGAGACC CCGGTCCGGG AGCAGGCACC GACCTGGATA TGGCACCGGT 
TACTTCCAGT ACGGTCTCCC GGACCTGGTA CCCGATCCCT ACTACATCCA GGCATCCACG 
TACGTACAAA AGATGTCTAT GTACAACCTG AGATGCGCTG CGGAAGAAAA CTGCCTGGCC 
AGTTCAGCAT ATAGGGCGGA TGTCAGAGAC TATGACCACA GGGTACTGCT ACGATTTCCT 
CAGAGAGTGA AAAACCAAGG GACGTCTGAC TTCTTACCAA GCCGCCCCCG CTACTCCTGG 
GAGTGGCACA GCTGCCACCA ACATTACCAC AGCATGGATG AATTCAGCCA CTACGACCTG 
CTGGATGCCA GCACACAGAG GAGAGTGGCC GAGGGCCACA AAGCAAGCTT CTGTCTGGAG 
GACACTTCCT GTGATTATGG GTACCACAGA CGATTTGCCT GTACTGCACA CACACAGGGG 
TTGAGTCCCG GATGTTATGA TACTTATGCA GCAGACATAG ACTGCCAGTG GATTGATATT 
ACAGATGTAC AACCCGGAAA TTACATTCTA AAGGTCAGTG TAAACCCCAG CTACCTGGTG 
CCTGAATCAG ACTACAGTAA CAATGTCGTA CGCTGTGAAA TTCGCTACAC AGGACATCAC 
GCCTATGCCT CAGGCTGCAC CATTTCACCG TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lox ( XM_006254715.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254777.1 Rattus norvegicus lysyl oxidase (Lox), transcript variant X3, mRNA.

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CloneID	ORa38381
Clone ID Related Accession (Same CDS sequence)	XM_006254715.3
Accession Version	XM_006254715.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	protein-lysine 6-oxidase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254715.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGTTTCG CCTGGACCGT GCTCTTTCTG GGACAGCTGC AGTTCTGTCC CCTTCTCCGC 
TGCGCCCCGC AGGCCCCGCG CGAGCCTCCC GCCGCCCCCG GTGCCTGGCG CCAGACAATC 
CAATGGGAGA ACAACGGGCA GGTGTTCAGT CTGTTGAGCC TGGGGGCGCA GTACCAGCCT 
CAGCGACGCC GCGACTCCAG CGCCACTGCC CCGAGAGCCG ACGGCAACGC TGCAGCACAG 
CCACGCACGC CCATTCTGCT GCTGCGTGAC AACCGCACTG CCTCTGCCCG TGCGAGGACT 
CCAAGCCCAT CTGGGGTCGC CGCGGGTCGT CCCCGGCCCG CAGCCCGCCA CTGGTTCCAA 
GTTGGTTTCT CGCCGTCGGG GGCCGGCGAT GGAGCCTCAA GGCGCGCAGC GAACCGGACT 
GCGTCGCCAC AGCCTCCGCA GCTCAGTAAT CTGAGGCCAC CCAGCCACGT AGATCGCATG 
GTGGGCGACG ACCCCTACAA TCCCTACAAG TACTCCGACG ACAACCCCTA TTATAACTAC 
TATGACACTT ATGAGAGACC CCGGTCCGGG AGCAGGCACC GACCTGGATA TGGCACCGGT 
TACTTCCAGT ACGGTCTCCC GGACCTGGTA CCCGATCCCT ACTACATCCA GGCATCCACG 
TACGTACAAA AGATGTCTAT GTACAACCTG AGATGCGCTG CGGAAGAAAA CTGCCTGGCC 
AGTTCAGCAT ATAGGGCGGA TGTCAGAGAC TATGACCACA GGGTACTGCT ACGATTTCCT 
CAGAGAGTGA AAAACCAAGG GACGTCTGAC TTCTTACCAA GCCGCCCCCG CTACTCCTGG 
GAGTGGCACA GCTGCCACCA ACATTACCAC AGCATGGATG AATTCAGCCA CTACGACCTG 
CTGGATGCCA GCACACAGAG GAGAGTGGCC GAGGGCCACA AAGCAAGCTT CTGTCTGGAG 
GACACTTCCT GTGATTATGG GTACCACAGA CGATTTGCCT GTACTGCACA CACACAGGGG 
TTGAGTCCCG GATGTTATGA TACTTATGCA GCAGACATAG ACTGCCAGTG GATTGATATT 
ACAGATGTAC AACCCGGAAA TTACATTCTA AAGGTCAGTG TAAACCCCAG CTACCTGGTG 
CCTGAATCAG ACTACAGTAA CAATGTCGTA CGCTGTGAAA TTCGCTACAC AGGACATCAC 
GCCTATGCCT CAGGCTGCAC CATTTCACCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254777.1
CDS	400..1632
Translation	MRFAWTVLFLGQLQFCPLLRCAPQAPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDSSATAPRADGNAAAQPRTPILLLRDNRTASARARTPSPSGVAAGRPRPAARHWFQVGFSPSGAGDGASRRAANRTASPQPPQLSNLRPPSHVDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRSGSRHRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISP

Target ORF information:

RefSeq Version	XM_006254715.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysyl oxidase (Lox), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254715.3

ORF Insert Sequence:

ATGCGTTTCG CCTGGACCGT GCTCTTTCTG GGACAGCTGC AGTTCTGTCC CCTTCTCCGC 
TGCGCCCCGC AGGCCCCGCG CGAGCCTCCC GCCGCCCCCG GTGCCTGGCG CCAGACAATC 
CAATGGGAGA ACAACGGGCA GGTGTTCAGT CTGTTGAGCC TGGGGGCGCA GTACCAGCCT 
CAGCGACGCC GCGACTCCAG CGCCACTGCC CCGAGAGCCG ACGGCAACGC TGCAGCACAG 
CCACGCACGC CCATTCTGCT GCTGCGTGAC AACCGCACTG CCTCTGCCCG TGCGAGGACT 
CCAAGCCCAT CTGGGGTCGC CGCGGGTCGT CCCCGGCCCG CAGCCCGCCA CTGGTTCCAA 
GTTGGTTTCT CGCCGTCGGG GGCCGGCGAT GGAGCCTCAA GGCGCGCAGC GAACCGGACT 
GCGTCGCCAC AGCCTCCGCA GCTCAGTAAT CTGAGGCCAC CCAGCCACGT AGATCGCATG 
GTGGGCGACG ACCCCTACAA TCCCTACAAG TACTCCGACG ACAACCCCTA TTATAACTAC 
TATGACACTT ATGAGAGACC CCGGTCCGGG AGCAGGCACC GACCTGGATA TGGCACCGGT 
TACTTCCAGT ACGGTCTCCC GGACCTGGTA CCCGATCCCT ACTACATCCA GGCATCCACG 
TACGTACAAA AGATGTCTAT GTACAACCTG AGATGCGCTG CGGAAGAAAA CTGCCTGGCC 
AGTTCAGCAT ATAGGGCGGA TGTCAGAGAC TATGACCACA GGGTACTGCT ACGATTTCCT 
CAGAGAGTGA AAAACCAAGG GACGTCTGAC TTCTTACCAA GCCGCCCCCG CTACTCCTGG 
GAGTGGCACA GCTGCCACCA ACATTACCAC AGCATGGATG AATTCAGCCA CTACGACCTG 
CTGGATGCCA GCACACAGAG GAGAGTGGCC GAGGGCCACA AAGCAAGCTT CTGTCTGGAG 
GACACTTCCT GTGATTATGG GTACCACAGA CGATTTGCCT GTACTGCACA CACACAGGGG 
TTGAGTCCCG GATGTTATGA TACTTATGCA GCAGACATAG ACTGCCAGTG GATTGATATT 
ACAGATGTAC AACCCGGAAA TTACATTCTA AAGGTCAGTG TAAACCCCAG CTACCTGGTG 
CCTGAATCAG ACTACAGTAA CAATGTCGTA CGCTGTGAAA TTCGCTACAC AGGACATCAC 
GCCTATGCCT CAGGCTGCAC CATTTCACCG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LOX-related collagen crosslink changes act as an initiator of bone fragility in a ZDF rats model.
Biochemical and biophysical research communications495(1)821-827(2018 01)
Xiao X,Ren J,Chen J,Liu Z,Tian Y,Nabar NR,Wang M,Hao L

Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism.
Journal of cellular and molecular medicine(2017 Dec)
Gao L,Wu C,Fu F,You X,Ma X,Qin F,Li T,Wang R,Yuan J

Targeting lysyl oxidase reduces peritoneal fibrosis.
PloS one12(8)e0183013(2017)
Harlow CR,Wu X,van Deemter M,Gardiner F,Poland C,Green R,Sarvi S,Brown P,Kadler KE,Lu Y,Mason JI,Critchley HOD,Hillier SG

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Lox cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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