Slc6a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

G?? subunit activation promotes dopamine efflux through the dopamine transporter.
Garcia-Olivares J, Baust T, Harris S, Hamilton P, Galli A, Amara SG, Torres GE
Molecular psychiatry22(12)1673-1679(2017 Dec)

The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.
Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL
The Journal of biological chemistry292(27)11250-11261(2017 07)

Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression.
Li Y, Xia B, Li R, Yin D, Liang W
Medical science monitor : international medical journal of experimental and clinical research232805-2815(2017 Jun)

Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene.
Vengeliene V, Bespalov A, Ro?manith M, Horschitz S, Berger S, Relo AL, Noori HR, Schneider P, Enkel T, Bartsch D, Schneider M, Behl B, Hansson AC, Schloss P, Spanagel R
Disease models & mechanisms10(4)451-461(2017 04)

Together these results support the hypothesis that sigma1R agonists promote dissociation of sigma1R multimers into monomers, which then interact with DAT to stabilize an outward-facing DAT conformation and enhance cocaine binding.
Title: The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.

Adolescent male Sprague-Dawley rats were split into three groups at four weeks of age: control (water), low-dose methylphenidate (MP) and high-dose MP. Immediately following treatment, HD MP-treated rats had increased DAT and D1R-like binding in several subregions of the basal ganglia. There were no differences between treatment groups in any measure following abstinence.
Title: Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats.

a new genetic rat model with a loss-of-function point mutation in the dopamine transporter (DAT) gene (Slc6a3_N157K) was used to systematically study the research domain criteria matrix.
Title: Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene.

The present study suggested that amphetamine-induced circling behavior indicated striatal dopaminergic alterations and that dopamine transporter (DAT) and dopamine D2 receptor binding could be key markers for predicting motor dysfunction after mild focal ischemia.
Title: Longitudinal imaging of the availability of dopamine transporter and D2 receptor in rat striatum following mild ischemia.

Study compared showing a clear-cut profile of either gambling proneness or aversion, found a selective down-regulation of i) serotonin transporter in prefrontal cortex, ii) tyrosine hydroxylase in ventral striatum, iii) dopamine transporter in lymphocytes was evidenced in "gambler" vs "non-gambler" rats.
Title: Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms.