Fgd4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgd4
Entrez Gene ID	246174
Full Name	FYVE, RhoGEF and PH domain containing 4
General protein information	Preferred Names FYVE, RhoGEF and PH domain containing 4 Names FYVE, RhoGEF and PH domain-containing protein 4 FGD1-related F-actin-binding protein actin filament-binding protein frabin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q23
Summary	binds actin filaments; regulates changes in cell shape; involved in c-Jun N-terminal kinase activation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_139263.1	NP_640356.1	FYVE, RhoGEF and PH domain-containing protein 4

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	fgd4a	NP_001171404.1
Canis lupus familiaris (dog)	FGD4	XP_005637050.1
Mus musculus (house mouse)	Fgd4	NP_631978.1
Rattus norvegicus (Norway rat)	Fgd4	NP_640356.1
Pan troglodytes (chimpanzee)	FGD4	XP_520721.3
	FGD4	XP_001084734.1
Homo sapiens (human)	FGD4	NP_640334.2
Bos taurus (cattle)	FGD4	XP_005206941.1
Xenopus tropicalis (tropical clawed frog)	fgd4	XP_002942337.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.
Delague V, Jacquier A, Hamadouche T, Poitelon Y, Baudot C, Boccaccio I, Chouery E, Chaouch M, Kassouri N, Jabbour R, Grid D, M?garban? A, Haase G, L?vy N
American journal of human genetics81(1)1-16(2007 Jul)

Identification of splicing variants of Frabin with partly different functions and tissue distribution.
Ikeda W, Nakanishi H, Takekuni K, Itoh S, Takai Y
Biochemical and biophysical research communications286(5)1066-72(2001 Sep)

Association of frabin with the actin cytoskeleton is essential for microspike formation through activation of Cdc42 small G protein.
Umikawa M, Obaishi H, Nakanishi H, Satoh-Horikawa K, Takahashi K, Hotta I, Matsuura Y, Takai Y
The Journal of biological chemistry274(36)25197-200(1999 Sep)

Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase.
Obaishi H, Nakanishi H, Mandai K, Satoh K, Satoh A, Takahashi K, Miyahara M, Nishioka H, Takaishi K, Takai Y
The Journal of biological chemistry273(30)18697-700(1998 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fgd4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgd4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42472	NM_139263.1 Latest version!	Rattus norvegicus FYVE, RhoGEF and PH domain containing 4 (Fgd4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgd4 ( NM_139263.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_640356.1 Rattus norvegicus FYVE, RhoGEF and PH domain containing 4 (Fgd4), mRNA.

Price & Availability↑

CloneID	ORa42472
Clone ID Related Accession (Same CDS sequence)	NM_139263.1
Accession Version	NM_139263.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2301bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	FYVE, RhoGEF and PH domain-containing protein 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF038388.1. ##Evidence-Data-START## Transcript exon combination :: AF038388.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAGGAGT CTAATCCAGC CCCTACTTCA TGTGCCTCAA AAGGGAAACA TAGTAAGGTG 
TCGGATCTCA TCAGTCACTT TGAAGGAGGC AGTGTCCTGT CAAGTTACAC TGATGTGCAA 
AAAGATTCTA CTATGAACCT AAATATTCCT CAAACTCCAA GACAGCATGG GCTAACCTCC 
ACAACTCCAC AAAAGCTTCC ATCCCACAAG TCTCCACAGA AGCAGGAAAA GGATTCAGAT 
CAGAATCAGG GCCAACACGG TTGTTTGGCC AATGGTGTGG CGGCTGCACA AAGCCAGATG 
GAGTGTGAAA CCGAGAAGGA GGCTGCCCTT AGTCCAGAGA CAGACACTCA GACTGCTGCT 
GCCTCTCCTG ATGCACATGT GCTGAATGGA GTAAGAAACG AAACCACCAC AGATTCTGCA 
TCCTCTGTAA CCAACAGCCA TGATGAAAAC GCTTGTGACA GCAGCTGCAG GACTCAAGGG 
ACTGACTTAG GGCTTCCCTC AAAAGAAGGA GAGCCAGTGA TAGAAGCTGA ACTCCAGGAG 
AGGGAAAATG GACTGAGCAC CGAGGGACTG AATCCGCTGG ACCAGCACCA TGAAGTGAAG 
GAGACTAATG AGCAGAAACT TCACAAAATA GCCACAGAAC TTTTGCTTAC AGAAAGAGCT 
TATGTCAGCC GGCTCAACCT CCTAGATCAG GTATTTTATT GCAAACTATT AGAAGAAGCA 
AACCGAGGCT CATTTCCTGC AGAGATGGTG AATAAAATCT TTTCTAACAT TTCATCAATA 
AATGCCTTCC ATAGTAAATT CCTATTACCT GAGCTGGAGA AGCGAATGCA AGAATGGGAA 
ACTACACCCA GAATTGGAGA TATCCTGCAA AAGTTGGCAC CATTCCTTAA GATGTATGGA 
GAATACGTAA AGGGATTTGA TAATGCGGTG GAACTGGTTA AAAACATGAC AGAGCGTGTT 
CCCCAGTTTA AATCAGTGAC TGAAGAGATT CAGAAACAGA AGATCTGTGG AAGCTTAACC 
CTACAGCATC ACATGCTGGA GCCTATCCAG CGGATCCCTC GCTACGAGAT GCTCCTTAAG 
GACTACCTGA AGAAGCTGTC TCCTGACGCC CCAGACTGGA ATGATGCAAA GAAGTCACTT 
GAAATTATAT CTACAGCAGC AAGCCATTCT AATAGTGCAA TAAGAAAAAT GGAGAACCTG 
AAGAAACTTT TAGAAATTTA TGAGATGTTG GGAGAAGAAG AGGATATTGT AAATCCCTCA 
AATGAACTAA TAAAAGAAGG ACAAATCCTC AAACTAGCAG CTCGGAACAC ATCAGCACAA 
GAGCGCTACC TCTTCTTATT CAACAACATG TTGCTATATT GTGTGCCCAG ATTCAGTTTG 
GTGGGCTCAA AATTCACAGT TCGAACCAGG GTTGGCATTG ATGGAATGAA AATTGTGGAG 
ACTCACAATG AAGAGTATCC ACACACTTTC CAGGTGTCTG GGAAAGAAAG AACCCTGGAG 
CTGCAGGCCA GTTCTGAGCA AGACAAAGAA GAATGGATCA AGGCACTTCA AGAGAGTATT 
GATGCTTTTC ATCAAAGGCA TGAAACCTTC AGAAATGCAA TTGCAAAGGA AAATGACATT 
CCCCTAGAGG TTTCTACTGC TGAACTAGGA AAACGAGCCC CAAGATGGAT ACGTGATAAC 
GAAGTGACCA TGTGCATGAA GTGCAAAGAG TCTTTCAATG CACTGACCAG GAGGCGGCAT 
CACTGCCGGG CGTGTGGACA TGTGGTTTGT TGGAAATGTT CTGACTACAA AGCTCAACTT 
GAGTATGACG GTGGAAGGTT GAACAAGGTC TGTAAAGACT GCTACCAGAT AATGAGTGGA 
TTCGCAGAGA GTGAAGAAAA GAAAAGAAGG GGCATTTTAG AGATTGAATC AGCAGAAGTA 
TCAGGAAATA GTGAAGTATG CAGTTTTCTC CAGTACATGG AAAAGTCAAA ACCCTGGCAG 
AAAATATGGT GTGTGATCCC CAAGCAAGAC CCCCTTGTGC TGTACATGTA TGGCGCTCCT 
CAGGATGTCA GAGCCCAAGC AACCATACCC CTCCTGGGCT ACATTGTGGA TGACATGCCT 
AAGAGTGCAG ATCTGCCGCA CAGTTTCAAG CTGACCCAGT CCAAGTCTGT GCACAGTTTT 
GCTGCAGACA GTGAGGAACT GAAACAGAAG TGGCTGAAAA TTATCCTTCT GGCTGTCACG 
GGTGAGACAC CAGACGGCCC GAGTGAGCAT CTAGACACCT TAGACAACCT CCCTGGACCC 
AAGGAAAAGT CAGAATGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_640356.1
CDS	1276..3576
Translation	MEESNPAPTSCASKGKHSKVSDLISHFEGGSVLSSYTDVQKDSTMNLNIPQTPRQHGLTSTTPQKLPSHKSPQKQEKDSDQNQGQHGCLANGVAAAQSQMECETEKEAALSPETDTQTAAASPDAHVLNGVRNETTTDSASSVTNSHDENACDSSCRTQGTDLGLPSKEGEPVIEAELQERENGLSTEGLNPLDQHHEVKETNEQKLHKIATELLLTERAYVSRLNLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKNMTERVPQFKSVTEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDAPDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNEEYPHTFQVSGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVSTAELGKRAPRWIRDNEVTMCMKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIMSGFAESEEKKRRGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYIVDDMPKSADLPHSFKLTQSKSVHSFAADSEELKQKWLKIILLAVTGETPDGPSEHLDTLDNLPGPKEKSEC

Target ORF information:

RefSeq Version	NM_139263.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FYVE, RhoGEF and PH domain containing 4 (Fgd4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139263.1

ORF Insert Sequence:

ATGGAGGAGT CTAATCCAGC CCCTACTTCA TGTGCCTCAA AAGGGAAACA TAGTAAGGTG 
TCGGATCTCA TCAGTCACTT TGAAGGAGGC AGTGTCCTGT CAAGTTACAC TGATGTGCAA 
AAAGATTCTA CTATGAACCT AAATATTCCT CAAACTCCAA GACAGCATGG GCTAACCTCC 
ACAACTCCAC AAAAGCTTCC ATCCCACAAG TCTCCACAGA AGCAGGAAAA GGATTCAGAT 
CAGAATCAGG GCCAACACGG TTGTTTGGCC AATGGTGTGG CGGCTGCACA AAGCCAGATG 
GAGTGTGAAA CCGAGAAGGA GGCTGCCCTT AGTCCAGAGA CAGACACTCA GACTGCTGCT 
GCCTCTCCTG ATGCACATGT GCTGAATGGA GTAAGAAACG AAACCACCAC AGATTCTGCA 
TCCTCTGTAA CCAACAGCCA TGATGAAAAC GCTTGTGACA GCAGCTGCAG GACTCAAGGG 
ACTGACTTAG GGCTTCCCTC AAAAGAAGGA GAGCCAGTGA TAGAAGCTGA ACTCCAGGAG 
AGGGAAAATG GACTGAGCAC CGAGGGACTG AATCCGCTGG ACCAGCACCA TGAAGTGAAG 
GAGACTAATG AGCAGAAACT TCACAAAATA GCCACAGAAC TTTTGCTTAC AGAAAGAGCT 
TATGTCAGCC GGCTCAACCT CCTAGATCAG GTATTTTATT GCAAACTATT AGAAGAAGCA 
AACCGAGGCT CATTTCCTGC AGAGATGGTG AATAAAATCT TTTCTAACAT TTCATCAATA 
AATGCCTTCC ATAGTAAATT CCTATTACCT GAGCTGGAGA AGCGAATGCA AGAATGGGAA 
ACTACACCCA GAATTGGAGA TATCCTGCAA AAGTTGGCAC CATTCCTTAA GATGTATGGA 
GAATACGTAA AGGGATTTGA TAATGCGGTG GAACTGGTTA AAAACATGAC AGAGCGTGTT 
CCCCAGTTTA AATCAGTGAC TGAAGAGATT CAGAAACAGA AGATCTGTGG AAGCTTAACC 
CTACAGCATC ACATGCTGGA GCCTATCCAG CGGATCCCTC GCTACGAGAT GCTCCTTAAG 
GACTACCTGA AGAAGCTGTC TCCTGACGCC CCAGACTGGA ATGATGCAAA GAAGTCACTT 
GAAATTATAT CTACAGCAGC AAGCCATTCT AATAGTGCAA TAAGAAAAAT GGAGAACCTG 
AAGAAACTTT TAGAAATTTA TGAGATGTTG GGAGAAGAAG AGGATATTGT AAATCCCTCA 
AATGAACTAA TAAAAGAAGG ACAAATCCTC AAACTAGCAG CTCGGAACAC ATCAGCACAA 
GAGCGCTACC TCTTCTTATT CAACAACATG TTGCTATATT GTGTGCCCAG ATTCAGTTTG 
GTGGGCTCAA AATTCACAGT TCGAACCAGG GTTGGCATTG ATGGAATGAA AATTGTGGAG 
ACTCACAATG AAGAGTATCC ACACACTTTC CAGGTGTCTG GGAAAGAAAG AACCCTGGAG 
CTGCAGGCCA GTTCTGAGCA AGACAAAGAA GAATGGATCA AGGCACTTCA AGAGAGTATT 
GATGCTTTTC ATCAAAGGCA TGAAACCTTC AGAAATGCAA TTGCAAAGGA AAATGACATT 
CCCCTAGAGG TTTCTACTGC TGAACTAGGA AAACGAGCCC CAAGATGGAT ACGTGATAAC 
GAAGTGACCA TGTGCATGAA GTGCAAAGAG TCTTTCAATG CACTGACCAG GAGGCGGCAT 
CACTGCCGGG CGTGTGGACA TGTGGTTTGT TGGAAATGTT CTGACTACAA AGCTCAACTT 
GAGTATGACG GTGGAAGGTT GAACAAGGTC TGTAAAGACT GCTACCAGAT AATGAGTGGA 
TTCGCAGAGA GTGAAGAAAA GAAAAGAAGG GGCATTTTAG AGATTGAATC AGCAGAAGTA 
TCAGGAAATA GTGAAGTATG CAGTTTTCTC CAGTACATGG AAAAGTCAAA ACCCTGGCAG 
AAAATATGGT GTGTGATCCC CAAGCAAGAC CCCCTTGTGC TGTACATGTA TGGCGCTCCT 
CAGGATGTCA GAGCCCAAGC AACCATACCC CTCCTGGGCT ACATTGTGGA TGACATGCCT 
AAGAGTGCAG ATCTGCCGCA CAGTTTCAAG CTGACCCAGT CCAAGTCTGT GCACAGTTTT 
GCTGCAGACA GTGAGGAACT GAAACAGAAG TGGCTGAAAA TTATCCTTCT GGCTGTCACG 
GGTGAGACAC CAGACGGCCC GAGTGAGCAT CTAGACACCT TAGACAACCT CCCTGGACCC 
AAGGAAAAGT CAGAATGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.
American journal of human genetics81(1)1-16(2007 Jul)
Delague V,Jacquier A,Hamadouche T,Poitelon Y,Baudot C,Boccaccio I,Chouery E,Chaouch M,Kassouri N,Jabbour R,Grid D,M?garban? A,Haase G,L?vy N

Identification of splicing variants of Frabin with partly different functions and tissue distribution.
Biochemical and biophysical research communications286(5)1066-72(2001 Sep)
Ikeda W,Nakanishi H,Takekuni K,Itoh S,Takai Y

Association of frabin with the actin cytoskeleton is essential for microspike formation through activation of Cdc42 small G protein.
The Journal of biological chemistry274(36)25197-200(1999 Sep)
Umikawa M,Obaishi H,Nakanishi H,Satoh-Horikawa K,Takahashi K,Hotta I,Matsuura Y,Takai Y

Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase.
The Journal of biological chemistry273(30)18697-700(1998 Jul)
Obaishi H,Nakanishi H,Mandai K,Satoh K,Satoh A,Takahashi K,Miyahara M,Nishioka H,Takaishi K,Takai Y

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Fgd4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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