Scn3b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scn3b
Entrez Gene ID	245956
Full Name	sodium voltage-gated channel beta subunit 3
Synonyms	Scnb3
General protein information	Preferred Names sodium voltage-gated channel beta subunit 3 Names sodium channel subunit beta-3 sodium channel beta 3 subunit sodium channel, voltage-gated, type III, beta subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q22
Summary	voltage-sensitive sodium channel auxiliary subunit; modulates channel gating with distinct kinetics [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243103.2	XP_006243165.1	sodium channel subunit beta-3 isoform X1
XM_017595466.1	XP_017450955.1	sodium channel subunit beta-3 isoform X2
NM_139097.3	NP_620797.1	sodium channel subunit beta-3 precursor
XM_006243102.2	XP_006243164.1	sodium channel subunit beta-3 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Scn3b	NP_001077386.1
Danio rerio (zebrafish)	scn3b	NP_001074271.1
Homo sapiens (human)	SCN3B	NP_001035241.1
Pan troglodytes (chimpanzee)	SCN3B	XP_522210.3
Rattus norvegicus (Norway rat)	Scn3b	NP_620797.1
	SCN3B	XP_001104555.2
Canis lupus familiaris (dog)	SCN3B	XP_005619701.1
Gallus gallus (chicken)	SCN3B	XP_417884.4
Xenopus tropicalis (tropical clawed frog)	scn3b	NP_001011299.1
Bos taurus (cattle)	SCN3B	NP_001039960.1

Gene Ontology
Bibliography

Related articles in PubMed

Age-dependent alterations of voltage-gated Na(+) channel isoforms in rat sinoatrial node.
Huang X, Du Y, Yang P, Lin S, Xi Y, Yang Z, Ma A
Mechanisms of ageing and development15280-90(2015 Dec)

Mutations in sodium channel ?-subunit SCN3B are associated with early-onset lone atrial fibrillation.
Olesen MS, Jespersen T, Nielsen JB, Liang B, M?ller DV, Hedley P, Christiansen M, Varr? A, Olesen SP, Hauns? S, Schmitt N, Svendsen JH
Cardiovascular research89(4)786-93(2011 Mar)

The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions.
Cusdin FS, Nietlispach D, Maman J, Dale TJ, Powell AJ, Clare JJ, Jackson AP
The Journal of biological chemistry285(43)33404-12(2010 Oct)

Sudden infant death syndrome-associated mutations in the sodium channel beta subunits.
Tan BH, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A, Makielski JC, Ackerman MJ
Heart rhythm7(6)771-8(2010 Jun)

Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation.
Valdivia CR, Medeiros-Domingo A, Ye B, Shen WK, Algiers TJ, Ackerman MJ, Makielski JC
Cardiovascular research86(3)392-400(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the presences of Nav1.1, Nav1.6, Navbeta1 and Navbeta3 mRNA and their reduced levels in rat SAN during aging.
Title: Age-dependent alterations of voltage-gated Na(+) channel isoforms in rat sinoatrial node.

The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions.
Title: The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions.

that sodium channel Na(v)1.1, Na(v)1.3 and beta(1) subunit up-regulation at the mRNA and protein levels of SER hippocampus might contribute to the generation of epileptiform activity and underlie the observed seizure phenotype in SER.
Title: Voltage-gated sodium channel Nav1.1, Nav1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat.

The following Scn3b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scn3b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13717	NM_139097.3 Latest version!	Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa13717	XM_006243103.2 Latest version!	Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa13717	XM_006243102.2 Latest version!	Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa62314	XM_017595466.1 Latest version!	Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scn3b ( NM_139097.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620797.1 Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), mRNA.

Price & Availability↑

CloneID	ORa13717
Clone ID Related Accession (Same CDS sequence)	XM_006243103.2 , NM_139097.3 , XM_006243102.2
Accession Version	NM_139097.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	sodium channel subunit beta-3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070899.1. On May 24, 2004 this sequence version replaced NM_139097.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070899.1, AF378093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGCCT TCAACAGATT GCTTCCCCTA GCTTCTCTAG TGCTCATCTA CTGGGTCAGA 
GTCTGCTTCC CTGTGTGTGT GGAAGTACCC TCGGAGACAG AAGCGGTGCA GGGTAATCCC 
ATGAAGCTGA GGTGCATCTC CTGCATGAAG AGGGAGGAGG TGGAGGCCAC CACTGTGGTG 
GAGTGGTTCT ACAGGCCTGA GGGCGGTAAA GATTTCCTTA TATATGAGTA TCGGAATGGC 
CACCAGGAAG TGGAGAGCCC CTTCCAAGGC CGTCTGCAGT GGAATGGGAG CAAAGACCTG 
CAGGACGTAT CCATCACTGT ACTCAATGTC ACTTTGAATG ACTCTGGCCT CTACACATGC 
AATGTGTCCA GGGAGTTCGA ATTCGAGGCA CACAGGCCTT TTGTGAAGAC CACGAGACTG 
ATACCTTTGC GAGTCACTGA AGAGGCGGGA GAAGACTTCA CCTCCGTGGT CTCGGAAATC 
ATGATGTACA TCCTCCTGGT CTTCCTCACC TTGTGGCTGT TTATTGAGAT GATCTATTGC 
TACAGAAAGG TCTCTAAGGC CGAAGAGGCA GCACAGGAAA ATGCGTCTGA CTACCTTGCT 
ATCCCTTCAG AGAACAAGGA GAACTCTGTG GTACCTGTGG AGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620797.1
CDS	378..1025
Translation	MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE

Target ORF information:

RefSeq Version	NM_139097.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139097.3

ORF Insert Sequence:

ATGCCTGCCT TCAACAGATT GCTTCCCCTA GCTTCTCTAG TGCTCATCTA CTGGGTCAGA 
GTCTGCTTCC CTGTGTGTGT GGAAGTACCC TCGGAGACAG AAGCGGTGCA GGGTAATCCC 
ATGAAGCTGA GGTGCATCTC CTGCATGAAG AGGGAGGAGG TGGAGGCCAC CACTGTGGTG 
GAGTGGTTCT ACAGGCCTGA GGGCGGTAAA GATTTCCTTA TATATGAGTA TCGGAATGGC 
CACCAGGAAG TGGAGAGCCC CTTCCAAGGC CGTCTGCAGT GGAATGGGAG CAAAGACCTG 
CAGGACGTAT CCATCACTGT ACTCAATGTC ACTTTGAATG ACTCTGGCCT CTACACATGC 
AATGTGTCCA GGGAGTTCGA ATTCGAGGCA CACAGGCCTT TTGTGAAGAC CACGAGACTG 
ATACCTTTGC GAGTCACTGA AGAGGCGGGA GAAGACTTCA CCTCCGTGGT CTCGGAAATC 
ATGATGTACA TCCTCCTGGT CTTCCTCACC TTGTGGCTGT TTATTGAGAT GATCTATTGC 
TACAGAAAGG TCTCTAAGGC CGAAGAGGCA GCACAGGAAA ATGCGTCTGA CTACCTTGCT 
ATCCCTTCAG AGAACAAGGA GAACTCTGTG GTACCTGTGG AGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scn3b ( XM_006243103.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243165.1 Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa13717
Clone ID Related Accession (Same CDS sequence)	XM_006243103.2 , NM_139097.3 , XM_006243102.2
Accession Version	XM_006243103.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	sodium channel subunit beta-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243103.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTGCCT TCAACAGATT GCTTCCCCTA GCTTCTCTAG TGCTCATCTA CTGGGTCAGA 
GTCTGCTTCC CTGTGTGTGT GGAAGTACCC TCGGAGACAG AAGCGGTGCA GGGTAATCCC 
ATGAAGCTGA GGTGCATCTC CTGCATGAAG AGGGAGGAGG TGGAGGCCAC CACTGTGGTG 
GAGTGGTTCT ACAGGCCTGA GGGCGGTAAA GATTTCCTTA TATATGAGTA TCGGAATGGC 
CACCAGGAAG TGGAGAGCCC CTTCCAAGGC CGTCTGCAGT GGAATGGGAG CAAAGACCTG 
CAGGACGTAT CCATCACTGT ACTCAATGTC ACTTTGAATG ACTCTGGCCT CTACACATGC 
AATGTGTCCA GGGAGTTCGA ATTCGAGGCA CACAGGCCTT TTGTGAAGAC CACGAGACTG 
ATACCTTTGC GAGTCACTGA AGAGGCGGGA GAAGACTTCA CCTCCGTGGT CTCGGAAATC 
ATGATGTACA TCCTCCTGGT CTTCCTCACC TTGTGGCTGT TTATTGAGAT GATCTATTGC 
TACAGAAAGG TCTCTAAGGC CGAAGAGGCA GCACAGGAAA ATGCGTCTGA CTACCTTGCT 
ATCCCTTCAG AGAACAAGGA GAACTCTGTG GTACCTGTGG AGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243165.1
CDS	461..1108
Translation	MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE

Target ORF information:

RefSeq Version	XM_006243103.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243103.2

ORF Insert Sequence:

ATGCCTGCCT TCAACAGATT GCTTCCCCTA GCTTCTCTAG TGCTCATCTA CTGGGTCAGA 
GTCTGCTTCC CTGTGTGTGT GGAAGTACCC TCGGAGACAG AAGCGGTGCA GGGTAATCCC 
ATGAAGCTGA GGTGCATCTC CTGCATGAAG AGGGAGGAGG TGGAGGCCAC CACTGTGGTG 
GAGTGGTTCT ACAGGCCTGA GGGCGGTAAA GATTTCCTTA TATATGAGTA TCGGAATGGC 
CACCAGGAAG TGGAGAGCCC CTTCCAAGGC CGTCTGCAGT GGAATGGGAG CAAAGACCTG 
CAGGACGTAT CCATCACTGT ACTCAATGTC ACTTTGAATG ACTCTGGCCT CTACACATGC 
AATGTGTCCA GGGAGTTCGA ATTCGAGGCA CACAGGCCTT TTGTGAAGAC CACGAGACTG 
ATACCTTTGC GAGTCACTGA AGAGGCGGGA GAAGACTTCA CCTCCGTGGT CTCGGAAATC 
ATGATGTACA TCCTCCTGGT CTTCCTCACC TTGTGGCTGT TTATTGAGAT GATCTATTGC 
TACAGAAAGG TCTCTAAGGC CGAAGAGGCA GCACAGGAAA ATGCGTCTGA CTACCTTGCT 
ATCCCTTCAG AGAACAAGGA GAACTCTGTG GTACCTGTGG AGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scn3b ( XM_006243102.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243164.1 Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13717
Clone ID Related Accession (Same CDS sequence)	XM_006243103.2 , NM_139097.3 , XM_006243102.2
Accession Version	XM_006243102.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	sodium channel subunit beta-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243102.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTGCCT TCAACAGATT GCTTCCCCTA GCTTCTCTAG TGCTCATCTA CTGGGTCAGA 
GTCTGCTTCC CTGTGTGTGT GGAAGTACCC TCGGAGACAG AAGCGGTGCA GGGTAATCCC 
ATGAAGCTGA GGTGCATCTC CTGCATGAAG AGGGAGGAGG TGGAGGCCAC CACTGTGGTG 
GAGTGGTTCT ACAGGCCTGA GGGCGGTAAA GATTTCCTTA TATATGAGTA TCGGAATGGC 
CACCAGGAAG TGGAGAGCCC CTTCCAAGGC CGTCTGCAGT GGAATGGGAG CAAAGACCTG 
CAGGACGTAT CCATCACTGT ACTCAATGTC ACTTTGAATG ACTCTGGCCT CTACACATGC 
AATGTGTCCA GGGAGTTCGA ATTCGAGGCA CACAGGCCTT TTGTGAAGAC CACGAGACTG 
ATACCTTTGC GAGTCACTGA AGAGGCGGGA GAAGACTTCA CCTCCGTGGT CTCGGAAATC 
ATGATGTACA TCCTCCTGGT CTTCCTCACC TTGTGGCTGT TTATTGAGAT GATCTATTGC 
TACAGAAAGG TCTCTAAGGC CGAAGAGGCA GCACAGGAAA ATGCGTCTGA CTACCTTGCT 
ATCCCTTCAG AGAACAAGGA GAACTCTGTG GTACCTGTGG AGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243164.1
CDS	461..1108
Translation	MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE

Target ORF information:

RefSeq Version	XM_006243102.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243102.2

ORF Insert Sequence:

ATGCCTGCCT TCAACAGATT GCTTCCCCTA GCTTCTCTAG TGCTCATCTA CTGGGTCAGA 
GTCTGCTTCC CTGTGTGTGT GGAAGTACCC TCGGAGACAG AAGCGGTGCA GGGTAATCCC 
ATGAAGCTGA GGTGCATCTC CTGCATGAAG AGGGAGGAGG TGGAGGCCAC CACTGTGGTG 
GAGTGGTTCT ACAGGCCTGA GGGCGGTAAA GATTTCCTTA TATATGAGTA TCGGAATGGC 
CACCAGGAAG TGGAGAGCCC CTTCCAAGGC CGTCTGCAGT GGAATGGGAG CAAAGACCTG 
CAGGACGTAT CCATCACTGT ACTCAATGTC ACTTTGAATG ACTCTGGCCT CTACACATGC 
AATGTGTCCA GGGAGTTCGA ATTCGAGGCA CACAGGCCTT TTGTGAAGAC CACGAGACTG 
ATACCTTTGC GAGTCACTGA AGAGGCGGGA GAAGACTTCA CCTCCGTGGT CTCGGAAATC 
ATGATGTACA TCCTCCTGGT CTTCCTCACC TTGTGGCTGT TTATTGAGAT GATCTATTGC 
TACAGAAAGG TCTCTAAGGC CGAAGAGGCA GCACAGGAAA ATGCGTCTGA CTACCTTGCT 
ATCCCTTCAG AGAACAAGGA GAACTCTGTG GTACCTGTGG AGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scn3b ( XM_017595466.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017450955.1 Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa62314
Clone ID Related Accession (Same CDS sequence)	XM_017595466.1
Accession Version	XM_017595466.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	sodium channel subunit beta-3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTGA GGTGCATCTC CTGCATGAAG AGGGAGGAGG TGGAGGCCAC CACTGTGGTG 
GAGTGGTTCT ACAGGCCTGA GGGCGGTAAA GATTTCCTTA TATATGAGTA TCGGAATGGC 
CACCAGGAAG TGGAGAGCCC CTTCCAAGGC CGTCTGCAGT GGAATGGGAG CAAAGACCTG 
CAGGACGTAT CCATCACTGT ACTCAATGTC ACTTTGAATG ACTCTGGCCT CTACACATGC 
AATGTGTCCA GGGAGTTCGA ATTCGAGGCA CACAGGCCTT TTGTGAAGAC CACGAGACTG 
ATACCTTTGC GAGTCACTGA AGAGGCGGGA GAAGACTTCA CCTCCGTGGT CTCGGAAATC 
ATGATGTACA TCCTCCTGGT CTTCCTCACC TTGTGGCTGT TTATTGAGAT GATCTATTGC 
TACAGAAAGG TCTCTAAGGC CGAAGAGGCA GCACAGGAAA ATGCGTCTGA CTACCTTGCT 
ATCCCTTCAG AGAACAAGGA GAACTCTGTG GTACCTGTGG AGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017450955.1
CDS	683..1210
Translation	MKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE

Target ORF information:

RefSeq Version	XM_017595466.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sodium voltage-gated channel beta subunit 3 (Scn3b), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017595466.1

ORF Insert Sequence:

ATGAAGCTGA GGTGCATCTC CTGCATGAAG AGGGAGGAGG TGGAGGCCAC CACTGTGGTG 
GAGTGGTTCT ACAGGCCTGA GGGCGGTAAA GATTTCCTTA TATATGAGTA TCGGAATGGC 
CACCAGGAAG TGGAGAGCCC CTTCCAAGGC CGTCTGCAGT GGAATGGGAG CAAAGACCTG 
CAGGACGTAT CCATCACTGT ACTCAATGTC ACTTTGAATG ACTCTGGCCT CTACACATGC 
AATGTGTCCA GGGAGTTCGA ATTCGAGGCA CACAGGCCTT TTGTGAAGAC CACGAGACTG 
ATACCTTTGC GAGTCACTGA AGAGGCGGGA GAAGACTTCA CCTCCGTGGT CTCGGAAATC 
ATGATGTACA TCCTCCTGGT CTTCCTCACC TTGTGGCTGT TTATTGAGAT GATCTATTGC 
TACAGAAAGG TCTCTAAGGC CGAAGAGGCA GCACAGGAAA ATGCGTCTGA CTACCTTGCT 
ATCCCTTCAG AGAACAAGGA GAACTCTGTG GTACCTGTGG AGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Age-dependent alterations of voltage-gated Na(+) channel isoforms in rat sinoatrial node.
Mechanisms of ageing and development15280-90(2015 Dec)
Huang X,Du Y,Yang P,Lin S,Xi Y,Yang Z,Ma A

Mutations in sodium channel ?-subunit SCN3B are associated with early-onset lone atrial fibrillation.
Cardiovascular research89(4)786-93(2011 Mar)
Olesen MS,Jespersen T,Nielsen JB,Liang B,M?ller DV,Hedley P,Christiansen M,Varr? A,Olesen SP,Hauns? S,Schmitt N,Svendsen JH

The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions.
The Journal of biological chemistry285(43)33404-12(2010 Oct)
Cusdin FS,Nietlispach D,Maman J,Dale TJ,Powell AJ,Clare JJ,Jackson AP

Sudden infant death syndrome-associated mutations in the sodium channel beta subunits.
Heart rhythm7(6)771-8(2010 Jun)
Tan BH,Pundi KN,Van Norstrand DW,Valdivia CR,Tester DJ,Medeiros-Domingo A,Makielski JC,Ackerman MJ

Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation.
Cardiovascular research86(3)392-400(2010 Jun)
Valdivia CR,Medeiros-Domingo A,Ye B,Shen WK,Algiers TJ,Ackerman MJ,Makielski JC

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Scn3b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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