Acvr1c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acvr1c
Entrez Gene ID	245921
Full Name	activin A receptor type 1C
Synonyms	Alk-7,Alk7,habrec1
General protein information	Preferred Names activin A receptor type 1C Names activin receptor type-1C ACTR-IC TGF-beta type 1 receptor activin A receptor, type IC activin receptor type IC activin receptor-like kinase 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q21
Summary	may play a role in neuronal maturation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_139090.1	NP_620790.1	activin receptor type-1C precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ACVR1C	NP_660302.2
Pan troglodytes (chimpanzee)	ACVR1C	XP_525945.2
Xenopus tropicalis (tropical clawed frog)	acvr1c	XP_002933316.2
	ACVR1C	XP_001088578.1
Mus musculus (house mouse)	Acvr1c	NP_001104500.1
Bos taurus (cattle)	ACVR1C	NP_001179808.2
Rattus norvegicus (Norway rat)	Acvr1c	NP_620790.1
Canis lupus familiaris (dog)	ACVR1C	XP_005640249.1
Gallus gallus (chicken)	ACVR1C	XP_422170.3

Gene Ontology
Bibliography

Related articles in PubMed

Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats.
Li WB, Zhao J, Liu L, Wang ZH, Han L, Zhong M, Zhang Y, Zhang W, Tang MX
Acta diabetologica52(4)717-26(2015 Aug)

Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 ?-cells.
Zhao F, Huang F, Tang M, Li X, Zhang N, Amfilochiadis A, Li Y, Hu R, Jin T, Peng C, Wang Q
American journal of physiology. Endocrinology and metabolism303(1)E132-43(2012 Jul)

The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.
Li Q, Liu X, Wu Y, An J, Hexige S, Ling Y, Zhang M, Yang X, Yu L
Molecular and cellular biochemistry359(1-2)115-23(2012 Jan)

Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity.
Andersson O, Korach-Andre M, Reissmann E, Ib??ez CF, Bertolino P
Proceedings of the National Academy of Sciences of the United States of America105(20)7252-6(2008 May)

The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line.
J?rnvall H, Blokzijl A, ten Dijke P, Ib??ez CF
The Journal of biological chemistry276(7)5140-6(2001 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ALK7 gene silencing has a protective effect on diabetes-induced aortic stiffness, insulin resistance and hyperlipidemia, thus implicating a new potential therapeutic approach to diabetic macrovascular stiffness.
Title: Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats.

Data suggest that up-regulation of Nodal expression increases apoptosis of beta cells and is associated with increased Alk7 expression, activation of Smad3 signaling, and down-regulation of apoptosis regulatory proteins.
Title: Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 ?-cells.

Regulation of nodal/activin receptor-like kinase 7 signaling pathway play a role in the control of ovarian follicular atresia.
Title: Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia.

pancreatic beta cell apoptosis induced by ALK7 activation occurs via the activation of two distinct downstream pathways
Title: Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines.

ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components
Title: Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.

The following Acvr1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acvr1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02137	NM_139090.1 Latest version!	Rattus norvegicus activin A receptor type 1C (Acvr1c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$293.30 $419.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acvr1c ( NM_139090.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620790.1 Rattus norvegicus activin A receptor type 1C (Acvr1c), mRNA.

Price & Availability↑

CloneID	ORa02137
Clone ID Related Accession (Same CDS sequence)	NM_139090.1
Accession Version	NM_139090.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	activin receptor type-1C precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U69702.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U69702.1, U35025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGACCCCAG CAAGCCGCTC CGCACTGAGC CTGGCCCTCC TGCTGGTGGC ACTGGCCTCC 
GACCTTGCGG CAGGACTGAA GTGTGTGTGT CTTTTGTGTG ATTCCTCAAA CTTTACCTGC 
CAAACCGAAG GAGCATGCTG GGCCTCTGTC ATGCTAACCA ACGGGAAAGA ACAGGTGATC 
AAATCGTGCG TGTCCCTCCC GGAACTAAAT GCTCAGGTCT TCTGTCACAG TTCCAACAAC 
GTGACCAAGA CCGAATGTTG CTTCACAGAC TTCTGCAACA ACATCACTCT GCACCTTCCC 
ACAGCATCTC CAGATGCCCC TAGACTTGGC CCCACAGAGC TGACAGTTGT TATCACTGTA 
CCTGTTTGCC TCCTGTCCAT CGCAGCCATG CTAACGATAT GGGCCTGCCA GGACCGCCAG 
TGCACATACA GGAAGACCAA GAGACACAAT GTGGAGGAAC CACTGGCAGA GTACAGCCTT 
GTCAATGCTG GAAAAACCCT CAAAGATCTG ATTTATGATG CCACTGCCTC GGGCTCAGGA 
TCTGGCCTGC CTCTTTTGGT TCAAAGAACC ATCGCAAGGA CAATTGTACT TCAAGAAATC 
GTAGGAAAAG GTCGGTTTGG GGAAGTGTGG CACGGAAGAT GGTGTGGAGA AGATGTGGCT 
GTGAAAATAT TCTCCTCCAG AGATGAGAGA TCTTGGTTCC GTGAGGCAGA AATTTATCAG 
ACGGTAATGC TGAGACATGA GAATATTCTC GGTTTCATCG CGGCCGACAA CAAAGATAAT 
GGAACCTGGA CTCAGCTTTG GCTTGTGTCA GAGTATCACG AGCAGGGCTC CTTATATGAC 
TATTTGAATA GAAACATAGT GACCGTGGCT GGAATGGTCA AGTTGGCGCT TTCAATAGCG 
AGTGGTCTGG CTCACCTACA CATGGAGATC GTGGGCACTC AAGGTAAGCC TGCTATTGCT 
CACCGAGATA TAAAGTCAAA GAATATCTTA GTCAAAAAGT GTGACACTTG TGCCATAGCT 
GACTTAGGGC TGGCTGTGAA ACATGATTCT ATCATGAACA CTATAGATAT ACCCCAGAAT 
CCTAAAGTGG GAACCAAGAG GTATATGGCT CCCGAAATGC TTGATGATAC AATGAACGTC 
AACATCTTTG AGTCCTTCAA GCGAGCTGAC ATCTATTCGG TGGGGCTGGT TTACTGGGAA 
ATAGCTCGAA GGTGTTCAGT TGGAGGACTT GTTGAAGAGT ACCAGTTGCC TTATTATGAC 
ATGGTGCCTT CAGATCCTTC CATAGAGGAA ATGAGGAAGG TCGTTTGTGA TCAGAAACTC 
CGACCAAATC TCCCAAACCA GTGGCAAAGC TGTGAGGCGC TCCGGGTCAT GGGAAGAATA 
ATGCGTGAGT GCTGGTATGC CAACGGGGCA GCTCGCCTGA CCGCCCTGCG CGTGAAGAAG 
ACCATTTCTC AGCTGTGTGT CAAGGAAGAC TGTAAGGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620790.1
CDS	147..1628
Translation	MTPASRSALSLALLLVALASDLAAGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPDAPRLGPTELTVVITVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSLVNAGKTLKDLIYDATASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCKA

Target ORF information:

RefSeq Version	NM_139090.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activin A receptor type 1C (Acvr1c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139090.1

ORF Insert Sequence:

ATGACCCCAG CAAGCCGCTC CGCACTGAGC CTGGCCCTCC TGCTGGTGGC ACTGGCCTCC 
GACCTTGCGG CAGGACTGAA GTGTGTGTGT CTTTTGTGTG ATTCCTCAAA CTTTACCTGC 
CAAACCGAAG GAGCATGCTG GGCCTCTGTC ATGCTAACCA ACGGGAAAGA ACAGGTGATC 
AAATCGTGCG TGTCCCTCCC GGAACTAAAT GCTCAGGTCT TCTGTCACAG TTCCAACAAC 
GTGACCAAGA CCGAATGTTG CTTCACAGAC TTCTGCAACA ACATCACTCT GCACCTTCCC 
ACAGCATCTC CAGATGCCCC TAGACTTGGC CCCACAGAGC TGACAGTTGT TATCACTGTA 
CCTGTTTGCC TCCTGTCCAT CGCAGCCATG CTAACGATAT GGGCCTGCCA GGACCGCCAG 
TGCACATACA GGAAGACCAA GAGACACAAT GTGGAGGAAC CACTGGCAGA GTACAGCCTT 
GTCAATGCTG GAAAAACCCT CAAAGATCTG ATTTATGATG CCACTGCCTC GGGCTCAGGA 
TCTGGCCTGC CTCTTTTGGT TCAAAGAACC ATCGCAAGGA CAATTGTACT TCAAGAAATC 
GTAGGAAAAG GTCGGTTTGG GGAAGTGTGG CACGGAAGAT GGTGTGGAGA AGATGTGGCT 
GTGAAAATAT TCTCCTCCAG AGATGAGAGA TCTTGGTTCC GTGAGGCAGA AATTTATCAG 
ACGGTAATGC TGAGACATGA GAATATTCTC GGTTTCATCG CGGCCGACAA CAAAGATAAT 
GGAACCTGGA CTCAGCTTTG GCTTGTGTCA GAGTATCACG AGCAGGGCTC CTTATATGAC 
TATTTGAATA GAAACATAGT GACCGTGGCT GGAATGGTCA AGTTGGCGCT TTCAATAGCG 
AGTGGTCTGG CTCACCTACA CATGGAGATC GTGGGCACTC AAGGTAAGCC TGCTATTGCT 
CACCGAGATA TAAAGTCAAA GAATATCTTA GTCAAAAAGT GTGACACTTG TGCCATAGCT 
GACTTAGGGC TGGCTGTGAA ACATGATTCT ATCATGAACA CTATAGATAT ACCCCAGAAT 
CCTAAAGTGG GAACCAAGAG GTATATGGCT CCCGAAATGC TTGATGATAC AATGAACGTC 
AACATCTTTG AGTCCTTCAA GCGAGCTGAC ATCTATTCGG TGGGGCTGGT TTACTGGGAA 
ATAGCTCGAA GGTGTTCAGT TGGAGGACTT GTTGAAGAGT ACCAGTTGCC TTATTATGAC 
ATGGTGCCTT CAGATCCTTC CATAGAGGAA ATGAGGAAGG TCGTTTGTGA TCAGAAACTC 
CGACCAAATC TCCCAAACCA GTGGCAAAGC TGTGAGGCGC TCCGGGTCAT GGGAAGAATA 
ATGCGTGAGT GCTGGTATGC CAACGGGGCA GCTCGCCTGA CCGCCCTGCG CGTGAAGAAG 
ACCATTTCTC AGCTGTGTGT CAAGGAAGAC TGTAAGGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats.
Acta diabetologica52(4)717-26(2015 Aug)
Li WB,Zhao J,Liu L,Wang ZH,Han L,Zhong M,Zhang Y,Zhang W,Tang MX

Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 ?-cells.
American journal of physiology. Endocrinology and metabolism303(1)E132-43(2012 Jul)
Zhao F,Huang F,Tang M,Li X,Zhang N,Amfilochiadis A,Li Y,Hu R,Jin T,Peng C,Wang Q

The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.
Molecular and cellular biochemistry359(1-2)115-23(2012 Jan)
Li Q,Liu X,Wu Y,An J,Hexige S,Ling Y,Zhang M,Yang X,Yu L

Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity.
Proceedings of the National Academy of Sciences of the United States of America105(20)7252-6(2008 May)
Andersson O,Korach-Andre M,Reissmann E,Ib??ez CF,Bertolino P

The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line.
The Journal of biological chemistry276(7)5140-6(2001 Feb)
J?rnvall H,Blokzijl A,ten Dijke P,Ib??ez CF

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Acvr1c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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