Myc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Myc
Entrez Gene ID	24577
Full Name	MYC proto-oncogene, bHLH transcription factor
Synonyms	RNCMYC,c-myc,mMyc
General protein information	Preferred Names MYC proto-oncogene, bHLH transcription factor Names myc proto-oncogene protein Avian myelocytomatosis viral (v-myc) oncogene homolog myelocytomatosis oncogene myelocytomatosis viral oncogene homolog proto-oncogene c-Myc transcription factor p64 v-myc avian myelocytomatosis viral oncogene homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q33
Summary	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012603.2	NP_036735.2	myc proto-oncogene protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MYC	NP_001039539.1
Xenopus tropicalis (tropical clawed frog)	MGC76254	NP_989390.1
Mus musculus (house mouse)	Myc	NP_034979.3
Homo sapiens (human)	MYC	NP_002458.2
Pan troglodytes (chimpanzee)	MYC	NP_001136266.1
Rattus norvegicus (Norway rat)	Myc	NP_036735.2
	MYC	NP_001136345.1
Danio rerio (zebrafish)	mycb	NP_956466.1
Canis lupus familiaris (dog)	MYC	NP_001003246.2
Gallus gallus (chicken)	MYC	NP_001026123.1
Danio rerio (zebrafish)	myca	NP_571487.2

Gene Ontology
Bibliography

Related articles in PubMed

WNT10A/??catenin pathway in tumorigenesis of papillary thyroid carcinoma.
Dong T, Zhang Z, Zhou W, Zhou X, Geng C, Chang LK, Tian X, Liu S
Oncology reports38(2)1287-1294(2017 Aug)

Down-regulation of the klf5-c-Myc interaction due to klf5 phosphorylation mediates resveratrol repressing the caveolin-1 transcription through the PI3K/PKD1/Akt pathway.
Yang H, Chen Q, Sun F, Zhao N, Wen L, Li L, Ran G
PloS one12(12)e0189156(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

loss of inhibition on c-myc-Bmi-1-p16 signaling pathway by let-7g may lead to PASMCs proliferation and vascular remodeling in pulmonary hypertension
Title: MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G

demonstrated that RSV activated klf5 phosphorylation by inhibiting PI3K/PKD1/Akt pathway, and then attenuated the interaction of klf5 with c-Myc
Title: Down-regulation of the klf5-c-Myc interaction due to klf5 phosphorylation mediates resveratrol repressing the caveolin-1 transcription through the PI3K/PKD1/Akt pathway.

By inducing Myc expression in the colonic epithelium, lithium promotes colonic regeneration after DSS-induced colitis.
Title: A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice.

JNK1 mediates pancreatic beta apoptotic cell death associated with increased Myc expression in IL1-beta treated cells.
Title: JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1?-Induced Apoptosis Associated with Abrogated Myc Expression.

Glucagon phosphorylates serine 552 of beta-catenin leading to increased expression of Ccnd1 and c-Myc in the isolated rat liver.
Title: Glucagon phosphorylates serine 552 of ?-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver.

The following Myc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13490	NM_012603.2 Latest version!	Rattus norvegicus MYC proto-oncogene, bHLH transcription factor (Myc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Myc ( NM_012603.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036735.2 Rattus norvegicus MYC proto-oncogene, bHLH transcription factor (Myc), mRNA.

Price & Availability↑

CloneID	ORa13490
Clone ID Related Accession (Same CDS sequence)	NM_012603.2
Accession Version	NM_012603.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Rattus norvegicus(Norway rat)
Product	myc proto-oncogene protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY679730.1. On Aug 23, 2004 this sequence version replaced NM_012603.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY679730.1, BC091699.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: full length.

CTGAATTTCC TTTGGGAGGT GGAAAACCCG ACAGTCACGA CGATGCCCCT CAACGTGAGC 
TTCGCTAACA GGAACTATGA CCTCGACTAC GACTCGGTGC AGCCCTATTT CATCTGCGAC 
GAGGAAGAGA ATTTCTATCA CCAGCAACAG CAGAGCGAGC TGCAGCCGCC CGCACCCAGT 
GAGGATATCT GGAAGAAATT CGAGCTGCTG CCCACCCCGC CCCTGTCCCC CAGCCGCCGC 
TCCGGGCTCT GCTCTCCGTC CTATGTTGCG GTCGCTACGT CCTTCTCCCC AAGGGAGGAC 
GATGACGGTG GCGGTGGCAA CTTCTCCACC GCCGATCAGC TGGAGATGAT GACCGAGCTA 
CTTGGAGGAG ACATGGTGAA TCAGAGCTTC ATCTGCGATC CTGACGATGA GACCTTCATC 
AAGAACATCA TCATCCAGGA CTGTATGTGG AGCGGCTTCT CGGCCGCTGC CAAACTGGTC 
TCCGAGAAGC TGGCCTCTTA CCAGGCTGCG CGCAAAGACA GCACCAGCCT GAGCCCCGCC 
CGCGGGCACA GCGTCTGCTC CACCTCCAGC CTGTACCTGC AGGACCTCAC CGCCGCAGCG 
TCCGAGTGCA TCGACCCCTC AGTGGTCTTC CCCTACCCGC TCAACGACAG CAGCTCGCCC 
AAATCCTGTA CCTCGTCCGA TTCCACGGCC TTCTCTTCTT CCTCGGACTC GCTGCTGTCC 
TCCGAGTCCT CCCCACGGGC CACCCCTGAG CCCCTAGTGC TGCATGAAGA GACACCGCCC 
ACCACCAGCA GCGACTCTGA AGAAGAACAA GATGATGAGG AAGAAATTGA TGTGGTGTCT 
GTGGAAAAGA GGCAACCCCC TGCCAAGAGG TCCGAGTCAG GGTCATCCCC ATCAAGAGGC 
CACAGCAAAC CTCCACACAG CCCACTGGTC CTCAAGAGGT GCCATGTCTC TACTCACCAG 
CACAATTATG CAGCACCCCC CTCCACAAGG AAGGACTATC CAGCTGCCAA GAGGGCCAAG 
TTGGACAGTG GCAGGGTCCT GAAACAGATC AGCAACAACC GCAAATGCTC CAGCCCCAGG 
TCCTCAGACA CCGAGGAAAA CGACAAGAGG CGGACACACA ACGTCTTGGA ACGTCAGAGG 
AGAAACGAGC TGAAGCGTAG CTTTTTTGCC CTGCGCGACC AGATCCCTGA GTTGGAAAAC 
AACGAAAAGG CCCCCAAGGT AGTTATCCTC AAAAAAGCCA CCGCCTACAT CCTGTCCGTT 
CAAGCAGATG AGCACAAACT CATCTCAGAA AAGGACTTAC TGAGGAAACG GCGAGAACAG 
TTGAAACACA AACTCGAACA GCTTCGAAAC TCTGGTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036735.2
CDS	537..1898
Translation	LNFLWEVENPTVTTMPLNVSFANRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSSSSDSLLSSESSPRATPEPLVLHEETPPTTSSDSEEEQDDEEEIDVVSVEKRQPPAKRSESGSSPSRGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQADEHKLISEKDLLRKRREQLKHKLEQLRNSGA

Target ORF information:

RefSeq Version	NM_012603.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MYC proto-oncogene, bHLH transcription factor (Myc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012603.2

ORF Insert Sequence:

CTGAATTTCC TTTGGGAGGT GGAAAACCCG ACAGTCACGA CGATGCCCCT CAACGTGAGC 
TTCGCTAACA GGAACTATGA CCTCGACTAC GACTCGGTGC AGCCCTATTT CATCTGCGAC 
GAGGAAGAGA ATTTCTATCA CCAGCAACAG CAGAGCGAGC TGCAGCCGCC CGCACCCAGT 
GAGGATATCT GGAAGAAATT CGAGCTGCTG CCCACCCCGC CCCTGTCCCC CAGCCGCCGC 
TCCGGGCTCT GCTCTCCGTC CTATGTTGCG GTCGCTACGT CCTTCTCCCC AAGGGAGGAC 
GATGACGGTG GCGGTGGCAA CTTCTCCACC GCCGATCAGC TGGAGATGAT GACCGAGCTA 
CTTGGAGGAG ACATGGTGAA TCAGAGCTTC ATCTGCGATC CTGACGATGA GACCTTCATC 
AAGAACATCA TCATCCAGGA CTGTATGTGG AGCGGCTTCT CGGCCGCTGC CAAACTGGTC 
TCCGAGAAGC TGGCCTCTTA CCAGGCTGCG CGCAAAGACA GCACCAGCCT GAGCCCCGCC 
CGCGGGCACA GCGTCTGCTC CACCTCCAGC CTGTACCTGC AGGACCTCAC CGCCGCAGCG 
TCCGAGTGCA TCGACCCCTC AGTGGTCTTC CCCTACCCGC TCAACGACAG CAGCTCGCCC 
AAATCCTGTA CCTCGTCCGA TTCCACGGCC TTCTCTTCTT CCTCGGACTC GCTGCTGTCC 
TCCGAGTCCT CCCCACGGGC CACCCCTGAG CCCCTAGTGC TGCATGAAGA GACACCGCCC 
ACCACCAGCA GCGACTCTGA AGAAGAACAA GATGATGAGG AAGAAATTGA TGTGGTGTCT 
GTGGAAAAGA GGCAACCCCC TGCCAAGAGG TCCGAGTCAG GGTCATCCCC ATCAAGAGGC 
CACAGCAAAC CTCCACACAG CCCACTGGTC CTCAAGAGGT GCCATGTCTC TACTCACCAG 
CACAATTATG CAGCACCCCC CTCCACAAGG AAGGACTATC CAGCTGCCAA GAGGGCCAAG 
TTGGACAGTG GCAGGGTCCT GAAACAGATC AGCAACAACC GCAAATGCTC CAGCCCCAGG 
TCCTCAGACA CCGAGGAAAA CGACAAGAGG CGGACACACA ACGTCTTGGA ACGTCAGAGG 
AGAAACGAGC TGAAGCGTAG CTTTTTTGCC CTGCGCGACC AGATCCCTGA GTTGGAAAAC 
AACGAAAAGG CCCCCAAGGT AGTTATCCTC AAAAAAGCCA CCGCCTACAT CCTGTCCGTT 
CAAGCAGATG AGCACAAACT CATCTCAGAA AAGGACTTAC TGAGGAAACG GCGAGAACAG 
TTGAAACACA AACTCGAACA GCTTCGAAAC TCTGGTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

WNT10A/??catenin pathway in tumorigenesis of papillary thyroid carcinoma.
Oncology reports38(2)1287-1294(2017 Aug)
Dong T,Zhang Z,Zhou W,Zhou X,Geng C,Chang LK,Tian X,Liu S

Down-regulation of the klf5-c-Myc interaction due to klf5 phosphorylation mediates resveratrol repressing the caveolin-1 transcription through the PI3K/PKD1/Akt pathway.
PloS one12(12)e0189156(2017)
Yang H,Chen Q,Sun F,Zhao N,Wen L,Li L,Ran G

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Myc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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