Mst1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mst1
Entrez Gene ID	24566
Full Name	macrophage stimulating 1
Synonyms	E2F2
General protein information	Preferred Names macrophage stimulating 1 Names hepatocyte growth factor-like protein D8h3f15s2 E2F transcription factor 2 Macrophage stimulating 1 (hepatocyte growth factor-like)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	ligand for receptor tyrosine kinase STK/RON; may mediate germ cell-germ cell interaction during spermatogenesis, and acquisition of sperm motility and/or fertilizing capacity in the epididymis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024352.1	NP_077328.1	hepatocyte growth factor-like protein precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MST1	NP_001069145.1
Xenopus tropicalis (tropical clawed frog)	mst1	XP_002936531.2
Pan troglodytes (chimpanzee)	MST1	XP_516465.4
Homo sapiens (human)	MST1	NP_066278.3
Canis lupus familiaris (dog)	MST1	XP_541884.3
Gallus gallus (chicken)	MST1	NP_990544.1
	MST1	XP_001107946.1
Rattus norvegicus (Norway rat)	Mst1	NP_077328.1
Danio rerio (zebrafish)	mst1	NP_694512.1
Mus musculus (house mouse)	Mst1	NP_032269.3

Gene Ontology
Bibliography

Related articles in PubMed

Roles of macrophage stimulating protein and tyrosine kinase receptor RON in smoke-induced airway inflammation of rats.
Wang T, Chen X, Zhang W, Xiang X, Leng C, Jia Q
International journal of clinical and experimental pathology8(8)8797-808(2015)

Mesenchymal stromal cells reset the scatter factor system and cytokine network in experimental kidney transplantation.
Gregorini M, Bosio F, Rocca C, Corradetti V, Valsania T, Pattonieri EF, Esposito P, Bedino G, Collesi C, Libetta C, Frassoni F, Dal Canton A, Rampino T
BMC immunology1544(2014 Oct)

Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.
Gurusamy D, Ruiz-Torres SJ, Johnson AL, Smith DA, Waltz SE
Mechanisms of development13311-22(2014 Aug)

Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1.
Yan G, Qin Q, Yi B, Chuprun K, Sun H, Huang S, Sun J
International journal of cardiology168(4)3291-9(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MSP and its receptor RON are involved in the smoke-induced airway inflammation in rats
Title: Roles of macrophage stimulating protein and tyrosine kinase receptor RON in smoke-induced airway inflammation of rats.

Mesenchymal stromal cells increased serum and tissue HGF levels, Met tubular expression and prevented the suppression of tubular MSP/RON expression.
Title: Mesenchymal stromal cells reset the scatter factor system and cytokine network in experimental kidney transplantation.

Interaction of Mst1 with GAPDH caused a robust phosphorylation of GAPDH and markedly increased the Mst1 activity in cardiomyocytes.
Title: Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.

MST1 and Fas death domain-associated protein (Daxx) mediate interferon (IFN)-gamma-induced apoptosis in microglia.
Title: Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.

MST1-FOXO1 signaling is an important link survival factor deprivation-induced neuronal cell death
Title: Regulation of neuronal cell death by MST1-FOXO1 signaling.

The following Mst1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mst1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06912	NM_024352.1 Latest version!	Rattus norvegicus macrophage stimulating 1 (Mst1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$419.30 $599.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mst1 ( NM_024352.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077328.1 Rattus norvegicus macrophage stimulating 1 (Mst1), mRNA.

Price & Availability↑

CloneID	ORa06912
Clone ID Related Accession (Same CDS sequence)	NM_024352.1
Accession Version	NM_024352.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2151bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-10
Organism	Rattus norvegicus(Norway rat)
Product	hepatocyte growth factor-like protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X95096.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X95096.1, BC089796.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGGGTGGC TCCCACTACT GCTGCTTCTG GCACAGTGTT CAAGGGCTCT TGGGCAGCGC 
TCACCGCTGA ATGACTTCCA GCTGCTTCGG GGCACAGAGT TAAGGAACCT GCTACATCCA 
GTGGTGCCAG GGCCATGGCA GGAGGATGTG GCAGATGCCG AGGAGTGTGC TAGACGCTGT 
GGGCCCCTTC TGGACTGCCG AGCCTTCCAC TACAATATGA GCAGCCATGG TTGCCAGCTA 
CTACCGTGGA CTCAGCACTC TCTGCGTGCA CAGCTACACC ATTCTAGCCT GTGCGATCTC 
TTCCAGAAGA AAGACTATGT ACGGACCTGC ATTATGGACA ATGGGGCCAG CTACCGGGGC 
ACTGTGGCCA GGACAGCTGA TGGCTTGCCC TGCCAAGCCT GGAGCCGCAG GTTCCCCAAT 
GACCACAAGT ACACGCCCAC ACCGAAGAAT GGCCTGGAAG AGAACTTCTG TCGGAACCCT 
GATGGGGACC CCAGAGGTCC CTGGTGCTAC ACGACAAACC GCAGCGTGCG TTTCCAGAGC 
TGCGGCATCA AATCATGCAG GGAGGCGGTT TGTGTTTGGT GCAACGGCGA GGATTACCGT 
GGCGAGGTAG ACGTTACAGA ATCGGGACGG GAGTGTCAAC GCTGGGACCT GCAGCACCCA 
CACTCGCACC CTTTCCACCC TGAAAAGTTC CCAGACAAAG CTCTGAAAGA CAACTATTGC 
CGTAATCCGG ATGCATCTGA GCGCCCCTGG TGCTACACCA CGGACCCGAA TGTTGAGCGA 
GAGTTCTGTG ACCTGCCCAG TTGCGGGCCC AACCTGCCAC CGACCACCAA AGGATCCAAG 
TCACAACAGC GCAACAAGGT CAAGGCTTCG AACTGCTTCC GCGGAAAAGG TGAAGACTAT 
CGAGGCACAA CCAATACCAC CTCTGCGGGT GTGCCCTGCC AGCGCTGGGA TGCGCAGAAT 
CCGCACCAGC ACCGCTTTGT GCCGGAGAAA TATGCTTGCA AGGACCTTCG TGAGAATTTC 
TGCCGGAATC CTGATGGCTC CGAGGCGCCT TGGTGCTTCA CATCTCGACC TGGTTTGCGT 
GTGGCCTTTT GCTACCAGAT CCCACGCTGC ACAGAAGAAG TGGTGCCAGA GGGCTGCTAC 
CATGGCTCAG GTGAACAGTA TCGTGGCTCA GTCAGCAAGA CACGCAAGGG CGTTCAGTGC 
CAGCACTGGT CCTCAGAGAC ACCACATAAG CCACAATTCA CACCCACCTC AGCACCACAT 
GCAGGCTTGG AGGCAAACTT TTGCCGGAAT CCGGATGGAG ATAGCCATGG GCCCTGGTGT 
TATACTTTGG ACCCAGAGAC CCTGTTTGAC TACTGTGCCC TAAAACGCTG TGATGATGAC 
CAGCCACCAT CCATCTTGGA CCCCCCAGTC CAGGTGCAGT TTGAAAAGTG TGGCAAGAGA 
GTTGACCAGA GTAATAGACT TCGTGTGGTG GGGGGTCATC CTGGGAACTC ACCGTGGACA 
GTCAGCTTGC GGAATCGACA GGGCCAGCAT TTCTGTGGGG GTTCCCTAGT GAAGGAGCAG 
TGGGTACTGA CCGCCCGGCA ATGCATCTGG TCATGCCATG ATCCTCTCAC AGGATATGAG 
GTATGGTTGG GTACAATTAA CCAGAACCCA CAGCCTGGAG AAGCAAACCT GCAGAGGGTC 
TCAGTGGCCA AGACAGTGTG CGGACCTGCA GGCTCCCAAC TTGTTCTGCT CAAGCTGGAG 
AGACCTGTGA TCCTGAACCA TCACGTGGCC AGGATTTGCC TACCTCCTGA ACAGTATGTG 
GTACCTCCAG GGACCAACTG CGAGATCGCT GGCTGGGGTG AATCCAAAGG TACAAGCAAT 
AGCACAGTCC TTCATGTGGC CAAAATGAAG GTCATCTCCA GTCAGGAATG TAATGTGAAG 
TACCGGAGAC GAGTACAAGA GAGTGAGATA TGCACCGAGG GGTTGCTGGC CCCTACGGGC 
GCTTGTGAGG GTGACTACGG GGGCCCACTT GCCTGCTATA CCCATGACTG CTGGGTCCTA 
CAGGGACTTA TCATCCCGAA CAGAGTGTGT GCACGGCCTC GCTGGCCAGC TATCTTCACA 
CGTGTGTCTG TGTTTGTGGA CTGGATTAAC AAGGTCGTGC AGCTGGAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077328.1
CDS	13..2163
Translation	MGWLPLLLLLAQCSRALGQRSPLNDFQLLRGTELRNLLHPVVPGPWQEDVADAEECARRCGPLLDCRAFHYNMSSHGCQLLPWTQHSLRAQLHHSSLCDLFQKKDYVRTCIMDNGASYRGTVARTADGLPCQAWSRRFPNDHKYTPTPKNGLEENFCRNPDGDPRGPWCYTTNRSVRFQSCGIKSCREAVCVWCNGEDYRGEVDVTESGRECQRWDLQHPHSHPFHPEKFPDKALKDNYCRNPDASERPWCYTTDPNVEREFCDLPSCGPNLPPTTKGSKSQQRNKVKASNCFRGKGEDYRGTTNTTSAGVPCQRWDAQNPHQHRFVPEKYACKDLRENFCRNPDGSEAPWCFTSRPGLRVAFCYQIPRCTEEVVPEGCYHGSGEQYRGSVSKTRKGVQCQHWSSETPHKPQFTPTSAPHAGLEANFCRNPDGDSHGPWCYTLDPETLFDYCALKRCDDDQPPSILDPPVQVQFEKCGKRVDQSNRLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWVLTARQCIWSCHDPLTGYEVWLGTINQNPQPGEANLQRVSVAKTVCGPAGSQLVLLKLERPVILNHHVARICLPPEQYVVPPGTNCEIAGWGESKGTSNSTVLHVAKMKVISSQECNVKYRRRVQESEICTEGLLAPTGACEGDYGGPLACYTHDCWVLQGLIIPNRVCARPRWPAIFTRVSVFVDWINKVVQLE

Target ORF information:

RefSeq Version	NM_024352.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus macrophage stimulating 1 (Mst1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024352.1

ORF Insert Sequence:

ATGGGGTGGC TCCCACTACT GCTGCTTCTG GCACAGTGTT CAAGGGCTCT TGGGCAGCGC 
TCACCGCTGA ATGACTTCCA GCTGCTTCGG GGCACAGAGT TAAGGAACCT GCTACATCCA 
GTGGTGCCAG GGCCATGGCA GGAGGATGTG GCAGATGCCG AGGAGTGTGC TAGACGCTGT 
GGGCCCCTTC TGGACTGCCG AGCCTTCCAC TACAATATGA GCAGCCATGG TTGCCAGCTA 
CTACCGTGGA CTCAGCACTC TCTGCGTGCA CAGCTACACC ATTCTAGCCT GTGCGATCTC 
TTCCAGAAGA AAGACTATGT ACGGACCTGC ATTATGGACA ATGGGGCCAG CTACCGGGGC 
ACTGTGGCCA GGACAGCTGA TGGCTTGCCC TGCCAAGCCT GGAGCCGCAG GTTCCCCAAT 
GACCACAAGT ACACGCCCAC ACCGAAGAAT GGCCTGGAAG AGAACTTCTG TCGGAACCCT 
GATGGGGACC CCAGAGGTCC CTGGTGCTAC ACGACAAACC GCAGCGTGCG TTTCCAGAGC 
TGCGGCATCA AATCATGCAG GGAGGCGGTT TGTGTTTGGT GCAACGGCGA GGATTACCGT 
GGCGAGGTAG ACGTTACAGA ATCGGGACGG GAGTGTCAAC GCTGGGACCT GCAGCACCCA 
CACTCGCACC CTTTCCACCC TGAAAAGTTC CCAGACAAAG CTCTGAAAGA CAACTATTGC 
CGTAATCCGG ATGCATCTGA GCGCCCCTGG TGCTACACCA CGGACCCGAA TGTTGAGCGA 
GAGTTCTGTG ACCTGCCCAG TTGCGGGCCC AACCTGCCAC CGACCACCAA AGGATCCAAG 
TCACAACAGC GCAACAAGGT CAAGGCTTCG AACTGCTTCC GCGGAAAAGG TGAAGACTAT 
CGAGGCACAA CCAATACCAC CTCTGCGGGT GTGCCCTGCC AGCGCTGGGA TGCGCAGAAT 
CCGCACCAGC ACCGCTTTGT GCCGGAGAAA TATGCTTGCA AGGACCTTCG TGAGAATTTC 
TGCCGGAATC CTGATGGCTC CGAGGCGCCT TGGTGCTTCA CATCTCGACC TGGTTTGCGT 
GTGGCCTTTT GCTACCAGAT CCCACGCTGC ACAGAAGAAG TGGTGCCAGA GGGCTGCTAC 
CATGGCTCAG GTGAACAGTA TCGTGGCTCA GTCAGCAAGA CACGCAAGGG CGTTCAGTGC 
CAGCACTGGT CCTCAGAGAC ACCACATAAG CCACAATTCA CACCCACCTC AGCACCACAT 
GCAGGCTTGG AGGCAAACTT TTGCCGGAAT CCGGATGGAG ATAGCCATGG GCCCTGGTGT 
TATACTTTGG ACCCAGAGAC CCTGTTTGAC TACTGTGCCC TAAAACGCTG TGATGATGAC 
CAGCCACCAT CCATCTTGGA CCCCCCAGTC CAGGTGCAGT TTGAAAAGTG TGGCAAGAGA 
GTTGACCAGA GTAATAGACT TCGTGTGGTG GGGGGTCATC CTGGGAACTC ACCGTGGACA 
GTCAGCTTGC GGAATCGACA GGGCCAGCAT TTCTGTGGGG GTTCCCTAGT GAAGGAGCAG 
TGGGTACTGA CCGCCCGGCA ATGCATCTGG TCATGCCATG ATCCTCTCAC AGGATATGAG 
GTATGGTTGG GTACAATTAA CCAGAACCCA CAGCCTGGAG AAGCAAACCT GCAGAGGGTC 
TCAGTGGCCA AGACAGTGTG CGGACCTGCA GGCTCCCAAC TTGTTCTGCT CAAGCTGGAG 
AGACCTGTGA TCCTGAACCA TCACGTGGCC AGGATTTGCC TACCTCCTGA ACAGTATGTG 
GTACCTCCAG GGACCAACTG CGAGATCGCT GGCTGGGGTG AATCCAAAGG TACAAGCAAT 
AGCACAGTCC TTCATGTGGC CAAAATGAAG GTCATCTCCA GTCAGGAATG TAATGTGAAG 
TACCGGAGAC GAGTACAAGA GAGTGAGATA TGCACCGAGG GGTTGCTGGC CCCTACGGGC 
GCTTGTGAGG GTGACTACGG GGGCCCACTT GCCTGCTATA CCCATGACTG CTGGGTCCTA 
CAGGGACTTA TCATCCCGAA CAGAGTGTGT GCACGGCCTC GCTGGCCAGC TATCTTCACA 
CGTGTGTCTG TGTTTGTGGA CTGGATTAAC AAGGTCGTGC AGCTGGAGTA G