Erbb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Erbb2
Entrez Gene ID	24337
Full Name	erb-b2 receptor tyrosine kinase 2
General protein information	Preferred Names erb-b2 receptor tyrosine kinase 2 Names receptor tyrosine-protein kinase erbB-2 Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) C-erbB-2 NEU proto-oncogene epidermal growth factor receptor-related protein p185erbB2 p185neu proto-oncogene NEU proto-oncogene c-ErbB-2 v-erb-b2 avian erythroblastic leukemia viral oncogene 2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	may play a role in cell proliferation and differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017003.2	NP_058699.2	receptor tyrosine-protein kinase erbB-2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ERBB2	XP_003315512.2
Mus musculus (house mouse)	Erbb2	NP_001003817.1
	ERBB2	XP_001090430.1
Rattus norvegicus (Norway rat)	Erbb2	NP_058699.2
Danio rerio (zebrafish)	erbb2	NP_956413.2
Homo sapiens (human)	ERBB2	NP_004439.2
Canis lupus familiaris (dog)	ERBB2	NP_001003217.1
Gallus gallus (chicken)	ERBB2	NP_001038126.1
Bos taurus (cattle)	ERBB2	XP_003587474.1
Xenopus tropicalis (tropical clawed frog)	erbb2	XP_002940420.2

Gene Ontology
Bibliography

Related articles in PubMed

Naked Polyamidoamine Polymers Intrinsically Inhibit Angiotensin II-Mediated EGFR and ErbB2 Transactivation in a Dendrimer Generation- and Surface Chemistry-Dependent Manner.
Akhtar S, El-Hashim AZ, Chandrasekhar B, Attur S, Benter IF
Molecular pharmaceutics13(5)1575-86(2016 05)

Crystal Structure and Substrate Specificity of PTPN12.
Li H, Yang F, Liu C, Xiao P, Xu Y, Liang Z, Liu C, Wang H, Wang W, Zheng W, Zhang W, Ma X, He D, Song X, Cui F, Xu Z, Yi F, Sun JP, Yu X
Cell reports15(6)1345-58(2016 05)

Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes.
Betz BB, Jenks SJ, Cronshaw AD, Lamont DJ, Cairns C, Manning JR, Goddard J, Webb DJ, Mullins JJ, Hughes J, McLachlan S, Strachan MWJ, Price JF, Conway BR
Kidney international89(5)1125-1135(2016 May)

Electrocardiographic Characterization of Cardiac Hypertrophy in Mice that Overexpress the ErbB2 Receptor Tyrosine Kinase.
Sysa-Shah P, S?rensen LL, Abraham MR, Gabrielson KL
Comparative medicine65(4)295-307(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PAMAM dendrimers as inhibitors of the Ang II/AT1/Src/EGFR-ErbB2/ERK1/2 signaling pathway.
Title: Naked Polyamidoamine Polymers Intrinsically Inhibit Angiotensin II-Mediated EGFR and ErbB2 Transactivation in a Dendrimer Generation- and Surface Chemistry-Dependent Manner.

A low uEGF/Cr ratio is associated with rapid decline in renal function and incident chronic kidney disease in diabetes.
Title: Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes.

ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.
Title: ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.

Report ECG phenotype of erbb2 over-expressing mice with left ventricular hypertrophy.
Title: Electrocardiographic Characterization of Cardiac Hypertrophy in Mice that Overexpress the ErbB2 Receptor Tyrosine Kinase.

Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt pathway and promoting erbB2-driven mammary/breast tumorigenesis.
Title: Increased erbB3 promotes erbB2/neu-driven mammary tumor proliferation and co-targeting of erbB2/erbB3 receptors exhibits potent inhibitory effects on breast cancer cells.

The following Erbb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Erbb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02457	NM_017003.2 Latest version!	Rattus norvegicus erb-b2 receptor tyrosine kinase 2 (Erbb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Erbb2 ( NM_017003.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058699.2 Rattus norvegicus erb-b2 receptor tyrosine kinase 2 (Erbb2), mRNA.

Price & Availability↑

CloneID	ORa02457
Clone ID Related Accession (Same CDS sequence)	NM_017003.2
Accession Version	NM_017003.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Rattus norvegicus(Norway rat)
Product	receptor tyrosine-protein kinase erbB-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY116182.1. On or before Jun 26, 2012 this sequence version replaced XM_003750918.1, XM_003752373.1, NM_017003.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY116182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATCATCA TGGAGCTGGC GGCCTGGTGC CGCTGGGGGT TCCTCCTCGC CCTCCTGCCC 
CCCGGAATCG CGGGCACCCA AGTGTGTACC GGCACAGACA TGAAGTTGCG GCTCCCTGCC 
AGTCCTGAGA CCCACCTGGA CATGCTCCGC CACCTGTACC AGGGCTGTCA GGTAGTGCAG 
GGCAACTTGG AGCTTACCTA CGTGCCTGCC AATGCCAGCC TCTCATTCCT GCAGGACATC 
CAGGAAGTTC AGGGTTACAT GCTCATCGCT CACAACCAGG TGAAGCGCGT CCCACTGCAA 
AGGCTGCGCA TCGTGAGAGG GACCCAGCTC TTTGAGGACA AGTATGCCCT GGCTGTGCTA 
GACAACCGAG ATCCTCAGGA CAATGTCGCC GCCTCCACCC CAGGCAGAAC CCCAGAGGGG 
CTGCGGGAGC TGCAGCTTCG AAGTCTCACA GAGATCCTGA AGGGAGGAGT TTTGATCCGT 
GGGAACCCTC AGCTCTGCTA CCAGGACATG GTTTTGTGGA AGGACGTCTT CCGCAAGAAT 
AACCAACTGG CTCCTGTCGA TATAGACACC AATCGTTCCC GGGCCTGTCC ACCTTGTGCC 
CCCGCCTGCA AAGACAATCA CTGTTGGGGT GAGAGTCCGG AAGACTGTCA GATCTTGACT 
GGCACCATCT GTACCAGTGG TTGTGCCCGG TGCAAGGGCC GGCTGCCCAC TGACTGCTGC 
CATGAGCAGT GTGCCGCAGG CTGCACGGGC CCCAAGCATT CTGACTGCCT GGCCTGCCTC 
CACTTCAATC ATAGTGGTAT CTGTGAGCTG CACTGCCCAG CCCTCGTCAC CTACAACACA 
GACACCTTTG AGTCCATGCA CAACCCTGAG GGTCGCTACA CCTTTGGTGC CAGCTGCGTG 
ACCACCTGCC CCTACAACTA CCTGTCTACG GAAGTGGGAT CCTGCACTCT GGTGTGTCCC 
CCGAATAACC AAGAGGTCAC AGCTGAGGAC GGAACACAGC GTTGTGAGAA ATGCAGCAAG 
CCCTGTGCTC GAGTGTGCTA TGGTCTGGGC ATGGAGCACC TTCGAGGGGC GAGGGCCATC 
ACCAGTGACA ATGTCCAGGA GTTTGATGGC TGCAAGAAGA TCTTTGGGAG CCTGGCATTT 
TTGCCGGAGA GCTTTGATGG GGACCCCTCC TCCGGCATTG CTCCGCTGAG GCCTGAGCAG 
CTCCAAGTGT TCGAAACCCT GGAGGAGATC ACAGGTTACC TGTACATCTC AGCATGGCCA 
GACAGTCTCC GTGACCTCAG TGTCTTCCAG AACCTTCGAA TCATTCGGGG ACGGATTCTC 
CACGATGGCG CGTACTCATT GACACTGCAA GGCCTGGGGA TCCACTCGCT GGGGCTGCGC 
TCACTGCGGG AGCTGGGCAG TGGATTGGCT CTGATTCACC GCAACGCCCA TCTCTGCTTT 
GTACACACTG TACCTTGGGA CCAGCTCTTC CGGAACCCAC ATCAGGCCCT GCTCCACAGT 
GGGAACCGGC CGGAAGAGGA TTGTGGTCTC GAGGGCTTGG TCTGTAACTC ACTGTGTGCC 
CACGGGCACT GCTGGGGGCC AGGGCCCACC CAGTGTGTCA ACTGCAGTCA TTTCCTTCGG 
GGCCAGGAGT GTGTGGAGGA GTGCCGAGTA TGGAAGGGGC TCCCCCGGGA GTATGTGAGT 
GACAAGCGCT GTCTGCCGTG TCACCCCGAG TGTCAGCCTC AAAACAGCTC AGAGACCTGC 
TTTGGATCGG AGGCTGATCA GTGTGCAGCC TGCGCCCACT ACAAGGACTC GTCCTCCTGT 
GTGGCTCGCT GCCCCAGTGG TGTGAAACCG GACCTCTCCT ACATGCCCAT CTGGAAGTAC 
CCGGATGAGG AGGGCATATG CCAGCCGTGC CCCATCAACT GCACCCACTC CTGTGTGGAT 
CTGGATGAAC GAGGCTGCCC AGCAGAGCAG AGAGCCAGCC CGGTGACATT CATCATTGCA 
ACTGTAGTGG GCGTCCTGCT GTTCCTGATC TTAGTGGTGG TCGTTGGAAT CCTAATCAAA 
CGAAGGAGAC AGAAGATCCG GAAGTATACG ATGCGTAGGC TGCTGCAGGA AACTGAGTTA 
GTGGAGCCGC TGACGCCCAG CGGAGCAATG CCCAACCAGG CTCAGATGCG GATCCTAAAA 
GAGACGGAGC TAAGGAAGGT GAAGGTGCTT GGATCAGGAG CTTTTGGCAC TGTCTACAAG 
GGCATCTGGA TCCCAGATGG GGAGAATGTG AAAATCCCCG TGGCTATCAA GGTGTTGAGA 
GAAAACACAT CTCCTAAAGC CAACAAAGAA ATTCTAGATG AAGCGTATGT GATGGCTGGT 
GTGGGTTCTC CGTATGTGTC CCGCCTCCTG GGCATCTGCC TGACATCCAC AGTACAGCTG 
GTGACACAGC TTATGCCCTA CGGCTGCCTT CTGGACCATG TCCGAGAACA CCGAGGTCGC 
CTAGGCTCCC AGGACCTGCT CAACTGGTGT GTTCAGATTG CCAAGGGGAT GAGCTACCTG 
GAGGACGTGC GGCTTGTACA CAGGGACCTG GCTGCCCGGA ATGTGCTAGT CAAGAGTCCC 
AACCACGTCA AGATTACAGA TTTCGGGCTG GCTCGGCTGC TGGACATTGA TGAGACAGAG 
TACCATGCAG ATGGGGGCAA GGTGCCCATC AAATGGATGG CATTGGAATC TATTCTCAGA 
CGCCGGTTCA CCCATCAGAG TGATGTGTGG AGCTATGGAG TGACTGTGTG GGAGCTGATG 
ACTTTTGGGG CCAAACCTTA CGATGGAATC CCAGCCCGGG AGATCCCTGA TTTGCTGGAG 
AAGGGAGAAC GCCTACCTCA GCCTCCAATC TGCACCATTG ATGTCTACAT GATTATGGTC 
AAATGTTGGA TGATTGACTC TGAATGTCGC CCGAGATTCC GGGAGTTGGT GTCAGAATTT 
TCACGTATGG CGAGGGACCC CCAGCGTTTT GTGGTCATCC AGAACGAGGA CTTGGGCCCA 
TCCAGCCCCA TGGACAGTAC CTTCTACCGT TCACTGCTGG AAGATGATGA CATGGGTGAC 
CTGGTAGACG CTGAAGAGTA TCTGGTGCCC CAGCAGGGAT TCTTCTCCCC GGACCCTACC 
CCAGGCACTG GGAGCACAGC CCATAGAAGG CACCGCAGCT CGTCCACCAG GAGTGGAGGT 
GGTGAGCTGA CACTGGGCCT GGAGCCCTCG GAAGAAGGGC CCCCCAGATC TCCACTGGCT 
CCCTCGGAAG GGGCTGGCTC CGATGTGTTT GATGGTGACC TGGCAATGGG GGTAACCAAA 
GGGCTGCAGA GCCTCTCTCC ACATGACCTC AGCCCTCTAC AGCGGTACAG CGAGGACCCC 
ACATTACCTC TGCCCCCCGA GACTGATGGC TATGTTGCTC CCCTGGCCTG CAGCCCCCAG 
CCCGAGTATG TGAACCAATC AGAGGTTCAG CCTCAGCCTC CTTTAACCCC AGAGGGTCCT 
CTGCCTCCTG TCCGGCCTGC TGGTGCTACT CTAGAAAGAC CCAAGACTCT CTCTCCTGGG 
AAGAATGGGG TTGTCAAAGA CGTTTTTGCC TTCGGGGGTG CTGTGGAGAA CCCTGAATAC 
TTAGTACCGA GAGAAGGCAC TGCCTCTCCG CCCCACCCTT CTCCTGCCTT CAGCCCAGCC 
TTTGACAACC TCTATTACTG GGACCAGAAC TCATCGGAGC AGGGGCCTCC ACCAAGTAAC 
TTTGAAGGGA CCCCCACTGC AGAGAACCCT GAGTACCTAG GCCTGGATGT ACCTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058699.2
CDS	106..3885
Translation	MIIMELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDCGLEGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLVPREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV

Target ORF information:

RefSeq Version	NM_017003.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus erb-b2 receptor tyrosine kinase 2 (Erbb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017003.2

ORF Insert Sequence:

ATGATCATCA TGGAGCTGGC GGCCTGGTGC CGCTGGGGGT TCCTCCTCGC CCTCCTGCCC 
CCCGGAATCG CGGGCACCCA AGTGTGTACC GGCACAGACA TGAAGTTGCG GCTCCCTGCC 
AGTCCTGAGA CCCACCTGGA CATGCTCCGC CACCTGTACC AGGGCTGTCA GGTAGTGCAG 
GGCAACTTGG AGCTTACCTA CGTGCCTGCC AATGCCAGCC TCTCATTCCT GCAGGACATC 
CAGGAAGTTC AGGGTTACAT GCTCATCGCT CACAACCAGG TGAAGCGCGT CCCACTGCAA 
AGGCTGCGCA TCGTGAGAGG GACCCAGCTC TTTGAGGACA AGTATGCCCT GGCTGTGCTA 
GACAACCGAG ATCCTCAGGA CAATGTCGCC GCCTCCACCC CAGGCAGAAC CCCAGAGGGG 
CTGCGGGAGC TGCAGCTTCG AAGTCTCACA GAGATCCTGA AGGGAGGAGT TTTGATCCGT 
GGGAACCCTC AGCTCTGCTA CCAGGACATG GTTTTGTGGA AGGACGTCTT CCGCAAGAAT 
AACCAACTGG CTCCTGTCGA TATAGACACC AATCGTTCCC GGGCCTGTCC ACCTTGTGCC 
CCCGCCTGCA AAGACAATCA CTGTTGGGGT GAGAGTCCGG AAGACTGTCA GATCTTGACT 
GGCACCATCT GTACCAGTGG TTGTGCCCGG TGCAAGGGCC GGCTGCCCAC TGACTGCTGC 
CATGAGCAGT GTGCCGCAGG CTGCACGGGC CCCAAGCATT CTGACTGCCT GGCCTGCCTC 
CACTTCAATC ATAGTGGTAT CTGTGAGCTG CACTGCCCAG CCCTCGTCAC CTACAACACA 
GACACCTTTG AGTCCATGCA CAACCCTGAG GGTCGCTACA CCTTTGGTGC CAGCTGCGTG 
ACCACCTGCC CCTACAACTA CCTGTCTACG GAAGTGGGAT CCTGCACTCT GGTGTGTCCC 
CCGAATAACC AAGAGGTCAC AGCTGAGGAC GGAACACAGC GTTGTGAGAA ATGCAGCAAG 
CCCTGTGCTC GAGTGTGCTA TGGTCTGGGC ATGGAGCACC TTCGAGGGGC GAGGGCCATC 
ACCAGTGACA ATGTCCAGGA GTTTGATGGC TGCAAGAAGA TCTTTGGGAG CCTGGCATTT 
TTGCCGGAGA GCTTTGATGG GGACCCCTCC TCCGGCATTG CTCCGCTGAG GCCTGAGCAG 
CTCCAAGTGT TCGAAACCCT GGAGGAGATC ACAGGTTACC TGTACATCTC AGCATGGCCA 
GACAGTCTCC GTGACCTCAG TGTCTTCCAG AACCTTCGAA TCATTCGGGG ACGGATTCTC 
CACGATGGCG CGTACTCATT GACACTGCAA GGCCTGGGGA TCCACTCGCT GGGGCTGCGC 
TCACTGCGGG AGCTGGGCAG TGGATTGGCT CTGATTCACC GCAACGCCCA TCTCTGCTTT 
GTACACACTG TACCTTGGGA CCAGCTCTTC CGGAACCCAC ATCAGGCCCT GCTCCACAGT 
GGGAACCGGC CGGAAGAGGA TTGTGGTCTC GAGGGCTTGG TCTGTAACTC ACTGTGTGCC 
CACGGGCACT GCTGGGGGCC AGGGCCCACC CAGTGTGTCA ACTGCAGTCA TTTCCTTCGG 
GGCCAGGAGT GTGTGGAGGA GTGCCGAGTA TGGAAGGGGC TCCCCCGGGA GTATGTGAGT 
GACAAGCGCT GTCTGCCGTG TCACCCCGAG TGTCAGCCTC AAAACAGCTC AGAGACCTGC 
TTTGGATCGG AGGCTGATCA GTGTGCAGCC TGCGCCCACT ACAAGGACTC GTCCTCCTGT 
GTGGCTCGCT GCCCCAGTGG TGTGAAACCG GACCTCTCCT ACATGCCCAT CTGGAAGTAC 
CCGGATGAGG AGGGCATATG CCAGCCGTGC CCCATCAACT GCACCCACTC CTGTGTGGAT 
CTGGATGAAC GAGGCTGCCC AGCAGAGCAG AGAGCCAGCC CGGTGACATT CATCATTGCA 
ACTGTAGTGG GCGTCCTGCT GTTCCTGATC TTAGTGGTGG TCGTTGGAAT CCTAATCAAA 
CGAAGGAGAC AGAAGATCCG GAAGTATACG ATGCGTAGGC TGCTGCAGGA AACTGAGTTA 
GTGGAGCCGC TGACGCCCAG CGGAGCAATG CCCAACCAGG CTCAGATGCG GATCCTAAAA 
GAGACGGAGC TAAGGAAGGT GAAGGTGCTT GGATCAGGAG CTTTTGGCAC TGTCTACAAG 
GGCATCTGGA TCCCAGATGG GGAGAATGTG AAAATCCCCG TGGCTATCAA GGTGTTGAGA 
GAAAACACAT CTCCTAAAGC CAACAAAGAA ATTCTAGATG AAGCGTATGT GATGGCTGGT 
GTGGGTTCTC CGTATGTGTC CCGCCTCCTG GGCATCTGCC TGACATCCAC AGTACAGCTG 
GTGACACAGC TTATGCCCTA CGGCTGCCTT CTGGACCATG TCCGAGAACA CCGAGGTCGC 
CTAGGCTCCC AGGACCTGCT CAACTGGTGT GTTCAGATTG CCAAGGGGAT GAGCTACCTG 
GAGGACGTGC GGCTTGTACA CAGGGACCTG GCTGCCCGGA ATGTGCTAGT CAAGAGTCCC 
AACCACGTCA AGATTACAGA TTTCGGGCTG GCTCGGCTGC TGGACATTGA TGAGACAGAG 
TACCATGCAG ATGGGGGCAA GGTGCCCATC AAATGGATGG CATTGGAATC TATTCTCAGA 
CGCCGGTTCA CCCATCAGAG TGATGTGTGG AGCTATGGAG TGACTGTGTG GGAGCTGATG 
ACTTTTGGGG CCAAACCTTA CGATGGAATC CCAGCCCGGG AGATCCCTGA TTTGCTGGAG 
AAGGGAGAAC GCCTACCTCA GCCTCCAATC TGCACCATTG ATGTCTACAT GATTATGGTC 
AAATGTTGGA TGATTGACTC TGAATGTCGC CCGAGATTCC GGGAGTTGGT GTCAGAATTT 
TCACGTATGG CGAGGGACCC CCAGCGTTTT GTGGTCATCC AGAACGAGGA CTTGGGCCCA 
TCCAGCCCCA TGGACAGTAC CTTCTACCGT TCACTGCTGG AAGATGATGA CATGGGTGAC 
CTGGTAGACG CTGAAGAGTA TCTGGTGCCC CAGCAGGGAT TCTTCTCCCC GGACCCTACC 
CCAGGCACTG GGAGCACAGC CCATAGAAGG CACCGCAGCT CGTCCACCAG GAGTGGAGGT 
GGTGAGCTGA CACTGGGCCT GGAGCCCTCG GAAGAAGGGC CCCCCAGATC TCCACTGGCT 
CCCTCGGAAG GGGCTGGCTC CGATGTGTTT GATGGTGACC TGGCAATGGG GGTAACCAAA 
GGGCTGCAGA GCCTCTCTCC ACATGACCTC AGCCCTCTAC AGCGGTACAG CGAGGACCCC 
ACATTACCTC TGCCCCCCGA GACTGATGGC TATGTTGCTC CCCTGGCCTG CAGCCCCCAG 
CCCGAGTATG TGAACCAATC AGAGGTTCAG CCTCAGCCTC CTTTAACCCC AGAGGGTCCT 
CTGCCTCCTG TCCGGCCTGC TGGTGCTACT CTAGAAAGAC CCAAGACTCT CTCTCCTGGG 
AAGAATGGGG TTGTCAAAGA CGTTTTTGCC TTCGGGGGTG CTGTGGAGAA CCCTGAATAC 
TTAGTACCGA GAGAAGGCAC TGCCTCTCCG CCCCACCCTT CTCCTGCCTT CAGCCCAGCC 
TTTGACAACC TCTATTACTG GGACCAGAAC TCATCGGAGC AGGGGCCTCC ACCAAGTAAC 
TTTGAAGGGA CCCCCACTGC AGAGAACCCT GAGTACCTAG GCCTGGATGT ACCTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Naked Polyamidoamine Polymers Intrinsically Inhibit Angiotensin II-Mediated EGFR and ErbB2 Transactivation in a Dendrimer Generation- and Surface Chemistry-Dependent Manner.
Molecular pharmaceutics13(5)1575-86(2016 05)
Akhtar S,El-Hashim AZ,Chandrasekhar B,Attur S,Benter IF

Crystal Structure and Substrate Specificity of PTPN12.
Cell reports15(6)1345-58(2016 05)
Li H,Yang F,Liu C,Xiao P,Xu Y,Liang Z,Liu C,Wang H,Wang W,Zheng W,Zhang W,Ma X,He D,Song X,Cui F,Xu Z,Yi F,Sun JP,Yu X

Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes.
Kidney international89(5)1125-1135(2016 May)
Betz BB,Jenks SJ,Cronshaw AD,Lamont DJ,Cairns C,Manning JR,Goddard J,Webb DJ,Mullins JJ,Hughes J,McLachlan S,Strachan MWJ,Price JF,Conway BR

Electrocardiographic Characterization of Cardiac Hypertrophy in Mice that Overexpress the ErbB2 Receptor Tyrosine Kinase.
Comparative medicine65(4)295-307(2015 Aug)
Sysa-Shah P,S?rensen LL,Abraham MR,Gabrielson KL