Epo cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Epo
Entrez Gene ID	24335
Full Name	erythropoietin
General protein information	Preferred Names erythropoietin Names erythropoietin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	acts as a regulator of erythropoiesis; may facilitate oxygen delivery in response to hypoxia [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017001.1	NP_058697.1	erythropoietin precursor
XM_006249101.2	XP_006249163.1	erythropoietin isoform X1

Pathways from BioSystems

Homologies

	EPO	NP_001036201.1
Danio rerio (zebrafish)	epo	NP_001033098.1
Danio rerio (zebrafish)	LOC100002479	XP_001342254.1
Bos taurus (cattle)	EPO	NP_776334.1
Pan troglodytes (chimpanzee)	EPO	XP_519268.2
Mus musculus (house mouse)	Epo	NP_031968.1
Xenopus tropicalis (tropical clawed frog)	epo	NP_001233194.1
Homo sapiens (human)	EPO	NP_000790.2
Canis lupus familiaris (dog)	EPO	NP_001006647.1
Rattus norvegicus (Norway rat)	Epo	NP_058697.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T, Ozcan A, Ozdemir MA, Garcia KC, Piehler J, Gazda HT, Klein DE, Sankaran VG
Cell168(6)1053-1064.e15(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present study aimed to determine the expression of erythropoietin (EPO) and the EPO receptor (EPOR) in spiral ganglion neurons (SGNs) in the inner ear of rats of various ages, and the associated neuronal apoptosis and hearing alterations.
Title: Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations.

EPO receptor ligand dimeric peptides AF41676 and AF43136 administered before reperfusion are able to reduce infarct size in a rat model of AMI.
Title: Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats.

Taken together, our results reveal that EPO and cEPO mediate MEF2 target gene expression via the regulation of HDAC5 phosphorylation at Ser259/498, and suggest that HDAC5 could be a mechanism contributing to the therapeutic actions of EPO and cEPO.
Title: Erythropoietin and carbamylated erythropoietin promote histone deacetylase 5 phosphorylation and nuclear export in rat hippocampal neurons.

this study is the first to elucidate the detailed mechanism by which AhR plays an indispensable role in the suppression of HIF activation by IS.
Title: Activation of aryl hydrocarbon receptor mediates suppression of hypoxia-inducible factor-dependent erythropoietin expression by indoxyl sulfate.

the hypercapnic hypoxia causes maximum activation of the synthesis and accumulation of erythropoietin HIF-1alpha, and permissive hypercapnia enhances their content more than hypoxic exposure.
Title: [Hypercapnia--alternative hypoxia signal incentives to increase HIF-1? and erythropoietin in the brain].

The following Epo gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Epo cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12735	NM_017001.1 Latest version!	Rattus norvegicus erythropoietin (Epo), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa34733	XM_006249101.2 Latest version!	Rattus norvegicus erythropoietin (Epo), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Epo ( NM_017001.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058697.1 Rattus norvegicus erythropoietin (Epo), mRNA.

Price & Availability↑

CloneID	ORa12735
Clone ID Related Accession (Same CDS sequence)	NM_017001.1
Accession Version	NM_017001.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	erythropoietin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D10763.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10763.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGTGC CCGAACGTCC CACCCTGCTG CTTTTACTAT CCTTGCTACT GATTCCTCTG 
GGCCTCCCAG TCCTCTGCGC TCCCCCACGC CTCATTTGCG ACAGTCGCGT TCTGGAGAGG 
TACATCTTGG AGGCCAAGGA GGCAGAAAAT GTCACAATGG GCTGTGCAGA AGGTCCCAGA 
CTGAGTGAGA ATATTACCGT CCCAGATACC AAAGTCAACT TCTACGCTTG GAAAAGAATG 
AAGGTGGAAG AACAGGCTGT AGAAGTTTGG CAAGGCCTGT CTCTGCTCTC AGAAGCCATC 
CTGCAGGCCC AGGCTCTGCA GGCCAATTCC TCCCAGCCAC CAGAGAGTCT TCAGCTTCAT 
ATAGACAAAG CCATCAGTGG GCTACGTAGC CTCACTTCAC TGCTTCGGGT GCTGGGAGCT 
CAGAAGGAAT TGATGTCGCC TCCAGACGCC ACCCAAGCCG CTCCACTCCG AACACTCACA 
GCGGATACTT TCTGCAAGCT CTTCCGGGTC TACTCCAACT TCCTCCGGGG GAAACTGAAG 
CTGTACACGG GGGAGGCCTG CAGGAGAGGG GACAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058697.1
CDS	23..601
Translation	MGVPERPTLLLLLSLLLIPLGLPVLCAPPRLICDSRVLERYILEAKEAENVTMGCAEGPRLSENITVPDTKVNFYAWKRMKVEEQAVEVWQGLSLLSEAILQAQALQANSSQPPESLQLHIDKAISGLRSLTSLLRVLGAQKELMSPPDATQAAPLRTLTADTFCKLFRVYSNFLRGKLKLYTGEACRRGDR

Target ORF information:

RefSeq Version	NM_017001.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus erythropoietin (Epo), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017001.1

ORF Insert Sequence:

ATGGGGGTGC CCGAACGTCC CACCCTGCTG CTTTTACTAT CCTTGCTACT GATTCCTCTG 
GGCCTCCCAG TCCTCTGCGC TCCCCCACGC CTCATTTGCG ACAGTCGCGT TCTGGAGAGG 
TACATCTTGG AGGCCAAGGA GGCAGAAAAT GTCACAATGG GCTGTGCAGA AGGTCCCAGA 
CTGAGTGAGA ATATTACCGT CCCAGATACC AAAGTCAACT TCTACGCTTG GAAAAGAATG 
AAGGTGGAAG AACAGGCTGT AGAAGTTTGG CAAGGCCTGT CTCTGCTCTC AGAAGCCATC 
CTGCAGGCCC AGGCTCTGCA GGCCAATTCC TCCCAGCCAC CAGAGAGTCT TCAGCTTCAT 
ATAGACAAAG CCATCAGTGG GCTACGTAGC CTCACTTCAC TGCTTCGGGT GCTGGGAGCT 
CAGAAGGAAT TGATGTCGCC TCCAGACGCC ACCCAAGCCG CTCCACTCCG AACACTCACA 
GCGGATACTT TCTGCAAGCT CTTCCGGGTC TACTCCAACT TCCTCCGGGG GAAACTGAAG 
CTGTACACGG GGGAGGCCTG CAGGAGAGGG GACAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Epo ( XM_006249101.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249163.1 Rattus norvegicus erythropoietin (Epo), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa34733
Clone ID Related Accession (Same CDS sequence)	XM_006249101.2
Accession Version	XM_006249101.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	erythropoietin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006249101.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGCCA CTCAGGCAGA GCCTAAGCAA TTGCAAGGTC GGGGTCAGCA GAGACTAGAA 
GGGCAGAGGG GTCTCGCTGA GCAAACCGGC CCCTGCAGTC CCACGGCCCC CTCCCCTCCC 
CTCCCTCCTC ACACTCAGCC TGCCTTTCTT ACAGAACGTC CCACCCTGCT GCTTTTACTA 
TCCTTGCTAC TGATTCCTCT GGGCCTCCCA GTCCTCTGCG CTCCCCCACG CCTCATTTGC 
GACAGTCGCG TTCTGGAGAG GTACATCTTG GAGGCCAAGG AGGCAGAAAA TGTCACAATG 
GGCTGTGCAG AAGGTCCCAG ACTGAGTGAG AATATTACCG TCCCAGATAC CAAAGTCAAC 
TTCTACGCTT GGAAAAGAAT GAAGGTGGAA GAACAGGCTG TAGAAGTTTG GCAAGGCCTG 
TCTCTGCTCT CAGAAGCCAT CCTGCAGGCC CAGGCTCTGC AGGCCAATTC CTCCCAGCCA 
CCAGAGAGTC TTCAGCTTCA TATAGACAAA GCCATCAGTG GGCTACGTAG CCTCACTTCA 
CTGCTTCGGG TGCTGGGAGC TCAGAAGGAA TTGATGTCGC CTCCAGACGC CACCCAAGCC 
GCTCCACTCC GAACACTCAC AGCGGATACT TTCTGCAAGC TCTTCCGGGT CTACTCCAAC 
TTCCTCCGGG GGAAACTGAA GCTGTACACG GGGGAGGCCT GCAGGAGAGG GGACAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249163.1
CDS	24..743
Translation	MKATQAEPKQLQGRGQQRLEGQRGLAEQTGPCSPTAPSPPLPPHTQPAFLTERPTLLLLLSLLLIPLGLPVLCAPPRLICDSRVLERYILEAKEAENVTMGCAEGPRLSENITVPDTKVNFYAWKRMKVEEQAVEVWQGLSLLSEAILQAQALQANSSQPPESLQLHIDKAISGLRSLTSLLRVLGAQKELMSPPDATQAAPLRTLTADTFCKLFRVYSNFLRGKLKLYTGEACRRGDR

Target ORF information:

RefSeq Version	XM_006249101.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus erythropoietin (Epo), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249101.2

ORF Insert Sequence:

ATGAAGGCCA CTCAGGCAGA GCCTAAGCAA TTGCAAGGTC GGGGTCAGCA GAGACTAGAA 
GGGCAGAGGG GTCTCGCTGA GCAAACCGGC CCCTGCAGTC CCACGGCCCC CTCCCCTCCC 
CTCCCTCCTC ACACTCAGCC TGCCTTTCTT ACAGAACGTC CCACCCTGCT GCTTTTACTA 
TCCTTGCTAC TGATTCCTCT GGGCCTCCCA GTCCTCTGCG CTCCCCCACG CCTCATTTGC 
GACAGTCGCG TTCTGGAGAG GTACATCTTG GAGGCCAAGG AGGCAGAAAA TGTCACAATG 
GGCTGTGCAG AAGGTCCCAG ACTGAGTGAG AATATTACCG TCCCAGATAC CAAAGTCAAC 
TTCTACGCTT GGAAAAGAAT GAAGGTGGAA GAACAGGCTG TAGAAGTTTG GCAAGGCCTG 
TCTCTGCTCT CAGAAGCCAT CCTGCAGGCC CAGGCTCTGC AGGCCAATTC CTCCCAGCCA 
CCAGAGAGTC TTCAGCTTCA TATAGACAAA GCCATCAGTG GGCTACGTAG CCTCACTTCA 
CTGCTTCGGG TGCTGGGAGC TCAGAAGGAA TTGATGTCGC CTCCAGACGC CACCCAAGCC 
GCTCCACTCC GAACACTCAC AGCGGATACT TTCTGCAAGC TCTTCCGGGT CTACTCCAAC 
TTCCTCCGGG GGAAACTGAA GCTGTACACG GGGGAGGCCT GCAGGAGAGG GGACAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
Cell168(6)1053-1064.e15(2017 Mar)
Kim AR,Ulirsch JC,Wilmes S,Unal E,Moraga I,Karakukcu M,Yuan D,Kazerounian S,Abdulhay NJ,King DS,Gupta N,Gabriel SB,Lander ES,Patiroglu T,Ozcan A,Ozdemir MA,Garcia KC,Piehler J,Gazda HT,Klein DE,Sankaran VG

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Epo cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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