C4a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	C4a
Entrez Gene ID	24233
Full Name	complement component 4A (Rodgers blood group)
Synonyms	C4,C4-1,C4b
General protein information	Preferred Names complement component 4A (Rodgers blood group) Names complement C4 complement C4-like complement component 4 (within H-2S) complement component 4, gene 1 complement component 4B (Chido blood group) complement component 4B (Childo blood group)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	complement protein, part of the classical activation pathway; localizes to the class III region of the MHC [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031504.3	NP_113692.2	complement C4 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	C4a	NP_035543.2
Danio rerio (zebrafish)	si:dkey-8k3.2	XP_001334640.1
Mus musculus (house mouse)	C4b	NP_033910.2
Rattus norvegicus (Norway rat)	C4b	NP_001002805.1
Homo sapiens (human)	C4A	NP_009224.2
Pan troglodytes (chimpanzee)	C4A	XP_003311220.1
Canis lupus familiaris (dog)	C4A	XP_005627805.1
Bos taurus (cattle)	C4A	NP_001159957.1
Gallus gallus (chicken)	C4	NP_001070701.1
Homo sapiens (human)	C4B	NP_001002029.3
Xenopus tropicalis (tropical clawed frog)	c4a	NP_001107156.1
Rattus norvegicus (Norway rat)	C4a	NP_113692.2

Gene Ontology
Bibliography

Related articles in PubMed

Schizophrenia risk from complex variation of complement component 4.
Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE, , Daly MJ, Carroll MC, Stevens B, McCarroll SA
Nature530(7589)177-83(2016 Feb)

Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes.
Dom?nguez-Rodr?guez A, Ruiz-Hurtado G, Sabourin J, G?mez AM, Alvarez JL, Benitah JP
Journal of molecular and cellular cardiology8774-8(2015 Oct)

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel S, Parker BL, Packer NH
The Journal of biological chemistry290(14)8789-802(2015 Apr)

Proteomic profiling of heterotopic heart-transplanted rats using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: potential biomarkers and drug targets.
Bao Y, Xiu DR, Zhang L
The Journal of international medical research41(3)628-35(2013 Jun)

Association between copy number variation of complement component C4 and Graves' disease.
Liu YH, Wan L, Chang CT, Liao WL, Chen WC, Tsai Y, Tsai CH, Tsai FJ
Journal of biomedical science1871(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our study provides the first evidence that sustained selective EPAC activation leads to an increase in TRPC3 and C4 protein expression and induces a proarrhythmic SOCE-like activity in adult rat ventricular cardiomyocytes
Title: Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes.

The expression of the complement component C3f and complement component 4A have potential for use in post-transplant diagnosis of rejection.
Title: Proteomic profiling of heterotopic heart-transplanted rats using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: potential biomarkers and drug targets.

MASP-2, C4, and C2 and their activation fragments have roles in complement activation via the lectin pathway
Title: Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway.

C3 and C4 may be involved in the immunopathology of allergic rhinitis.
Title: [MRNA expression of complement C3 and C4 in rat nasal mucosa with allergic rhinitis].

This study presents the genomic organization of the two C4 gene-containing modules and the expression of the two C4 genes in the rat (Rattus norvegicus).
Title: The rat expresses two complement factor C4 proteins, but only one isotype is expressed in the liver.

The following C4a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C4a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07929	NM_031504.3 Latest version!	Rattus norvegicus complement C4A (C4a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$951.30 $1359.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C4a ( NM_031504.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113692.2 Rattus norvegicus complement C4A (C4a), mRNA.

Price & Availability↑

CloneID	ORa07929
Clone ID Related Accession (Same CDS sequence)	NM_031504.3
Accession Version	NM_031504.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	complement C4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM045174.1, AY149995.1, FM042803.1, CK600071.1, CO564028.1 and CO555571.1. On Sep 22, 2009 this sequence version replaced NM_031504.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2689599, SAMN01906355 [ECO:0000350] ##Evidence-Data-END##

ATGCGGCTCC TCTGGGGCCT GGCCTGGGCA TTCAGCTTCT TCGCCTCCTC TCTGCAGAAG 
CCCAGGTTGC TCCTGTTCTC CCCTTCTGTG GTTAATTTGG GGACCCCCCT GTCAGTAGGG 
GTGCAGCTCC TGGATGCCCC TGCAGGACAG GAGGTGAAAG GCTCAGTGTA CCTCAGAAAC 
CCAACAAGCG GTCCCTGCTC CCCAAAGAAG GACTTTAAGC TCAGCTCGGG AAATGACTTT 
GTGCTTCTCA GACTTGAGGT CCCACTGAAA GATGTGAGGA GTTGTGGCCT CTTTGGCCTG 
CGCAGAGCCC CCCACATCCA GCTGGTGGCT CACTCTCCGT GGCTAAAGAA CACAGCATCC 
AAAGCCACCG AGACTCAGGG GGTCAACCTG CTTTTCTCTT CCCGACGAGG CCACATCTTT 
GTGCAGACCG ATCAGCCTAT CTATAACCCT GGGCAGCGGG TTCGTTATCG GGTCTTTGCA 
CTGGATCAAA AGATGCGTCC ATCTACTGAC ACCCTCACGG TCACAGTGGA GAACTCCCAT 
GGCCTCCGTG TACGCAAGAA GGAGGTATTT GCCCCCACAT CCATCTTCCA AGATGACTTC 
ATAATTCCAG ACATCTCAGA GCCGGGGACC TGGAAGATCT CAGCTAGGTT CTCAGATGGC 
CTCGAGTCCA ACAGAAGCAC CCACTTCGAA GTGAAGAAAT ATGTCCTTCC CAACTTTGAG 
GTGAAGCTTA CTCCTTGGAA GCCATATATC CTGACAGTGC CTAGCTACCG TGAAGAAATA 
CAATTAGACG TCCAGGCCAG ATACGTCTAC GGGAAGCCCG TGCAGGGCGT GGCATATACC 
CGCTTCGCAC TCATGGATGA GCAGGGGAAG AAGTCTTTCC TCCGGGGCCT AGAGACCCAG 
ACCAAGTTGG TGGAAGGCCA GACTCACATC TCCATCTCAA GGGACCAGTT CCAGGCTGCC 
CTGGGTAAAG TGAATACTGA GATCGGAGAC CTGGAGGGGC TGCGGCTCTA CGCTGCCGTA 
GCTGTCATTG AGTCTCCAGG AGGAGAGATG GAGGAGGCGG AGCTCACATC CTGGCCCTTC 
GTGTCATCTG CCTTCTCCTT GGATCTCAGC CACACCAAGC AGCATCTTGT GCCCGGGGCC 
CCCTTCCTGC TGCAGGCCCT GGTTCGAGAA ATGTCAGGCT CTGAAGCCTC TGATGTTCCT 
GTCAAAGTCT CTGCCACATT GTTGTCTGGG TCCGACTCGA AAGTCCTTGA CTTTCAACAG 
AACACCAATG GGATTGGCCA AGTCAGCTTT TCCATCCATG TCCCGCCAAC CATCACCGAA 
CTTCGACTCT TGGTATCTGC CGGTTCCCTC TACCCAGCTG TAGCCAAGCT CACCGTGCAA 
GCCCCACCTT CAAGAGGCCC CGGCTTTCTG TCCATTGAGC CATTAGACCT TCGGTCCCCT 
CGTGTGGGGG ACACCTTCGT CCTGAGCCTT CGAACCGTGG GCATCCCTAT GCCTACCTTC 
TCTCATTACT ACTACATGAT CATCTCCAGA GGCCAGATCA TGGCCATGAG TCGGGAGCCC 
AGGAGGGCCC TGACCTCCAT CTCTGTCTTG GTGGACCATC ACCTGGCTCC CTCTTTCTAC 
TTTGTGGCCT ACTTCTATCA CCAAGGACTC CCAGTGGCCA ACTCCCTGCT CATCAACGTC 
CAGCCCGGGG ACTGTGAGGG CAAGCTGGAA TTGAAGGTGG ATGGTGCCAA GGAGTATCGC 
AATGGAGACA GCATGAAGCT CCAACTTCAA ACTGACTCTG AAGCCCTGGT GGCACTGGGA 
GCTGTGGACA CAGCTCTGTA TGCTGTGGGT GGCCGGTCTC ACAAACCCCT CGACATGAGC 
AAGGTCTTTG AAGTAATGAA CAGCTACAAC CTTGGCTGTG GTCCCGGAGG CGGGGACGAT 
GCCCTTCAGG TGTTCCAGAC TGCTGGTCTG GCCTTTTCTG ACGGTGATCG ACTAACTCAG 
ACCAAAGAGA ACCTGAGCTG TCCCAAGGAG AAGAAAAGTC GGCAAAAGCG AAATGTTAAC 
TTCCAGAAGG CTATTAGCGA GAAGTTGGGC CAGTATTCCT CTCCAGACAC CAAGCGCTGC 
TGCCAGGATG GGATGACCAA GCTGCCCATG GCACGCACCT GCGAGCAGAG GGCAGCCCGC 
GTGCCTCAGC CAGCCTGCCG GGAGCCCTTC TTGTCCTGTT GCAAGTTTGC TGAGGACCTC 
CGCAGGAACC AGACCAGGAG CCAGGCGGGC CTCGCCCGAG CCCAGGACAT GCTGCAGGAG 
GAGGATCTGA TAGATGAAGA TGACATTCTC GTGCGCAGCT TCTTCCCAGA GAACTGGCTC 
TGGAGAGTGG AACCTGTGGA CCGCTCCAAA CTGTTGACTG TGTGGCTCCC TGACTCTCTG 
ACCACATGGG AGATTCATGG TGTGAGCCTG TCCAAAAGCA AAGGCTTGTG TGTAGCCAAG 
CCAACTCGCG TGCGAGTGTT CCGAGAATTC CACCTGCACC TGCGCCTGCC CATCTCTGTC 
CGGCGCTTCG AGCAGCTTGA ATTACGGCCC GTTCTCTACA ACTATCTGAG TGAGGACGTG 
ACTGTAAGTG TCCATGTGTC CCCAGTGGAG GGGCTGTGCC TGGCTGGTGG TGGATTGCTG 
GCCCAGCAAG TATCAGTGCC TGCAGGCTCC GCCCGGCCTG TGGCCTTCTC TGTGGTACCC 
ACAGCTGCTG CCAGCATACC CCTGAAAGTG GTGGCTCGGG GGTCTTTTAC TATAGGGGAT 
GCTGTGTCTA AGATTCTCCA AATTGAGAAG GAAGGGGCCA TCCACAGAGA AGAGATAGTC 
TACAACCTCG ACCCCCTAAA TAACCTTGGT CGGAGTTTGG AAATCCCTGG CAGCTCAGAC 
CCCAACGTCA TTCCTGATGG AGATTTCAGC AGCTTCGTCA GGGTTACAGC CTCCGAACCC 
TTGGAGACTT TGGGCTCCGA AGGCGCCTTG TCCCCAGGCG GAGTGGCCTC CCTCCTGAGG 
CTCCCTAGAG GCTGTGCAGA ACAAACCATG ATCTATTTGG CCCCTACCCT GACTGCTTCC 
CACTACCTGG ACAGGACGGA GCAGTGGAGC AAACTGCCCC CTGAGACAAA GGACCATGCT 
GTGGATCTGA TTCAGAAAGG CCACATGCGG ATCCAGCAGT TTCGGAAGAA AGATGGCTCC 
TTTGGGGCAT GGTTACACCG GGACAGCAGC ACCTGGCTCA CGGCTTTTGT GCTGAAGATT 
CTGAGTCTGG CCCAGGAACA GATTGGTGAC TCCCCCGAGA AGCTGCAAGA GACCGCTGGG 
TGGCTGCTGG GCCAGCAGCT GGACGATGGC TCATTCCACG ACCCGTGTCC AGTCATCCAC 
AGAGGCATGC AGGGGGGCTT GGTGGGAACC GATGAGACCG TGGCACTGAC CGCCTTTGTG 
GTCATCGCCC TTCACCACGG GCTGGCCGTC TTCCAGGACG AGAACTCACA GCAGCTGAAG 
AAGAGGGTGG AAGCCTCCAT CACGAAGGCG AACTCGTTCT TGGGGCAGAA GGCAAGTGCT 
GGGCTCCTGG GTGCACACGC ATCCGCCATC ACAGCCTATG CCCTGACACT GACCAAGGCC 
TCGGAGGACC TGCGGAATGT TGCCCACAAC AGCCTGATGG CCATGGCTGA GGAAACAGGG 
GAAAACCTCT ACTGGGGCTC AGCCATTGGC TCTCAGGACA ACGTTGTGTC GTCCACCCCA 
GCCCCTCGTA ATCCCTCAGA ACCTGTGCCC CAGGCCCCAG CCCTGTGGAT CGAAACCACA 
GCCTACGGCC TGCTACATCT GCTGCTGCGG GAGGGGAAGG GAGAAATGGC TGACAAGGTG 
GCAACCTGGC TCACACACCA GGGAAGCTTC CAAGGGGGAT TCCGCAGTAC CCAGGACACT 
GTGGTCACCC TGGATGCCCT GTCTGCATAC TGGATCGCTT CACACACCAC CGAGGAGAAG 
GCACTCAATG TGACTCTCAG CTCCATGGGC CGCAATGGGT ACAAGTCCCA CCTGCTACAG 
CTGAACAACC ACCAAGTCAA GGGCCTGGAG GAGGAGCTGA AGTTCTCCCT GGGCAGCACC 
ATCAATGTGA AAGTGGGAGG AAACAGCAAA GGCACCTTAA AGATCCTTCG TACCTACAAC 
GTCCTGGACA TGAAGAACAC AACATGCCAA GACCTTCGGA TAGAAGTGAC GGTCACAGGC 
TATGTGGAAT ATACAAGGGA GGCCAACGAA GACTATGAAT ACGACTATGA TATGCCAGCC 
GCAGATGACC CCAGTGTCCA CTCGCAGCCT GTGACACCCC TGCAGCTGTT TGAGGGTCGT 
CGGAGCCGCC GCAGGAGGGA GGCCCCCAAG GCTGCGGATG AGCAGGAGTC CAGAGTGCAG 
TACACCGTGT GCATCTGGCG GAACGGTAAC CTGGGGCTGT CTGGGATGGC CATTGCTGAC 
ATCACCCTCC TGAGTGGATT CCAAGCCCTG AGGGCCGACC TGGAGAAGCT GACCTCCCTC 
TCTGACCGTT ACGTGAGTCA CTTTGAGACC GACGGGCCCC ACGTCCTACT ATACTTTGAC 
TCGGTCCCGA CCACCCGGGA GTGTGTGGGC TTTGGAGCCT TGCAGGAGGT GGCCGTGGGG 
CTGGTGCAGC CAGCCAGTGC TGTCCTATAT GACTACTACA GCCCTGATCA CAAGTGCTCT 
GTGTTCTATG CTGCACCCAC CAAGAGCAAG CTCCTCTCCA CCTTGTGCTC TGCAGACGTC 
TGCCAGTGCG CTGAAGGGAA GTGTCCTCGA CAGCGAAGGT CACTGGAGCG AGGGGTGGAG 
GACAAGGATG GTTACCGGAT GAAGTTCGCC TGCTATTATC CCCGAGTGGA GTATGGCTTC 
CAGGTTAAGG TTCTCCGAGA AGACAGCAGA GCTGCCTTCC GCCTCTTTGA GACCAAGATC 
ACCCAAGTCC TGCATTTCAC AAAGGATGCC AAGGCCTCCA TAGGTCAGAC CCGCAACTTT 
CTGGTCCGGG CCTCTTGCCG CCTTCGTTTG GAGCCTAGCA AAGAGTACTT AATCATGGGG 
ATGGACGGAG TCACCAGTGA CCTCAAGGGA GACCCCCAGT ACTTGCTGGA CTCAAATACT 
TGGATCGAGG AGATGCCATC TGAGCGCCTG TGCAGGAGCA CCCGTCAGCG GGCAGCCTGT 
GGCCAGCTCA ATGACTTTCT GCAGGAGTAC AGCAGCCAGG GGTGCCAGGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113692.2
CDS	43..5256
Translation	MRLLWGLAWAFSFFASSLQKPRLLLFSPSVVNLGTPLSVGVQLLDAPAGQEVKGSVYLRNPTSGPCSPKKDFKLSSGNDFVLLRLEVPLKDVRSCGLFGLRRAPHIQLVAHSPWLKNTASKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDTLTVTVENSHGLRVRKKEVFAPTSIFQDDFIIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDVQARYVYGKPVQGVAYTRFALMDEQGKKSFLRGLETQTKLVEGQTHISISRDQFQAALGKVNTEIGDLEGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLLQALVREMSGSEASDVPVKVSATLLSGSDSKVLDFQQNTNGIGQVSFSIHVPPTITELRLLVSAGSLYPAVAKLTVQAPPSRGPGFLSIEPLDLRSPRVGDTFVLSLRTVGIPMPTFSHYYYMIISRGQIMAMSREPRRALTSISVLVDHHLAPSFYFVAYFYHQGLPVANSLLINVQPGDCEGKLELKVDGAKEYRNGDSMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEVMNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKENLSCPKEKKSRQKRNVNFQKAISEKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAGLARAQDMLQEEDLIDEDDILVRSFFPENWLWRVEPVDRSKLLTVWLPDSLTTWEIHGVSLSKSKGLCVAKPTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSEDVTVSVHVSPVEGLCLAGGGLLAQQVSVPAGSARPVAFSVVPTAAASIPLKVVARGSFTIGDAVSKILQIEKEGAIHREEIVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSFVRVTASEPLETLGSEGALSPGGVASLLRLPRGCAEQTMIYLAPTLTASHYLDRTEQWSKLPPETKDHAVDLIQKGHMRIQQFRKKDGSFGAWLHRDSSTWLTAFVLKILSLAQEQIGDSPEKLQETAGWLLGQQLDDGSFHDPCPVIHRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRVEASITKANSFLGQKASAGLLGAHASAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGSAIGSQDNVVSSTPAPRNPSEPVPQAPALWIETTAYGLLHLLLREGKGEMADKVATWLTHQGSFQGGFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGSTINVKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTVTGYVEYTREANEDYEYDYDMPAADDPSVHSQPVTPLQLFEGRRSRRRREAPKAADEQESRVQYTVCIWRNGNLGLSGMAIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGALQEVAVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSKLLSTLCSADVCQCAEGKCPRQRRSLERGVEDKDGYRMKFACYYPRVEYGFQVKVLREDSRAAFRLFETKITQVLHFTKDAKASIGQTRNFLVRASCRLRLEPSKEYLIMGMDGVTSDLKGDPQYLLDSNTWIEEMPSERLCRSTRQRAACGQLNDFLQEYSSQGCQV

Target ORF information:

RefSeq Version	NM_031504.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement C4A (C4a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031504.3

ORF Insert Sequence:

ATGCGGCTCC TCTGGGGCCT GGCCTGGGCA TTCAGCTTCT TCGCCTCCTC TCTGCAGAAG 
CCCAGGTTGC TCCTGTTCTC CCCTTCTGTG GTTAATTTGG GGACCCCCCT GTCAGTAGGG 
GTGCAGCTCC TGGATGCCCC TGCAGGACAG GAGGTGAAAG GCTCAGTGTA CCTCAGAAAC 
CCAACAAGCG GTCCCTGCTC CCCAAAGAAG GACTTTAAGC TCAGCTCGGG AAATGACTTT 
GTGCTTCTCA GACTTGAGGT CCCACTGAAA GATGTGAGGA GTTGTGGCCT CTTTGGCCTG 
CGCAGAGCCC CCCACATCCA GCTGGTGGCT CACTCTCCGT GGCTAAAGAA CACAGCATCC 
AAAGCCACCG AGACTCAGGG GGTCAACCTG CTTTTCTCTT CCCGACGAGG CCACATCTTT 
GTGCAGACCG ATCAGCCTAT CTATAACCCT GGGCAGCGGG TTCGTTATCG GGTCTTTGCA 
CTGGATCAAA AGATGCGTCC ATCTACTGAC ACCCTCACGG TCACAGTGGA GAACTCCCAT 
GGCCTCCGTG TACGCAAGAA GGAGGTATTT GCCCCCACAT CCATCTTCCA AGATGACTTC 
ATAATTCCAG ACATCTCAGA GCCGGGGACC TGGAAGATCT CAGCTAGGTT CTCAGATGGC 
CTCGAGTCCA ACAGAAGCAC CCACTTCGAA GTGAAGAAAT ATGTCCTTCC CAACTTTGAG 
GTGAAGCTTA CTCCTTGGAA GCCATATATC CTGACAGTGC CTAGCTACCG TGAAGAAATA 
CAATTAGACG TCCAGGCCAG ATACGTCTAC GGGAAGCCCG TGCAGGGCGT GGCATATACC 
CGCTTCGCAC TCATGGATGA GCAGGGGAAG AAGTCTTTCC TCCGGGGCCT AGAGACCCAG 
ACCAAGTTGG TGGAAGGCCA GACTCACATC TCCATCTCAA GGGACCAGTT CCAGGCTGCC 
CTGGGTAAAG TGAATACTGA GATCGGAGAC CTGGAGGGGC TGCGGCTCTA CGCTGCCGTA 
GCTGTCATTG AGTCTCCAGG AGGAGAGATG GAGGAGGCGG AGCTCACATC CTGGCCCTTC 
GTGTCATCTG CCTTCTCCTT GGATCTCAGC CACACCAAGC AGCATCTTGT GCCCGGGGCC 
CCCTTCCTGC TGCAGGCCCT GGTTCGAGAA ATGTCAGGCT CTGAAGCCTC TGATGTTCCT 
GTCAAAGTCT CTGCCACATT GTTGTCTGGG TCCGACTCGA AAGTCCTTGA CTTTCAACAG 
AACACCAATG GGATTGGCCA AGTCAGCTTT TCCATCCATG TCCCGCCAAC CATCACCGAA 
CTTCGACTCT TGGTATCTGC CGGTTCCCTC TACCCAGCTG TAGCCAAGCT CACCGTGCAA 
GCCCCACCTT CAAGAGGCCC CGGCTTTCTG TCCATTGAGC CATTAGACCT TCGGTCCCCT 
CGTGTGGGGG ACACCTTCGT CCTGAGCCTT CGAACCGTGG GCATCCCTAT GCCTACCTTC 
TCTCATTACT ACTACATGAT CATCTCCAGA GGCCAGATCA TGGCCATGAG TCGGGAGCCC 
AGGAGGGCCC TGACCTCCAT CTCTGTCTTG GTGGACCATC ACCTGGCTCC CTCTTTCTAC 
TTTGTGGCCT ACTTCTATCA CCAAGGACTC CCAGTGGCCA ACTCCCTGCT CATCAACGTC 
CAGCCCGGGG ACTGTGAGGG CAAGCTGGAA TTGAAGGTGG ATGGTGCCAA GGAGTATCGC 
AATGGAGACA GCATGAAGCT CCAACTTCAA ACTGACTCTG AAGCCCTGGT GGCACTGGGA 
GCTGTGGACA CAGCTCTGTA TGCTGTGGGT GGCCGGTCTC ACAAACCCCT CGACATGAGC 
AAGGTCTTTG AAGTAATGAA CAGCTACAAC CTTGGCTGTG GTCCCGGAGG CGGGGACGAT 
GCCCTTCAGG TGTTCCAGAC TGCTGGTCTG GCCTTTTCTG ACGGTGATCG ACTAACTCAG 
ACCAAAGAGA ACCTGAGCTG TCCCAAGGAG AAGAAAAGTC GGCAAAAGCG AAATGTTAAC 
TTCCAGAAGG CTATTAGCGA GAAGTTGGGC CAGTATTCCT CTCCAGACAC CAAGCGCTGC 
TGCCAGGATG GGATGACCAA GCTGCCCATG GCACGCACCT GCGAGCAGAG GGCAGCCCGC 
GTGCCTCAGC CAGCCTGCCG GGAGCCCTTC TTGTCCTGTT GCAAGTTTGC TGAGGACCTC 
CGCAGGAACC AGACCAGGAG CCAGGCGGGC CTCGCCCGAG CCCAGGACAT GCTGCAGGAG 
GAGGATCTGA TAGATGAAGA TGACATTCTC GTGCGCAGCT TCTTCCCAGA GAACTGGCTC 
TGGAGAGTGG AACCTGTGGA CCGCTCCAAA CTGTTGACTG TGTGGCTCCC TGACTCTCTG 
ACCACATGGG AGATTCATGG TGTGAGCCTG TCCAAAAGCA AAGGCTTGTG TGTAGCCAAG 
CCAACTCGCG TGCGAGTGTT CCGAGAATTC CACCTGCACC TGCGCCTGCC CATCTCTGTC 
CGGCGCTTCG AGCAGCTTGA ATTACGGCCC GTTCTCTACA ACTATCTGAG TGAGGACGTG 
ACTGTAAGTG TCCATGTGTC CCCAGTGGAG GGGCTGTGCC TGGCTGGTGG TGGATTGCTG 
GCCCAGCAAG TATCAGTGCC TGCAGGCTCC GCCCGGCCTG TGGCCTTCTC TGTGGTACCC 
ACAGCTGCTG CCAGCATACC CCTGAAAGTG GTGGCTCGGG GGTCTTTTAC TATAGGGGAT 
GCTGTGTCTA AGATTCTCCA AATTGAGAAG GAAGGGGCCA TCCACAGAGA AGAGATAGTC 
TACAACCTCG ACCCCCTAAA TAACCTTGGT CGGAGTTTGG AAATCCCTGG CAGCTCAGAC 
CCCAACGTCA TTCCTGATGG AGATTTCAGC AGCTTCGTCA GGGTTACAGC CTCCGAACCC 
TTGGAGACTT TGGGCTCCGA AGGCGCCTTG TCCCCAGGCG GAGTGGCCTC CCTCCTGAGG 
CTCCCTAGAG GCTGTGCAGA ACAAACCATG ATCTATTTGG CCCCTACCCT GACTGCTTCC 
CACTACCTGG ACAGGACGGA GCAGTGGAGC AAACTGCCCC CTGAGACAAA GGACCATGCT 
GTGGATCTGA TTCAGAAAGG CCACATGCGG ATCCAGCAGT TTCGGAAGAA AGATGGCTCC 
TTTGGGGCAT GGTTACACCG GGACAGCAGC ACCTGGCTCA CGGCTTTTGT GCTGAAGATT 
CTGAGTCTGG CCCAGGAACA GATTGGTGAC TCCCCCGAGA AGCTGCAAGA GACCGCTGGG 
TGGCTGCTGG GCCAGCAGCT GGACGATGGC TCATTCCACG ACCCGTGTCC AGTCATCCAC 
AGAGGCATGC AGGGGGGCTT GGTGGGAACC GATGAGACCG TGGCACTGAC CGCCTTTGTG 
GTCATCGCCC TTCACCACGG GCTGGCCGTC TTCCAGGACG AGAACTCACA GCAGCTGAAG 
AAGAGGGTGG AAGCCTCCAT CACGAAGGCG AACTCGTTCT TGGGGCAGAA GGCAAGTGCT 
GGGCTCCTGG GTGCACACGC ATCCGCCATC ACAGCCTATG CCCTGACACT GACCAAGGCC 
TCGGAGGACC TGCGGAATGT TGCCCACAAC AGCCTGATGG CCATGGCTGA GGAAACAGGG 
GAAAACCTCT ACTGGGGCTC AGCCATTGGC TCTCAGGACA ACGTTGTGTC GTCCACCCCA 
GCCCCTCGTA ATCCCTCAGA ACCTGTGCCC CAGGCCCCAG CCCTGTGGAT CGAAACCACA 
GCCTACGGCC TGCTACATCT GCTGCTGCGG GAGGGGAAGG GAGAAATGGC TGACAAGGTG 
GCAACCTGGC TCACACACCA GGGAAGCTTC CAAGGGGGAT TCCGCAGTAC CCAGGACACT 
GTGGTCACCC TGGATGCCCT GTCTGCATAC TGGATCGCTT CACACACCAC CGAGGAGAAG 
GCACTCAATG TGACTCTCAG CTCCATGGGC CGCAATGGGT ACAAGTCCCA CCTGCTACAG 
CTGAACAACC ACCAAGTCAA GGGCCTGGAG GAGGAGCTGA AGTTCTCCCT GGGCAGCACC 
ATCAATGTGA AAGTGGGAGG AAACAGCAAA GGCACCTTAA AGATCCTTCG TACCTACAAC 
GTCCTGGACA TGAAGAACAC AACATGCCAA GACCTTCGGA TAGAAGTGAC GGTCACAGGC 
TATGTGGAAT ATACAAGGGA GGCCAACGAA GACTATGAAT ACGACTATGA TATGCCAGCC 
GCAGATGACC CCAGTGTCCA CTCGCAGCCT GTGACACCCC TGCAGCTGTT TGAGGGTCGT 
CGGAGCCGCC GCAGGAGGGA GGCCCCCAAG GCTGCGGATG AGCAGGAGTC CAGAGTGCAG 
TACACCGTGT GCATCTGGCG GAACGGTAAC CTGGGGCTGT CTGGGATGGC CATTGCTGAC 
ATCACCCTCC TGAGTGGATT CCAAGCCCTG AGGGCCGACC TGGAGAAGCT GACCTCCCTC 
TCTGACCGTT ACGTGAGTCA CTTTGAGACC GACGGGCCCC ACGTCCTACT ATACTTTGAC 
TCGGTCCCGA CCACCCGGGA GTGTGTGGGC TTTGGAGCCT TGCAGGAGGT GGCCGTGGGG 
CTGGTGCAGC CAGCCAGTGC TGTCCTATAT GACTACTACA GCCCTGATCA CAAGTGCTCT 
GTGTTCTATG CTGCACCCAC CAAGAGCAAG CTCCTCTCCA CCTTGTGCTC TGCAGACGTC 
TGCCAGTGCG CTGAAGGGAA GTGTCCTCGA CAGCGAAGGT CACTGGAGCG AGGGGTGGAG 
GACAAGGATG GTTACCGGAT GAAGTTCGCC TGCTATTATC CCCGAGTGGA GTATGGCTTC 
CAGGTTAAGG TTCTCCGAGA AGACAGCAGA GCTGCCTTCC GCCTCTTTGA GACCAAGATC 
ACCCAAGTCC TGCATTTCAC AAAGGATGCC AAGGCCTCCA TAGGTCAGAC CCGCAACTTT 
CTGGTCCGGG CCTCTTGCCG CCTTCGTTTG GAGCCTAGCA AAGAGTACTT AATCATGGGG 
ATGGACGGAG TCACCAGTGA CCTCAAGGGA GACCCCCAGT ACTTGCTGGA CTCAAATACT 
TGGATCGAGG AGATGCCATC TGAGCGCCTG TGCAGGAGCA CCCGTCAGCG GGCAGCCTGT 
GGCCAGCTCA ATGACTTTCT GCAGGAGTAC AGCAGCCAGG GGTGCCAGGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Schizophrenia risk from complex variation of complement component 4.
Nature530(7589)177-83(2016 Feb)
Sekar A,Bialas AR,de Rivera H,Davis A,Hammond TR,Kamitaki N,Tooley K,Presumey J,Baum M,Van Doren V,Genovese G,Rose SA,Handsaker RE,,Daly MJ,Carroll MC,Stevens B,McCarroll SA

Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes.
Journal of molecular and cellular cardiology8774-8(2015 Oct)
Dom?nguez-Rodr?guez A,Ruiz-Hurtado G,Sabourin J,G?mez AM,Alvarez JL,Benitah JP

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
The Journal of biological chemistry290(14)8789-802(2015 Apr)
Thaysen-Andersen M,Venkatakrishnan V,Loke I,Laurini C,Diestel S,Parker BL,Packer NH

Proteomic profiling of heterotopic heart-transplanted rats using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: potential biomarkers and drug targets.
The Journal of international medical research41(3)628-35(2013 Jun)
Bao Y,Xiu DR,Zhang L

Association between copy number variation of complement component C4 and Graves' disease.
Journal of biomedical science1871(2011 Sep)
Liu YH,Wan L,Chang CT,Liao WL,Chen WC,Tsai Y,Tsai CH,Tsai FJ

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C4a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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