Dnph1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dnph1
Entrez Gene ID	171047
Full Name	2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Synonyms	C6orf108,RGD620382,Rcl
General protein information	Preferred Names 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Names 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382 c-Myc-responsive protein Rcl deoxyribonucleoside 5'-monophosphate N-glycosidase putative c-Myc-responsive
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12
Summary	displays increased expression in response to Coptidis Rhizoma treatment; may play a role in the regulation of cell growth and anti-apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133525.1	NP_598209.1	2'-deoxynucleoside 5'-phosphate N-hydrolase 1

Pathways from BioSystems

Homologies

	C4H6orf108	XP_001093715.1
Mus musculus (house mouse)	Dnph1	NP_997044.2
Rattus norvegicus (Norway rat)	Dnph1	NP_598209.1
Canis lupus familiaris (dog)	C12H6orf108	XP_538931.3
Pan troglodytes (chimpanzee)	C6H6orf108	XP_518907.1
Bos taurus (cattle)	C23H6orf108	XP_003587733.2
Danio rerio (zebrafish)	dnph1	NP_001156671.1
Homo sapiens (human)	DNPH1	NP_006434.1

Gene Ontology
Bibliography

Related articles in PubMed

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S
European journal of medicinal chemistry85418-37(2014 Oct)

Structure of the oncoprotein Rcl bound to three nucleotide analogues.
Padilla A, Amiable C, Pochet S, Kaminski PA, Labesse G
Acta crystallographica. Section D, Biological crystallography69(Pt 2)247-55(2013 Feb)

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Buhrke T, Lengler I, Lampen A
Development, growth & differentiation53(3)411-26(2011 Apr)

Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108.
Dupouy C, Zhang C, Padilla A, Pochet S, Kaminski PA
The Journal of biological chemistry285(53)41806-14(2010 Dec)

Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors.
Yang Y, Padilla A, Zhang C, Labesse G, Kaminski PA
Journal of molecular biology394(3)435-47(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The crystal structure of oncoprotein Rcl bound to thymidine analogue 6-RADP-1-C6PA confirms and more precisely reveals the organization of its nucleotide-binding site.
Title: Structure of the oncoprotein Rcl bound to three nucleotide analogues.

analysis of human deoxynucleotide N-hydrolase Rcl and rat gene c6orf108
Title: Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108.

ligand-induced stabilization of the dimer structure of the enzyme
Title: Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors.

RCL is a symmetric homodimer, with each monomer consisting of a five-stranded parallel beta-sheet sandwiched between five alpha-helices. Three of the helices form the dimer interface, allowing two monomers to pack side by side.
Title: Solution structure of RCL, a novel 2'-deoxyribonucleoside 5'-monophosphate N-glycosidase.

C6orf108 encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase
Title: The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase.

The following Dnph1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dnph1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00824	NM_133525.1 Latest version!	Rattus norvegicus 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (Dnph1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dnph1 ( NM_133525.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598209.1 Rattus norvegicus 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (Dnph1), mRNA.

Price & Availability↑

CloneID	ORa00824
Clone ID Related Accession (Same CDS sequence)	NM_133525.1
Accession Version	NM_133525.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U82591.1. ##Evidence-Data-START## Transcript exon combination :: U82591.1, BF556597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCAT CCGGGGAGCA GGCTCCATGC TCCGTGTACT TCTGCGGGAG CATCCGCGGC 
GGGCGCGAGG ACCAAGCACT GTATGCGCGG ATCGTGTCGC GGCTCCGACG CTATGGGAAG 
GTGCTCACTG AGCACGTGGC TGATGCTGAG TTGGAGCCGC TTGGGGAAGA GGCTGCTGGG 
GGTGACCAGT TCATCCATGA GCAGGACCTG AACTGGCTGC AGCAAGCAGA TGTGGTAGTG 
GCGGAAGTGA CACAGCCATC CTTGGGTGTT GGCTATGAAC TGGGCCGGGC AGTAGCTCTT 
GGGAAGCCAA TTCTGTGCCT GTTTCGACCA CAGTCTGGCC GAGTGCTTTC CGCCATGATC 
CGCGGAGCAG CAGATGGCTC GAGGTTCCAG GTATGGGACT ACGCAGAAGG AGAAGTGGAG 
ACCATGCTCG ATCGGTACTT TGAGGCATAT CTTCCTCAGA AGACGGCTTC CTCCAGTCAC 
CCAAGTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598209.1
CDS	21..512
Translation	MAASGEQAPCSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVADAELEPLGEEAAGGDQFIHEQDLNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLPQKTASSSHPSA

Target ORF information:

RefSeq Version	NM_133525.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (Dnph1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133525.1

ORF Insert Sequence:

ATGGCGGCAT CCGGGGAGCA GGCTCCATGC TCCGTGTACT TCTGCGGGAG CATCCGCGGC 
GGGCGCGAGG ACCAAGCACT GTATGCGCGG ATCGTGTCGC GGCTCCGACG CTATGGGAAG 
GTGCTCACTG AGCACGTGGC TGATGCTGAG TTGGAGCCGC TTGGGGAAGA GGCTGCTGGG 
GGTGACCAGT TCATCCATGA GCAGGACCTG AACTGGCTGC AGCAAGCAGA TGTGGTAGTG 
GCGGAAGTGA CACAGCCATC CTTGGGTGTT GGCTATGAAC TGGGCCGGGC AGTAGCTCTT 
GGGAAGCCAA TTCTGTGCCT GTTTCGACCA CAGTCTGGCC GAGTGCTTTC CGCCATGATC 
CGCGGAGCAG CAGATGGCTC GAGGTTCCAG GTATGGGACT ACGCAGAAGG AGAAGTGGAG 
ACCATGCTCG ATCGGTACTT TGAGGCATAT CTTCCTCAGA AGACGGCTTC CTCCAGTCAC 
CCAAGTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
European journal of medicinal chemistry85418-37(2014 Oct)
Amiable C,Paoletti J,Haouz A,Padilla A,Labesse G,Kaminski PA,Pochet S

Structure of the oncoprotein Rcl bound to three nucleotide analogues.
Acta crystallographica. Section D, Biological crystallography69(Pt 2)247-55(2013 Feb)
Padilla A,Amiable C,Pochet S,Kaminski PA,Labesse G

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Development, growth & differentiation53(3)411-26(2011 Apr)
Buhrke T,Lengler I,Lampen A

Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108.
The Journal of biological chemistry285(53)41806-14(2010 Dec)
Dupouy C,Zhang C,Padilla A,Pochet S,Kaminski PA

Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors.
Journal of molecular biology394(3)435-47(2009 Dec)
Yang Y,Padilla A,Zhang C,Labesse G,Kaminski PA

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Dnph1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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