Bcl2a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bcl2a1
Entrez Gene ID	170929
Full Name	BCL2-related protein A1
Synonyms	Bcl2a1d
General protein information	Preferred Names BCL2-related protein A1 Names bcl-2-related protein A1 B-cell leukemia/lymphoma 2 related protein A1 B-cell leukemia/lymphoma 2 related protein A1d BCL2-related protein A1d
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_133416.1	NP_596907.1	bcl-2-related protein A1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BCL2A1	XP_003314865.1
	BCL2A1	XP_001109281.2
Mus musculus (house mouse)	Bcl2a1b	NP_031560.2
Mus musculus (house mouse)	Bcl2a1d	NP_031562.1
Canis lupus familiaris (dog)	BCL2A1	XP_545888.4
Bos taurus (cattle)	BCL2A1	NP_001032177.1
Rattus norvegicus (Norway rat)	Bcl2a1	NP_596907.1
Homo sapiens (human)	BCL2A1	NP_004040.1
Mus musculus (house mouse)	Bcl2a1a	NP_033872.1
Gallus gallus (chicken)	BCL2A1	NP_990197.1

Gene Ontology
Bibliography

Related articles in PubMed

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1?-induced apoptosis via Bim/A1 imbalance.
Miani M, Barthson J, Colli ML, Brozzi F, Cnop M, Eizirik DL
Cell death & disease4e701(2013 Jul)

The Bcl-2 apoptotic switch in cancer development and therapy.
Adams JM, Cory S
Oncogene26(9)1324-37(2007 Feb)

Bcl-2-related protein family gene expression during oligodendroglial differentiation.
Itoh T, Itoh A, Pleasure D
Journal of neurochemistry85(6)1500-12(2003 Jun)

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation.
Xiang Z, Ahmed AA, M?ller C, Nakayama K, Hatakeyama S, Nilsson G
The Journal of experimental medicine194(11)1561-69(2001 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-1beta sensitizes pancreatic beta cells to apoptosis mainly via an imbalance in the ratio of the anti-apoptotic A1 and the pro-apoptotic BH3-only protein Bim.
Title: Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1?-induced apoptosis via Bim/A1 imbalance.

The following Bcl2a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcl2a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12099	NM_133416.1 Latest version!	Rattus norvegicus BCL2-related protein A1 (Bcl2a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcl2a1 ( NM_133416.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_596907.1 Rattus norvegicus BCL2-related protein A1 (Bcl2a1), mRNA.

Price & Availability↑

CloneID	ORa12099
Clone ID Related Accession (Same CDS sequence)	NM_133416.1
Accession Version	NM_133416.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-related protein A1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF378332.1. ##Evidence-Data-START## Transcript exon combination :: AF378332.1, FM094896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACAGACT GTGAGTTCAT GTATATCCAC TCCCTGGCTG AGAACTATCT TCAGTATGTC 
CTGCAGGTAC CTGCCTTTGA ATCGGCTCCA AGCAAAACGT CCAGAGTGCT ACAGAGAGTT 
GCTTTCTCTG TACAAAAGGA AGTTGAAAAG AATCTGAAGC CATACTTGGA TGACTTTCAC 
GTGGAATCCA TAGATACTGC CAGAATAATA TTCAACCAAG TGATGGAAAA AGAATTTGAA 
GATGGCATCA TTAACTGGGG AAGGATTGTG ACTATATTTG CCTTTGGGGG TGTTCTCCTG 
AAAAAGCTTC CACAAGAGCA GATTGGCCTG GATGTGGATA CTTACAAGCA AGTTTCCAGT 
TTTGTGGCGG AATTCATAAT GAATAACACA GGAGAATGGA TACAGCAGAA TGGAGGCTGG 
GAAGATGGCT TCACAAAGAA GTTTGAACCT AAATCTGGCT GGCTGACTTT TCTGCAGATG 
ACAGGGAAGA TCTGGGAAAT GCTCTTTCTC CTCAAGCAAC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_596907.1
CDS	21..548
Translation	MTDCEFMYIHSLAENYLQYVLQVPAFESAPSKTSRVLQRVAFSVQKEVEKNLKPYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIGLDVDTYKQVSSFVAEFIMNNTGEWIQQNGGWEDGFTKKFEPKSGWLTFLQMTGKIWEMLFLLKQHY

Target ORF information:

RefSeq Version	NM_133416.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BCL2-related protein A1 (Bcl2a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133416.1

ORF Insert Sequence:

ATGACAGACT GTGAGTTCAT GTATATCCAC TCCCTGGCTG AGAACTATCT TCAGTATGTC 
CTGCAGGTAC CTGCCTTTGA ATCGGCTCCA AGCAAAACGT CCAGAGTGCT ACAGAGAGTT 
GCTTTCTCTG TACAAAAGGA AGTTGAAAAG AATCTGAAGC CATACTTGGA TGACTTTCAC 
GTGGAATCCA TAGATACTGC CAGAATAATA TTCAACCAAG TGATGGAAAA AGAATTTGAA 
GATGGCATCA TTAACTGGGG AAGGATTGTG ACTATATTTG CCTTTGGGGG TGTTCTCCTG 
AAAAAGCTTC CACAAGAGCA GATTGGCCTG GATGTGGATA CTTACAAGCA AGTTTCCAGT 
TTTGTGGCGG AATTCATAAT GAATAACACA GGAGAATGGA TACAGCAGAA TGGAGGCTGG 
GAAGATGGCT TCACAAAGAA GTTTGAACCT AAATCTGGCT GGCTGACTTT TCTGCAGATG 
ACAGGGAAGA TCTGGGAAAT GCTCTTTCTC CTCAAGCAAC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1?-induced apoptosis via Bim/A1 imbalance.
Cell death & disease4e701(2013 Jul)
Miani M,Barthson J,Colli ML,Brozzi F,Cnop M,Eizirik DL

The Bcl-2 apoptotic switch in cancer development and therapy.
Oncogene26(9)1324-37(2007 Feb)
Adams JM,Cory S

Bcl-2-related protein family gene expression during oligodendroglial differentiation.
Journal of neurochemistry85(6)1500-12(2003 Jun)
Itoh T,Itoh A,Pleasure D

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation.
The Journal of experimental medicine194(11)1561-69(2001 Dec)
Xiang Z,Ahmed AA,M?ller C,Nakayama K,Hatakeyama S,Nilsson G