Khdrbs2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Khdrbs2
Entrez Gene ID	170843
Full Name	KH RNA binding domain containing, signal transduction associated 2
Synonyms	Slm1
General protein information	Preferred Names KH RNA binding domain containing, signal transduction associated 2 Names KH domain-containing, RNA-binding, signal transduction-associated protein 2 KH domain containing, RNA binding, signal transduction associated 2 SLM-1 Sam68-like mammalian protein 1 rSLM-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q21
Summary	mouse homolog binds RNA, also binds SH2 and SH3 domain containing proteins; is tyrosine phosphorylated by Src and may act as a Src adapter protein during mitosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133318.1	NP_579852.1	KH domain-containing, RNA-binding, signal transduction-associated protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	KHDRBS2	NP_689901.2
Canis lupus familiaris (dog)	KHDRBS2	XP_005627566.1
Bos taurus (cattle)	KHDRBS2	XP_005223340.1
Danio rerio (zebrafish)	khdrbs2	NP_001070758.1
	LOC713180	XP_001111106.2
Mus musculus (house mouse)	Khdrbs2	NP_573498.1
Xenopus tropicalis (tropical clawed frog)	khdrbs2	NP_001072215.1
Pan troglodytes (chimpanzee)	KHDRBS2	XP_001141327.1
Rattus norvegicus (Norway rat)	Khdrbs2	NP_579852.1
Gallus gallus (chicken)	KHDRBS2	XP_426201.2

Gene Ontology
Bibliography

Related articles in PubMed

SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P
Cell147(7)1601-14(2011 Dec)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.
Heinrich B, Zhang Z, Raitskin O, Hiller M, Benderska N, Hartmann AM, Bracco L, Elliott D, Ben-Ari S, Soreq H, Sperling J, Sperling R, Stamm S
The Journal of biological chemistry284(21)14303-15(2009 May)

p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.
Stoss O, Novoyatleva T, Gencheva M, Olbrich M, Benderska N, Stamm S
Molecular and cellular neurosciences27(1)8-21(2004 Sep)

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.
Di Fruscio M, Chen T, Richard S
Proceedings of the National Academy of Sciences of the United States of America96(6)2710-5(1999 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SLM-1 is a tissue-specific splicing factor whose activity is regulated by tyrosine phosphorylation signals emanating from p59(fyn).
Title: p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.

The following Khdrbs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Khdrbs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00609	NM_133318.1 Latest version!	Rattus norvegicus KH RNA binding domain containing, signal transduction associated 2 (Khdrbs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Khdrbs2 ( NM_133318.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_579852.1 Rattus norvegicus KH RNA binding domain containing, signal transduction associated 2 (Khdrbs2), mRNA.

Price & Availability↑

CloneID	ORa00609
Clone ID Related Accession (Same CDS sequence)	NM_133318.1
Accession Version	NM_133318.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	KH domain-containing, RNA-binding, signal transduction-associated protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF305618.1. ##Evidence-Data-START## Transcript exon combination :: AF305618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGAGAAG AGAAATACTT GCCTGAGCTG ATGGCAGAGA AGGATAGCCT TGATCCATCT 
TTTGTGCACG CGTCGCGCCT TCTGGCGGAA GAAATTGAGA AATTCCAAGG CTCGGATGGA 
AGAAAAGAAG ATGAGGAAAA GAAGTATCTC GATGTCATCA GCAACAAAAA CATAAAGCTC 
TCGGAAAGGG TATTGATCCC CGTGAAACAG TATCCAAAGT TCAATTTTGT GGGGAAATTG 
CTTGGACCAA GAGGAAACTC CTTGAAGAGG CTACAAGAAG AAACGGGTGC TAAAATGTCT 
ATCCTGGGCA AAGGATCGAT GCGTGACAAG GCAAAGGAAG AAGAGCTGAG GAAGAGTGGG 
GAGGCCAAGT ATGCCCACCT GAGTGACGAA CTGCACGTAT TAATTGAAGT GTTTGCTCCA 
CCCGGGGAAG CTTACTCACG GATGAGTCAT GCTTTGGAAG AGATTAAAAA ATTCCTGGTT 
CCTGACTACA ATGATGAAAT TCGTCAAGAG CAACTCCGGG AGTTGTCTTA CTTGAATGGC 
TCAGAAGAGT CTGGCCGGGG CCGAGGTATT AGAGGCAGAG GGATCAGAAT AACTCCCACA 
GCTCCTTCAA GGGGCCGTGG GGGTGCTGTT CCACCACCAC CACCACCTGG ACGAGGTGTT 
CTTACCCCTC GGGGAACCAC TGTGACCCGC GGAGCTCTCC CAGTACCCCC AGTAGCAAGA 
GGTGTCCCAA CACCTCGAGC CCGGGGAACA GCAGCGGTCC CAGGATACAG AGCGCCCCCA 
CCTCCAGCTC CTGAGGCTTA TGAAGAGTAT GGGTACGATG ATGGCTATGG GGGTGAATAT 
GATGACCAGA CCTATGAGGC TTATGATAAT AGCTACGTGA CCCCGACACA AAGTGTGCCT 
GAATACTATG ACTATGGTCA TGGAGTAAAT GAGGATGCCT ATGACAGCTA CGCACCAGAA 
GAATGGACCA CAACCCGCTC CAGCCTGAAG GCACCACCAC CAAGGTCAGC CAGAGGGGGA 
TACAGGGAAC ACCCCTATGG TAGATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579852.1
CDS	154..1203
Translation	MGEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGRKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEESGRGRGIRGRGIRITPTAPSRGRGGAVPPPPPPGRGVLTPRGTTVTRGALPVPPVARGVPTPRARGTAAVPGYRAPPPPAPEAYEEYGYDDGYGGEYDDQTYEAYDNSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEEWTTTRSSLKAPPPRSARGGYREHPYGRY

Target ORF information:

RefSeq Version	NM_133318.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus KH RNA binding domain containing, signal transduction associated 2 (Khdrbs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133318.1

ORF Insert Sequence:

ATGGGAGAAG AGAAATACTT GCCTGAGCTG ATGGCAGAGA AGGATAGCCT TGATCCATCT 
TTTGTGCACG CGTCGCGCCT TCTGGCGGAA GAAATTGAGA AATTCCAAGG CTCGGATGGA 
AGAAAAGAAG ATGAGGAAAA GAAGTATCTC GATGTCATCA GCAACAAAAA CATAAAGCTC 
TCGGAAAGGG TATTGATCCC CGTGAAACAG TATCCAAAGT TCAATTTTGT GGGGAAATTG 
CTTGGACCAA GAGGAAACTC CTTGAAGAGG CTACAAGAAG AAACGGGTGC TAAAATGTCT 
ATCCTGGGCA AAGGATCGAT GCGTGACAAG GCAAAGGAAG AAGAGCTGAG GAAGAGTGGG 
GAGGCCAAGT ATGCCCACCT GAGTGACGAA CTGCACGTAT TAATTGAAGT GTTTGCTCCA 
CCCGGGGAAG CTTACTCACG GATGAGTCAT GCTTTGGAAG AGATTAAAAA ATTCCTGGTT 
CCTGACTACA ATGATGAAAT TCGTCAAGAG CAACTCCGGG AGTTGTCTTA CTTGAATGGC 
TCAGAAGAGT CTGGCCGGGG CCGAGGTATT AGAGGCAGAG GGATCAGAAT AACTCCCACA 
GCTCCTTCAA GGGGCCGTGG GGGTGCTGTT CCACCACCAC CACCACCTGG ACGAGGTGTT 
CTTACCCCTC GGGGAACCAC TGTGACCCGC GGAGCTCTCC CAGTACCCCC AGTAGCAAGA 
GGTGTCCCAA CACCTCGAGC CCGGGGAACA GCAGCGGTCC CAGGATACAG AGCGCCCCCA 
CCTCCAGCTC CTGAGGCTTA TGAAGAGTAT GGGTACGATG ATGGCTATGG GGGTGAATAT 
GATGACCAGA CCTATGAGGC TTATGATAAT AGCTACGTGA CCCCGACACA AAGTGTGCCT 
GAATACTATG ACTATGGTCA TGGAGTAAAT GAGGATGCCT ATGACAGCTA CGCACCAGAA 
GAATGGACCA CAACCCGCTC CAGCCTGAAG GCACCACCAC CAAGGTCAGC CAGAGGGGGA 
TACAGGGAAC ACCCCTATGG TAGATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Cell147(7)1601-14(2011 Dec)
Iijima T,Wu K,Witte H,Hanno-Iijima Y,Glatter T,Richard S,Scheiffele P

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.
The Journal of biological chemistry284(21)14303-15(2009 May)
Heinrich B,Zhang Z,Raitskin O,Hiller M,Benderska N,Hartmann AM,Bracco L,Elliott D,Ben-Ari S,Soreq H,Sperling J,Sperling R,Stamm S

p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.
Molecular and cellular neurosciences27(1)8-21(2004 Sep)
Stoss O,Novoyatleva T,Gencheva M,Olbrich M,Benderska N,Stamm S

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.
Proceedings of the National Academy of Sciences of the United States of America96(6)2710-5(1999 Mar)
Di Fruscio M,Chen T,Richard S

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Khdrbs2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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