Abcb6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcb6
Entrez Gene ID	140669
Full Name	ATP binding cassette subfamily B member 6
Synonyms	MTABC3
General protein information	Preferred Names ATP binding cassette subfamily B member 6 Names ATP-binding cassette sub-family B member 6, mitochondrial ATP-binding cassette, sub-family B (MDR/TAP), member 6 ATP-binding cassette, subfamily B (MDR/TAP), member 6 mammalian mitochondrial ABC protein 3 ubiquitously-expressed mammalian ABC half transporter
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33
Summary	ATP-binding cassette (ABC) half-transporter that together with its dimerization partner alters the localization of toxic substances [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080582.1	NP_542149.1	ATP-binding cassette sub-family B member 6, mitochondrial

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ABCB6	XP_001161097.1
	ABCB6	XP_002799099.1
Bos taurus (cattle)	ABCB6	NP_001091625.1
Schizosaccharomyces pombe (fission yeast)	hmt1	NP_588371.3
Magnaporthe oryzae (rice blast fungus)	MGG_05190	XP_003712732.1
Xenopus tropicalis (tropical clawed frog)	abcb6	NP_001072643.1
Homo sapiens (human)	ABCB6	NP_005680.1
Canis lupus familiaris (dog)	ABCB6	XP_005640740.1
Mus musculus (house mouse)	Abcb6	NP_076221.1
Danio rerio (zebrafish)	abcb6a	NP_001139165.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002278	XP_307900.5
Neurospora crassa	NCU00010	XP_956997.2
Rattus norvegicus (Norway rat)	Abcb6	NP_542149.1
Gallus gallus (chicken)	ABCB6	XP_423449.4
Drosophila melanogaster (fruit fly)	Hmt-1	NP_650503.1
Caenorhabditis elegans (roundworm)	hmt-1	NP_001022812.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in ABCB6 cause dyschromatosis universalis hereditaria.
Zhang C, Li D, Zhang J, Chen X, Huang M, Archacki S, Tian Y, Ren W, Mei A, Zhang Q, Fang M, Su Z, Yin Y, Liu D, Chen Y, Cui X, Li C, Yang H, Wang Q, Wang J, Liu M, Deng Y
The Journal of investigative dermatology133(9)2221-8(2013 Sep)

ABCB6 mutations cause ocular coloboma.
Wang L, Wang L, He F, Bu J, Zhen Y, Liu X, Liu X, Du W, Dong J, Cooney JD, Dubey SK, Shi Y, Gong B, Li J, McBride PF, Jia Y, Lu F, Soltis KA, Lin Y, Namburi P, Liang C, Sundaresan P, Paw BH, Li W, Li DY, Phillips JD, Yang Z
American journal of human genetics90(1)40-8(2012 Jan)

Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia.
Aldahmesh MA, Mohamed JY, Alkuraya HS, Verma IC, Puri RD, Alaiya AA, Rizzo WB, Alkuraya FS
American journal of human genetics89(6)745-50(2011 Dec)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus.
Tsuchida M, Emi Y, Kida Y, Sakaguchi M
Biochemical and biophysical research communications369(2)369-75(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In summary, these results demonstrate that rAbcb6 is a glycosylated protein targeted to intracellular vesicular membranes and suggest involvement of rAbcb6 in transition metal homeostasis.
Title: Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6.

The following Abcb6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcb6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12489	NM_080582.1 Latest version!	Rattus norvegicus ATP binding cassette subfamily B member 6 (Abcb6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$489.30 $699.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcb6 ( NM_080582.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_542149.1 Rattus norvegicus ATP binding cassette subfamily B member 6 (Abcb6), mRNA.

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CloneID	ORa12489
Clone ID Related Accession (Same CDS sequence)	NM_080582.1
Accession Version	NM_080582.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2511bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	ATP-binding cassette sub-family B member 6, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ003004.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ003004.1, BC085712.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCGG CGGGGCCGGC ATGGACTCAG 
AATGGCTTGA GTCCCTGCTT CTTCTACACT CTAGTGCCCT CGACACTCAT GACTTTGGGG 
GTACTGGCCT TGGTGCTGGT TCTTCCCTGC AGGCGTCGGG AGGTGCCTGC TGGCACAGAG 
GAGCTATCTT GGGCGGCTGG CCCTCGGGTC GCTCCCTATG CGCTGCAGCT GTCTCTGGCG 
ATACTTCAGA TGGCACTGCC CCTGGCCAGT CTGGCTGGCC GAGTGGGCAC TGCTCGGGGG 
GTCCGCCTGC CAGGTTACCT ACTGCTGGCT TCTGTGCTGG AGAGTCTAGC CAGTGCCTGT 
GGCTTGTGGC TGCTCGTGGT GGAACGGAGC CAGGCACGGC AGAGTCTGGC AATGGGCGTC 
TGGATGAAGT TCAGGCATAG CTTGGGTCTT CTGCTCCTCT GGACTGTGAC ATTTGCAGCC 
GAGAACTTGG TCCTGGTATC TTGGAACAGC CCACAGTGGT GGTGGTCCAG GGCAGATCTG 
GGCCAGCAGG TTCAATTTGG CCTATGGGTC CTGCGTTATA TGACCTCTGG AGGGCTATTT 
ATCCTGGGGC TCTGGGCCCC TGGACTTCGC CCCCAGTCTT ATACCCTACA TGTTAATGAA 
GAAGACCAAG ATGGAGGAAG GAACCAGGGC CGCTCAACAG ACCCACGATC CACTTGGAGA 
GACCTCGGCA GGAAGCTTCG ACTGCTGAGT GGCTACTTGT GGCCTCGGGG GAGTCCATCT 
CTGCAGCTGA CTGTGCTCCT ATGCATGGGC CTCATGGGGT TGGACCGAGC ACTCAATGTG 
TTGGTCCCCA TCTTCTATAG GGACATTGTG AACTTACTGA CTTCGAAGGC TCCTTGGAGC 
TCCCTGGCCT GGACCGTTAC CACCTATGTC TTCCTCAAGT TCCTGCAGGG GGGTGGCACT 
GGCAGTACAG GTTTTGTGAG CAACCTTCGA ACCTTCCTGT GGATCCGGGT GCAGCAGTTC 
ACGTCCCGAG GTGTGGAACT CCGTCTCTTC TCTCATCTGC ATGAACTCTC ACTGCGCTGG 
CACCTGGGCC GTCGGACTGG GGAGGTGCTT CGGATTGTGG ACCGGGGAAC ATCCAGTGTC 
ACAGGACTGC TCAGCTACCT GGTGTTCAAC ATCATCCCCA CCCTGGCCGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAT GCCTGGTTTG GCCTCATTGT GTTCCTGTGC 
ATGAGTCTTT ACCTCATCCT CACTATTATG GTCACTGAGT GGAGAGCCAA GTTTCGCCGT 
GATATGAACA CACAGGAAAA TGCCACCCGG GCACGAGCAG TAGACTCTCT GCTAAACTTT 
GAGACGGTGA AATACTACAA TGCGGAGGGT TATGAGTTAG AACGCTATCG AGAGGCCATC 
CTCAAGTTTC AGGGTTTGGA GTGGAAGTCA ACGGCTTCAC TGGTTTTACT GAATCAGACC 
CAGAACATGG TGATTGGATT TGGGCTCCTT GCTGGCTCCT TGCTTTGTGC ATACTTCGTC 
AGCGAGCGAC GGCTACAGGT TGGGGACTTT GTGCTTTTTG GCACTTATAT CACCCAACTG 
TACATGCCTC TCAACTGGTT CGGCACCTAC TACAGAATGA TCCAGACTAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GTTGAAAGAG GAAACAGAGG TGAAGGACGT CCCTGGAGCA 
GGGCCCCTTC GTTTTCATAA GGGCCGGGTT GAGTTTGAAA ATGTGCACTT CAGCTACGCT 
GATGGGCGGG AGACCTTACA AGATGTGTCC TTCACTGTGA TGCCTGGACA GACGGTGGCT 
CTGGTAGGCC CATCTGGGGC AGGAAAGAGC ACAATTTTAC GCCTGCTGTT TCGCTTCTAT 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGACAGGACA TTTCACAGGT AACCCAGATC 
TCTCTCCGGT CTCACATTGG AGTTGTGCCC CAGGACACTG TCCTCTTCAA CGACACCATT 
GCCAACAATA TCCGCTATGG CCGTGTTACA GCTGGGGACA GTGAGATACA GGCTGCTGCT 
CAGGCTGCGG GCATCCATGA TGCCATCTTG TCTTTCCCTG AAGGGTATGA GACACAGGTT 
GGGGAGCGGG GTCTGAAGCT GAGTGGTGGC GAGAAGCAGC GAGTGGCCAT TGCCCGCACC 
ATCCTTAAGG CTCCTGACAT CATTCTGCTG GATGAGGCAA CATCAGCACT GGATACATCT 
AATGAGAGAG CCATCCAGGC CTCTCTGGCC AAAGTCTGCA CCAACCGCAC CACCATCGTA 
GTAGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TTCTTGTCAT CAAGGATGGC 
TGCATCATAG AGAGAGGAAG GCACGAAGCC CTGCTATCCC GAGGTGGCGT GTATGCTGAG 
ATGTGGCAGC TGCAGCAGCA AGGACAAGAA ACTGTCCCTG AAGACTCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542149.1
CDS	155..2665
Translation	MVTVGNYCEAEGPAGPAWTQNGLSPCFFYTLVPSTLMTLGVLALVLVLPCRRREVPAGTEELSWAAGPRVAPYALQLSLAILQMALPLASLAGRVGTARGVRLPGYLLLASVLESLASACGLWLLVVERSQARQSLAMGVWMKFRHSLGLLLLWTVTFAAENLVLVSWNSPQWWWSRADLGQQVQFGLWVLRYMTSGGLFILGLWAPGLRPQSYTLHVNEEDQDGGRNQGRSTDPRSTWRDLGRKLRLLSGYLWPRGSPSLQLTVLLCMGLMGLDRALNVLVPIFYRDIVNLLTSKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFNIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIMVTEWRAKFRRDMNTQENATRARAVDSLLNFETVKYYNAEGYELERYREAILKFQGLEWKSTASLVLLNQTQNMVIGFGLLAGSLLCAYFVSERRLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFHKGRVEFENVHFSYADGRETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEIQAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVVAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEDS

Target ORF information:

RefSeq Version	NM_080582.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily B member 6 (Abcb6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080582.1

ORF Insert Sequence:

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCGG CGGGGCCGGC ATGGACTCAG 
AATGGCTTGA GTCCCTGCTT CTTCTACACT CTAGTGCCCT CGACACTCAT GACTTTGGGG 
GTACTGGCCT TGGTGCTGGT TCTTCCCTGC AGGCGTCGGG AGGTGCCTGC TGGCACAGAG 
GAGCTATCTT GGGCGGCTGG CCCTCGGGTC GCTCCCTATG CGCTGCAGCT GTCTCTGGCG 
ATACTTCAGA TGGCACTGCC CCTGGCCAGT CTGGCTGGCC GAGTGGGCAC TGCTCGGGGG 
GTCCGCCTGC CAGGTTACCT ACTGCTGGCT TCTGTGCTGG AGAGTCTAGC CAGTGCCTGT 
GGCTTGTGGC TGCTCGTGGT GGAACGGAGC CAGGCACGGC AGAGTCTGGC AATGGGCGTC 
TGGATGAAGT TCAGGCATAG CTTGGGTCTT CTGCTCCTCT GGACTGTGAC ATTTGCAGCC 
GAGAACTTGG TCCTGGTATC TTGGAACAGC CCACAGTGGT GGTGGTCCAG GGCAGATCTG 
GGCCAGCAGG TTCAATTTGG CCTATGGGTC CTGCGTTATA TGACCTCTGG AGGGCTATTT 
ATCCTGGGGC TCTGGGCCCC TGGACTTCGC CCCCAGTCTT ATACCCTACA TGTTAATGAA 
GAAGACCAAG ATGGAGGAAG GAACCAGGGC CGCTCAACAG ACCCACGATC CACTTGGAGA 
GACCTCGGCA GGAAGCTTCG ACTGCTGAGT GGCTACTTGT GGCCTCGGGG GAGTCCATCT 
CTGCAGCTGA CTGTGCTCCT ATGCATGGGC CTCATGGGGT TGGACCGAGC ACTCAATGTG 
TTGGTCCCCA TCTTCTATAG GGACATTGTG AACTTACTGA CTTCGAAGGC TCCTTGGAGC 
TCCCTGGCCT GGACCGTTAC CACCTATGTC TTCCTCAAGT TCCTGCAGGG GGGTGGCACT 
GGCAGTACAG GTTTTGTGAG CAACCTTCGA ACCTTCCTGT GGATCCGGGT GCAGCAGTTC 
ACGTCCCGAG GTGTGGAACT CCGTCTCTTC TCTCATCTGC ATGAACTCTC ACTGCGCTGG 
CACCTGGGCC GTCGGACTGG GGAGGTGCTT CGGATTGTGG ACCGGGGAAC ATCCAGTGTC 
ACAGGACTGC TCAGCTACCT GGTGTTCAAC ATCATCCCCA CCCTGGCCGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAT GCCTGGTTTG GCCTCATTGT GTTCCTGTGC 
ATGAGTCTTT ACCTCATCCT CACTATTATG GTCACTGAGT GGAGAGCCAA GTTTCGCCGT 
GATATGAACA CACAGGAAAA TGCCACCCGG GCACGAGCAG TAGACTCTCT GCTAAACTTT 
GAGACGGTGA AATACTACAA TGCGGAGGGT TATGAGTTAG AACGCTATCG AGAGGCCATC 
CTCAAGTTTC AGGGTTTGGA GTGGAAGTCA ACGGCTTCAC TGGTTTTACT GAATCAGACC 
CAGAACATGG TGATTGGATT TGGGCTCCTT GCTGGCTCCT TGCTTTGTGC ATACTTCGTC 
AGCGAGCGAC GGCTACAGGT TGGGGACTTT GTGCTTTTTG GCACTTATAT CACCCAACTG 
TACATGCCTC TCAACTGGTT CGGCACCTAC TACAGAATGA TCCAGACTAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GTTGAAAGAG GAAACAGAGG TGAAGGACGT CCCTGGAGCA 
GGGCCCCTTC GTTTTCATAA GGGCCGGGTT GAGTTTGAAA ATGTGCACTT CAGCTACGCT 
GATGGGCGGG AGACCTTACA AGATGTGTCC TTCACTGTGA TGCCTGGACA GACGGTGGCT 
CTGGTAGGCC CATCTGGGGC AGGAAAGAGC ACAATTTTAC GCCTGCTGTT TCGCTTCTAT 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGACAGGACA TTTCACAGGT AACCCAGATC 
TCTCTCCGGT CTCACATTGG AGTTGTGCCC CAGGACACTG TCCTCTTCAA CGACACCATT 
GCCAACAATA TCCGCTATGG CCGTGTTACA GCTGGGGACA GTGAGATACA GGCTGCTGCT 
CAGGCTGCGG GCATCCATGA TGCCATCTTG TCTTTCCCTG AAGGGTATGA GACACAGGTT 
GGGGAGCGGG GTCTGAAGCT GAGTGGTGGC GAGAAGCAGC GAGTGGCCAT TGCCCGCACC 
ATCCTTAAGG CTCCTGACAT CATTCTGCTG GATGAGGCAA CATCAGCACT GGATACATCT 
AATGAGAGAG CCATCCAGGC CTCTCTGGCC AAAGTCTGCA CCAACCGCAC CACCATCGTA 
GTAGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TTCTTGTCAT CAAGGATGGC 
TGCATCATAG AGAGAGGAAG GCACGAAGCC CTGCTATCCC GAGGTGGCGT GTATGCTGAG 
ATGTGGCAGC TGCAGCAGCA AGGACAAGAA ACTGTCCCTG AAGACTCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in ABCB6 cause dyschromatosis universalis hereditaria.
The Journal of investigative dermatology133(9)2221-8(2013 Sep)
Zhang C,Li D,Zhang J,Chen X,Huang M,Archacki S,Tian Y,Ren W,Mei A,Zhang Q,Fang M,Su Z,Yin Y,Liu D,Chen Y,Cui X,Li C,Yang H,Wang Q,Wang J,Liu M,Deng Y

ABCB6 mutations cause ocular coloboma.
American journal of human genetics90(1)40-8(2012 Jan)
Wang L,Wang L,He F,Bu J,Zhen Y,Liu X,Liu X,Du W,Dong J,Cooney JD,Dubey SK,Shi Y,Gong B,Li J,McBride PF,Jia Y,Lu F,Soltis KA,Lin Y,Namburi P,Liang C,Sundaresan P,Paw BH,Li W,Li DY,Phillips JD,Yang Z

Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia.
American journal of human genetics89(6)745-50(2011 Dec)
Aldahmesh MA,Mohamed JY,Alkuraya HS,Verma IC,Puri RD,Alaiya AA,Rizzo WB,Alkuraya FS

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus.
Biochemical and biophysical research communications369(2)369-75(2008 May)
Tsuchida M,Emi Y,Kida Y,Sakaguchi M

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Abcb6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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