Slc8a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc8a2
Entrez Gene ID	140447
Full Name	solute carrier family 8 member A2
Synonyms	Ncx2
General protein information	Preferred Names solute carrier family 8 member A2 Names sodium/calcium exchanger 2 Na(+)/Ca(2+)-exchange protein 2 solute carrier family 8 (sodium/calcium exchanger), member 2 solute carrier family 8 member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	isoform 2 of sodium/calcium exchanger; regulates intracellular calcium levels and maintains calcium homeostasis; may be important for the control of synaptic plasticity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_078619.1	NP_511174.1	sodium/calcium exchanger 2 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	slc8a2b	NP_001116756.1
Bos taurus (cattle)	SLC8A2	XP_002695230.2
Homo sapiens (human)	SLC8A2	NP_055878.1
Rattus norvegicus (Norway rat)	Slc8a2	NP_511174.1
Xenopus tropicalis (tropical clawed frog)	slc8a2	XP_002939292.1
Canis lupus familiaris (dog)	SLC8A2	XP_005616441.1
Mus musculus (house mouse)	Slc8a2	NP_683748.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.
Giladi M, Lee SY, Ariely Y, Teldan Y, Granit R, Strulovich R, Haitin Y, Chung KY, Khananshvili D
Scientific reports7(1)993(2017 Apr)

Kinetic and equilibrium properties of regulatory Ca(2+)-binding domains in sodium-calcium exchangers 2 and 3.
Tal I, Kozlovsky T, Brisker D, Giladi M, Khananshvili D
Cell calcium59(4)181-8(2016 04)

Effects of preconditioning with normobaric hyperoxia on Na?/Ca?? exchanger in the rat brain.
Mohammadi E, Bigdeli MR
Neuroscience237277-84(2013 May)

Sodium-calcium exchangers in rat trigeminal ganglion neurons.
Kuroda H, Sobhan U, Sato M, Tsumura M, Ichinohe T, Tazaki M, Shibukawa Y
Molecular pain922(2013 Apr)

High level over-expression of different NCX isoforms in HEK293 cell lines and primary neuronal cultures is protective following oxygen glucose deprivation.
Cross JL, Boulos S, Shepherd KL, Craig AJ, Lee S, Bakker AJ, Knuckey NW, Meloni BP
Neuroscience research73(3)191-8(2012 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analyze the equilibrium and kinetic properties of Ca(2+) binding to purified preparations of CBD1, CBD2, and CBD12 from NCX2 and from NCX3 splice variants
Title: Kinetic and equilibrium properties of regulatory Ca(2+)-binding domains in sodium-calcium exchangers 2 and 3.

This study showed that normobaric hyperoxia changes the patterns of expression NCX2 in the penumbra and spinal cordcore.
Title: Effects of preconditioning with normobaric hyperoxia on Na?/Ca?? exchanger in the rat brain.

NCX isoforms (NCX1, NCX2, and NCX3) were expressed in primary cultured rat trigeminal ganglion neurons.
Title: Sodium-calcium exchangers in rat trigeminal ganglion neurons.

High levels of NCX2 overexpression increase neuronal survival following hypoxia-ischemia and improve neuronal calcium management.
Title: High level over-expression of different NCX isoforms in HEK293 cell lines and primary neuronal cultures is protective following oxygen glucose deprivation.

The presence of NCX2, together with multiple sodium channel isoforms, in free nerve endings may have important functional implications.
Title: Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals.

The following Slc8a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc8a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11706	NM_078619.1 Latest version!	Rattus norvegicus solute carrier family 8 member A2 (Slc8a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc8a2 ( NM_078619.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_511174.1 Rattus norvegicus solute carrier family 8 member A2 (Slc8a2), mRNA.

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CloneID	ORa11706
Clone ID Related Accession (Same CDS sequence)	NM_078619.1
Accession Version	NM_078619.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2766bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	sodium/calcium exchanger 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U08141.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U08141.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCCCT TGGCTTTGGT AGGGGTTGCC CTCCTTCTGG GGGCACCCCA CTGCTTGGGG 
GAAGCTACTC CGACCCCATC CCTGCCACCT CCCCCAGCTA ATGACAGCGA TGCCAGCCCA 
GGCGGCTGCC AAGGTTCCTA CCGCTGCCAA CCAGGGGTGC TGCTGCCTGT GTGGGAACCC 
GACGACCCAT CACTGGGGGA CAAGGCTGCA CGGGCCGTGG TGTACTTTGT GGCCATGGTC 
TACATGTTCT TGGGTCTGTC TATCATTGCT GATCGTTTTA TGGCATCCAT TGAGGTCATC 
ACATCCAAGG AGAAAGAGAT CACCATCACC AAGGCAAATG GGGAGACCAG CGTGGGCACT 
GTACGCATCT GGAATGAAAC GGTGTCCAAC CTTACACTCA TGGCCCTGGG CTCCTCAGCA 
CCTGAGATTC TGCTGTCTGT CATCGAGGTC TGTGGCCACA ACTTCCAGGC GGGTGAGCTA 
GGCCCAGGCA CCATCGTGGG CAGTGCCGCC TTCAACATGT TTGTGGTCAT TGCTGTGTGT 
GTGTATGTCA TCCCGGCTGG TGAGAGCCGT AAGATCAAGC ACTTAAGGGT CTTCTTCGTC 
ACAGCCTCTT GGAGCATCTT TGCCTATGTC TGGCTTTATC TCATTCTAGC AGTTTTCTCT 
CCAGGCGTGG TCCAGGTGTG GGAGGCACTG CTCACGCTGG TCTTCTTCCC GGTGTGTGTG 
GTGTTCGCCT GGATGGCGGA CAAGCGACTG CTCTTCTACA AGTACGTGTA CAAGCGCTAT 
CGCACCGACC CTCGCAGCGG AATCATCATC GGGGCAGAGG GAGACCCGCC CAAGAGCATC 
GAGCTGGATG GCACATTCGT GGGCACTGAG GTCCCAGGCG AGCTGGGTGC ATTGGGCACA 
GGTCCCGCTG AGGCGCGTGA GCTGGACGCC AGCCGGCGCG AGGTCATCCA GATTCTTAAG 
GACTTAAAGC AGAAGCACCC GGATAAGGAC CTGGAGCAGC TGGTGGGCAT CGCCAAGTAC 
TATGCACTGC TGCACCAGCA GAAGAGCCGT GCCTTCTACC GCATCCAGGC CACGCGGCTG 
ATGACAGGTG CGGGCAACGT GCTGCGCCGA CACGCTGCGG ATGCTGCCCG CAGGCCTGGG 
GCCAACGATG GTGCCCCCGA TGATGAGGAC GATGGTGCCA GCCGCATCTT CTTTGAGCCC 
AGCCTCTACC ACTGCCTGGA GAACTGCGGG TCAGTGCTGC TGTCGGTGGC TTGCCAGGGT 
GGTGAGGGCA ACAGCACCTT CTACGTGGAT TACCGCACGG AGGATGGCTC TGCAAAGGCA 
GGCTCCGATT ATGAGTACAG CGAGGGCACG CTGGTGTTCA AGCCCGGGGA GACGCAGAAG 
GAGCTGCGCA TCGGCATCAT CGACGACGAC ATCTTCGAGG AGGACGAGCA CTTCTTCGTG 
AGGCTGCTGA ACCTGCGTGT GGGCGATGCT CAGGGCATGT TCGAGCCCGA CGGCGGTGGG 
CGGCCCAAGG GGCGGCTGGT GGCGCCACTG CTGGCCACCG TCACCATTCT GGACGACGAC 
CACGCGGGCA TCTTCTCCTT CCAGGACCGC CTGCTGCATG TGAGCGAGTG CATGGGCACC 
GTGGATGTGC GTGTGGTGCG CAGCTCTGGC GCACGTGGCA CCGTACGCCT TCCCTACCGC 
ACAGTGGACG GCACGGCTCG TGGTGGTGGT GTGCACTACG AGGATGCTTG TGGAGAGCTG 
GAGTTCGGCG ATGACGAGAC CATGAAGACT CTTCAGGTCA AGATAGTGGA CGACGAAGAG 
TATGAGAAGA AGGACAACTT CTTCATCGAG CTGGGCCAGC CCCAGTGGCT TAAGCGGGGC 
ATCTCAGCTC TGCTACTCAA CCAAGGGGAT GGAGACAGGA AGCTGACTGC AGAGGAGGAG 
GAGGCCCAGA GGATAGCAGA GATGGGCAAG CCAGTTCTTG GGGAGAACTG TCGCCTCGAG 
GTCATCATCG AGGAGTCTTA TGACTTTAAG AATACGGTGG ATAAACTCAT AAAGAAAACA 
AACCTGGCCT TGGTGATTGG GACCCACTCA TGGAGGGAGC AGTTTTTAGA GGCAGTTACA 
GTGAGCGCAG GGGACGAGGA GGAGGATGAG GATGGGTCTC GTGAGGAGCG GCTGCCATCC 
TGCTTTGACT ACGTGATGCA CTTCCTGACG GTGTTCTGGA AAGTTCTGTT CGCCTGCCTT 
CCACCCACGG AGTACTGCCA TGGCTGGGCC TGCTTTGGTG TCTGCATCCT GGTCATTGGT 
CTGCTCACTG CCCTCATCGG AGACCTGGCC TCACACTTTG GGTGCACCGT GGGCCTCAAG 
GACTCAGTCA ACGCCGTGGT CTTCGTGGCT CTGGGCACCT CCATCCCTGA CACGTTTGCC 
AGCAAGGTGG CCGCGCTGCA GGACCAGTGC GCCGACGCGT CCATCGGTAA CGTGACCGGC 
TCCAATGCGG TGAACGTGTT CCTGGGCCTG GGTGTGGCCT GGTCGGTGGC CGCAGTGTAC 
TGGGCGGTGC AGGGTCGCCC CTTCGAGGTG CGTACAGGCA CGCTGGCCTT CTCGGTCACA 
CTGTTCACCG TCTTCGCCTT CGTGGGCATC GCAGTGCTCT TGTACCGGCG CCGGCCACAC 
ATCGGCGGCG AGCTGGGCGG CCCGCGGGGA CCCAAGCTAG CCACCACCGC TCTCTTCCTG 
GGCCTCTGGT TCCTCTACAT TCTCTTCGCC AGCCTGGAGG CTTATTGCCA CATTCGGGGC 
TTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_511174.1
CDS	1..2766
Translation	MAPLALVGVALLLGAPHCLGEATPTPSLPPPPANDSDASPGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGLSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPGANDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEAQRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAVTVSAGDEEEDEDGSREERLPSCFDYVMHFLTVFWKVLFACLPPTEYCHGWACFGVCILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWFLYILFASLEAYCHIRGF

Target ORF information:

RefSeq Version	NM_078619.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 8 member A2 (Slc8a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078619.1

ORF Insert Sequence:

ATGGCTCCCT TGGCTTTGGT AGGGGTTGCC CTCCTTCTGG GGGCACCCCA CTGCTTGGGG 
GAAGCTACTC CGACCCCATC CCTGCCACCT CCCCCAGCTA ATGACAGCGA TGCCAGCCCA 
GGCGGCTGCC AAGGTTCCTA CCGCTGCCAA CCAGGGGTGC TGCTGCCTGT GTGGGAACCC 
GACGACCCAT CACTGGGGGA CAAGGCTGCA CGGGCCGTGG TGTACTTTGT GGCCATGGTC 
TACATGTTCT TGGGTCTGTC TATCATTGCT GATCGTTTTA TGGCATCCAT TGAGGTCATC 
ACATCCAAGG AGAAAGAGAT CACCATCACC AAGGCAAATG GGGAGACCAG CGTGGGCACT 
GTACGCATCT GGAATGAAAC GGTGTCCAAC CTTACACTCA TGGCCCTGGG CTCCTCAGCA 
CCTGAGATTC TGCTGTCTGT CATCGAGGTC TGTGGCCACA ACTTCCAGGC GGGTGAGCTA 
GGCCCAGGCA CCATCGTGGG CAGTGCCGCC TTCAACATGT TTGTGGTCAT TGCTGTGTGT 
GTGTATGTCA TCCCGGCTGG TGAGAGCCGT AAGATCAAGC ACTTAAGGGT CTTCTTCGTC 
ACAGCCTCTT GGAGCATCTT TGCCTATGTC TGGCTTTATC TCATTCTAGC AGTTTTCTCT 
CCAGGCGTGG TCCAGGTGTG GGAGGCACTG CTCACGCTGG TCTTCTTCCC GGTGTGTGTG 
GTGTTCGCCT GGATGGCGGA CAAGCGACTG CTCTTCTACA AGTACGTGTA CAAGCGCTAT 
CGCACCGACC CTCGCAGCGG AATCATCATC GGGGCAGAGG GAGACCCGCC CAAGAGCATC 
GAGCTGGATG GCACATTCGT GGGCACTGAG GTCCCAGGCG AGCTGGGTGC ATTGGGCACA 
GGTCCCGCTG AGGCGCGTGA GCTGGACGCC AGCCGGCGCG AGGTCATCCA GATTCTTAAG 
GACTTAAAGC AGAAGCACCC GGATAAGGAC CTGGAGCAGC TGGTGGGCAT CGCCAAGTAC 
TATGCACTGC TGCACCAGCA GAAGAGCCGT GCCTTCTACC GCATCCAGGC CACGCGGCTG 
ATGACAGGTG CGGGCAACGT GCTGCGCCGA CACGCTGCGG ATGCTGCCCG CAGGCCTGGG 
GCCAACGATG GTGCCCCCGA TGATGAGGAC GATGGTGCCA GCCGCATCTT CTTTGAGCCC 
AGCCTCTACC ACTGCCTGGA GAACTGCGGG TCAGTGCTGC TGTCGGTGGC TTGCCAGGGT 
GGTGAGGGCA ACAGCACCTT CTACGTGGAT TACCGCACGG AGGATGGCTC TGCAAAGGCA 
GGCTCCGATT ATGAGTACAG CGAGGGCACG CTGGTGTTCA AGCCCGGGGA GACGCAGAAG 
GAGCTGCGCA TCGGCATCAT CGACGACGAC ATCTTCGAGG AGGACGAGCA CTTCTTCGTG 
AGGCTGCTGA ACCTGCGTGT GGGCGATGCT CAGGGCATGT TCGAGCCCGA CGGCGGTGGG 
CGGCCCAAGG GGCGGCTGGT GGCGCCACTG CTGGCCACCG TCACCATTCT GGACGACGAC 
CACGCGGGCA TCTTCTCCTT CCAGGACCGC CTGCTGCATG TGAGCGAGTG CATGGGCACC 
GTGGATGTGC GTGTGGTGCG CAGCTCTGGC GCACGTGGCA CCGTACGCCT TCCCTACCGC 
ACAGTGGACG GCACGGCTCG TGGTGGTGGT GTGCACTACG AGGATGCTTG TGGAGAGCTG 
GAGTTCGGCG ATGACGAGAC CATGAAGACT CTTCAGGTCA AGATAGTGGA CGACGAAGAG 
TATGAGAAGA AGGACAACTT CTTCATCGAG CTGGGCCAGC CCCAGTGGCT TAAGCGGGGC 
ATCTCAGCTC TGCTACTCAA CCAAGGGGAT GGAGACAGGA AGCTGACTGC AGAGGAGGAG 
GAGGCCCAGA GGATAGCAGA GATGGGCAAG CCAGTTCTTG GGGAGAACTG TCGCCTCGAG 
GTCATCATCG AGGAGTCTTA TGACTTTAAG AATACGGTGG ATAAACTCAT AAAGAAAACA 
AACCTGGCCT TGGTGATTGG GACCCACTCA TGGAGGGAGC AGTTTTTAGA GGCAGTTACA 
GTGAGCGCAG GGGACGAGGA GGAGGATGAG GATGGGTCTC GTGAGGAGCG GCTGCCATCC 
TGCTTTGACT ACGTGATGCA CTTCCTGACG GTGTTCTGGA AAGTTCTGTT CGCCTGCCTT 
CCACCCACGG AGTACTGCCA TGGCTGGGCC TGCTTTGGTG TCTGCATCCT GGTCATTGGT 
CTGCTCACTG CCCTCATCGG AGACCTGGCC TCACACTTTG GGTGCACCGT GGGCCTCAAG 
GACTCAGTCA ACGCCGTGGT CTTCGTGGCT CTGGGCACCT CCATCCCTGA CACGTTTGCC 
AGCAAGGTGG CCGCGCTGCA GGACCAGTGC GCCGACGCGT CCATCGGTAA CGTGACCGGC 
TCCAATGCGG TGAACGTGTT CCTGGGCCTG GGTGTGGCCT GGTCGGTGGC CGCAGTGTAC 
TGGGCGGTGC AGGGTCGCCC CTTCGAGGTG CGTACAGGCA CGCTGGCCTT CTCGGTCACA 
CTGTTCACCG TCTTCGCCTT CGTGGGCATC GCAGTGCTCT TGTACCGGCG CCGGCCACAC 
ATCGGCGGCG AGCTGGGCGG CCCGCGGGGA CCCAAGCTAG CCACCACCGC TCTCTTCCTG 
GGCCTCTGGT TCCTCTACAT TCTCTTCGCC AGCCTGGAGG CTTATTGCCA CATTCGGGGC 
TTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.
Scientific reports7(1)993(2017 Apr)
Giladi M,Lee SY,Ariely Y,Teldan Y,Granit R,Strulovich R,Haitin Y,Chung KY,Khananshvili D

Kinetic and equilibrium properties of regulatory Ca(2+)-binding domains in sodium-calcium exchangers 2 and 3.
Cell calcium59(4)181-8(2016 04)
Tal I,Kozlovsky T,Brisker D,Giladi M,Khananshvili D

Effects of preconditioning with normobaric hyperoxia on Na?/Ca?? exchanger in the rat brain.
Neuroscience237277-84(2013 May)
Mohammadi E,Bigdeli MR

Sodium-calcium exchangers in rat trigeminal ganglion neurons.
Molecular pain922(2013 Apr)
Kuroda H,Sobhan U,Sato M,Tsumura M,Ichinohe T,Tazaki M,Shibukawa Y

High level over-expression of different NCX isoforms in HEK293 cell lines and primary neuronal cultures is protective following oxygen glucose deprivation.
Neuroscience research73(3)191-8(2012 Jul)
Cross JL,Boulos S,Shepherd KL,Craig AJ,Lee S,Bakker AJ,Knuckey NW,Meloni BP

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Slc8a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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