Sv2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sv2a
Entrez Gene ID	117559
Full Name	synaptic vesicle glycoprotein 2a
Synonyms	Sv2
General protein information	Preferred Names synaptic vesicle glycoprotein 2a Names synaptic vesicle glycoprotein 2A synaptic vesicle protein 2 synaptic vesicle protein 2A synaptic vesicle transmembrane transporter (SV2) RNA
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	membrane glycoprotein; acts as a synaptic vesicle-specific transporter [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057210.2	NP_476558.2	synaptic vesicle glycoprotein 2A
XM_006232952.3	XP_006233014.1	synaptic vesicle glycoprotein 2A isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SV2A	NP_776387.1
Pan troglodytes (chimpanzee)	SV2A	XP_001166824.1
	LOC715018	XP_001105076.2
Homo sapiens (human)	SV2A	NP_055664.3
Rattus norvegicus (Norway rat)	Sv2a	NP_476558.2
Danio rerio (zebrafish)	LOC568033	XP_696434.2
Xenopus tropicalis (tropical clawed frog)	sv2a	XP_002938508.1
Canis lupus familiaris (dog)	SV2A	XP_003639668.1
Mus musculus (house mouse)	Sv2a	NP_071313.1

Gene Ontology
Bibliography

Related articles in PubMed

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.
Tokudome K, Okumura T, Shimizu S, Mashimo T, Takizawa A, Serikawa T, Terada R, Ishihara S, Kunisawa N, Sasa M, Ohno Y
Scientific reports627420(2016 Jun)

Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.
Shi J, Zhou F, Wang LK, Wu GF
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban35(5)716-22(2015 Oct)

Hippocampal low-frequency stimulation increased SV2A expression and inhibited the seizure degree in pharmacoresistant amygdala-kindling epileptic rats.
Wang L, Shi J, Wu G, Zhou F, Hong Z
Epilepsy research108(9)1483-91(2014 Nov)

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kr?hnert K, Sch?fer C, Rammner B, Koo SJ, Cla?en GA, Krauss M, Haucke V, Urlaub H, Rizzoli SO
Science (New York, N.Y.)344(6187)1023-8(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sv2a expression is decreased in amygdaloid-kindling pharmacoresistant epileptic rats.
Title: Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.

The SV2A expression significantly decreased in the pharmacoresistant amygdaloid-kindling epileptic rats compared with the pharmacosensitive epileptic rats.
Title: Hippocampal low-frequency stimulation increased SV2A expression and inhibited the seizure degree in pharmacoresistant amygdala-kindling epileptic rats.

agents that act on the conformation of SV2A might hold great potential in the search for new SV2A-based anticonvulsant therapies
Title: Modulation of the conformational state of the SV2A protein by an allosteric mechanism as evidenced by ligand binding assays.

A tyrosine-based endocytosis motif in the vesicle protein SV2 is required for trafficking to synaptic vesicles of both SV2 and the calcium sensor protein synaptotagmin
Title: Cotrafficking of SV2 and synaptotagmin at the synapse.

Synaptic vesicle protein 2 binds adenine nucleotides
Title: Synaptic vesicle protein 2 binds adenine nucleotides.

The following Sv2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sv2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11647	NM_057210.2 Latest version!	Rattus norvegicus synaptic vesicle glycoprotein 2a (Sv2a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
ORa11647	XM_006232952.3 Latest version!	Rattus norvegicus synaptic vesicle glycoprotein 2a (Sv2a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sv2a ( NM_057210.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476558.2 Rattus norvegicus synaptic vesicle glycoprotein 2a (Sv2a), mRNA.

Price & Availability↑

CloneID	ORa11647
Clone ID Related Accession (Same CDS sequence)	NM_057210.2 , XM_006232952.3
Accession Version	NM_057210.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2229bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Rattus norvegicus(Norway rat)
Product	synaptic vesicle glycoprotein 2A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092132.1. On Jun 10, 2007 this sequence version replaced NM_057210.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092132.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGAAG GCTTTCGAGA CCGAGCAGCG TTCATCCGTG GGGCCAAAGA CATTGCCAAG 
GAAGTTAAGA AGCACGCGGC CAAGAAGGTG GTGAAGGGTC TCGACAGAGT CCAGGATGAA 
TATTCCCGAA GGTCCTACTC CCGCTTTGAG GAGGAGGAGG ATGATGATGA CTTCCCTGCC 
CCTGCTGACG GCTATTACCG CGGAGAAGGG GCCCAGGATG AGGAGGAAGG TGGCGCTTCC 
AGTGATGCCA CTGAGGGCCA CGATGAGGAT GATGAGATCT ACGAGGGAGA ATATCAGGGC 
ATCCCCCGGG CAGAGTCTGG GGGCAAAGGC GAACGGATGG CAGATGGGGC ACCCCTGGCT 
GGAGTGAGAG GGGGCTTAAG TGATGGGGAG GGTCCCCCTG GGGGTCGCGG GGAGGCGCAG 
CGGCGTAAAG ATCGGGAAGA ATTGGCTCAG CAGTATGAGA CCATCCTCCG GGAGTGCGGC 
CATGGTCGCT TCCAGTGGAC ACTCTACTTC GTGCTGGGTC TGGCGCTGAT GGCCGATGGT 
GTAGAGGTCT TTGTGGTGGG CTTTGTGCTG CCCAGTGCTG AGAAAGATAT GTGCCTGTCG 
GACTCCAACA AAGGCATGCT AGGCCTCATT GTGTACCTGG GCATGATGGT GGGGGCCTTC 
CTCTGGGGAG GCCTGGCTGA TCGGCTGGGT CGGAGACAGT GTCTGCTCAT CTCGCTCTCA 
GTCAACAGCG TCTTCGCTTT CTTCTCATCC TTCGTCCAGG GTTATGGCAC CTTCCTTTTC 
TGCCGCCTCC TTTCTGGGGT TGGGATTGGT GGTTCCATCC CCATTGTCTT CTCCTATTTT 
TCGGAGTTTC TGGCCCAGGA GAAACGTGGG GAGCATTTGA GCTGGCTCTG TATGTTCTGG 
ATGATTGGTG GCGTGTATGC AGCTGCAATG GCCTGGGCCA TCATCCCCCA CTATGGGTGG 
AGTTTCCAGA TGGGCTCTGC TTACCAGTTC CACAGCTGGA GGGTCTTTGT CCTCGTCTGT 
GCCTTTCCCT CTGTGTTTGC CATCGGGGCT CTGACTACGC AGCCGGAGAG TCCCCGCTTC 
TTCTTAGAGA ATGGGAAGCA CGATGAGGCC TGGATGGTGC TGAAGCAGGT TCATGACACC 
AACATGCGAG CCAAGGGCCA TCCTGAGCGA GTCTTCTCAG TAACCCACAT TAAAACGATT 
CATCAGGAGG ATGAATTGAT TGAGATCCAG TCAGACACAG GAACCTGGTA CCAGCGCTGG 
GGAGTGCGGG CTTTGAGCCT GGGGGGTCAG GTTTGGGGGA ACTTCCTCTC CTGCTTCAGT 
CCAGAGTACC GGCGCATCAC TCTGATGATG ATGGGGGTAT GGTTCACCAT GTCCTTCAGC 
TACTACGGTT TGACTGTCTG GTTTCCCGAC ATGATCCGCC ATCTCCAGGC TGTGGACTAT 
GCAGCCCGAA CCAAAGTGTT CCCAGGGGAG CGCGTGGAGC ACGTGACATT TAACTTCACA 
CTGGAGAATC AGATCCACCG AGGGGGACAG TACTTCAATG ACAAGTTCAT CGGGCTGCGT 
CTGAAGTCAG TGTCCTTTGA GGATTCCCTG TTTGAGGAAT GTTACTTTGA AGATGTCACA 
TCCAGCAACA CATTCTTCCG CAACTGCACA TTCATCAACA CCGTGTTCTA CAACACGGAC 
CTGTTTGAGT ACAAGTTCGT GAACAGCCGC CTGGTGAACA GCACATTCCT GCACAATAAG 
GAAGGTTGCC CACTAGATGT GACAGGGACG GGCGAAGGTG CCTACATGGT GTACTTTGTC 
AGCTTCTTGG GGACACTGGC TGTGCTCCCT GGAAATATTG TGTCTGCTCT GCTCATGGAC 
AAGATTGGCA GGCTCAGAAT GCTTGCTGGT TCCAGTGTGT TGTCCTGTGT TTCCTGCTTC 
TTCCTGTCTT TTGGGAACAG TGAGTCAGCC ATGATCGCTC TGCTCTGCCT TTTTGGGGGA 
GTCAGTATTG CATCCTGGAA CGCGCTGGAC GTGCTGACTG TTGAACTCTA CCCTTCCGAC 
AAGAGGACGA CGGCCTTCGG CTTCCTGAAT GCCCTGTGTA AGCTGGCAGC TGTACTGGGC 
ATCAGCATCT TCACGTCCTT TGTGGGAATC ACCAAGGCCG CTCCCATCCT CTTCGCCTCA 
GCTGCGCTTG CCCTTGGTAG CTCTCTGGCT CTGAAGCTGC CTGAGACCCG GGGACAGGTG 
CTGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476558.2
CDS	54..2282
Translation	MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEEDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ

Target ORF information:

RefSeq Version	NM_057210.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptic vesicle glycoprotein 2a (Sv2a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057210.2

ORF Insert Sequence:

ATGGAAGAAG GCTTTCGAGA CCGAGCAGCG TTCATCCGTG GGGCCAAAGA CATTGCCAAG 
GAAGTTAAGA AGCACGCGGC CAAGAAGGTG GTGAAGGGTC TCGACAGAGT CCAGGATGAA 
TATTCCCGAA GGTCCTACTC CCGCTTTGAG GAGGAGGAGG ATGATGATGA CTTCCCTGCC 
CCTGCTGACG GCTATTACCG CGGAGAAGGG GCCCAGGATG AGGAGGAAGG TGGCGCTTCC 
AGTGATGCCA CTGAGGGCCA CGATGAGGAT GATGAGATCT ACGAGGGAGA ATATCAGGGC 
ATCCCCCGGG CAGAGTCTGG GGGCAAAGGC GAACGGATGG CAGATGGGGC ACCCCTGGCT 
GGAGTGAGAG GGGGCTTAAG TGATGGGGAG GGTCCCCCTG GGGGTCGCGG GGAGGCGCAG 
CGGCGTAAAG ATCGGGAAGA ATTGGCTCAG CAGTATGAGA CCATCCTCCG GGAGTGCGGC 
CATGGTCGCT TCCAGTGGAC ACTCTACTTC GTGCTGGGTC TGGCGCTGAT GGCCGATGGT 
GTAGAGGTCT TTGTGGTGGG CTTTGTGCTG CCCAGTGCTG AGAAAGATAT GTGCCTGTCG 
GACTCCAACA AAGGCATGCT AGGCCTCATT GTGTACCTGG GCATGATGGT GGGGGCCTTC 
CTCTGGGGAG GCCTGGCTGA TCGGCTGGGT CGGAGACAGT GTCTGCTCAT CTCGCTCTCA 
GTCAACAGCG TCTTCGCTTT CTTCTCATCC TTCGTCCAGG GTTATGGCAC CTTCCTTTTC 
TGCCGCCTCC TTTCTGGGGT TGGGATTGGT GGTTCCATCC CCATTGTCTT CTCCTATTTT 
TCGGAGTTTC TGGCCCAGGA GAAACGTGGG GAGCATTTGA GCTGGCTCTG TATGTTCTGG 
ATGATTGGTG GCGTGTATGC AGCTGCAATG GCCTGGGCCA TCATCCCCCA CTATGGGTGG 
AGTTTCCAGA TGGGCTCTGC TTACCAGTTC CACAGCTGGA GGGTCTTTGT CCTCGTCTGT 
GCCTTTCCCT CTGTGTTTGC CATCGGGGCT CTGACTACGC AGCCGGAGAG TCCCCGCTTC 
TTCTTAGAGA ATGGGAAGCA CGATGAGGCC TGGATGGTGC TGAAGCAGGT TCATGACACC 
AACATGCGAG CCAAGGGCCA TCCTGAGCGA GTCTTCTCAG TAACCCACAT TAAAACGATT 
CATCAGGAGG ATGAATTGAT TGAGATCCAG TCAGACACAG GAACCTGGTA CCAGCGCTGG 
GGAGTGCGGG CTTTGAGCCT GGGGGGTCAG GTTTGGGGGA ACTTCCTCTC CTGCTTCAGT 
CCAGAGTACC GGCGCATCAC TCTGATGATG ATGGGGGTAT GGTTCACCAT GTCCTTCAGC 
TACTACGGTT TGACTGTCTG GTTTCCCGAC ATGATCCGCC ATCTCCAGGC TGTGGACTAT 
GCAGCCCGAA CCAAAGTGTT CCCAGGGGAG CGCGTGGAGC ACGTGACATT TAACTTCACA 
CTGGAGAATC AGATCCACCG AGGGGGACAG TACTTCAATG ACAAGTTCAT CGGGCTGCGT 
CTGAAGTCAG TGTCCTTTGA GGATTCCCTG TTTGAGGAAT GTTACTTTGA AGATGTCACA 
TCCAGCAACA CATTCTTCCG CAACTGCACA TTCATCAACA CCGTGTTCTA CAACACGGAC 
CTGTTTGAGT ACAAGTTCGT GAACAGCCGC CTGGTGAACA GCACATTCCT GCACAATAAG 
GAAGGTTGCC CACTAGATGT GACAGGGACG GGCGAAGGTG CCTACATGGT GTACTTTGTC 
AGCTTCTTGG GGACACTGGC TGTGCTCCCT GGAAATATTG TGTCTGCTCT GCTCATGGAC 
AAGATTGGCA GGCTCAGAAT GCTTGCTGGT TCCAGTGTGT TGTCCTGTGT TTCCTGCTTC 
TTCCTGTCTT TTGGGAACAG TGAGTCAGCC ATGATCGCTC TGCTCTGCCT TTTTGGGGGA 
GTCAGTATTG CATCCTGGAA CGCGCTGGAC GTGCTGACTG TTGAACTCTA CCCTTCCGAC 
AAGAGGACGA CGGCCTTCGG CTTCCTGAAT GCCCTGTGTA AGCTGGCAGC TGTACTGGGC 
ATCAGCATCT TCACGTCCTT TGTGGGAATC ACCAAGGCCG CTCCCATCCT CTTCGCCTCA 
GCTGCGCTTG CCCTTGGTAG CTCTCTGGCT CTGAAGCTGC CTGAGACCCG GGGACAGGTG 
CTGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sv2a ( XM_006232952.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233014.1 Rattus norvegicus synaptic vesicle glycoprotein 2a (Sv2a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa11647
Clone ID Related Accession (Same CDS sequence)	NM_057210.2 , XM_006232952.3
Accession Version	XM_006232952.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2229bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	synaptic vesicle glycoprotein 2A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006232952.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGAAG GCTTTCGAGA CCGAGCAGCG TTCATCCGTG GGGCCAAAGA CATTGCCAAG 
GAAGTTAAGA AGCACGCGGC CAAGAAGGTG GTGAAGGGTC TCGACAGAGT CCAGGATGAA 
TATTCCCGAA GGTCCTACTC CCGCTTTGAG GAGGAGGAGG ATGATGATGA CTTCCCTGCC 
CCTGCTGACG GCTATTACCG CGGAGAAGGG GCCCAGGATG AGGAGGAAGG TGGCGCTTCC 
AGTGATGCCA CTGAGGGCCA CGATGAGGAT GATGAGATCT ACGAGGGAGA ATATCAGGGC 
ATCCCCCGGG CAGAGTCTGG GGGCAAAGGC GAACGGATGG CAGATGGGGC ACCCCTGGCT 
GGAGTGAGAG GGGGCTTAAG TGATGGGGAG GGTCCCCCTG GGGGTCGCGG GGAGGCGCAG 
CGGCGTAAAG ATCGGGAAGA ATTGGCTCAG CAGTATGAGA CCATCCTCCG GGAGTGCGGC 
CATGGTCGCT TCCAGTGGAC ACTCTACTTC GTGCTGGGTC TGGCGCTGAT GGCCGATGGT 
GTAGAGGTCT TTGTGGTGGG CTTTGTGCTG CCCAGTGCTG AGAAAGATAT GTGCCTGTCG 
GACTCCAACA AAGGCATGCT AGGCCTCATT GTGTACCTGG GCATGATGGT GGGGGCCTTC 
CTCTGGGGAG GCCTGGCTGA TCGGCTGGGT CGGAGACAGT GTCTGCTCAT CTCGCTCTCA 
GTCAACAGCG TCTTCGCTTT CTTCTCATCC TTCGTCCAGG GTTATGGCAC CTTCCTTTTC 
TGCCGCCTCC TTTCTGGGGT TGGGATTGGT GGTTCCATCC CCATTGTCTT CTCCTATTTT 
TCGGAGTTTC TGGCCCAGGA GAAACGTGGG GAGCATTTGA GCTGGCTCTG TATGTTCTGG 
ATGATTGGTG GCGTGTATGC AGCTGCAATG GCCTGGGCCA TCATCCCCCA CTATGGGTGG 
AGTTTCCAGA TGGGCTCTGC TTACCAGTTC CACAGCTGGA GGGTCTTTGT CCTCGTCTGT 
GCCTTTCCCT CTGTGTTTGC CATCGGGGCT CTGACTACGC AGCCGGAGAG TCCCCGCTTC 
TTCTTAGAGA ATGGGAAGCA CGATGAGGCC TGGATGGTGC TGAAGCAGGT TCATGACACC 
AACATGCGAG CCAAGGGCCA TCCTGAGCGA GTCTTCTCAG TAACCCACAT TAAAACGATT 
CATCAGGAGG ATGAATTGAT TGAGATCCAG TCAGACACAG GAACCTGGTA CCAGCGCTGG 
GGAGTGCGGG CTTTGAGCCT GGGGGGTCAG GTTTGGGGGA ACTTCCTCTC CTGCTTCAGT 
CCAGAGTACC GGCGCATCAC TCTGATGATG ATGGGGGTAT GGTTCACCAT GTCCTTCAGC 
TACTACGGTT TGACTGTCTG GTTTCCCGAC ATGATCCGCC ATCTCCAGGC TGTGGACTAT 
GCAGCCCGAA CCAAAGTGTT CCCAGGGGAG CGCGTGGAGC ACGTGACATT TAACTTCACA 
CTGGAGAATC AGATCCACCG AGGGGGACAG TACTTCAATG ACAAGTTCAT CGGGCTGCGT 
CTGAAGTCAG TGTCCTTTGA GGATTCCCTG TTTGAGGAAT GTTACTTTGA AGATGTCACA 
TCCAGCAACA CATTCTTCCG CAACTGCACA TTCATCAACA CCGTGTTCTA CAACACGGAC 
CTGTTTGAGT ACAAGTTCGT GAACAGCCGC CTGGTGAACA GCACATTCCT GCACAATAAG 
GAAGGTTGCC CACTAGATGT GACAGGGACG GGCGAAGGTG CCTACATGGT GTACTTTGTC 
AGCTTCTTGG GGACACTGGC TGTGCTCCCT GGAAATATTG TGTCTGCTCT GCTCATGGAC 
AAGATTGGCA GGCTCAGAAT GCTTGCTGGT TCCAGTGTGT TGTCCTGTGT TTCCTGCTTC 
TTCCTGTCTT TTGGGAACAG TGAGTCAGCC ATGATCGCTC TGCTCTGCCT TTTTGGGGGA 
GTCAGTATTG CATCCTGGAA CGCGCTGGAC GTGCTGACTG TTGAACTCTA CCCTTCCGAC 
AAGAGGACGA CGGCCTTCGG CTTCCTGAAT GCCCTGTGTA AGCTGGCAGC TGTACTGGGC 
ATCAGCATCT TCACGTCCTT TGTGGGAATC ACCAAGGCCG CTCCCATCCT CTTCGCCTCA 
GCTGCGCTTG CCCTTGGTAG CTCTCTGGCT CTGAAGCTGC CTGAGACCCG GGGACAGGTG 
CTGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233014.1
CDS	482..2710
Translation	MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEEDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ

Target ORF information:

RefSeq Version	XM_006232952.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptic vesicle glycoprotein 2a (Sv2a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006232952.3

ORF Insert Sequence:

ATGGAAGAAG GCTTTCGAGA CCGAGCAGCG TTCATCCGTG GGGCCAAAGA CATTGCCAAG 
GAAGTTAAGA AGCACGCGGC CAAGAAGGTG GTGAAGGGTC TCGACAGAGT CCAGGATGAA 
TATTCCCGAA GGTCCTACTC CCGCTTTGAG GAGGAGGAGG ATGATGATGA CTTCCCTGCC 
CCTGCTGACG GCTATTACCG CGGAGAAGGG GCCCAGGATG AGGAGGAAGG TGGCGCTTCC 
AGTGATGCCA CTGAGGGCCA CGATGAGGAT GATGAGATCT ACGAGGGAGA ATATCAGGGC 
ATCCCCCGGG CAGAGTCTGG GGGCAAAGGC GAACGGATGG CAGATGGGGC ACCCCTGGCT 
GGAGTGAGAG GGGGCTTAAG TGATGGGGAG GGTCCCCCTG GGGGTCGCGG GGAGGCGCAG 
CGGCGTAAAG ATCGGGAAGA ATTGGCTCAG CAGTATGAGA CCATCCTCCG GGAGTGCGGC 
CATGGTCGCT TCCAGTGGAC ACTCTACTTC GTGCTGGGTC TGGCGCTGAT GGCCGATGGT 
GTAGAGGTCT TTGTGGTGGG CTTTGTGCTG CCCAGTGCTG AGAAAGATAT GTGCCTGTCG 
GACTCCAACA AAGGCATGCT AGGCCTCATT GTGTACCTGG GCATGATGGT GGGGGCCTTC 
CTCTGGGGAG GCCTGGCTGA TCGGCTGGGT CGGAGACAGT GTCTGCTCAT CTCGCTCTCA 
GTCAACAGCG TCTTCGCTTT CTTCTCATCC TTCGTCCAGG GTTATGGCAC CTTCCTTTTC 
TGCCGCCTCC TTTCTGGGGT TGGGATTGGT GGTTCCATCC CCATTGTCTT CTCCTATTTT 
TCGGAGTTTC TGGCCCAGGA GAAACGTGGG GAGCATTTGA GCTGGCTCTG TATGTTCTGG 
ATGATTGGTG GCGTGTATGC AGCTGCAATG GCCTGGGCCA TCATCCCCCA CTATGGGTGG 
AGTTTCCAGA TGGGCTCTGC TTACCAGTTC CACAGCTGGA GGGTCTTTGT CCTCGTCTGT 
GCCTTTCCCT CTGTGTTTGC CATCGGGGCT CTGACTACGC AGCCGGAGAG TCCCCGCTTC 
TTCTTAGAGA ATGGGAAGCA CGATGAGGCC TGGATGGTGC TGAAGCAGGT TCATGACACC 
AACATGCGAG CCAAGGGCCA TCCTGAGCGA GTCTTCTCAG TAACCCACAT TAAAACGATT 
CATCAGGAGG ATGAATTGAT TGAGATCCAG TCAGACACAG GAACCTGGTA CCAGCGCTGG 
GGAGTGCGGG CTTTGAGCCT GGGGGGTCAG GTTTGGGGGA ACTTCCTCTC CTGCTTCAGT 
CCAGAGTACC GGCGCATCAC TCTGATGATG ATGGGGGTAT GGTTCACCAT GTCCTTCAGC 
TACTACGGTT TGACTGTCTG GTTTCCCGAC ATGATCCGCC ATCTCCAGGC TGTGGACTAT 
GCAGCCCGAA CCAAAGTGTT CCCAGGGGAG CGCGTGGAGC ACGTGACATT TAACTTCACA 
CTGGAGAATC AGATCCACCG AGGGGGACAG TACTTCAATG ACAAGTTCAT CGGGCTGCGT 
CTGAAGTCAG TGTCCTTTGA GGATTCCCTG TTTGAGGAAT GTTACTTTGA AGATGTCACA 
TCCAGCAACA CATTCTTCCG CAACTGCACA TTCATCAACA CCGTGTTCTA CAACACGGAC 
CTGTTTGAGT ACAAGTTCGT GAACAGCCGC CTGGTGAACA GCACATTCCT GCACAATAAG 
GAAGGTTGCC CACTAGATGT GACAGGGACG GGCGAAGGTG CCTACATGGT GTACTTTGTC 
AGCTTCTTGG GGACACTGGC TGTGCTCCCT GGAAATATTG TGTCTGCTCT GCTCATGGAC 
AAGATTGGCA GGCTCAGAAT GCTTGCTGGT TCCAGTGTGT TGTCCTGTGT TTCCTGCTTC 
TTCCTGTCTT TTGGGAACAG TGAGTCAGCC ATGATCGCTC TGCTCTGCCT TTTTGGGGGA 
GTCAGTATTG CATCCTGGAA CGCGCTGGAC GTGCTGACTG TTGAACTCTA CCCTTCCGAC 
AAGAGGACGA CGGCCTTCGG CTTCCTGAAT GCCCTGTGTA AGCTGGCAGC TGTACTGGGC 
ATCAGCATCT TCACGTCCTT TGTGGGAATC ACCAAGGCCG CTCCCATCCT CTTCGCCTCA 
GCTGCGCTTG CCCTTGGTAG CTCTCTGGCT CTGAAGCTGC CTGAGACCCG GGGACAGGTG 
CTGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.
Scientific reports627420(2016 Jun)
Tokudome K,Okumura T,Shimizu S,Mashimo T,Takizawa A,Serikawa T,Terada R,Ishihara S,Kunisawa N,Sasa M,Ohno Y

Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban35(5)716-22(2015 Oct)
Shi J,Zhou F,Wang LK,Wu GF

Hippocampal low-frequency stimulation increased SV2A expression and inhibited the seizure degree in pharmacoresistant amygdala-kindling epileptic rats.
Epilepsy research108(9)1483-91(2014 Nov)
Wang L,Shi J,Wu G,Zhou F,Hong Z

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Science (New York, N.Y.)344(6187)1023-8(2014 May)
Wilhelm BG,Mandad S,Truckenbrodt S,Kr?hnert K,Sch?fer C,Rammner B,Koo SJ,Cla?en GA,Krauss M,Haucke V,Urlaub H,Rizzoli SO

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Sv2a cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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