Sh3gl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sh3gl2
Entrez Gene ID	116743
Full Name	SH3 domain containing GRB2 like 2, endophilin A1
Synonyms	Sh3d2a,Sh3p4
General protein information	Preferred Names SH3 domain containing GRB2 like 2, endophilin A1 Names endophilin-A1 SH3 domain protein 2A SH3 domain-containing GRB2-like 2 SH3 domain-containing GRB2-like protein 2 SH3-domain GRB2-like 2 endophilin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q31
Summary	interacts with synaptojanin and dynamin I; may be involved in synaptic vesicle recycling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017593124.1	XP_017448613.1	endophilin-A1 isoform X1
XM_006238359.3	XP_006238421.1	endophilin-A1 isoform X2
NM_053935.1	NP_446387.1	endophilin-A1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SH3GL2	NP_001070308.1
Pan troglodytes (chimpanzee)	SH3GL2	XP_520501.3
Homo sapiens (human)	SH3GL2	NP_003017.1
Mus musculus (house mouse)	Sh3gl2	NP_062408.2
Schizosaccharomyces pombe (fission yeast)	SPBC19C2.10	NP_595695.1
Xenopus tropicalis (tropical clawed frog)	sh3gl2	NP_001090766.1
Rattus norvegicus (Norway rat)	Sh3gl2	NP_446387.1
Gallus gallus (chicken)	SH3GL2	NP_989861.1
Danio rerio (zebrafish)	LOC794400	NP_001188266.1
	SH3GL2	XP_001102732.2
Canis lupus familiaris (dog)	SH3GL2	XP_853971.2

Gene Ontology
Bibliography

Related articles in PubMed

Structural inhibition of dynamin-mediated membrane fission by endophilin.
Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A
eLife6(2017 Sep)

Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells.
Liu Y, Gao M, Ma MM, Tang YB, Zhou JG, Wang GL, Du YH, Guan YY
Journal of molecular and cellular cardiology92122-33(2016 Mar)

A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.
Wuertenberger S, Groemping Y
FEBS letters589(10)1156-63(2015 Apr)

Endophilin marks and controls a clathrin-independent endocytic pathway.
Boucrot E, Ferreira AP, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon HT
Nature517(7535)460-5(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggested a role of EndoII in protecting BASMCs apoptosis induced by H2O2, possibly by inhibiting the addressing of Bax to mitochondria. Targeting on EndoII may be a new strategy to treat apoptosis-associated diseases.
Title: Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells.

We find that the phosphomimetic mutation S75D favors vesicle formation by inhibiting this conformational switch, acting to regulate endophilin A1-mediated curvature.
Title: Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation.

Kinetics of endophilin N-BAR domain dimerization and membrane interactions.
Title: Kinetics of endophilin N-BAR domain dimerization and membrane interactions.

a coarse-grained model was used to study various membrane remodeling scenarios induced by endophilin N-terminal helix and Bin/amphiphysin/Rvs domains.
Title: Understanding the role of amphipathic helices in N-BAR domain driven membrane remodeling.

Endophilin I and endophilin II interact with N-type Ca2+ channel carboxyl-terminal fragments in clathrin-mediated endocytosis.
Title: Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I.

The following Sh3gl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sh3gl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa11104	NM_053935.1 Latest version!	Rattus norvegicus SH3 domain containing GRB2 like 2, endophilin A1 (Sh3gl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa28285	XM_006238359.3 Latest version!	Rattus norvegicus SH3 domain-containing GRB2-like 2 (Sh3gl2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa61094	XM_017593124.1 Latest version!	Rattus norvegicus SH3 domain-containing GRB2-like 2 (Sh3gl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sh3gl2 ( NM_053935.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446387.1 Rattus norvegicus SH3 domain containing GRB2 like 2, endophilin A1 (Sh3gl2), mRNA.

Price & Availability↑

CloneID	ORa11104
Clone ID Related Accession (Same CDS sequence)	NM_053935.1
Accession Version	NM_053935.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	endophilin-A1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07049079.1. On or before Jul 29, 2012 this sequence version replaced XM_001070855.2, XM_342857.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGTGG CAGGGCTGAA GAAGCAGTTC CACAAAGCCA CTCAGAAAGT GAGTGAGAAG 
GTGGGAGGAG CCGAAGGCAC CAAGCTCGAT GATGACTTCA AAGAGATGGA GAGGAAAGTG 
GATGTTACCA GCAGGGCCGT GATGGAGATA ATGACGAAAA CAATTGAATA CCTCCAACCC 
AATCCAGCTT CCAGGGCTAA ACTCAGTATG ATCAACACCA TGTCGAAAAT CCGTGGCCAA 
GAGAAGGGGC CAGGCTATCC TCAGGCAGAA GCACTGCTGG CAGAGGCTAT GCTCAAGTTC 
GGCAGGGAGC TCGGCGATGA TTGCAACTTT GGTCCGGCTC TTGGTGAGGT AGGAGAAGCC 
ATGAGGGAGC TCTCGGAGGT CAAGGACTCT TTGGACATGG AAGTGAAGCA GAACTTCATC 
GACCCCCTTC AGAATCTTCA TGACAAAGAT CTGAGGGAGA TTCAGCATCA CCTGAAAAAG 
CTGGAAGGCC GACGCTTAGA CTTTGATTAT AAGAAGAAGC GACAAGGAAA GATTCCAGAC 
GAAGAACTCC GCCAAGCTCT GGAGAAATTT GATGAGTCTA AAGAAATCGC TGAGTCGAGC 
ATGTTCAACC TCTTGGAGAT GGATATTGAA CAGGTGAGCC AGCTCTCTGC ACTTGTTCAG 
GCTCAGCTGG AGTACCACAA ACAGGCTGTG CAGATCCTGC AACAGGTCAC TGTCAGGCTG 
GAAGAGAGAA TAAGACAAGC TTCATCTCAA CCAAGAAGGG AATATCAGCC CAAACCACGA 
ATGAGCCTAG AGTTTGCCAC TGGAGACGGT ACGCAGCCCA ACGGGGGTCT CTCCCACACA 
GGCACACCCA AACCTGCAGG TGTCCAAATG GATCAGCCTT GCTGCCGAGC CCTGTATGAC 
TTTGAACCTG AAAATGAAGG GGAGTTGGGT TTTAAAGAGG GTGATATCAT CACGCTCACT 
AATCAGATTG ATGAGAACTG GTATGAGGGG ATGCTTCATG GCCAGTCCGG CTTTTTCCCC 
ATCAACTATG TAGAAATTCT GGTTGCTCTG CCCCATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446387.1
CDS	87..1145
Translation	MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDGTQPNGGLSHTGTPKPAGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH

Target ORF information:

RefSeq Version	NM_053935.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SH3 domain containing GRB2 like 2, endophilin A1 (Sh3gl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053935.1

ORF Insert Sequence:

ATGTCGGTGG CAGGGCTGAA GAAGCAGTTC CACAAAGCCA CTCAGAAAGT GAGTGAGAAG 
GTGGGAGGAG CCGAAGGCAC CAAGCTCGAT GATGACTTCA AAGAGATGGA GAGGAAAGTG 
GATGTTACCA GCAGGGCCGT GATGGAGATA ATGACGAAAA CAATTGAATA CCTCCAACCC 
AATCCAGCTT CCAGGGCTAA ACTCAGTATG ATCAACACCA TGTCGAAAAT CCGTGGCCAA 
GAGAAGGGGC CAGGCTATCC TCAGGCAGAA GCACTGCTGG CAGAGGCTAT GCTCAAGTTC 
GGCAGGGAGC TCGGCGATGA TTGCAACTTT GGTCCGGCTC TTGGTGAGGT AGGAGAAGCC 
ATGAGGGAGC TCTCGGAGGT CAAGGACTCT TTGGACATGG AAGTGAAGCA GAACTTCATC 
GACCCCCTTC AGAATCTTCA TGACAAAGAT CTGAGGGAGA TTCAGCATCA CCTGAAAAAG 
CTGGAAGGCC GACGCTTAGA CTTTGATTAT AAGAAGAAGC GACAAGGAAA GATTCCAGAC 
GAAGAACTCC GCCAAGCTCT GGAGAAATTT GATGAGTCTA AAGAAATCGC TGAGTCGAGC 
ATGTTCAACC TCTTGGAGAT GGATATTGAA CAGGTGAGCC AGCTCTCTGC ACTTGTTCAG 
GCTCAGCTGG AGTACCACAA ACAGGCTGTG CAGATCCTGC AACAGGTCAC TGTCAGGCTG 
GAAGAGAGAA TAAGACAAGC TTCATCTCAA CCAAGAAGGG AATATCAGCC CAAACCACGA 
ATGAGCCTAG AGTTTGCCAC TGGAGACGGT ACGCAGCCCA ACGGGGGTCT CTCCCACACA 
GGCACACCCA AACCTGCAGG TGTCCAAATG GATCAGCCTT GCTGCCGAGC CCTGTATGAC 
TTTGAACCTG AAAATGAAGG GGAGTTGGGT TTTAAAGAGG GTGATATCAT CACGCTCACT 
AATCAGATTG ATGAGAACTG GTATGAGGGG ATGCTTCATG GCCAGTCCGG CTTTTTCCCC 
ATCAACTATG TAGAAATTCT GGTTGCTCTG CCCCATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh3gl2 ( XM_006238359.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006238421.1 Rattus norvegicus SH3 domain-containing GRB2-like 2 (Sh3gl2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa28285
Clone ID Related Accession (Same CDS sequence)	XM_006238359.3
Accession Version	XM_006238359.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	endophilin-A1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006238359.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCCAA TTTCTAAGAA GAAAGTGAGT GAGAAGGTGG GAGGAGCCGA AGGCACCAAG 
CTCGATGATG ACTTCAAAGA GATGGAGAGG AAAGTGGATG TTACCAGCAG GGCCGTGATG 
GAGATAATGA CGAAAACAAT TGAATACCTC CAACCCAATC CAGCTTCCAG GGCTAAACTC 
AGTATGATCA ACACCATGTC GAAAATCCGT GGCCAAGAGA AGGGGCCAGG CTATCCTCAG 
GCAGAAGCAC TGCTGGCAGA GGCTATGCTC AAGTTCGGCA GGGAGCTCGG CGATGATTGC 
AACTTTGGTC CGGCTCTTGG TGAGGTAGGA GAAGCCATGA GGGAGCTCTC GGAGGTCAAG 
GACTCTTTGG ACATGGAAGT GAAGCAGAAC TTCATCGACC CCCTTCAGAA TCTTCATGAC 
AAAGATCTGA GGGAGATTCA GCATCACCTG AAAAAGCTGG AAGGCCGACG CTTAGACTTT 
GATTATAAGA AGAAGCGACA AGGAAAGATT CCAGACGAAG AACTCCGCCA AGCTCTGGAG 
AAATTTGATG AGTCTAAAGA AATCGCTGAG TCGAGCATGT TCAACCTCTT GGAGATGGAT 
ATTGAACAGG TGAGCCAGCT CTCTGCACTT GTTCAGGCTC AGCTGGAGTA CCACAAACAG 
GCTGTGCAGA TCCTGCAACA GGTCACTGTC AGGCTGGAAG AGAGAATAAG ACAAGCTTCA 
TCTCAACCAA GAAGGGAATA TCAGCCCAAA CCACGAATGA GCCTAGAGTT TGCCACTGGA 
GACGGTACGC AGCCCAACGG GGGTCTCTCC CACACAGGCA CACCCAAACC TGCAGGTGTC 
CAAATGGATC AGCCTTGCTG CCGAGCCCTG TATGACTTTG AACCTGAAAA TGAAGGGGAG 
TTGGGTTTTA AAGAGGGTGA TATCATCACG CTCACTAATC AGATTGATGA GAACTGGTAT 
GAGGGGATGC TTCATGGCCA GTCCGGCTTT TTCCCCATCA ACTATGTAGA AATTCTGGTT 
GCTCTGCCCC ATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006238421.1
CDS	1479..2513
Translation	MLPISKKKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDGTQPNGGLSHTGTPKPAGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH

Target ORF information:

RefSeq Version	XM_006238359.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SH3 domain-containing GRB2-like 2 (Sh3gl2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006238359.3

ORF Insert Sequence:

ATGCTCCCAA TTTCTAAGAA GAAAGTGAGT GAGAAGGTGG GAGGAGCCGA AGGCACCAAG 
CTCGATGATG ACTTCAAAGA GATGGAGAGG AAAGTGGATG TTACCAGCAG GGCCGTGATG 
GAGATAATGA CGAAAACAAT TGAATACCTC CAACCCAATC CAGCTTCCAG GGCTAAACTC 
AGTATGATCA ACACCATGTC GAAAATCCGT GGCCAAGAGA AGGGGCCAGG CTATCCTCAG 
GCAGAAGCAC TGCTGGCAGA GGCTATGCTC AAGTTCGGCA GGGAGCTCGG CGATGATTGC 
AACTTTGGTC CGGCTCTTGG TGAGGTAGGA GAAGCCATGA GGGAGCTCTC GGAGGTCAAG 
GACTCTTTGG ACATGGAAGT GAAGCAGAAC TTCATCGACC CCCTTCAGAA TCTTCATGAC 
AAAGATCTGA GGGAGATTCA GCATCACCTG AAAAAGCTGG AAGGCCGACG CTTAGACTTT 
GATTATAAGA AGAAGCGACA AGGAAAGATT CCAGACGAAG AACTCCGCCA AGCTCTGGAG 
AAATTTGATG AGTCTAAAGA AATCGCTGAG TCGAGCATGT TCAACCTCTT GGAGATGGAT 
ATTGAACAGG TGAGCCAGCT CTCTGCACTT GTTCAGGCTC AGCTGGAGTA CCACAAACAG 
GCTGTGCAGA TCCTGCAACA GGTCACTGTC AGGCTGGAAG AGAGAATAAG ACAAGCTTCA 
TCTCAACCAA GAAGGGAATA TCAGCCCAAA CCACGAATGA GCCTAGAGTT TGCCACTGGA 
GACGGTACGC AGCCCAACGG GGGTCTCTCC CACACAGGCA CACCCAAACC TGCAGGTGTC 
CAAATGGATC AGCCTTGCTG CCGAGCCCTG TATGACTTTG AACCTGAAAA TGAAGGGGAG 
TTGGGTTTTA AAGAGGGTGA TATCATCACG CTCACTAATC AGATTGATGA GAACTGGTAT 
GAGGGGATGC TTCATGGCCA GTCCGGCTTT TTCCCCATCA ACTATGTAGA AATTCTGGTT 
GCTCTGCCCC ATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sh3gl2 ( XM_017593124.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017448613.1 Rattus norvegicus SH3 domain-containing GRB2-like 2 (Sh3gl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61094
Clone ID Related Accession (Same CDS sequence)	XM_017593124.1
Accession Version	XM_017593124.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	endophilin-A1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAAACGA ATGCTCCTCA GAAAGTGAGT GAGAAGGTGG GAGGAGCCGA AGGCACCAAG 
CTCGATGATG ACTTCAAAGA GATGGAGAGG AAAGTGGATG TTACCAGCAG GGCCGTGATG 
GAGATAATGA CGAAAACAAT TGAATACCTC CAACCCAATC CAGCTTCCAG GGCTAAACTC 
AGTATGATCA ACACCATGTC GAAAATCCGT GGCCAAGAGA AGGGGCCAGG CTATCCTCAG 
GCAGAAGCAC TGCTGGCAGA GGCTATGCTC AAGTTCGGCA GGGAGCTCGG CGATGATTGC 
AACTTTGGTC CGGCTCTTGG TGAGGTAGGA GAAGCCATGA GGGAGCTCTC GGAGGTCAAG 
GACTCTTTGG ACATGGAAGT GAAGCAGAAC TTCATCGACC CCCTTCAGAA TCTTCATGAC 
AAAGATCTGA GGGAGATTCA GCATCACCTG AAAAAGCTGG AAGGCCGACG CTTAGACTTT 
GATTATAAGA AGAAGCGACA AGGAAAGATT CCAGACGAAG AACTCCGCCA AGCTCTGGAG 
AAATTTGATG AGTCTAAAGA AATCGCTGAG TCGAGCATGT TCAACCTCTT GGAGATGGAT 
ATTGAACAGG TGAGCCAGCT CTCTGCACTT GTTCAGGCTC AGCTGGAGTA CCACAAACAG 
GCTGTGCAGA TCCTGCAACA GGTCACTGTC AGGCTGGAAG AGAGAATAAG ACAAGCTTCA 
TCTCAACCAA GAAGGGAATA TCAGCCCAAA CCACGAATGA GCCTAGAGTT TGCCACTGGA 
GACGGTACGC AGCCCAACGG GGGTCTCTCC CACACAGGCA CACCCAAACC TGCAGGTGTC 
CAAATGGATC AGCCTTGCTG CCGAGCCCTG TATGACTTTG AACCTGAAAA TGAAGGGGAG 
TTGGGTTTTA AAGAGGGTGA TATCATCACG CTCACTAATC AGATTGATGA GAACTGGTAT 
GAGGGGATGC TTCATGGCCA GTCCGGCTTT TTCCCCATCA ACTATGTAGA AATTCTGGTT 
GCTCTGCCCC ATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017448613.1
CDS	847..1881
Translation	MQTNAPQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDGTQPNGGLSHTGTPKPAGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH

Target ORF information:

RefSeq Version	XM_017593124.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SH3 domain-containing GRB2-like 2 (Sh3gl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017593124.1

ORF Insert Sequence:

ATGCAAACGA ATGCTCCTCA GAAAGTGAGT GAGAAGGTGG GAGGAGCCGA AGGCACCAAG 
CTCGATGATG ACTTCAAAGA GATGGAGAGG AAAGTGGATG TTACCAGCAG GGCCGTGATG 
GAGATAATGA CGAAAACAAT TGAATACCTC CAACCCAATC CAGCTTCCAG GGCTAAACTC 
AGTATGATCA ACACCATGTC GAAAATCCGT GGCCAAGAGA AGGGGCCAGG CTATCCTCAG 
GCAGAAGCAC TGCTGGCAGA GGCTATGCTC AAGTTCGGCA GGGAGCTCGG CGATGATTGC 
AACTTTGGTC CGGCTCTTGG TGAGGTAGGA GAAGCCATGA GGGAGCTCTC GGAGGTCAAG 
GACTCTTTGG ACATGGAAGT GAAGCAGAAC TTCATCGACC CCCTTCAGAA TCTTCATGAC 
AAAGATCTGA GGGAGATTCA GCATCACCTG AAAAAGCTGG AAGGCCGACG CTTAGACTTT 
GATTATAAGA AGAAGCGACA AGGAAAGATT CCAGACGAAG AACTCCGCCA AGCTCTGGAG 
AAATTTGATG AGTCTAAAGA AATCGCTGAG TCGAGCATGT TCAACCTCTT GGAGATGGAT 
ATTGAACAGG TGAGCCAGCT CTCTGCACTT GTTCAGGCTC AGCTGGAGTA CCACAAACAG 
GCTGTGCAGA TCCTGCAACA GGTCACTGTC AGGCTGGAAG AGAGAATAAG ACAAGCTTCA 
TCTCAACCAA GAAGGGAATA TCAGCCCAAA CCACGAATGA GCCTAGAGTT TGCCACTGGA 
GACGGTACGC AGCCCAACGG GGGTCTCTCC CACACAGGCA CACCCAAACC TGCAGGTGTC 
CAAATGGATC AGCCTTGCTG CCGAGCCCTG TATGACTTTG AACCTGAAAA TGAAGGGGAG 
TTGGGTTTTA AAGAGGGTGA TATCATCACG CTCACTAATC AGATTGATGA GAACTGGTAT 
GAGGGGATGC TTCATGGCCA GTCCGGCTTT TTCCCCATCA ACTATGTAGA AATTCTGGTT 
GCTCTGCCCC ATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural inhibition of dynamin-mediated membrane fission by endophilin.
eLife6(2017 Sep)
Hohendahl A,Talledge N,Galli V,Shen PS,Humbert F,De Camilli P,Frost A,Roux A

Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells.
Journal of molecular and cellular cardiology92122-33(2016 Mar)
Liu Y,Gao M,Ma MM,Tang YB,Zhou JG,Wang GL,Du YH,Guan YY

A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.
FEBS letters589(10)1156-63(2015 Apr)
Wuertenberger S,Groemping Y

Endophilin marks and controls a clathrin-independent endocytic pathway.
Nature517(7535)460-5(2015 Jan)
Boucrot E,Ferreira AP,Almeida-Souza L,Debard S,Vallis Y,Howard G,Bertot L,Sauvonnet N,McMahon HT

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Sh3gl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

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