Csnk2a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Csnk2a1
Entrez Gene ID	116549
Full Name	casein kinase 2 alpha 1
General protein information	Preferred Names casein kinase 2 alpha 1 Names casein kinase II subunit alpha CK II alpha casein kinase 2, alpha 1 polypeptide casein kinase II, alpha 1 polypeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q41
Summary	Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006235221.3	XP_006235283.1	casein kinase II subunit alpha isoform X1
NM_053824.2	NP_446276.1	casein kinase II subunit alpha
XM_006235220.3	XP_006235282.1	casein kinase II subunit alpha isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CSNK2A1	XP_005634959.1
Rattus norvegicus (Norway rat)	Csnk2a1	NP_446276.1
Drosophila melanogaster (fruit fly)	CkIIalpha	NP_730775.1
Saccharomyces cerevisiae (baker's yeast)	CKA2	NP_014704.1
Magnaporthe oryzae (rice blast fungus)	MGG_03696	XP_003716185.1
Mus musculus (house mouse)	Csnk2a1	NP_031814.2
Gallus gallus (chicken)	CSNK2A1	NP_001002242.1
Arabidopsis thaliana (thale cress)	AT2G23070	NP_179889.1
Xenopus tropicalis (tropical clawed frog)	LOC100498392	XP_004920495.1
Homo sapiens (human)	CSNK2A1	NP_808227.1
Danio rerio (zebrafish)	LOC100535532	XP_003199454.1
Eremothecium gossypii	AGOS_ADR204W	NP_984300.1
Neurospora crassa	NCU03124	XP_964983.2
Bos taurus (cattle)	CSNK2A1	NP_777060.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005569	XP_315576.4
Caenorhabditis elegans (roundworm)	kin-3	NP_492811.1
Pan troglodytes (chimpanzee)	CSNK2A1	XP_003953729.1
	CSNK2A1	XP_002798227.1
Kluyveromyces lactis	KLLA0F16467g	XP_455820.1
Schizosaccharomyces pombe (fission yeast)	cka1	NP_593642.1

Gene Ontology
Bibliography

Related articles in PubMed

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
Wadey KS, Brown BA, Sala-Newby GB, Jayaraman PS, Gaston K, George SJ
Vascular pharmacology9934-44(2017 Dec)

Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain.
Ottaviani D, Marin O, Arrigoni G, Franchin C, Vilardell J, Sandre M, Li W, Parfitt DA, Pinna LA, Cheetham ME, Ruzzene M
Human molecular genetics26(3)611-623(2017 02)

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.
Wei H, Liu L, Chen Q
Biochimica et biophysica acta1853(10 Pt B)2784-90(2015 Oct)

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.
de Thonel A, Hazoum? A, Kochin V, Isoniemi K, Jego G, Fourmaux E, Hammann A, Mjahed H, Filhol O, Micheau O, Rocchi P, Mezger V, Eriksson JE, Rangnekar VM, Garrido C
Cell death & disease5e1016(2014 Jan)

The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator.
Szab? A, Papin C, Zorn D, Ponien P, Weber F, Raabe T, Rouyer F
PLoS biology11(8)e1001645(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
Title: Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.

Phosphorylation by CK2 impairs Par-4 proapoptotic functions.
Title: Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.

CK2 down regulation facilitates TNF-alpha-mediated chondrocyte death through apoptosis and autophagy
Title: Downregulation of protein kinase CK2 activity facilitates tumor necrosis factor-?-mediated chondrocyte death through apoptosis and autophagy.

Nuclear localization of B23 and CK2 is dynamically regulated in response to altered growth status in the cell.
Title: Protein B23/nucleophosmin/numatrin nuclear dynamics in relation to protein kinase CK2 and apoptotic activity in prostate cells.

Data show that Golgi apparatus casein kinase (G-CK) catalyzes the phosphorylation of rhBMP-15 and rhGDF-9.
Title: Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9.

The following Csnk2a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Csnk2a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa10782	NM_053824.2 Latest version!	Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa10782	XM_006235221.3 Latest version!	Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa10782	XM_006235220.3 Latest version!	Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Csnk2a1 ( NM_053824.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446276.1 Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), mRNA.

Price & Availability↑

CloneID	ORa10782
Clone ID Related Accession (Same CDS sequence)	XM_006235221.3 , NM_053824.2 , XM_006235220.3
Accession Version	NM_053824.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	casein kinase II subunit alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC091130.1. On Jun 10, 2007 this sequence version replaced NM_053824.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC091130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAACAC ACACAGACCC 
CGAGAGTACT GGGACTATGA ATCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTTGTTCGAA AATTAGGCAG GGGCAAATAC AGTGAAGTGT TTGAAGCCAT CAATATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTAAGAGGT GGGCCCAACA TCATCACACT TGCAGACATT 
GTGAAAGACC CTGTGTCTCG AACCCCTGCC TTGGTTTTTG AACATGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGACATTC GATTTTACAT GTATGAAATT 
CTGAAAGCCC TGGATTATTG TCACAGCATG GGGATTATGC ACAGAGACGT GAAACCGCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTTCGGCTAA TAGATTGGGG TTTAGCAGAG 
TTTTACCATC CTGGCCAAGA GTATAATGTC CGAGTTGCTT CCCGATATTT CAAAGGTCCA 
GAGCTACTTG TAGATTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG CTTGGGTTGT 
ATGCTGGCAA GTATGATCTT CCGGAAGGAG CCATTTTTCC ATGGACATGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GGTTCTGGGA ACGGAAGATT TATATGACTA TATTGACAAG 
TACAACATTG AATTAGATCC ACGTTTCAAC GATATCTTGG GCAGACACTC CCGTAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAACCAG CACCTTGTCA GCCCCGAGGC CTTGGATTTT 
CTGGACAAGC TGCTGCGATA CGACCACCAG TCTCGGCTCA CTGCAAGAGA GGCCATGGAG 
CACCCTTACT TCTACACTGT CGTGAAGGAC CAGGCTCGAA TGAGTTCGGC TGGCATGGCA 
GGGGGCAGCA CACCTGTCAG TAGCGCCAAT ATGATGTCAG GGATTTCTTC AGTGCCAACC 
CCTTCACCCC TGGGACCTCT GGCAGGCTCA CCCGTGATTG CTGCTGCCAA CTCACTTGGG 
ATACCTGTAC CAGCTGCCGC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446276.1
CDS	186..1361
Translation	MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSAGMAGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ

Target ORF information:

RefSeq Version	NM_053824.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053824.2

ORF Insert Sequence:

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAACAC ACACAGACCC 
CGAGAGTACT GGGACTATGA ATCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTTGTTCGAA AATTAGGCAG GGGCAAATAC AGTGAAGTGT TTGAAGCCAT CAATATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTAAGAGGT GGGCCCAACA TCATCACACT TGCAGACATT 
GTGAAAGACC CTGTGTCTCG AACCCCTGCC TTGGTTTTTG AACATGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGACATTC GATTTTACAT GTATGAAATT 
CTGAAAGCCC TGGATTATTG TCACAGCATG GGGATTATGC ACAGAGACGT GAAACCGCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTTCGGCTAA TAGATTGGGG TTTAGCAGAG 
TTTTACCATC CTGGCCAAGA GTATAATGTC CGAGTTGCTT CCCGATATTT CAAAGGTCCA 
GAGCTACTTG TAGATTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG CTTGGGTTGT 
ATGCTGGCAA GTATGATCTT CCGGAAGGAG CCATTTTTCC ATGGACATGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GGTTCTGGGA ACGGAAGATT TATATGACTA TATTGACAAG 
TACAACATTG AATTAGATCC ACGTTTCAAC GATATCTTGG GCAGACACTC CCGTAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAACCAG CACCTTGTCA GCCCCGAGGC CTTGGATTTT 
CTGGACAAGC TGCTGCGATA CGACCACCAG TCTCGGCTCA CTGCAAGAGA GGCCATGGAG 
CACCCTTACT TCTACACTGT CGTGAAGGAC CAGGCTCGAA TGAGTTCGGC TGGCATGGCA 
GGGGGCAGCA CACCTGTCAG TAGCGCCAAT ATGATGTCAG GGATTTCTTC AGTGCCAACC 
CCTTCACCCC TGGGACCTCT GGCAGGCTCA CCCGTGATTG CTGCTGCCAA CTCACTTGGG 
ATACCTGTAC CAGCTGCCGC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Csnk2a1 ( XM_006235221.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006235283.1 Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa10782
Clone ID Related Accession (Same CDS sequence)	XM_006235221.3 , NM_053824.2 , XM_006235220.3
Accession Version	XM_006235221.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	casein kinase II subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006235221.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAACAC ACACAGACCC 
CGAGAGTACT GGGACTATGA ATCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTTGTTCGAA AATTAGGCAG GGGCAAATAC AGTGAAGTGT TTGAAGCCAT CAATATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTAAGAGGT GGGCCCAACA TCATCACACT TGCAGACATT 
GTGAAAGACC CTGTGTCTCG AACCCCTGCC TTGGTTTTTG AACATGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGACATTC GATTTTACAT GTATGAAATT 
CTGAAAGCCC TGGATTATTG TCACAGCATG GGGATTATGC ACAGAGACGT GAAACCGCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTTCGGCTAA TAGATTGGGG TTTAGCAGAG 
TTTTACCATC CTGGCCAAGA GTATAATGTC CGAGTTGCTT CCCGATATTT CAAAGGTCCA 
GAGCTACTTG TAGATTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG CTTGGGTTGT 
ATGCTGGCAA GTATGATCTT CCGGAAGGAG CCATTTTTCC ATGGACATGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GGTTCTGGGA ACGGAAGATT TATATGACTA TATTGACAAG 
TACAACATTG AATTAGATCC ACGTTTCAAC GATATCTTGG GCAGACACTC CCGTAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAACCAG CACCTTGTCA GCCCCGAGGC CTTGGATTTT 
CTGGACAAGC TGCTGCGATA CGACCACCAG TCTCGGCTCA CTGCAAGAGA GGCCATGGAG 
CACCCTTACT TCTACACTGT CGTGAAGGAC CAGGCTCGAA TGAGTTCGGC TGGCATGGCA 
GGGGGCAGCA CACCTGTCAG TAGCGCCAAT ATGATGTCAG GGATTTCTTC AGTGCCAACC 
CCTTCACCCC TGGGACCTCT GGCAGGCTCA CCCGTGATTG CTGCTGCCAA CTCACTTGGG 
ATACCTGTAC CAGCTGCCGC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006235283.1
CDS	289..1464
Translation	MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSAGMAGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ

Target ORF information:

RefSeq Version	XM_006235221.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235221.3

ORF Insert Sequence:

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAACAC ACACAGACCC 
CGAGAGTACT GGGACTATGA ATCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTTGTTCGAA AATTAGGCAG GGGCAAATAC AGTGAAGTGT TTGAAGCCAT CAATATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTAAGAGGT GGGCCCAACA TCATCACACT TGCAGACATT 
GTGAAAGACC CTGTGTCTCG AACCCCTGCC TTGGTTTTTG AACATGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGACATTC GATTTTACAT GTATGAAATT 
CTGAAAGCCC TGGATTATTG TCACAGCATG GGGATTATGC ACAGAGACGT GAAACCGCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTTCGGCTAA TAGATTGGGG TTTAGCAGAG 
TTTTACCATC CTGGCCAAGA GTATAATGTC CGAGTTGCTT CCCGATATTT CAAAGGTCCA 
GAGCTACTTG TAGATTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG CTTGGGTTGT 
ATGCTGGCAA GTATGATCTT CCGGAAGGAG CCATTTTTCC ATGGACATGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GGTTCTGGGA ACGGAAGATT TATATGACTA TATTGACAAG 
TACAACATTG AATTAGATCC ACGTTTCAAC GATATCTTGG GCAGACACTC CCGTAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAACCAG CACCTTGTCA GCCCCGAGGC CTTGGATTTT 
CTGGACAAGC TGCTGCGATA CGACCACCAG TCTCGGCTCA CTGCAAGAGA GGCCATGGAG 
CACCCTTACT TCTACACTGT CGTGAAGGAC CAGGCTCGAA TGAGTTCGGC TGGCATGGCA 
GGGGGCAGCA CACCTGTCAG TAGCGCCAAT ATGATGTCAG GGATTTCTTC AGTGCCAACC 
CCTTCACCCC TGGGACCTCT GGCAGGCTCA CCCGTGATTG CTGCTGCCAA CTCACTTGGG 
ATACCTGTAC CAGCTGCCGC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Csnk2a1 ( XM_006235220.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006235282.1 Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa10782
Clone ID Related Accession (Same CDS sequence)	XM_006235221.3 , NM_053824.2 , XM_006235220.3
Accession Version	XM_006235220.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	casein kinase II subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006235220.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAACAC ACACAGACCC 
CGAGAGTACT GGGACTATGA ATCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTTGTTCGAA AATTAGGCAG GGGCAAATAC AGTGAAGTGT TTGAAGCCAT CAATATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTAAGAGGT GGGCCCAACA TCATCACACT TGCAGACATT 
GTGAAAGACC CTGTGTCTCG AACCCCTGCC TTGGTTTTTG AACATGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGACATTC GATTTTACAT GTATGAAATT 
CTGAAAGCCC TGGATTATTG TCACAGCATG GGGATTATGC ACAGAGACGT GAAACCGCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTTCGGCTAA TAGATTGGGG TTTAGCAGAG 
TTTTACCATC CTGGCCAAGA GTATAATGTC CGAGTTGCTT CCCGATATTT CAAAGGTCCA 
GAGCTACTTG TAGATTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG CTTGGGTTGT 
ATGCTGGCAA GTATGATCTT CCGGAAGGAG CCATTTTTCC ATGGACATGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GGTTCTGGGA ACGGAAGATT TATATGACTA TATTGACAAG 
TACAACATTG AATTAGATCC ACGTTTCAAC GATATCTTGG GCAGACACTC CCGTAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAACCAG CACCTTGTCA GCCCCGAGGC CTTGGATTTT 
CTGGACAAGC TGCTGCGATA CGACCACCAG TCTCGGCTCA CTGCAAGAGA GGCCATGGAG 
CACCCTTACT TCTACACTGT CGTGAAGGAC CAGGCTCGAA TGAGTTCGGC TGGCATGGCA 
GGGGGCAGCA CACCTGTCAG TAGCGCCAAT ATGATGTCAG GGATTTCTTC AGTGCCAACC 
CCTTCACCCC TGGGACCTCT GGCAGGCTCA CCCGTGATTG CTGCTGCCAA CTCACTTGGG 
ATACCTGTAC CAGCTGCCGC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006235282.1
CDS	248..1423
Translation	MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSAGMAGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ

Target ORF information:

RefSeq Version	XM_006235220.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235220.3

ORF Insert Sequence:

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAACAC ACACAGACCC 
CGAGAGTACT GGGACTATGA ATCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTTGTTCGAA AATTAGGCAG GGGCAAATAC AGTGAAGTGT TTGAAGCCAT CAATATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTAAGAGGT GGGCCCAACA TCATCACACT TGCAGACATT 
GTGAAAGACC CTGTGTCTCG AACCCCTGCC TTGGTTTTTG AACATGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGACATTC GATTTTACAT GTATGAAATT 
CTGAAAGCCC TGGATTATTG TCACAGCATG GGGATTATGC ACAGAGACGT GAAACCGCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTTCGGCTAA TAGATTGGGG TTTAGCAGAG 
TTTTACCATC CTGGCCAAGA GTATAATGTC CGAGTTGCTT CCCGATATTT CAAAGGTCCA 
GAGCTACTTG TAGATTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG CTTGGGTTGT 
ATGCTGGCAA GTATGATCTT CCGGAAGGAG CCATTTTTCC ATGGACATGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GGTTCTGGGA ACGGAAGATT TATATGACTA TATTGACAAG 
TACAACATTG AATTAGATCC ACGTTTCAAC GATATCTTGG GCAGACACTC CCGTAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAACCAG CACCTTGTCA GCCCCGAGGC CTTGGATTTT 
CTGGACAAGC TGCTGCGATA CGACCACCAG TCTCGGCTCA CTGCAAGAGA GGCCATGGAG 
CACCCTTACT TCTACACTGT CGTGAAGGAC CAGGCTCGAA TGAGTTCGGC TGGCATGGCA 
GGGGGCAGCA CACCTGTCAG TAGCGCCAAT ATGATGTCAG GGATTTCTTC AGTGCCAACC 
CCTTCACCCC TGGGACCTCT GGCAGGCTCA CCCGTGATTG CTGCTGCCAA CTCACTTGGG 
ATACCTGTAC CAGCTGCCGC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
Vascular pharmacology9934-44(2017 Dec)
Wadey KS,Brown BA,Sala-Newby GB,Jayaraman PS,Gaston K,George SJ

Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain.
Human molecular genetics26(3)611-623(2017 02)
Ottaviani D,Marin O,Arrigoni G,Franchin C,Vilardell J,Sandre M,Li W,Parfitt DA,Pinna LA,Cheetham ME,Ruzzene M

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.
Biochimica et biophysica acta1853(10 Pt B)2784-90(2015 Oct)
Wei H,Liu L,Chen Q

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.
Cell death & disease5e1016(2014 Jan)
de Thonel A,Hazoum? A,Kochin V,Isoniemi K,Jego G,Fourmaux E,Hammann A,Mjahed H,Filhol O,Micheau O,Rocchi P,Mezger V,Eriksson JE,Rangnekar VM,Garrido C

The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator.
PLoS biology11(8)e1001645(2013)
Szab? A,Papin C,Zorn D,Ponien P,Weber F,Raabe T,Rouyer F

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Csnk2a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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