Mapk8ip1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mapk8ip1
Entrez Gene ID	116457
Full Name	mitogen-activated protein kinase 8 interacting protein 1
Synonyms	JIP1,Jip-1,Mapk8ip
General protein information	Preferred Names mitogen-activated protein kinase 8 interacting protein 1 Names C-Jun-amino-terminal kinase-interacting protein 1 IB-1 JIP-1-related protein JNK MAP kinase scaffold protein 1 JNK-interacting protein 1 JRP islet-brain-1 mitogen activated protein kinase 8 interacting protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q24
Summary	may play a role in the SAPK mediated stress-induced cellular responses [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053777.1	NP_446229.1	C-Jun-amino-terminal kinase-interacting protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAPK8IP1	NP_005447.1
Canis lupus familiaris (dog)	MAPK8IP1	XP_005631786.1
Rattus norvegicus (Norway rat)	Mapk8ip1	NP_446229.1
Gallus gallus (chicken)	MAPK8IP1	XP_421126.4
	MAPK8IP1	XP_001113132.1
Danio rerio (zebrafish)	LOC100333948	XP_005172441.1
Bos taurus (cattle)	MAPK8IP1	NP_001095978.1
Pan troglodytes (chimpanzee)	MAPK8IP1	XP_001160866.1
Mus musculus (house mouse)	Mapk8ip1	NP_035292.2
Xenopus tropicalis (tropical clawed frog)	mapk8ip1	XP_002934139.2

Gene Ontology
Bibliography

Related articles in PubMed

Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.
Blakeslee WW, Lin YH, Stratton MS, Tatman PD, Hu T, Ferguson BS, McKinsey TA
Journal of molecular and cellular cardiology11274-82(2017 Nov)

Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.
Brajkovic S, Ferdaoussi M, Pawlowski V, Ezanno H, Plaisance V, Zmuda E, Hai T, Annicotte JS, Waeber G, Abderrahmani A
Journal of diabetes research20169158562(2016)

JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization.
Deng CY, Lei WL, Xu XH, Ju XC, Liu Y, Luo ZG
The Journal of neuroscience : the official journal of the Society for Neuroscience34(5)1710-23(2014 Jan)

The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.
Cunningham CA, Knudson KM, Peng BJ, Teixeiro E, Daniels MA
European journal of immunology43(12)3361-71(2013 Dec)

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or A? production.
Vagnoni A, Glennon EB, Perkinton MS, Gray EH, Noble W, Miller CC
Human molecular genetics22(22)4646-52(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suppression of IB1 level mimicked the harmful effects of palmitate on the beta cell survival and GSIS. Conversely, ectopic expression of IB1 counteracted the deleterious effects of palmitate on the beta cell survival and insulin secretion
Title: Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.

this study demonistrated that JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization
Title: JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization.

study found levels of JIP1 are not altered in Alzheimer's disease brains
Title: Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or A? production.

SOCS3 binds to the carboxyl terminus of C-Jun N-terminal kinase-interacting protein-1 (JIP1), increases its serine phosphorylation, and increases its binding to kinesin.
Title: Two cytokine signaling molecules co-operate to promote axonal transport and growth.

JIP1 and JIP3 play important roles in the activation of JNK during simulated ischemia-reperfusion challenge in H9c2 cells.
Title: Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusion.

The following Mapk8ip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mapk8ip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12669	NM_053777.1 Latest version!	Rattus norvegicus mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$412.30 $589.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mapk8ip1 ( NM_053777.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446229.1 Rattus norvegicus mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1), mRNA.

Price & Availability↑

CloneID	ORa12669
Clone ID Related Accession (Same CDS sequence)	NM_053777.1
Accession Version	NM_053777.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2100bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	C-Jun-amino-terminal kinase-interacting protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF109774.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF109774.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCTGG TACTGAAGAT GGATTCGAGC CCAGACAATG ACAGCTGGTT GGAGGATCAG 
TGGGAACGCT GGCTCACCCA TGATATCAGC CTGGAGGAGT TTGAGGATGA AGACCTTTCG 
GAGATCACTG ATGAGTGTGG CATCAGCCTG CAGTGCAAAG ACACCTTGTC TCTCCGGCCC 
CCGCGCGCCG GGCTACTGTC TGCGGGTAGC AGCGGTAGCG CGGGGAGCCG GCTGCAGGCG 
GAGATGCTGC AGATGGACCT GATCGACGCG GCAAGTGACA CTCCGGGCGC CGAGGACGAC 
GAAGAGGACG ACGACGAGCT CGCTGCCCAA CGGCCAGGAG TGGGGCCTTC CAAAGCCGAG 
TCTGGCCAGG AGCCGGCGTC TCGCAGCCAG GGTCAGGGCC AGGGCCCCGG CACAGGCAGC 
GGAGACACCT ACCGGCCCAA GAGGCCTACC ACGCTCAACC TTTTCCCGCA GGTGCCGCGG 
TCTCAGGACA CGCTGAATAA TAACTCTTTA GGCAAAAAGC ACAGTTGGCA GGACCGTGTG 
TCTCGATCAT CCTCCCCTCT GAAGACAGGG GAGCAGACGC CTCCACATGA ACATATCTGC 
CTGAGTGATG AGCTGCCGCC CCAGGGCAGT CCTGTTCCCA CCCAGGATCG TGGCACTTCC 
ACCGACAGCC CTTGTCGCCG TACTGCAGCC ACCCAGATGG CACCTCCAAG TGGTCCCCCT 
GCCACTGCAC CTGGTGGCCG GGGCCACTCC CATCGAGATC GAATCCACTA TCAGGCAGAT 
GTGCGGCTCG AGGCGACTGA GGAGATCTAC CTGACCCCAG TGCAGAGGCC CCCAGACCCT 
GCAGAACCCA CCTCCACCTT CTTGCCACCC ACTGAGAGCC GGATGTCTGT CAGCTCGGAT 
CCTGACCCTG CCGCTTACTC TGTAACTGCA GGGCGACCGC ACCCTTCCAT CAGTGAAGAG 
GATGAGGGCT TCGACTGTCT GTCATCCCCA GAGCAAGCTG AGCCACCAGG TGGAGGGTGG 
CGGGGAAGCC TCGGGGAGCC ACCACCGCCT CCACGGGCCT CACTGAGCTC GGACACCAGC 
GCACTGTCCT ACGACTCTGT CAAGTACACA CTGGTGGTGG ATGAGCATGC CCAGCTTGAG 
TTGGTGAGCC TGCGGCCATG TTTTGGAGAT TACAGTGACG AAAGCGACTC TGCCACTGTC 
TATGACAACT GTGCCTCTGC CTCCTCGCCC TACGAGTCAG CCATTGGTGA GGAATATGAG 
GAGGCCCCTC AACCCCGGCC TCCCACCTGC CTGTCAGAGG ACTCCACACC GGATGAGCCT 
GACGTCCACT TCTCTAAGAA GTTTCTGAAT GTCTTCATGA GTGGCCGCTC TCGTTCCTCC 
AGTGCCGAGT CCTTTGGGCT GTTCTCCTGT GTCATCAATG GGGAGGAGCA TGAGCAAACC 
CATCGGGCTA TATTCAGGTT TGTGCCTCGG CATGAAGATG AACTTGAGCT GGAAGTGGAC 
GACCCTCTGC TGGTGGAGCT GCAGGCAGAA GACTATTGGT ATGAGGCCTA TAACATGCGC 
ACTGGAGCCC GTGGTGTCTT TCCTGCCTAC TATGCCATTG AGGTCACCAA GGAGCCTGAG 
CACATGGCAG CCCTTGCCAA AAACAGCGAC TGGATTGACC AGTTCCGGGT GAAGTTCCTG 
GGCTCTGTCC AGGTTCCTTA TCACAAGGGC AATGATGTCC TCTGTGCTGC TATGCAAAAG 
ATCGCCACCA CCCGCCGGCT CACCGTGCAC TTTAACCCGC CCTCCAGCTG TGTCCTTGAA 
ATCAGCGTTA GGGGTGTCAA GATAGGTGTC AAAGCTGATG AAGCTCAGGA GGCCAAGGGA 
AATAAATGTA GCCACTTTTT CCAGCTAAAA AACATCTCTT TCTGTGGGTA CCATCCAAAG 
AACAACAAGT ACTTTGGGTT TATCACTAAG CACCCTGCTG ACCACCGGTT TGCCTGCCAT 
GTCTTTGTGT CTGAAGATTC CACCAAAGCC CTGGCAGAGT CTGTGGGGCG TGCATTTCAG 
CAGTTCTACA AGCAATTTGT GGAATATACC TGTCCTACAG AAGATATCTA CTTGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446229.1
CDS	218..2317
Translation	MQLVLKMDSSPDNDSWLEDQWERWLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAASDTPGAEDDEEDDDELAAQRPGVGPSKAESGQEPASRSQGQGQGPGTGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRGTSTDSPCRRTAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDPAEPTSTFLPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDCLSSPEQAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADEAQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE

Target ORF information:

RefSeq Version	NM_053777.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053777.1

ORF Insert Sequence:

ATGCAGCTGG TACTGAAGAT GGATTCGAGC CCAGACAATG ACAGCTGGTT GGAGGATCAG 
TGGGAACGCT GGCTCACCCA TGATATCAGC CTGGAGGAGT TTGAGGATGA AGACCTTTCG 
GAGATCACTG ATGAGTGTGG CATCAGCCTG CAGTGCAAAG ACACCTTGTC TCTCCGGCCC 
CCGCGCGCCG GGCTACTGTC TGCGGGTAGC AGCGGTAGCG CGGGGAGCCG GCTGCAGGCG 
GAGATGCTGC AGATGGACCT GATCGACGCG GCAAGTGACA CTCCGGGCGC CGAGGACGAC 
GAAGAGGACG ACGACGAGCT CGCTGCCCAA CGGCCAGGAG TGGGGCCTTC CAAAGCCGAG 
TCTGGCCAGG AGCCGGCGTC TCGCAGCCAG GGTCAGGGCC AGGGCCCCGG CACAGGCAGC 
GGAGACACCT ACCGGCCCAA GAGGCCTACC ACGCTCAACC TTTTCCCGCA GGTGCCGCGG 
TCTCAGGACA CGCTGAATAA TAACTCTTTA GGCAAAAAGC ACAGTTGGCA GGACCGTGTG 
TCTCGATCAT CCTCCCCTCT GAAGACAGGG GAGCAGACGC CTCCACATGA ACATATCTGC 
CTGAGTGATG AGCTGCCGCC CCAGGGCAGT CCTGTTCCCA CCCAGGATCG TGGCACTTCC 
ACCGACAGCC CTTGTCGCCG TACTGCAGCC ACCCAGATGG CACCTCCAAG TGGTCCCCCT 
GCCACTGCAC CTGGTGGCCG GGGCCACTCC CATCGAGATC GAATCCACTA TCAGGCAGAT 
GTGCGGCTCG AGGCGACTGA GGAGATCTAC CTGACCCCAG TGCAGAGGCC CCCAGACCCT 
GCAGAACCCA CCTCCACCTT CTTGCCACCC ACTGAGAGCC GGATGTCTGT CAGCTCGGAT 
CCTGACCCTG CCGCTTACTC TGTAACTGCA GGGCGACCGC ACCCTTCCAT CAGTGAAGAG 
GATGAGGGCT TCGACTGTCT GTCATCCCCA GAGCAAGCTG AGCCACCAGG TGGAGGGTGG 
CGGGGAAGCC TCGGGGAGCC ACCACCGCCT CCACGGGCCT CACTGAGCTC GGACACCAGC 
GCACTGTCCT ACGACTCTGT CAAGTACACA CTGGTGGTGG ATGAGCATGC CCAGCTTGAG 
TTGGTGAGCC TGCGGCCATG TTTTGGAGAT TACAGTGACG AAAGCGACTC TGCCACTGTC 
TATGACAACT GTGCCTCTGC CTCCTCGCCC TACGAGTCAG CCATTGGTGA GGAATATGAG 
GAGGCCCCTC AACCCCGGCC TCCCACCTGC CTGTCAGAGG ACTCCACACC GGATGAGCCT 
GACGTCCACT TCTCTAAGAA GTTTCTGAAT GTCTTCATGA GTGGCCGCTC TCGTTCCTCC 
AGTGCCGAGT CCTTTGGGCT GTTCTCCTGT GTCATCAATG GGGAGGAGCA TGAGCAAACC 
CATCGGGCTA TATTCAGGTT TGTGCCTCGG CATGAAGATG AACTTGAGCT GGAAGTGGAC 
GACCCTCTGC TGGTGGAGCT GCAGGCAGAA GACTATTGGT ATGAGGCCTA TAACATGCGC 
ACTGGAGCCC GTGGTGTCTT TCCTGCCTAC TATGCCATTG AGGTCACCAA GGAGCCTGAG 
CACATGGCAG CCCTTGCCAA AAACAGCGAC TGGATTGACC AGTTCCGGGT GAAGTTCCTG 
GGCTCTGTCC AGGTTCCTTA TCACAAGGGC AATGATGTCC TCTGTGCTGC TATGCAAAAG 
ATCGCCACCA CCCGCCGGCT CACCGTGCAC TTTAACCCGC CCTCCAGCTG TGTCCTTGAA 
ATCAGCGTTA GGGGTGTCAA GATAGGTGTC AAAGCTGATG AAGCTCAGGA GGCCAAGGGA 
AATAAATGTA GCCACTTTTT CCAGCTAAAA AACATCTCTT TCTGTGGGTA CCATCCAAAG 
AACAACAAGT ACTTTGGGTT TATCACTAAG CACCCTGCTG ACCACCGGTT TGCCTGCCAT 
GTCTTTGTGT CTGAAGATTC CACCAAAGCC CTGGCAGAGT CTGTGGGGCG TGCATTTCAG 
CAGTTCTACA AGCAATTTGT GGAATATACC TGTCCTACAG AAGATATCTA CTTGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.
Journal of molecular and cellular cardiology11274-82(2017 Nov)
Blakeslee WW,Lin YH,Stratton MS,Tatman PD,Hu T,Ferguson BS,McKinsey TA

Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.
Journal of diabetes research20169158562(2016)
Brajkovic S,Ferdaoussi M,Pawlowski V,Ezanno H,Plaisance V,Zmuda E,Hai T,Annicotte JS,Waeber G,Abderrahmani A

JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(5)1710-23(2014 Jan)
Deng CY,Lei WL,Xu XH,Ju XC,Liu Y,Luo ZG

The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.
European journal of immunology43(12)3361-71(2013 Dec)
Cunningham CA,Knudson KM,Peng BJ,Teixeiro E,Daniels MA

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or A? production.
Human molecular genetics22(22)4646-52(2013 Nov)
Vagnoni A,Glennon EB,Perkinton MS,Gray EH,Noble W,Miller CC

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Mapk8ip1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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