Rgs14 cDNA ORF clone, Rattus norvegicus(Norway rat)

Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain.
Squires KE, Gerber KJ, Pare JF, Branch MR, Smith Y, Hepler JR
Brain structure & function223(1)233-253(2018 Jan)

Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus.
Branch MR, Hepler JR
PloS one12(9)e0184497(2017)

Assembly and function of the regulator of G protein signaling 14 (RGS14)?H-Ras signaling complex in live cells are regulated by G?i1 and G?i-linked G protein-coupled receptors.
Vellano CP, Brown NE, Blumer JB, Hepler JR
The Journal of biological chemistry288(5)3620-31(2013 Feb)

A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
Urabe Y, Tanikawa C, Takahashi A, Okada Y, Morizono T, Tsunoda T, Kamatani N, Kohri K, Chayama K, Kubo M, Nakamura Y, Matsuda K
PLoS genetics8(3)e1002541(2012)

Results show that endogenous RGS14 localizes to subcellular compartments not previously recognized in studies of recombinant RGS14 in unnatural host cells. The two most surprising observations were that RGS14 is not enriched at the plasma membrane, and that it is found within chromatin-rich regions of the nucleus in close proximity with active RNA Pol-II.
Title: Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus.

Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.
Title: Assembly and function of the regulator of G protein signaling 14 (RGS14)?H-Ras signaling complex in live cells are regulated by G?i1 and G?i-linked G protein-coupled receptors.

RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A
Title: G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14?G?i1 complex in live cells.

RGS proteins with with GTPase-activating protein (GAP) activity affect both stress resistance and longevity in several species.
Title: Regulation of longevity by regulator of G-protein signaling protein, Loco.

RGS14 facilitates the formation of a selective Ras.GTP-Raf-MEK-ERK multiprotein complex to promote sustained ERK activation and regulate H-Ras-dependent neuritogenesis.
Title: Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.