Ankh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ankh
Entrez Gene ID	114506
Full Name	ANKH inorganic pyrophosphate transport regulator
Synonyms	Ank,SLC61A1
General protein information	Preferred Names ANKH inorganic pyrophosphate transport regulator Names progressive ankylosis protein homolog ankylosis, progressive homolog progressive ankylosis homolog solute carrier family 61 member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_053714.1	NP_446166.1	progressive ankylosis protein homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANKH	NP_473368.1
Canis lupus familiaris (dog)	ANKH	XP_005619485.1
	ANKH	XP_002804357.1
Mus musculus (house mouse)	Ank	NP_065065.3
Pan troglodytes (chimpanzee)	ANKH	XP_003310678.1
Bos taurus (cattle)	ANKH	NP_001103263.1
Rattus norvegicus (Norway rat)	Ankh	NP_446166.1
Gallus gallus (chicken)	ANKH	NP_001012580.1
Xenopus tropicalis (tropical clawed frog)	ankh	XP_002933168.1
Danio rerio (zebrafish)	ankhb	NP_919351.1

Gene Ontology
Bibliography

Related articles in PubMed

The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes.
Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Lutz MK, Dubyak GR, Ryan LM
Arthritis research & therapy15(5)R154(2013 Oct)

JNK phosphorylation promotes natural degeneration of cervical endplate chondrocytes by down-regulating expression of ANK.
Xu HG, Cheng JF, Peng HX, Lv K, Wang H, Liu P, Zhong M, Zhang MY
European review for medical and pharmacological sciences17(17)2335-44(2013 Sep)

Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression.
Zhao G, Xu MJ, Zhao MM, Dai XY, Kong W, Wilson GM, Guan Y, Wang CY, Wang X
Kidney international82(1)34-44(2012 Jul)

Intermittent Cyclic Mechanical Tension-Induced Calcification and downregulation of ankh gene expression of end plate chondrocytes.
Xu HG, Zhang XH, Wang H, Liu P, Wang LT, Zuo CJ, Tong WX, Zhang XL
Spine37(14)1192-7(2012 Jun)

Effects of mechanical strain on ANK, ENPP1 and TGF-?1 expression in rat endplate chondrocytes in vitro.
Xu HG, Hu CJ, Wang H, Liu P, Yang XM, Zhang Y, Wang LT
Molecular medicine reports4(5)831-5(2011 Sep-Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Phosphorylation of JNK promotes natural degeneration of cervical endplate chondrocytes, likely by down-regulating ANK expression
Title: JNK phosphorylation promotes natural degeneration of cervical endplate chondrocytes by down-regulating expression of ANK.

TNF-activated NF-kappaB promotes inflammation-accelerated vascular calcification by inhibiting ankylosis protein homolog expression and consequent pyrophosphate secretion.
Title: Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression.

Results show that Cyclic Mechanical Tension (ICMT) induced the calcification and downregulation of ankh gene expression of end plate chondrocytes.
Title: Intermittent Cyclic Mechanical Tension-Induced Calcification and downregulation of ankh gene expression of end plate chondrocytes.

The effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-beta1 protein expression in rat endplate chondrocytes, were investigated.
Title: Effects of mechanical strain on ANK, ENPP1 and TGF-?1 expression in rat endplate chondrocytes in vitro.

The following Ankh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ankh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10394	NM_053714.1 Latest version!	Rattus norvegicus ANKH inorganic pyrophosphate transport regulator (Ankh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ankh ( NM_053714.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446166.1 Rattus norvegicus ANKH inorganic pyrophosphate transport regulator (Ankh), mRNA.

Price & Availability↑

CloneID	ORa10394
Clone ID Related Accession (Same CDS sequence)	NM_053714.1
Accession Version	NM_053714.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	progressive ankylosis protein homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF393241.1. On Jan 12, 2005 this sequence version replaced XM_346618.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF393241.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGAAAT TCCCGGCGCT CACGCACTAC TGGCCCCTGA TCCGGTTCCT GGTGCCCCTT 
GGCATCACCA ACATAGCCAT CGACTTCGGG GAGCAGGCCT TGAACCGGGG CATTGCTGCA 
GTCAAGGAAG ATGCAGTAGA GATGCTGGCC AGCTATGGGC TGGCGTATTC TCTGATGAAG 
TTCTTCGCGG GACCCATGAG TGACTTCAAG AATGTGGGCC TGGTGTTTGT GAACAGCAAG 
AGAGACAGGG CCAAAGCTGT CCTGTGCATG GTGGTGGCCG GTGCCATTGC TGCAGTCTTC 
CACACCCTGA TAGCCTACAG TGACTTAGGG TACTACATCA TCAACAAGCT ACATCATGTG 
GACGAGTCTG TGGGGAGCAA AACACGAAGG GCCTTCCTGT ATCTCGCTGC CTTCCCTTTT 
ATGGATGCCA TGGCGTGGAC TCATGCTGGC ATTCTCTTAA AACACAAATA CAGTTTCCTG 
GTGGGATGTG CCTCAATCTC AGATGTCATA GCTCAGGTTG TGTTCGTAGC CATTTTACTT 
CACAGTCACC TGGAATGCCG AGAGCCGCTG CTCATCCCCA TCCTGTCTCT GTACATGGGT 
GCACTTGTGC GCTGTACCAC GCTGTGCCTG GGCTACTACA GGAACATCCA CGACATCATC 
CCTGACAGGA GCGGCCCAGA GCTGGGGGGC GACGCAACCA TAAGAAAGAT GCTGAGCTTC 
TGGTGGCCTC TGGCTCTGAT TCTGGCCACG CAGCGCATCA GCCGGCCCAT TGTCAACCTC 
TTTGTGTCCC GGGATCTTGG TGGCAGTTCT GCTGCTACAG AGGCAGTGGC CATTCTGACA 
GCTACCTACC CCGTGGGTCA CATGCCATAT GGCTGGTTGA CAGAAATCCG TGCTGTCTAC 
CCTGCTTTTG ACAAGAATAA CCCCAGCAAT AAACTGGCCA ACACGAACAA CACGGTCACC 
TCGGCCCACA TCAAGAAGTT CACCTTCGTC TGCATGGCAC TGTCACTGAC GCTCTGTTTT 
GTAATGTTCT GGACCCCCAA CGTCTCTGAG AAGATTTTGA TAGACATCAT TGGAGTGGAC 
TTCGCCTTTG CAGAACTCTG TGTCATTCCT CTGCGTATCT TCTCCTTCTT CCCAGTGCCA 
GTGACTGTGA GAGCTCATCT CACTGGATGG TTGATGACAC TTAAGAAAAC CTTTGTTCTG 
GCACCCAGCT CCGTGCTGCG GATCATCGTC CTCATCACCA GCCTTGTGGT TCTGCCTTAC 
CTGGGGGTGC ATGGAGCCAC ACTAGGTGTG GGCTCCCTTC TAGCAGGGTT TGTGGGAGAG 
TCTACCATGG TTGCCCTCGC AGCATGCTAT GTGTATCGGA AGCAGAAAAA GAAGATGGAG 
AATGAGTCAG CCACCGAGGG GGAAGACTCG GCCATGACCG ACATGCCTCC AGCAGAGGAG 
GTGACAGACA TCGTAGAGAT GAGAGAGGAA AATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446166.1
CDS	304..1782
Translation	MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFAGPMSDFKNVGLVFVNSKRDRAKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLANTNNTVTSAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVIPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLITSLVVLPYLGVHGATLGVGSLLAGFVGESTMVALAACYVYRKQKKKMENESATEGEDSAMTDMPPAEEVTDIVEMREENE

Target ORF information:

RefSeq Version	NM_053714.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ANKH inorganic pyrophosphate transport regulator (Ankh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053714.1

ORF Insert Sequence:

ATGGTGAAAT TCCCGGCGCT CACGCACTAC TGGCCCCTGA TCCGGTTCCT GGTGCCCCTT 
GGCATCACCA ACATAGCCAT CGACTTCGGG GAGCAGGCCT TGAACCGGGG CATTGCTGCA 
GTCAAGGAAG ATGCAGTAGA GATGCTGGCC AGCTATGGGC TGGCGTATTC TCTGATGAAG 
TTCTTCGCGG GACCCATGAG TGACTTCAAG AATGTGGGCC TGGTGTTTGT GAACAGCAAG 
AGAGACAGGG CCAAAGCTGT CCTGTGCATG GTGGTGGCCG GTGCCATTGC TGCAGTCTTC 
CACACCCTGA TAGCCTACAG TGACTTAGGG TACTACATCA TCAACAAGCT ACATCATGTG 
GACGAGTCTG TGGGGAGCAA AACACGAAGG GCCTTCCTGT ATCTCGCTGC CTTCCCTTTT 
ATGGATGCCA TGGCGTGGAC TCATGCTGGC ATTCTCTTAA AACACAAATA CAGTTTCCTG 
GTGGGATGTG CCTCAATCTC AGATGTCATA GCTCAGGTTG TGTTCGTAGC CATTTTACTT 
CACAGTCACC TGGAATGCCG AGAGCCGCTG CTCATCCCCA TCCTGTCTCT GTACATGGGT 
GCACTTGTGC GCTGTACCAC GCTGTGCCTG GGCTACTACA GGAACATCCA CGACATCATC 
CCTGACAGGA GCGGCCCAGA GCTGGGGGGC GACGCAACCA TAAGAAAGAT GCTGAGCTTC 
TGGTGGCCTC TGGCTCTGAT TCTGGCCACG CAGCGCATCA GCCGGCCCAT TGTCAACCTC 
TTTGTGTCCC GGGATCTTGG TGGCAGTTCT GCTGCTACAG AGGCAGTGGC CATTCTGACA 
GCTACCTACC CCGTGGGTCA CATGCCATAT GGCTGGTTGA CAGAAATCCG TGCTGTCTAC 
CCTGCTTTTG ACAAGAATAA CCCCAGCAAT AAACTGGCCA ACACGAACAA CACGGTCACC 
TCGGCCCACA TCAAGAAGTT CACCTTCGTC TGCATGGCAC TGTCACTGAC GCTCTGTTTT 
GTAATGTTCT GGACCCCCAA CGTCTCTGAG AAGATTTTGA TAGACATCAT TGGAGTGGAC 
TTCGCCTTTG CAGAACTCTG TGTCATTCCT CTGCGTATCT TCTCCTTCTT CCCAGTGCCA 
GTGACTGTGA GAGCTCATCT CACTGGATGG TTGATGACAC TTAAGAAAAC CTTTGTTCTG 
GCACCCAGCT CCGTGCTGCG GATCATCGTC CTCATCACCA GCCTTGTGGT TCTGCCTTAC 
CTGGGGGTGC ATGGAGCCAC ACTAGGTGTG GGCTCCCTTC TAGCAGGGTT TGTGGGAGAG 
TCTACCATGG TTGCCCTCGC AGCATGCTAT GTGTATCGGA AGCAGAAAAA GAAGATGGAG 
AATGAGTCAG CCACCGAGGG GGAAGACTCG GCCATGACCG ACATGCCTCC AGCAGAGGAG 
GTGACAGACA TCGTAGAGAT GAGAGAGGAA AATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes.
Arthritis research & therapy15(5)R154(2013 Oct)
Rosenthal AK,Gohr CM,Mitton-Fitzgerald E,Lutz MK,Dubyak GR,Ryan LM

JNK phosphorylation promotes natural degeneration of cervical endplate chondrocytes by down-regulating expression of ANK.
European review for medical and pharmacological sciences17(17)2335-44(2013 Sep)
Xu HG,Cheng JF,Peng HX,Lv K,Wang H,Liu P,Zhong M,Zhang MY

Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression.
Kidney international82(1)34-44(2012 Jul)
Zhao G,Xu MJ,Zhao MM,Dai XY,Kong W,Wilson GM,Guan Y,Wang CY,Wang X

Intermittent Cyclic Mechanical Tension-Induced Calcification and downregulation of ankh gene expression of end plate chondrocytes.
Spine37(14)1192-7(2012 Jun)
Xu HG,Zhang XH,Wang H,Liu P,Wang LT,Zuo CJ,Tong WX,Zhang XL

Effects of mechanical strain on ANK, ENPP1 and TGF-?1 expression in rat endplate chondrocytes in vitro.
Molecular medicine reports4(5)831-5(2011 Sep-Oct)
Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Ankh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報